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Cytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases

Background Many studies have indicated a role for cytokines in chronic kidney disease (CKD). The aim of this study was to evaluate plasma and urinary levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), transforming growth factor-beta1 (TGF-β1), and interleukin-8 (IL-8/CXCL8) in pediatric pati... Full description

Journal Title: Pediatric nephrology (Berlin West), 2012, Vol.28 (3), p.463-469
Main Author: Vianna, Heloisa Reniers
Other Authors: Soares, Cristina Maria Bouissou M , Silveira, Katia Daniela , Elmiro, Gustavo Siqueira , Mendes, Philipe Melgaço , de Sousa Tavares, Marcelo , Teixeira, Mauro Martins , Miranda, Débora Marques , Simões e Silva, Ana Cristina
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/23161207
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title: Cytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases
format: Article
creator:
  • Vianna, Heloisa Reniers
  • Soares, Cristina Maria Bouissou M
  • Silveira, Katia Daniela
  • Elmiro, Gustavo Siqueira
  • Mendes, Philipe Melgaço
  • de Sousa Tavares, Marcelo
  • Teixeira, Mauro Martins
  • Miranda, Débora Marques
  • Simões e Silva, Ana Cristina
subjects:
  • Adolescent
  • Albumin
  • Biomarkers - blood
  • Biomarkers - urine
  • Care and treatment
  • Case-Control Studies
  • Chemokine CCL2 - blood
  • Chemokine CCL2 - urine
  • Child
  • Cholesterol - blood
  • Chronic kidney failure
  • Creatinine - urine
  • Cross-Sectional Studies
  • Cytokines
  • Diagnosis
  • Dyslipidemias - blood
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Genetic aspects
  • Glomerulonephritis - complications
  • Glomerulonephritis - immunology
  • Humans
  • Inflammation Mediators - blood
  • Inflammation Mediators - urine
  • Interleukin-8 - blood
  • Interleukin-8 - urine
  • Male
  • Medicine
  • Medicine & Public Health
  • Nephrology
  • Original Article
  • Pediatrics
  • Physiological aspects
  • Renal Insufficiency, Chronic - blood
  • Renal Insufficiency, Chronic - etiology
  • Renal Insufficiency, Chronic - immunology
  • Renal Insufficiency, Chronic - urine
  • Transforming Growth Factor beta1 - blood
  • Transforming Growth Factor beta1 - urine
  • Triglycerides - blood
  • Urogenital Abnormalities
  • Urology
  • Vesico-Ureteral Reflux - complications
  • Vesico-Ureteral Reflux - immunology
ispartof: Pediatric nephrology (Berlin, West), 2012, Vol.28 (3), p.463-469
description: Background Many studies have indicated a role for cytokines in chronic kidney disease (CKD). The aim of this study was to evaluate plasma and urinary levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), transforming growth factor-beta1 (TGF-β1), and interleukin-8 (IL-8/CXCL8) in pediatric patients with CKD stages 2–4. Methods Cytokines were measured in 37 healthy controls and in 42 CKD patients by enzyme-linked immunoassay. Patients were divided into groups according to CKD etiology: glomerular disease (group 1, n  = 11) and congenital anomalies of the kidney and urinary tract (group 2, n  = 31). Urinary cytokine measurements were standardized for creatinine. Results Plasma and urinary levels of MCP-1/CCL2 were significantly higher in both CKD groups compared to the control group. Between the two CKD groups, only urinary MCP-1/CCL2 levels were significantly different, with MCP-1/CCL2 levels higher in group 1 patients. Plasma and urinary levels of IL-8/CXCL8 and TGF-β1 were undetectable in the control group but comparable between the two CKD groups. In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. In group 2 patients, urinary levels of IL-8/CXCL8 were negatively correlated with the estimated glomerular filtration rate and positively correlated with body mass index. Conclusions Differences in cytokine profiles may be related to CKD etiology and other disease-associated alterations.
