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Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study

Context: In subjects with normal glucose tolerance (NGT) 1-hour postload plasma glucose (1-h oral glucose tolerance test [OGTT]) of >155 mg/dL predicts type 2 diabetes (T2DM) and is associated with subclinical atherosclerosis. Objective: The purpose of this study was to evaluate β-cell function, ins... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2013, Vol.98 (5), p.2100-2105
Main Author: Bianchi, Cristina
Other Authors: Miccoli, Roberto , Trombetta, Maddalena , Giorgino, Francesco , Frontoni, Simona , Faloia, Emanuela , Marchesini, Giulio , Dolci, Maria A , Cavalot, Franco , Cavallo, Gisella , Leonetti, Frida , Bonadonna, Riccardo C , Del Prato, Stefano
Format: Electronic Article Electronic Article
Language: English
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Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
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title: Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study
format: Article
creator:
  • Bianchi, Cristina
  • Miccoli, Roberto
  • Trombetta, Maddalena
  • Giorgino, Francesco
  • Frontoni, Simona
  • Faloia, Emanuela
  • Marchesini, Giulio
  • Dolci, Maria A
  • Cavalot, Franco
  • Cavallo, Gisella
  • Leonetti, Frida
  • Bonadonna, Riccardo C
  • Del Prato, Stefano
subjects:
  • Abridged Index Medicus
  • Adult
  • Beta
  • Biological and medical sciences
  • Blood Glucose - analysis
  • Body Mass Index
  • Cardiovascular Diseases - epidemiology
  • Cardiovascular Diseases - etiology
  • cell function
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 - epidemiology
  • Diabetes Mellitus, Type 2 - etiology
  • endocrine system diseases
  • Endocrinopathies
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Glucose Intolerance - blood
  • Glucose Intolerance - complications
  • Glucose Intolerance - metabolism
  • Glucose Intolerance - physiopathology
  • Glucose Tolerance Test
  • hormone antagonists
  • hormone substitutes
  • hormones
  • Humans
  • Impaired fasting glucose
  • Impaired glucose tolerance
  • Insulin - blood
  • Insulin - metabolism
  • Insulin Resistance
  • Insulin Secretion
  • Insulin-Secreting Cells - metabolism
  • Italy - epidemiology
  • Male
  • Medical sciences
  • metabolic diseases
  • Middle Aged
  • Models, Biological
  • nutritional
  • Overweight - complications
  • Prediabetes
  • Prediabetic State - blood
  • Prediabetic State - complications
  • Prediabetic State - metabolism
  • Prediabetic State - physiopathology
  • Risk
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vertebrates: endocrinology
ispartof: The journal of clinical endocrinology and metabolism, 2013, Vol.98 (5), p.2100-2105
description: Context: In subjects with normal glucose tolerance (NGT) 1-hour postload plasma glucose (1-h oral glucose tolerance test [OGTT]) of >155 mg/dL predicts type 2 diabetes (T2DM) and is associated with subclinical atherosclerosis. Objective: The purpose of this study was to evaluate β-cell function, insulin resistance, and cardiovascular risk profile in subjects with NGT with a 1-h OGTT glucose of >155 mg/dL. Patients and Methods: The GENFIEV (Genetics, PHYsiopathology, and Evolution of Type 2 diabetes) study is a multicenter study recruiting individuals at high risk of T2DM. A total of 926 subjects underwent a 75-g OGTT for assessment of plasma glucose and C-peptide for mathematical modeling of β-cell function (derivative and proportional control). Fasting insulin, lipid profile, and clinical parameters were determined as well. Results: A 1-hour OGTT glucose of >155 mg/dL was found in 39% of subjects with NGT, 76% with impaired fasting glucose (IFG), 90% with impaired glucose tolerance (IGT), and 99% and 98% with IFG + IGT or newly diagnosed T2DM, respectively. Among subjects with NGT (n = 474), those with 1-hour OGTT glucose of >155 mg/dL were more insulin-resistant and had worse β-cell function than those with 1-hour OGTT glucose of ≤155 mg/dL. Moreover, glycosylated hemoglobin, blood pressure, low-density lipoprotein cholesterol, and triglycerides were higher in subjects with NGT with 1-hour OGTT glucose of >155 mg/dL, whereas high-density lipoprotein cholesterol was lower compared with that in subjects with NGT with 1-hour OGTT glucose of ≤155 mg/dL. Compared with subjects with IGT, those with NGT with 1-hour OGTT glucose of >155 mg/dL had comparable cardiovascular risk profile and insulin resistance but slightly better β-cell function. Conclusions: Among subjects with NGT, those with 1-hour OGTT glucose of >155 mg/dL showed lower insulin sensitivity, impaired β-cell function, and worse cardiovascular risk profile and therefore are at greater risk of developing T2DM and cardiovascular disease.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleElevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study
creatorBianchi, Cristina ; Miccoli, Roberto ; Trombetta, Maddalena ; Giorgino, Francesco ; Frontoni, Simona ; Faloia, Emanuela ; Marchesini, Giulio ; Dolci, Maria A ; Cavalot, Franco ; Cavallo, Gisella ; Leonetti, Frida ; Bonadonna, Riccardo C ; Del Prato, Stefano
creatorcontribBianchi, Cristina ; Miccoli, Roberto ; Trombetta, Maddalena ; Giorgino, Francesco ; Frontoni, Simona ; Faloia, Emanuela ; Marchesini, Giulio ; Dolci, Maria A ; Cavalot, Franco ; Cavallo, Gisella ; Leonetti, Frida ; Bonadonna, Riccardo C ; Del Prato, Stefano ; GENFIEV Investigators ; on behalf of the GENFIEV Investigators
descriptionContext: In subjects with normal glucose tolerance (NGT) 1-hour postload plasma glucose (1-h oral glucose tolerance test [OGTT]) of >155 mg/dL predicts type 2 diabetes (T2DM) and is associated with subclinical atherosclerosis. Objective: The purpose of this study was to evaluate β-cell function, insulin resistance, and cardiovascular risk profile in subjects with NGT with a 1-h OGTT glucose of >155 mg/dL. Patients and Methods: The GENFIEV (Genetics, PHYsiopathology, and Evolution of Type 2 diabetes) study is a multicenter study recruiting individuals at high risk of T2DM. A total of 926 subjects underwent a 75-g OGTT for assessment of plasma glucose and C-peptide for mathematical modeling of β-cell function (derivative and proportional control). Fasting insulin, lipid profile, and clinical parameters were determined as well. Results: A 1-hour OGTT glucose of >155 mg/dL was found in 39% of subjects with NGT, 76% with impaired fasting glucose (IFG), 90% with impaired glucose tolerance (IGT), and 99% and 98% with IFG + IGT or newly diagnosed T2DM, respectively. Among subjects with NGT (n = 474), those with 1-hour OGTT glucose of >155 mg/dL were more insulin-resistant and had worse β-cell function than those with 1-hour OGTT glucose of ≤155 mg/dL. Moreover, glycosylated hemoglobin, blood pressure, low-density lipoprotein cholesterol, and triglycerides were higher in subjects with NGT with 1-hour OGTT glucose of >155 mg/dL, whereas high-density lipoprotein cholesterol was lower compared with that in subjects with NGT with 1-hour OGTT glucose of ≤155 mg/dL. Compared with subjects with IGT, those with NGT with 1-hour OGTT glucose of >155 mg/dL had comparable cardiovascular risk profile and insulin resistance but slightly better β-cell function. Conclusions: Among subjects with NGT, those with 1-hour OGTT glucose of >155 mg/dL showed lower insulin sensitivity, impaired β-cell function, and worse cardiovascular risk profile and therefore are at greater risk of developing T2DM and cardiovascular disease.
