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NMDA receptor antagonists distort visual grouping in rats performing a modified two-choice visual discrimination task

Rationale Visual perception is impaired during pathological psychosis, which can be mimicked by NMDA receptor antagonists. However, the underlying mechanisms are poorly understood, partly due to limits of current rodent models for visual integration. Objectives The objectives of the study are (1) to... Full description

Journal Title: Psychopharmacology 2013-05-07, Vol.229 (4), p.627-637
Main Author: Ward, Katja Clarissa
Other Authors: Khattak, Halima Zainab , Richardson, Louise , Lee, Jonathan Loon Choon , Vreugdenhil, Martin
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0033-3158
Link: https://www.ncbi.nlm.nih.gov/pubmed/23649884
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recordid: cdi_proquest_miscellaneous_1443375470
title: NMDA receptor antagonists distort visual grouping in rats performing a modified two-choice visual discrimination task
format: Article
creator:
  • Ward, Katja Clarissa
  • Khattak, Halima Zainab
  • Richardson, Louise
  • Lee, Jonathan Loon Choon
  • Vreugdenhil, Martin
subjects:
  • Animals
  • Biomedical and Life Sciences
  • Biomedicine
  • Choice Behavior - drug effects
  • Discrimination Learning - drug effects
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug therapy
  • Excitatory Amino Acid Antagonists - administration & dosage
  • Excitatory Amino Acid Antagonists - pharmacology
  • Impulsive Behavior - chemically induced
  • Ketamine
  • Ketamine - administration & dosage
  • Ketamine - pharmacology
  • Male
  • Memory - drug effects
  • Methyl aspartate
  • Neurons
  • Neurosciences
  • Operant conditioning
  • Original Investigation
  • Pharmacology/Toxicology
  • Phencyclidine
  • Phencyclidine - administration & dosage
  • Phencyclidine - pharmacology
  • Physiological aspects
  • Psychiatry
  • Psychological aspects
  • Psychometrics
  • Psychotic Disorders - physiopathology
  • Rats
  • Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
  • Stereotyped Behavior - drug effects
  • Visual perception
  • Visual Perception - drug effects
  • Visual task performance
ispartof: Psychopharmacology, 2013-05-07, Vol.229 (4), p.627-637
description: Rationale Visual perception is impaired during pathological psychosis, which can be mimicked by NMDA receptor antagonists. However, the underlying mechanisms are poorly understood, partly due to limits of current rodent models for visual integration. Objectives The objectives of the study are (1) to develop a rodent task that can differentiate between effects on perception and nonspecific effects on task performance and (2) to test whether NMDA receptor antagonists affect visual perception in rats. Methods We used an adaptation of Glass patterns to assess visual grouping in rats using a two-choice visual discrimination task in an infrared touch screen conditioning chamber. After rats learned to discriminate between a radial and a concentric bipole pattern, the ability to discriminate between these patterns was tested at various levels of distortion and a psychometric function was fit to obtain the maximum task performance and signal level needed for half-maximum performance. Results NMDA receptor antagonists ketamine and phencyclidine at low doses increased the signal quality needed to discriminate between the visual patterns, without affecting the ability to discriminate between undistorted images. At higher doses, the ability to perform the task even with undistorted images was impaired, which was associated with stereotypic behaviour and increased impulsivity. Conclusions The Glass pattern-based visual grouping task is able to differentiate the effect of psychotomimetic NMDA receptor antagonists on visual perception from the effects on motor and memory functions. The half-maximum performance signal level allows quantification of cognitive psychosis in rodents, which can be translated to human psychometric functions and can be used in the development of more effective treatments.
language: eng
source:
identifier: ISSN: 0033-3158
fulltext: no_fulltext
issn:
  • 0033-3158
  • 1432-2072
url: Link


