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Osteopontin in bone mineral density of very old Brazilians

Recent evidence suggests that changes in plasma levels of osteopontin (OPN) may be a promising marker for early diagnosis of bone disorders. We hypothesized that a frequent OPN gene polymorphism may be useful for identifying very old individuals with alterations in plasma OPN levels and consequently... Full description

Journal Title: Journal of bone and mineral metabolism 2013-03-21, Vol.31 (4), p.449-454
Main Author: Souza, Vinícius C
Other Authors: Freitas, Wladimir M , Quaglia, Luiz A , Santos, Simone N , Córdova, Cláudio , Sposito, Andrei C , Nóbrega, Otávio T
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Tokyo: Springer Japan
ID: ISSN: 0914-8779
Link: https://www.ncbi.nlm.nih.gov/pubmed/23515922
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title: Osteopontin in bone mineral density of very old Brazilians
format: Article
creator:
  • Souza, Vinícius C
  • Freitas, Wladimir M
  • Quaglia, Luiz A
  • Santos, Simone N
  • Córdova, Cláudio
  • Sposito, Andrei C
  • Nóbrega, Otávio T
subjects:
  • Aged, 80 and over
  • Analysis
  • Anthropometry
  • Autoimmunity
  • Body Mass Index
  • Bone Density - genetics
  • Bones
  • Brazil
  • Density
  • Enzyme-linked immunosorbent assay
  • Enzymes
  • Female
  • Genes
  • Humans
  • Male
  • Medical colleges
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Original Article
  • Orthopedics
  • Osteopontin - blood
  • Osteopontin - genetics
  • Osteoporosis
  • Polymorphism, Single Nucleotide - genetics
ispartof: Journal of bone and mineral metabolism, 2013-03-21, Vol.31 (4), p.449-454
description: Recent evidence suggests that changes in plasma levels of osteopontin (OPN) may be a promising marker for early diagnosis of bone disorders. We hypothesized that a frequent OPN gene polymorphism may be useful for identifying very old individuals with alterations in plasma OPN levels and consequently at risk of abnormal bone density scores. Men and women (80 years or older) living in the Brazilian Federal District underwent assessments with dual energy X-ray absorptiometry for bone mineral density (BMD) of the femoral neck, femoral head and lumbosacral (L1 to S5) regions. Clinical inspection was performed to assess other physical traits and to exclude co-morbidities (cardiovascular, autoimmunity, infections or neoplastic diseases). Serum concentrations of OPN were determined with an enzyme-linked immunosorbent assay, whereas the A7385G polymorphism (rs1126772) was determined by direct sequencing of a polymerase chain reaction product. Among the two hundred and ten subjects enrolled, no differential scores for bone mineral density could be observed across genotypes, but a greater content of circulating OPN was found among carriers of the A allele ( P  ≤ 0.05) even after adjustments. Serum OPN levels were negatively correlated with femoral neck density ( P  = 0.050 for BMD; P  = 0.032 for T scores) but not with scores of the other regions investigated. Analyses with the sample dichotomized to age and body mass revealed that this inverse relationship was noticeable only among those aged within the highest and weighing within the lowest intervals. Our findings indicate elevated circulating osteopontin levels in patients with decreased bone mineral density, consistent with a modest contribution of an OPN allelic variation to its expression. Assessing the clinical relevance of our findings demands forthcoming studies.
language: eng
source:
identifier: ISSN: 0914-8779
fulltext: no_fulltext
issn:
  • 0914-8779
  • 1435-5604
url: Link


