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Dim Light at Night Exaggerates Weight Gain and Inflammation Associated With a High-Fat Diet in Male Mice

Elevated nighttime light exposure is associated with symptoms of metabolic syndrome. In industrialized societies, high-fat diet (HFD) and exposure to light at night (LAN) often cooccur and may contribute to the increasing obesity epidemic. Thus, we hypothesized that dim LAN (dLAN) would provoke addi... Full description

Journal Title: Endocrinology (Philadelphia) 2013-10, Vol.154 (10), p.3817-3825
Main Author: Fonken, Laura K
Other Authors: Lieberman, Rebecca A , Weil, Zachary M , Nelson, Randy J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Chevy Chase, MD: Endocrine Society
ID: ISSN: 0013-7227
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recordid: cdi_proquest_miscellaneous_1435844486
title: Dim Light at Night Exaggerates Weight Gain and Inflammation Associated With a High-Fat Diet in Male Mice
format: Article
creator:
  • Fonken, Laura K
  • Lieberman, Rebecca A
  • Weil, Zachary M
  • Nelson, Randy J
subjects:
  • Abridged Index Medicus
  • Adipose Tissue, White - immunology
  • Adipose Tissue, White - metabolism
  • Adipose Tissue, White - pathology
  • Animals
  • Appetite Regulation - radiation effects
  • Arcuate Nucleus of Hypothalamus - immunology
  • Arcuate Nucleus of Hypothalamus - metabolism
  • Arcuate Nucleus of Hypothalamus - pathology
  • Behavior, Animal - radiation effects
  • Biological and medical sciences
  • CD11b Antigen - biosynthesis
  • CD11b Antigen - genetics
  • CD11b Antigen - metabolism
  • Circadian Rhythm
  • Cytokines - biosynthesis
  • Cytokines - genetics
  • Cytokines - metabolism
  • Diet, High-Fat - adverse effects
  • Feeding Behavior - radiation effects
  • Fundamental and applied biological sciences. Psychology
  • Gene Expression Regulation
  • Glucose Intolerance - etiology
  • Glucose Intolerance - immunology
  • Glucose Intolerance - metabolism
  • Glucose Intolerance - pathology
  • I-kappa B Kinase - biosynthesis
  • I-kappa B Kinase - genetics
  • I-kappa B Kinase - metabolism
  • Insulin Resistance
  • Lighting - adverse effects
  • Male
  • Mice
  • Microglia - immunology
  • Microglia - metabolism
  • Microglia - pathology
  • Nerve Tissue Proteins - biosynthesis
  • Nerve Tissue Proteins - genetics
  • Nerve Tissue Proteins - metabolism
  • Obesity - etiology
  • Obesity - immunology
  • Obesity - metabolism
  • Obesity - pathology
  • Random Allocation
  • Vertebrates: endocrinology
  • Weight Gain
ispartof: Endocrinology (Philadelphia), 2013-10, Vol.154 (10), p.3817-3825
description: Elevated nighttime light exposure is associated with symptoms of metabolic syndrome. In industrialized societies, high-fat diet (HFD) and exposure to light at night (LAN) often cooccur and may contribute to the increasing obesity epidemic. Thus, we hypothesized that dim LAN (dLAN) would provoke additional and sustained body mass gain in mice on a HFD. Male mice were housed in either a standard light/dark cycle or dLAN and fed either chow or HFD. Exposure to dLAN and HFD increase weight gain, reduce glucose tolerance, and alter insulin secretion as compared with light/dark cycle and chow, respectively. The effects of dLAN and HFD appear additive, because mice exposed to dLAN that were fed HFD display the greatest increases in body mass. Exposure to both dLAN and HFD also change the timing of food intake and increase TNFα and MAC1 gene expression in white adipose tissue after 4 experimental weeks. Changes in MAC1 gene expression occur more rapidly due to HFD as compared with dLAN; after 5 days of experimental conditions, mice fed HFD already increase MAC1 gene expression in white adipose tissue. HFD also elevates microglia activation in the arcuate nucleus of the hypothalamus and hypothalamic TNFα, IL-6, and Ikbkb gene expression. Microglia activation is increased by dLAN, but only among chow-fed mice and dLAN does not affect inflammatory gene expression. These results suggest that dLAN exaggerates weight gain and peripheral inflammation associated with HFD.
