schliessen

Filtern

 

Bibliotheken

Cover Image

Is flow-mediated dilation nitric oxide mediated?: A meta-analysis

Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie,... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2014, Vol.63 (2), p.376-82
Main Author: Green, D.J
Other Authors: Dawson, E.A , Groenewoud, H.M , Jones, H , Thijssen, D.H.J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Brachial Artery - physiology
Cardiology. Vascular system
Endothelium, Vascular - metabolism
Humans
Medical sciences
Nitric Oxide - metabolism
Regional Blood Flow - physiology
Stress, Mechanical
Vasodilation - physiology
Publisher: Hagerstown, MD: American Heart Association, Inc
ID: ISSN: 0194-911X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1490751662
title: Is flow-mediated dilation nitric oxide mediated?: A meta-analysis
format: Article
creator:
  • Green, D.J
  • Dawson, E.A
  • Groenewoud, H.M
  • Jones, H
  • Thijssen, D.H.J
subjects:
  • Arterial hypertension. Arterial hypotension
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Brachial Artery - physiology
  • Cardiology. Vascular system
  • Endothelium, Vascular - metabolism
  • Humans
  • Medical sciences
  • Nitric Oxide - metabolism
  • Regional Blood Flow - physiology
  • Stress, Mechanical
  • Vasodilation - physiology
ispartof: Hypertension (Dallas, Tex. 1979), 2014, Vol.63 (2), p.376-82
description: Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.753324
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_1490751662
sourceformatXML
sourcesystemPC
sourcerecordid1490751662
originalsourceidFETCH-LOGICAL-14464-ca3c0161f59e64cef66da7999d21d069462e7cde5a9b38d4cf165897204c77050
addsrcrecordideNqNkFFLHDEUhYO06Gr9CzI-FHwZTWYyyaQgMsjqLoiW1oI-hbtJBmOzkzWZYfXfG921ik99Cjn5Ts69B6F9gg8JYeRocvtz_Ot6fPl7enXZTJokloe4wJRuoBGpCprTipVf0AgTQXNByM0W2o7xHmNCKeWbaKugBeecVSPUTGPWOr_M50Zb6I3OtHXQW99lne2DVZl_tNpkb88nP7ImXXrIoQP3FG38hr624KLZXZ876M_Z-Pp0kl9cnU9Pm4s8hTKaKygVTsO3lTCMKtMypoELIXRBNGaCssJwpU0FYlbWmqqWsKoWPK2lOMcV3kEHq38XwT8MJvZybqMyzkFn_BAloQLzijBWJFSsUBV8jMG0chHsHMKTJFi-NCg_NZjEUr42mLx765hhlpb-53yrLAHf1wBEBa4N0Ckb37masJpjnrjjFbf0rjch_nXD0gR5Z8D1d_81yNrfQfgYEAbpwcpgFj7a3idlmHUvaudkgRmTpKxLRvEzs2CjqQ
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1490751662
display
typearticle
titleIs flow-mediated dilation nitric oxide mediated?: A meta-analysis
creatorGreen, D.J ; Dawson, E.A ; Groenewoud, H.M ; Jones, H ; Thijssen, D.H.J
creatorcontribGreen, D.J ; Dawson, E.A ; Groenewoud, H.M ; Jones, H ; Thijssen, D.H.J
descriptionFlow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P<0.001). Stage 2 analysis focused on studies that used the most commonly adopted approach in healthy volunteers (ie, distal cuff placement, approximately 5-minute occlusion), which similarly revealed a significant NO contribution to FMD (FMD(saline), 6.5% [95% CI, 5.7%-7.3%]; FMD(L-NMMA), 0.9% [95% CI, 0.5%-1.3%]; P<0.001). Stage 3 meta-analyzed the studies that adopted the commonly adopted approach and automated, continuous method of analysis, which also revealed a significant contribution of NO to the FMD (FMD(saline), 6.9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO.
identifier
0ISSN: 0194-911X
1EISSN: 1524-4563
2DOI: 10.1161/HYPERTENSIONAHA.113.02044
3PMID: 24277765
4CODEN: HPRTDN
languageeng
publisherHagerstown, MD: American Heart Association, Inc
subjectArterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Brachial Artery - physiology ; Cardiology. Vascular system ; Endothelium, Vascular - metabolism ; Humans ; Medical sciences ; Nitric Oxide - metabolism ; Regional Blood Flow - physiology ; Stress, Mechanical ; Vasodilation - physiology
ispartofHypertension (Dallas, Tex. 1979), 2014, Vol.63 (2), p.376-82
rights
0info:eu-repo/semantics/closedAccess
12014 American Heart Association, Inc
22015 INIST-CNRS
lds50peer_reviewed
oafree_for_read
citesFETCH-LOGICAL-14464-ca3c0161f59e64cef66da7999d21d069462e7cde5a9b38d4cf165897204c77050
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28168707$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24277765$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Green, D.J
1Dawson, E.A
2Groenewoud, H.M
3Jones, H