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


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titleCytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases
creatorVianna, Heloisa Reniers ; Soares, Cristina Maria Bouissou M ; Silveira, Katia Daniela ; Elmiro, Gustavo Siqueira ; Mendes, Philipe Melgaço ; de Sousa Tavares, Marcelo ; Teixeira, Mauro Martins ; Miranda, Débora Marques ; Simões e Silva, Ana Cristina
creatorcontribVianna, Heloisa Reniers ; Soares, Cristina Maria Bouissou M ; Silveira, Katia Daniela ; Elmiro, Gustavo Siqueira ; Mendes, Philipe Melgaço ; de Sousa Tavares, Marcelo ; Teixeira, Mauro Martins ; Miranda, Débora Marques ; Simões e Silva, Ana Cristina
descriptionBackground Many studies have indicated a role for cytokines in chronic kidney disease (CKD). The aim of this study was to evaluate plasma and urinary levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), transforming growth factor-beta1 (TGF-β1), and interleukin-8 (IL-8/CXCL8) in pediatric patients with CKD stages 2–4. Methods Cytokines were measured in 37 healthy controls and in 42 CKD patients by enzyme-linked immunoassay. Patients were divided into groups according to CKD etiology: glomerular disease (group 1, n  = 11) and congenital anomalies of the kidney and urinary tract (group 2, n  = 31). Urinary cytokine measurements were standardized for creatinine. Results Plasma and urinary levels of MCP-1/CCL2 were significantly higher in both CKD groups compared to the control group. Between the two CKD groups, only urinary MCP-1/CCL2 levels were significantly different, with MCP-1/CCL2 levels higher in group 1 patients. Plasma and urinary levels of IL-8/CXCL8 and TGF-β1 were undetectable in the control group but comparable between the two CKD groups. In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. In group 2 patients, urinary levels of IL-8/CXCL8 were negatively correlated with the estimated glomerular filtration rate and positively correlated with body mass index. Conclusions Differences in cytokine profiles may be related to CKD etiology and other disease-associated alterations.
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languageeng
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subjectAdolescent ; Albumin ; Biomarkers - blood ; Biomarkers - urine ; Care and treatment ; Case-Control Studies ; Chemokine CCL2 - blood ; Chemokine CCL2 - urine ; Child ; Cholesterol - blood ; Chronic kidney failure ; Creatinine - urine ; Cross-Sectional Studies ; Cytokines ; Diagnosis ; Dyslipidemias - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Genetic aspects ; Glomerulonephritis - complications ; Glomerulonephritis - immunology ; Humans ; Inflammation Mediators - blood ; Inflammation Mediators - urine ; Interleukin-8 - blood ; Interleukin-8 - urine ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Pediatrics ; Physiological aspects ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - etiology ; Renal Insufficiency, Chronic - immunology ; Renal Insufficiency, Chronic - urine ; Transforming Growth Factor beta1 - blood ; Transforming Growth Factor beta1 - urine ; Triglycerides - blood ; Urogenital Abnormalities ; Urology ; Vesico-Ureteral Reflux - complications ; Vesico-Ureteral Reflux - immunology
ispartofPediatric nephrology (Berlin, West), 2012, Vol.28 (3), p.463-469
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1Soares, Cristina Maria Bouissou M
2Silveira, Katia Daniela
3Elmiro, Gustavo Siqueira
4Mendes, Philipe Melgaço
5de Sousa Tavares, Marcelo
6Teixeira, Mauro Martins
7Miranda, Débora Marques
8Simões e Silva, Ana Cristina
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0Cytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases
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descriptionBackground Many studies have indicated a role for cytokines in chronic kidney disease (CKD). The aim of this study was to evaluate plasma and urinary levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), transforming growth factor-beta1 (TGF-β1), and interleukin-8 (IL-8/CXCL8) in pediatric patients with CKD stages 2–4. Methods Cytokines were measured in 37 healthy controls and in 42 CKD patients by enzyme-linked immunoassay. Patients were divided into groups according to CKD etiology: glomerular disease (group 1, n  = 11) and congenital anomalies of the kidney and urinary tract (group 2, n  = 31). Urinary cytokine measurements were standardized for creatinine. Results Plasma and urinary levels of MCP-1/CCL2 were significantly higher in both CKD groups compared to the control group. Between the two CKD groups, only urinary MCP-1/CCL2 levels were significantly different, with MCP-1/CCL2 levels higher in group 1 patients. Plasma and urinary levels of IL-8/CXCL8 and TGF-β1 were undetectable in the control group but comparable between the two CKD groups. In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. In group 2 patients, urinary levels of IL-8/CXCL8 were negatively correlated with the estimated glomerular filtration rate and positively correlated with body mass index. Conclusions Differences in cytokine profiles may be related to CKD etiology and other disease-associated alterations.