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titleNMDA receptor antagonists distort visual grouping in rats performing a modified two-choice visual discrimination task
creatorWard, Katja Clarissa ; Khattak, Halima Zainab ; Richardson, Louise ; Lee, Jonathan Loon Choon ; Vreugdenhil, Martin
creatorcontribWard, Katja Clarissa ; Khattak, Halima Zainab ; Richardson, Louise ; Lee, Jonathan Loon Choon ; Vreugdenhil, Martin
descriptionRationale Visual perception is impaired during pathological psychosis, which can be mimicked by NMDA receptor antagonists. However, the underlying mechanisms are poorly understood, partly due to limits of current rodent models for visual integration. Objectives The objectives of the study are (1) to develop a rodent task that can differentiate between effects on perception and nonspecific effects on task performance and (2) to test whether NMDA receptor antagonists affect visual perception in rats. Methods We used an adaptation of Glass patterns to assess visual grouping in rats using a two-choice visual discrimination task in an infrared touch screen conditioning chamber. After rats learned to discriminate between a radial and a concentric bipole pattern, the ability to discriminate between these patterns was tested at various levels of distortion and a psychometric function was fit to obtain the maximum task performance and signal level needed for half-maximum performance. Results NMDA receptor antagonists ketamine and phencyclidine at low doses increased the signal quality needed to discriminate between the visual patterns, without affecting the ability to discriminate between undistorted images. At higher doses, the ability to perform the task even with undistorted images was impaired, which was associated with stereotypic behaviour and increased impulsivity. Conclusions The Glass pattern-based visual grouping task is able to differentiate the effect of psychotomimetic NMDA receptor antagonists on visual perception from the effects on motor and memory functions. The half-maximum performance signal level allows quantification of cognitive psychosis in rodents, which can be translated to human psychometric functions and can be used in the development of more effective treatments.
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subjectAnimals ; Biomedical and Life Sciences ; Biomedicine ; Choice Behavior - drug effects ; Discrimination Learning - drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug therapy ; Excitatory Amino Acid Antagonists - administration & dosage ; Excitatory Amino Acid Antagonists - pharmacology ; Impulsive Behavior - chemically induced ; Ketamine ; Ketamine - administration & dosage ; Ketamine - pharmacology ; Male ; Memory - drug effects ; Methyl aspartate ; Neurons ; Neurosciences ; Operant conditioning ; Original Investigation ; Pharmacology/Toxicology ; Phencyclidine ; Phencyclidine - administration & dosage ; Phencyclidine - pharmacology ; Physiological aspects ; Psychiatry ; Psychological aspects ; Psychometrics ; Psychotic Disorders - physiopathology ; Rats ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Stereotyped Behavior - drug effects ; Visual perception ; Visual Perception - drug effects ; Visual task performance
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descriptionRationale Visual perception is impaired during pathological psychosis, which can be mimicked by NMDA receptor antagonists. However, the underlying mechanisms are poorly understood, partly due to limits of current rodent models for visual integration. Objectives The objectives of the study are (1) to develop a rodent task that can differentiate between effects on perception and nonspecific effects on task performance and (2) to test whether NMDA receptor antagonists affect visual perception in rats. Methods We used an adaptation of Glass patterns to assess visual grouping in rats using a two-choice visual discrimination task in an infrared touch screen conditioning chamber. After rats learned to discriminate between a radial and a concentric bipole pattern, the ability to discriminate between these patterns was tested at various levels of distortion and a psychometric function was fit to obtain the maximum task performance and signal level needed for half-maximum performance. Results NMDA receptor antagonists ketamine and phencyclidine at low doses increased the signal quality needed to discriminate between the visual patterns, without affecting the ability to discriminate between undistorted images. At higher doses, the ability to perform the task even with undistorted images was impaired, which was associated with stereotypic behaviour and increased impulsivity. Conclusions The Glass pattern-based visual grouping task is able to differentiate the effect of psychotomimetic NMDA receptor antagonists on visual perception from the effects on motor and memory functions. The half-maximum performance signal level allows quantification of cognitive psychosis in rodents, which can be translated to human psychometric functions and can be used in the development of more effective treatments.
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22Phencyclidine
23Phencyclidine - administration & dosage
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31Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
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34Visual Perception - drug effects
35Visual task performance
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32Stereotyped Behavior - drug effects
33Visual perception
34Visual Perception - drug effects
35Visual task performance
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abstractRationale Visual perception is impaired during pathological psychosis, which can be mimicked by NMDA receptor antagonists. However, the underlying mechanisms are poorly understood, partly due to limits of current rodent models for visual integration. Objectives The objectives of the study are (1) to develop a rodent task that can differentiate between effects on perception and nonspecific effects on task performance and (2) to test whether NMDA receptor antagonists affect visual perception in rats. Methods We used an adaptation of Glass patterns to assess visual grouping in rats using a two-choice visual discrimination task in an infrared touch screen conditioning chamber. After rats learned to discriminate between a radial and a concentric bipole pattern, the ability to discriminate between these patterns was tested at various levels of distortion and a psychometric function was fit to obtain the maximum task performance and signal level needed for half-maximum performance. Results NMDA receptor antagonists ketamine and phencyclidine at low doses increased the signal quality needed to discriminate between the visual patterns, without affecting the ability to discriminate between undistorted images. At higher doses, the ability to perform the task even with undistorted images was impaired, which was associated with stereotypic behaviour and increased impulsivity. Conclusions The Glass pattern-based visual grouping task is able to differentiate the effect of psychotomimetic NMDA receptor antagonists on visual perception from the effects on motor and memory functions. The half-maximum performance signal level allows quantification of cognitive psychosis in rodents, which can be translated to human psychometric functions and can be used in the development of more effective treatments.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid23649884
doi10.1007/s00213-013-3123-8