language: eng
source:
identifier: ISSN: 0013-7227
fulltext: no_fulltext
issn:
  • 0013-7227
  • 1945-7170
url: Link


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titleDim Light at Night Exaggerates Weight Gain and Inflammation Associated With a High-Fat Diet in Male Mice
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descriptionElevated nighttime light exposure is associated with symptoms of metabolic syndrome. In industrialized societies, high-fat diet (HFD) and exposure to light at night (LAN) often cooccur and may contribute to the increasing obesity epidemic. Thus, we hypothesized that dim LAN (dLAN) would provoke additional and sustained body mass gain in mice on a HFD. Male mice were housed in either a standard light/dark cycle or dLAN and fed either chow or HFD. Exposure to dLAN and HFD increase weight gain, reduce glucose tolerance, and alter insulin secretion as compared with light/dark cycle and chow, respectively. The effects of dLAN and HFD appear additive, because mice exposed to dLAN that were fed HFD display the greatest increases in body mass. Exposure to both dLAN and HFD also change the timing of food intake and increase TNFα and MAC1 gene expression in white adipose tissue after 4 experimental weeks. Changes in MAC1 gene expression occur more rapidly due to HFD as compared with dLAN; after 5 days of experimental conditions, mice fed HFD already increase MAC1 gene expression in white adipose tissue. HFD also elevates microglia activation in the arcuate nucleus of the hypothalamus and hypothalamic TNFα, IL-6, and Ikbkb gene expression. Microglia activation is increased by dLAN, but only among chow-fed mice and dLAN does not affect inflammatory gene expression. These results suggest that dLAN exaggerates weight gain and peripheral inflammation associated with HFD.
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subjectAbridged Index Medicus ; Adipose Tissue, White - immunology ; Adipose Tissue, White - metabolism ; Adipose Tissue, White - pathology ; Animals ; Appetite Regulation - radiation effects ; Arcuate Nucleus of Hypothalamus - immunology ; Arcuate Nucleus of Hypothalamus - metabolism ; Arcuate Nucleus of Hypothalamus - pathology ; Behavior, Animal - radiation effects ; Biological and medical sciences ; CD11b Antigen - biosynthesis ; CD11b Antigen - genetics ; CD11b Antigen - metabolism ; Circadian Rhythm ; Cytokines - biosynthesis ; Cytokines - genetics ; Cytokines - metabolism ; Diet, High-Fat - adverse effects ; Feeding Behavior - radiation effects ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Glucose Intolerance - etiology ; Glucose Intolerance - immunology ; Glucose Intolerance - metabolism ; Glucose Intolerance - pathology ; I-kappa B Kinase - biosynthesis ; I-kappa B Kinase - genetics ; I-kappa B Kinase - metabolism ; Insulin Resistance ; Lighting - adverse effects ; Male ; Mice ; Microglia - immunology ; Microglia - metabolism ; Microglia - pathology ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Obesity - etiology ; Obesity - immunology ; Obesity - metabolism ; Obesity - pathology ; Random Allocation ; Vertebrates: endocrinology ; Weight Gain
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1Lieberman, Rebecca A
2Weil, Zachary M
3Nelson, Randy J
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0Dim Light at Night Exaggerates Weight Gain and Inflammation Associated With a High-Fat Diet in Male Mice
1Endocrinology (Philadelphia)
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descriptionElevated nighttime light exposure is associated with symptoms of metabolic syndrome. In industrialized societies, high-fat diet (HFD) and exposure to light at night (LAN) often cooccur and may contribute to the increasing obesity epidemic. Thus, we hypothesized that dim LAN (dLAN) would provoke additional and sustained body mass gain in mice on a HFD. Male mice were housed in either a standard light/dark cycle or dLAN and fed either chow or HFD. Exposure to dLAN and HFD increase weight gain, reduce glucose tolerance, and alter insulin secretion as compared with light/dark cycle and chow, respectively. The effects of dLAN and HFD appear additive, because mice exposed to dLAN that were fed HFD display the greatest increases in body mass. Exposure to both dLAN and HFD also change the timing of food intake and increase TNFα and MAC1 gene expression in white adipose tissue after 4 experimental weeks. Changes in MAC1 gene expression occur more rapidly due to HFD as compared with dLAN; after 5 days of experimental conditions, mice fed HFD already increase MAC1 gene expression in white adipose tissue. HFD also elevates microglia activation in the arcuate nucleus of the hypothalamus and hypothalamic TNFα, IL-6, and Ikbkb gene expression. Microglia activation is increased by dLAN, but only among chow-fed mice and dLAN does not affect inflammatory gene expression. These results suggest that dLAN exaggerates weight gain and peripheral inflammation associated with HFD.