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0ISSN: 0021-972X
1EISSN: 1945-7197
2DOI: 10.1210/jc.2012-3971
3PMID: 23539736
4CODEN: JCEMAZ
languageeng
publisherBethesda, MD: Endocrine Society
subjectAbridged Index Medicus ; Adult ; Beta ; Biological and medical sciences ; Blood Glucose - analysis ; Body Mass Index ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; cell function ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; endocrine system diseases ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Intolerance - blood ; Glucose Intolerance - complications ; Glucose Intolerance - metabolism ; Glucose Intolerance - physiopathology ; Glucose Tolerance Test ; hormone antagonists ; hormone substitutes ; hormones ; Humans ; Impaired fasting glucose ; Impaired glucose tolerance ; Insulin - blood ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; Insulin-Secreting Cells - metabolism ; Italy - epidemiology ; Male ; Medical sciences ; metabolic diseases ; Middle Aged ; Models, Biological ; nutritional ; Overweight - complications ; Prediabetes ; Prediabetic State - blood ; Prediabetic State - complications ; Prediabetic State - metabolism ; Prediabetic State - physiopathology ; Risk ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology
ispartofThe journal of clinical endocrinology and metabolism, 2013, Vol.98 (5), p.2100-2105
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0Bianchi, Cristina
1Miccoli, Roberto
2Trombetta, Maddalena
3Giorgino, Francesco
4Frontoni, Simona
5Faloia, Emanuela
6Marchesini, Giulio
7Dolci, Maria A
8Cavalot, Franco
9Cavallo, Gisella
10Leonetti, Frida
11Bonadonna, Riccardo C
12Del Prato, Stefano
13GENFIEV Investigators
14on behalf of the GENFIEV Investigators
title
0Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
descriptionContext: In subjects with normal glucose tolerance (NGT) 1-hour postload plasma glucose (1-h oral glucose tolerance test [OGTT]) of >155 mg/dL predicts type 2 diabetes (T2DM) and is associated with subclinical atherosclerosis. Objective: The purpose of this study was to evaluate β-cell function, insulin resistance, and cardiovascular risk profile in subjects with NGT with a 1-h OGTT glucose of >155 mg/dL. Patients and Methods: The GENFIEV (Genetics, PHYsiopathology, and Evolution of Type 2 diabetes) study is a multicenter study recruiting individuals at high risk of T2DM. A total of 926 subjects underwent a 75-g OGTT for assessment of plasma glucose and C-peptide for mathematical modeling of β-cell function (derivative and proportional control). Fasting insulin, lipid profile, and clinical parameters were determined as well. Results: A 1-hour OGTT glucose of >155 mg/dL was found in 39% of subjects with NGT, 76% with impaired fasting glucose (IFG), 90% with impaired glucose tolerance (IGT), and 99% and 98% with IFG + IGT or newly diagnosed T2DM, respectively. Among subjects with NGT (n = 474), those with 1-hour OGTT glucose of >155 mg/dL were more insulin-resistant and had worse β-cell function than those with 1-hour OGTT glucose of ≤155 mg/dL. Moreover, glycosylated hemoglobin, blood pressure, low-density lipoprotein cholesterol, and triglycerides were higher in subjects with NGT with 1-hour OGTT glucose of >155 mg/dL, whereas high-density lipoprotein cholesterol was lower compared with that in subjects with NGT with 1-hour OGTT glucose of ≤155 mg/dL. Compared with subjects with IGT, those with NGT with 1-hour OGTT glucose of >155 mg/dL had comparable cardiovascular risk profile and insulin resistance but slightly better β-cell function. Conclusions: Among subjects with NGT, those with 1-hour OGTT glucose of >155 mg/dL showed lower insulin sensitivity, impaired β-cell function, and worse cardiovascular risk profile and therefore are at greater risk of developing T2DM and cardiovascular disease.
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0Abridged Index Medicus
1Adult
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4Blood Glucose - analysis
5Body Mass Index
6Cardiovascular Diseases - epidemiology
7Cardiovascular Diseases - etiology
8cell function
9Cross-Sectional Studies
10Diabetes Mellitus, Type 2 - epidemiology
11Diabetes Mellitus, Type 2 - etiology
12endocrine system diseases
13Endocrinopathies
14Feeding. Feeding behavior
15Female
16Fundamental and applied biological sciences. Psychology
17Glucose Intolerance - blood
18Glucose Intolerance - complications
19Glucose Intolerance - metabolism
20Glucose Intolerance - physiopathology
21Glucose Tolerance Test
22hormone antagonists
23hormone substitutes
24hormones
25Humans
26Impaired fasting glucose
27Impaired glucose tolerance
28Insulin - blood
29Insulin - metabolism
30Insulin Resistance
31Insulin Secretion
32Insulin-Secreting Cells - metabolism
33Italy - epidemiology
34Male
35Medical sciences
36metabolic diseases
37Middle Aged
38Models, Biological
39nutritional
40Overweight - complications
41Prediabetes
42Prediabetic State - blood
