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Protective effect of total phenylethanoid glycosides from Monochasma savatieri Franch on myocardial ischemia injury

The present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and... Full description

Journal Title: Phytomedicine (Stuttgart) 2013, Vol.20 (14), p.1251-1255
Main Author: Shi, Mengfan
Other Authors: He, Wenjun , Liu, Yanli , Li, Xiaoran , Yang, Shilin , Xu, Qiongming
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
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recordid: cdi_proquest_miscellaneous_1443996254
title: Protective effect of total phenylethanoid glycosides from Monochasma savatieri Franch on myocardial ischemia injury
format: Article
creator:
  • Shi, Mengfan
  • He, Wenjun
  • Liu, Yanli
  • Li, Xiaoran
  • Yang, Shilin
  • Xu, Qiongming
subjects:
  • Animals
  • Antioxidant
  • Cardiac oxidative injury
  • Cardiotonic Agents - isolation & purification
  • Cardiotonic Agents - pharmacology
  • Cardiotonic Agents - therapeutic use
  • Cell Survival - drug effects
  • Glycosides
  • Glycosides - isolation & purification
  • Glycosides - pharmacology
  • Glycosides - therapeutic use
  • Health aspects
  • Heart - drug effects
  • Heart - physiopathology
  • Heart attack
  • Humans
  • Hydrogen Peroxide
  • Isoproterenol
  • Medicinal plants
  • Monochasma savatieri Franch
  • Myocardial ischemia
  • Myocardial Ischemia - chemically induced
  • Myocardial Ischemia - drug therapy
  • Myocardial Ischemia - pathology
  • Myocardial Ischemia - physiopathology
  • Myocardium - pathology
  • Myocytes, Cardiac - drug effects
  • Orobanchaceae - chemistry
  • Phenols - isolation & purification
  • Phenols - pharmacology
  • Phenols - therapeutic use
  • Phenylethanoid glycosides
  • Physiological aspects
  • Phytotherapy
  • Plant Extracts - chemistry
  • Plant Extracts - pharmacology
  • Plant Extracts - therapeutic use
  • Rats
  • Rats, Sprague-Dawley
ispartof: Phytomedicine (Stuttgart), 2013, Vol.20 (14), p.1251-1255
description: The present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and inhibited morphological changes on H9c2 cardiomyocytes induced by H2O2 or Na2S2O4. In addition, TPG significantly decreased T-wave elevation and histopathological changes of heart tissues in myocardial infracted rats induced by isoproterenol. It also significantly reduced the infarct size induced by ligating the coronary artery in rats, increased the activities of antioxidative enzymes superoxide dismutase (SOD), the content of glutathione (GSH), and decreased the leakage of lactic dehydrogenase (LDH), the activities of creatine kinase (CK) and the content of maleic dialdehyde (MDA). In conclusion, these results suggested that TPG from Monochasma savatieri Franch might be developed as new natural medicine or food additives with effects of prevention of coronary artery disease due to its significant antioxidant activity.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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descriptionThe present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and inhibited morphological changes on H9c2 cardiomyocytes induced by H2O2 or Na2S2O4. In addition, TPG significantly decreased T-wave elevation and histopathological changes of heart tissues in myocardial infracted rats induced by isoproterenol. It also significantly reduced the infarct size induced by ligating the coronary artery in rats, increased the activities of antioxidative enzymes superoxide dismutase (SOD), the content of glutathione (GSH), and decreased the leakage of lactic dehydrogenase (LDH), the activities of creatine kinase (CK) and the content of maleic dialdehyde (MDA). In conclusion, these results suggested that TPG from Monochasma savatieri Franch might be developed as new natural medicine or food additives with effects of prevention of coronary artery disease due to its significant antioxidant activity.
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languageeng
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subjectAnimals ; Antioxidant ; Cardiac oxidative injury ; Cardiotonic Agents - isolation & purification ; Cardiotonic Agents - pharmacology ; Cardiotonic Agents - therapeutic use ; Cell Survival - drug effects ; Glycosides ; Glycosides - isolation & purification ; Glycosides - pharmacology ; Glycosides - therapeutic use ; Health aspects ; Heart - drug effects ; Heart - physiopathology ; Heart attack ; Humans ; Hydrogen Peroxide ; Isoproterenol ; Medicinal plants ; Monochasma savatieri Franch ; Myocardial ischemia ; Myocardial Ischemia - chemically induced ; Myocardial Ischemia - drug therapy ; Myocardial Ischemia - pathology ; Myocardial Ischemia - physiopathology ; Myocardium - pathology ; Myocytes, Cardiac - drug effects ; Orobanchaceae - chemistry ; Phenols - isolation & purification ; Phenols - pharmacology ; Phenols - therapeutic use ; Phenylethanoid glycosides ; Physiological aspects ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; Rats, Sprague-Dawley
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descriptionThe present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and inhibited morphological changes on H9c2 cardiomyocytes induced by H2O2 or Na2S2O4. In addition, TPG significantly decreased T-wave elevation and histopathological changes of heart tissues in myocardial infracted rats induced by isoproterenol. It also significantly reduced the infarct size induced by ligating the coronary artery in rats, increased the activities of antioxidative enzymes superoxide dismutase (SOD), the content of glutathione (GSH), and decreased the leakage of lactic dehydrogenase (LDH), the activities of creatine kinase (CK) and the content of maleic dialdehyde (MDA). In conclusion, these results suggested that TPG from Monochasma savatieri Franch might be developed as new natural medicine or food additives with effects of prevention of coronary artery disease due to its significant antioxidant activity.
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27Orobanchaceae - chemistry
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30Phenols - therapeutic use
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34Plant Extracts - chemistry
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titleProtective effect of total phenylethanoid glycosides from Monochasma savatieri Franch on myocardial ischemia injury
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abstractThe present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and inhibited morphological changes on H9c2 cardiomyocytes induced by H2O2 or Na2S2O4. In addition, TPG significantly decreased T-wave elevation and histopathological changes of heart tissues in myocardial infracted rats induced by isoproterenol. It also significantly reduced the infarct size induced by ligating the coronary artery in rats, increased the activities of antioxidative enzymes superoxide dismutase (SOD), the content of glutathione (GSH), and decreased the leakage of lactic dehydrogenase (LDH), the activities of creatine kinase (CK) and the content of maleic dialdehyde (MDA). In conclusion, these results suggested that TPG from Monochasma savatieri Franch might be developed as new natural medicine or food additives with effects of prevention of coronary artery disease due to its significant antioxidant activity.
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