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1Albumin
2Biomarkers - blood
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4Care and treatment
5Case-Control Studies
6Chemokine CCL2 - blood
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8Child
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10Chronic kidney failure
11Creatinine - urine
12Cross-Sectional Studies
13Cytokines
14Diagnosis
15Dyslipidemias - blood
16Enzyme-Linked Immunosorbent Assay
17Female
18Genetic aspects
19Glomerulonephritis - complications
20Glomerulonephritis - immunology
21Humans
22Inflammation Mediators - blood
23Inflammation Mediators - urine
24Interleukin-8 - blood
25Interleukin-8 - urine
26Male
27Medicine
28Medicine & Public Health
29Nephrology
30Original Article
31Pediatrics
32Physiological aspects
33Renal Insufficiency, Chronic - blood
34Renal Insufficiency, Chronic - etiology
35Renal Insufficiency, Chronic - immunology
36Renal Insufficiency, Chronic - urine
37Transforming Growth Factor beta1 - blood
38Transforming Growth Factor beta1 - urine
39Triglycerides - blood
40Urogenital Abnormalities
41Urology
42Vesico-Ureteral Reflux - complications
43Vesico-Ureteral Reflux - immunology
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titleCytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases
authorVianna, Heloisa Reniers ; Soares, Cristina Maria Bouissou M ; Silveira, Katia Daniela ; Elmiro, Gustavo Siqueira ; Mendes, Philipe Melgaço ; de Sousa Tavares, Marcelo ; Teixeira, Mauro Martins ; Miranda, Débora Marques ; Simões e Silva, Ana Cristina
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0Adolescent
1Albumin
2Biomarkers - blood
3Biomarkers - urine
4Care and treatment
5Case-Control Studies
6Chemokine CCL2 - blood
7Chemokine CCL2 - urine
8Child
9Cholesterol - blood
10Chronic kidney failure
11Creatinine - urine
12Cross-Sectional Studies
13Cytokines
14Diagnosis
15Dyslipidemias - blood
16Enzyme-Linked Immunosorbent Assay
17Female
18Genetic aspects
19Glomerulonephritis - complications
20Glomerulonephritis - immunology
21Humans
22Inflammation Mediators - blood
23Inflammation Mediators - urine
24Interleukin-8 - blood
25Interleukin-8 - urine
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28Medicine & Public Health
29Nephrology
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31Pediatrics
32Physiological aspects
33Renal Insufficiency, Chronic - blood
34Renal Insufficiency, Chronic - etiology
35Renal Insufficiency, Chronic - immunology
36Renal Insufficiency, Chronic - urine
37Transforming Growth Factor beta1 - blood
38Transforming Growth Factor beta1 - urine
39Triglycerides - blood
40Urogenital Abnormalities
41Urology
42Vesico-Ureteral Reflux - complications
43Vesico-Ureteral Reflux - immunology
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1Soares, Cristina Maria Bouissou M
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6Teixeira, Mauro Martins
7Miranda, Débora Marques
8Simões e Silva, Ana Cristina
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1Soares, Cristina Maria Bouissou M
2Silveira, Katia Daniela
3Elmiro, Gustavo Siqueira
4Mendes, Philipe Melgaço
5de Sousa Tavares, Marcelo
6Teixeira, Mauro Martins
7Miranda, Débora Marques
8Simões e Silva, Ana Cristina
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atitleCytokines in chronic kidney disease: potential link of MCP-1 and dyslipidemia in glomerular diseases
jtitlePediatric nephrology (Berlin, West)
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date2012-11-18
risdate2012
volume28
issue3
spage463
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pages463-469
issn0931-041X
eissn1432-198X
abstractBackground Many studies have indicated a role for cytokines in chronic kidney disease (CKD). The aim of this study was to evaluate plasma and urinary levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), transforming growth factor-beta1 (TGF-β1), and interleukin-8 (IL-8/CXCL8) in pediatric patients with CKD stages 2–4. Methods Cytokines were measured in 37 healthy controls and in 42 CKD patients by enzyme-linked immunoassay. Patients were divided into groups according to CKD etiology: glomerular disease (group 1, n  = 11) and congenital anomalies of the kidney and urinary tract (group 2, n  = 31). Urinary cytokine measurements were standardized for creatinine. Results Plasma and urinary levels of MCP-1/CCL2 were significantly higher in both CKD groups compared to the control group. Between the two CKD groups, only urinary MCP-1/CCL2 levels were significantly different, with MCP-1/CCL2 levels higher in group 1 patients. Plasma and urinary levels of IL-8/CXCL8 and TGF-β1 were undetectable in the control group but comparable between the two CKD groups. In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. In group 2 patients, urinary levels of IL-8/CXCL8 were negatively correlated with the estimated glomerular filtration rate and positively correlated with body mass index. Conclusions Differences in cytokine profiles may be related to CKD etiology and other disease-associated alterations.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid23161207
doi10.1007/s00467-012-2363-x