4Thijssen, D.H.J
title
0Is flow-mediated dilation nitric oxide mediated?: A meta-analysis
1Hypertension (Dallas, Tex. 1979)
addtitleHypertension
descriptionFlow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P<0.001). Stage 2 analysis focused on studies that used the most commonly adopted approach in healthy volunteers (ie, distal cuff placement, approximately 5-minute occlusion), which similarly revealed a significant NO contribution to FMD (FMD(saline), 6.5% [95% CI, 5.7%-7.3%]; FMD(L-NMMA), 0.9% [95% CI, 0.5%-1.3%]; P<0.001). Stage 3 meta-analyzed the studies that adopted the commonly adopted approach and automated, continuous method of analysis, which also revealed a significant contribution of NO to the FMD (FMD(saline), 6.9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO.
subject
0Arterial hypertension. Arterial hypotension
1Biological and medical sciences
2Blood and lymphatic vessels
3Brachial Artery - physiology
4Cardiology. Vascular system
5Endothelium, Vascular - metabolism
6Humans
7Medical sciences
8Nitric Oxide - metabolism
9Regional Blood Flow - physiology
10Stress, Mechanical
11Vasodilation - physiology
issn
00194-911X
11524-4563
fulltextfalse
rsrctypearticle
creationdate2014
recordtypearticle
recordideNqNkFFLHDEUhYO06Gr9CzI-FHwZTWYyyaQgMsjqLoiW1oI-hbtJBmOzkzWZYfXfG921ik99Cjn5Ts69B6F9gg8JYeRocvtz_Ot6fPl7enXZTJokloe4wJRuoBGpCprTipVf0AgTQXNByM0W2o7xHmNCKeWbaKugBeecVSPUTGPWOr_M50Zb6I3OtHXQW99lne2DVZl_tNpkb88nP7ImXXrIoQP3FG38hr624KLZXZ876M_Z-Pp0kl9cnU9Pm4s8hTKaKygVTsO3lTCMKtMypoELIXRBNGaCssJwpU0FYlbWmqqWsKoWPK2lOMcV3kEHq38XwT8MJvZybqMyzkFn_BAloQLzijBWJFSsUBV8jMG0chHsHMKTJFi-NCg_NZjEUr42mLx765hhlpb-53yrLAHf1wBEBa4N0Ckb37masJpjnrjjFbf0rjch_nXD0gR5Z8D1d_81yNrfQfgYEAbpwcpgFj7a3idlmHUvaudkgRmTpKxLRvEzs2CjqQ
startdate2014
enddate2014
creator
0Green, D.J
1Dawson, E.A
2Groenewoud, H.M
3Jones, H
4Thijssen, D.H.J
general
0American Heart Association, Inc
1Lippincott Williams & Wilkins
scope
05DI
15DJ
2QVL
3IQODW
4CGR
5CUY
6CVF
7ECM
8EIF
9NPM
10AAYXX
11CITATION
127X8
sort
creationdate2014
titleIs flow-mediated dilation nitric oxide mediated?: A meta-analysis
authorGreen, D.J ; Dawson, E.A ; Groenewoud, H.M ; Jones, H ; Thijssen, D.H.J
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-14464-ca3c0161f59e64cef66da7999d21d069462e7cde5a9b38d4cf165897204c77050
rsrctypearticles
prefilterarticles
languageeng
creationdate2014
topic
0Arterial hypertension. Arterial hypotension
1Biological and medical sciences
2Blood and lymphatic vessels
3Brachial Artery - physiology
4Cardiology. Vascular system
5Endothelium, Vascular - metabolism
6Humans
7Medical sciences
8Nitric Oxide - metabolism
9Regional Blood Flow - physiology
10Stress, Mechanical
11Vasodilation - physiology
toplevelpeer_reviewed
creatorcontrib
0Green, D.J
1Dawson, E.A
2Groenewoud, H.M
3Jones, H
4Thijssen, D.H.J
collection
0NARCIS
1NARCIS: Datasets
2NARCIS:Publications
3Pascal-Francis
4Medline
5MEDLINE
6MEDLINE (Ovid)
7MEDLINE
8MEDLINE
9PubMed
10CrossRef
11MEDLINE - Academic
jtitleHypertension (Dallas, Tex. 1979)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Green, D.J
1Dawson, E.A
2Groenewoud, H.M
3Jones, H
4Thijssen, D.H.J
formatjournal
genrearticle
ristypeJOUR
atitleIs flow-mediated dilation nitric oxide mediated?: A meta-analysis
jtitleHypertension (Dallas, Tex. 1979)
addtitleHypertension
date2014
risdate2014
volume63
issue2
spage376
epage82
pages376-82
issn0194-911X
eissn1524-4563
codenHPRTDN
abstractFlow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P<0.001). Stage 2 analysis focused on studies that used the most commonly adopted approach in healthy volunteers (ie, distal cuff placement, approximately 5-minute occlusion), which similarly revealed a significant NO contribution to FMD (FMD(saline), 6.5% [95% CI, 5.7%-7.3%]; FMD(L-NMMA), 0.9% [95% CI, 0.5%-1.3%]; P<0.001). Stage 3 meta-analyzed the studies that adopted the commonly adopted approach and automated, continuous method of analysis, which also revealed a significant contribution of NO to the FMD (FMD(saline), 6.9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO.
copHagerstown, MD
pubAmerican Heart Association, Inc
pmid24277765
doi10.1161/HYPERTENSIONAHA.113.02044
oafree_for_read