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titleOsteopontin in bone mineral density of very old Brazilians
creatorSouza, Vinícius C ; Freitas, Wladimir M ; Quaglia, Luiz A ; Santos, Simone N ; Córdova, Cláudio ; Sposito, Andrei C ; Nóbrega, Otávio T
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descriptionRecent evidence suggests that changes in plasma levels of osteopontin (OPN) may be a promising marker for early diagnosis of bone disorders. We hypothesized that a frequent OPN gene polymorphism may be useful for identifying very old individuals with alterations in plasma OPN levels and consequently at risk of abnormal bone density scores. Men and women (80 years or older) living in the Brazilian Federal District underwent assessments with dual energy X-ray absorptiometry for bone mineral density (BMD) of the femoral neck, femoral head and lumbosacral (L1 to S5) regions. Clinical inspection was performed to assess other physical traits and to exclude co-morbidities (cardiovascular, autoimmunity, infections or neoplastic diseases). Serum concentrations of OPN were determined with an enzyme-linked immunosorbent assay, whereas the A7385G polymorphism (rs1126772) was determined by direct sequencing of a polymerase chain reaction product. Among the two hundred and ten subjects enrolled, no differential scores for bone mineral density could be observed across genotypes, but a greater content of circulating OPN was found among carriers of the A allele ( P  ≤ 0.05) even after adjustments. Serum OPN levels were negatively correlated with femoral neck density ( P  = 0.050 for BMD; P  = 0.032 for T scores) but not with scores of the other regions investigated. Analyses with the sample dichotomized to age and body mass revealed that this inverse relationship was noticeable only among those aged within the highest and weighing within the lowest intervals. Our findings indicate elevated circulating osteopontin levels in patients with decreased bone mineral density, consistent with a modest contribution of an OPN allelic variation to its expression. Assessing the clinical relevance of our findings demands forthcoming studies.
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subjectAged, 80 and over ; Analysis ; Anthropometry ; Autoimmunity ; Body Mass Index ; Bone Density - genetics ; Bones ; Brazil ; Density ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; Genes ; Humans ; Male ; Medical colleges ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article ; Orthopedics ; Osteopontin - blood ; Osteopontin - genetics ; Osteoporosis ; Polymorphism, Single Nucleotide - genetics
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descriptionRecent evidence suggests that changes in plasma levels of osteopontin (OPN) may be a promising marker for early diagnosis of bone disorders. We hypothesized that a frequent OPN gene polymorphism may be useful for identifying very old individuals with alterations in plasma OPN levels and consequently at risk of abnormal bone density scores. Men and women (80 years or older) living in the Brazilian Federal District underwent assessments with dual energy X-ray absorptiometry for bone mineral density (BMD) of the femoral neck, femoral head and lumbosacral (L1 to S5) regions. Clinical inspection was performed to assess other physical traits and to exclude co-morbidities (cardiovascular, autoimmunity, infections or neoplastic diseases). Serum concentrations of OPN were determined with an enzyme-linked immunosorbent assay, whereas the A7385G polymorphism (rs1126772) was determined by direct sequencing of a polymerase chain reaction product. Among the two hundred and ten subjects enrolled, no differential scores for bone mineral density could be observed across genotypes, but a greater content of circulating OPN was found among carriers of the A allele ( P  ≤ 0.05) even after adjustments. Serum OPN levels were negatively correlated with femoral neck density ( P  = 0.050 for BMD; P  = 0.032 for T scores) but not with scores of the other regions investigated. Analyses with the sample dichotomized to age and body mass revealed that this inverse relationship was noticeable only among those aged within the highest and weighing within the lowest intervals. Our findings indicate elevated circulating osteopontin levels in patients with decreased bone mineral density, consistent with a modest contribution of an OPN allelic variation to its expression. Assessing the clinical relevance of our findings demands forthcoming studies.
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authorSouza, Vinícius C ; Freitas, Wladimir M ; Quaglia, Luiz A ; Santos, Simone N ; Córdova, Cláudio ; Sposito, Andrei C ; Nóbrega, Otávio T
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abstractRecent evidence suggests that changes in plasma levels of osteopontin (OPN) may be a promising marker for early diagnosis of bone disorders. We hypothesized that a frequent OPN gene polymorphism may be useful for identifying very old individuals with alterations in plasma OPN levels and consequently at risk of abnormal bone density scores. Men and women (80 years or older) living in the Brazilian Federal District underwent assessments with dual energy X-ray absorptiometry for bone mineral density (BMD) of the femoral neck, femoral head and lumbosacral (L1 to S5) regions. Clinical inspection was performed to assess other physical traits and to exclude co-morbidities (cardiovascular, autoimmunity, infections or neoplastic diseases). Serum concentrations of OPN were determined with an enzyme-linked immunosorbent assay, whereas the A7385G polymorphism (rs1126772) was determined by direct sequencing of a polymerase chain reaction product. Among the two hundred and ten subjects enrolled, no differential scores for bone mineral density could be observed across genotypes, but a greater content of circulating OPN was found among carriers of the A allele ( P  ≤ 0.05) even after adjustments. Serum OPN levels were negatively correlated with femoral neck density ( P  = 0.050 for BMD; P  = 0.032 for T scores) but not with scores of the other regions investigated. Analyses with the sample dichotomized to age and body mass revealed that this inverse relationship was noticeable only among those aged within the highest and weighing within the lowest intervals. Our findings indicate elevated circulating osteopontin levels in patients with decreased bone mineral density, consistent with a modest contribution of an OPN allelic variation to its expression. Assessing the clinical relevance of our findings demands forthcoming studies.
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