43Prediabetic State - complications
44Prediabetic State - metabolism
45Prediabetic State - physiopathology
46Risk
47Vertebrates: anatomy and physiology, studies on body, several organs or systems
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2Trombetta, Maddalena
3Giorgino, Francesco
4Frontoni, Simona
5Faloia, Emanuela
6Marchesini, Giulio
7Dolci, Maria A
8Cavalot, Franco
9Cavallo, Gisella
10Leonetti, Frida
11Bonadonna, Riccardo C
12Del Prato, Stefano
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titleElevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study
authorBianchi, Cristina ; Miccoli, Roberto ; Trombetta, Maddalena ; Giorgino, Francesco ; Frontoni, Simona ; Faloia, Emanuela ; Marchesini, Giulio ; Dolci, Maria A ; Cavalot, Franco ; Cavallo, Gisella ; Leonetti, Frida ; Bonadonna, Riccardo C ; Del Prato, Stefano
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0Abridged Index Medicus
1Adult
2Beta
3Biological and medical sciences
4Blood Glucose - analysis
5Body Mass Index
6Cardiovascular Diseases - epidemiology
7Cardiovascular Diseases - etiology
8cell function
9Cross-Sectional Studies
10Diabetes Mellitus, Type 2 - epidemiology
11Diabetes Mellitus, Type 2 - etiology
12endocrine system diseases
13Endocrinopathies
14Feeding. Feeding behavior
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16Fundamental and applied biological sciences. Psychology
17Glucose Intolerance - blood
18Glucose Intolerance - complications
19Glucose Intolerance - metabolism
20Glucose Intolerance - physiopathology
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23hormone substitutes
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35Medical sciences
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42Prediabetic State - blood
43Prediabetic State - complications
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45Prediabetic State - physiopathology
46Risk
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48Vertebrates: endocrinology
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1Miccoli, Roberto
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3Giorgino, Francesco
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5Faloia, Emanuela
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7Dolci, Maria A
8Cavalot, Franco
9Cavallo, Gisella
10Leonetti, Frida
11Bonadonna, Riccardo C
12Del Prato, Stefano
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7Dolci, Maria A
8Cavalot, Franco
9Cavallo, Gisella
10Leonetti, Frida
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atitleElevated 1-Hour Postload Plasma Glucose Levels Identify Subjects With Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study
jtitleThe journal of clinical endocrinology and metabolism
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abstractContext: In subjects with normal glucose tolerance (NGT) 1-hour postload plasma glucose (1-h oral glucose tolerance test [OGTT]) of >155 mg/dL predicts type 2 diabetes (T2DM) and is associated with subclinical atherosclerosis. Objective: The purpose of this study was to evaluate β-cell function, insulin resistance, and cardiovascular risk profile in subjects with NGT with a 1-h OGTT glucose of >155 mg/dL. Patients and Methods: The GENFIEV (Genetics, PHYsiopathology, and Evolution of Type 2 diabetes) study is a multicenter study recruiting individuals at high risk of T2DM. A total of 926 subjects underwent a 75-g OGTT for assessment of plasma glucose and C-peptide for mathematical modeling of β-cell function (derivative and proportional control). Fasting insulin, lipid profile, and clinical parameters were determined as well. Results: A 1-hour OGTT glucose of >155 mg/dL was found in 39% of subjects with NGT, 76% with impaired fasting glucose (IFG), 90% with impaired glucose tolerance (IGT), and 99% and 98% with IFG + IGT or newly diagnosed T2DM, respectively. Among subjects with NGT (n = 474), those with 1-hour OGTT glucose of >155 mg/dL were more insulin-resistant and had worse β-cell function than those with 1-hour OGTT glucose of ≤155 mg/dL. Moreover, glycosylated hemoglobin, blood pressure, low-density lipoprotein cholesterol, and triglycerides were higher in subjects with NGT with 1-hour OGTT glucose of >155 mg/dL, whereas high-density lipoprotein cholesterol was lower compared with that in subjects with NGT with 1-hour OGTT glucose of ≤155 mg/dL. Compared with subjects with IGT, those with NGT with 1-hour OGTT glucose of >155 mg/dL had comparable cardiovascular risk profile and insulin resistance but slightly better β-cell function. Conclusions: Among subjects with NGT, those with 1-hour OGTT glucose of >155 mg/dL showed lower insulin sensitivity, impaired β-cell function, and worse cardiovascular risk profile and therefore are at greater risk of developing T2DM and cardiovascular disease.
copBethesda, MD
pubEndocrine Society
pmid23539736
doi10.1210/jc.2012-3971
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