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0Abridged Index Medicus
1Adipose Tissue, White - immunology
2Adipose Tissue, White - metabolism
3Adipose Tissue, White - pathology
4Animals
5Appetite Regulation - radiation effects
6Arcuate Nucleus of Hypothalamus - immunology
7Arcuate Nucleus of Hypothalamus - metabolism
8Arcuate Nucleus of Hypothalamus - pathology
9Behavior, Animal - radiation effects
10Biological and medical sciences
11CD11b Antigen - biosynthesis
12CD11b Antigen - genetics
13CD11b Antigen - metabolism
14Circadian Rhythm
15Cytokines - biosynthesis
16Cytokines - genetics
17Cytokines - metabolism
18Diet, High-Fat - adverse effects
19Feeding Behavior - radiation effects
20Fundamental and applied biological sciences. Psychology
21Gene Expression Regulation
22Glucose Intolerance - etiology
23Glucose Intolerance - immunology
24Glucose Intolerance - metabolism
25Glucose Intolerance - pathology
26I-kappa B Kinase - biosynthesis
27I-kappa B Kinase - genetics
28I-kappa B Kinase - metabolism
29Insulin Resistance
30Lighting - adverse effects
31Male
32Mice
33Microglia - immunology
34Microglia - metabolism
35Microglia - pathology
36Nerve Tissue Proteins - biosynthesis
37Nerve Tissue Proteins - genetics
38Nerve Tissue Proteins - metabolism
39Obesity - etiology
40Obesity - immunology
41Obesity - metabolism
42Obesity - pathology
43Random Allocation
44Vertebrates: endocrinology
45Weight Gain
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titleDim Light at Night Exaggerates Weight Gain and Inflammation Associated With a High-Fat Diet in Male Mice
authorFonken, Laura K ; Lieberman, Rebecca A ; Weil, Zachary M ; Nelson, Randy J
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1Adipose Tissue, White - immunology
2Adipose Tissue, White - metabolism
3Adipose Tissue, White - pathology
4Animals
5Appetite Regulation - radiation effects
6Arcuate Nucleus of Hypothalamus - immunology
7Arcuate Nucleus of Hypothalamus - metabolism
8Arcuate Nucleus of Hypothalamus - pathology
9Behavior, Animal - radiation effects
10Biological and medical sciences
11CD11b Antigen - biosynthesis
12CD11b Antigen - genetics
13CD11b Antigen - metabolism
14Circadian Rhythm
15Cytokines - biosynthesis
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18Diet, High-Fat - adverse effects
19Feeding Behavior - radiation effects
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22Glucose Intolerance - etiology
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24Glucose Intolerance - metabolism
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26I-kappa B Kinase - biosynthesis
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28I-kappa B Kinase - metabolism
29Insulin Resistance
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36Nerve Tissue Proteins - biosynthesis
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38Nerve Tissue Proteins - metabolism
39Obesity - etiology
40Obesity - immunology
41Obesity - metabolism
42Obesity - pathology
43Random Allocation
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abstractElevated nighttime light exposure is associated with symptoms of metabolic syndrome. In industrialized societies, high-fat diet (HFD) and exposure to light at night (LAN) often cooccur and may contribute to the increasing obesity epidemic. Thus, we hypothesized that dim LAN (dLAN) would provoke additional and sustained body mass gain in mice on a HFD. Male mice were housed in either a standard light/dark cycle or dLAN and fed either chow or HFD. Exposure to dLAN and HFD increase weight gain, reduce glucose tolerance, and alter insulin secretion as compared with light/dark cycle and chow, respectively. The effects of dLAN and HFD appear additive, because mice exposed to dLAN that were fed HFD display the greatest increases in body mass. Exposure to both dLAN and HFD also change the timing of food intake and increase TNFα and MAC1 gene expression in white adipose tissue after 4 experimental weeks. Changes in MAC1 gene expression occur more rapidly due to HFD as compared with dLAN; after 5 days of experimental conditions, mice fed HFD already increase MAC1 gene expression in white adipose tissue. HFD also elevates microglia activation in the arcuate nucleus of the hypothalamus and hypothalamic TNFα, IL-6, and Ikbkb gene expression. Microglia activation is increased by dLAN, but only among chow-fed mice and dLAN does not affect inflammatory gene expression. These results suggest that dLAN exaggerates weight gain and peripheral inflammation associated with HFD.
copChevy Chase, MD
pubEndocrine Society
pmid23861373
doi10.1210/en.2013-1121
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