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Is flow-mediated dilation nitric oxide mediated?: A meta-analysis

Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie,... Full description

Journal Title: Hypertension (Dallas Tex. 1979), 2014, Vol.63 (2), p.376-82
Main Author: Green, D.J
Other Authors: Dawson, E.A , Groenewoud, H.M , Jones, H , Thijssen, D.H.J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Hagerstown, MD: American Heart Association, Inc
ID: ISSN: 0194-911X
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recordid: cdi_proquest_miscellaneous_1490751662
title: Is flow-mediated dilation nitric oxide mediated?: A meta-analysis
format: Article
creator:
  • Green, D.J
  • Dawson, E.A
  • Groenewoud, H.M
  • Jones, H
  • Thijssen, D.H.J
subjects:
  • Arterial hypertension. Arterial hypotension
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Brachial Artery - physiology
  • Cardiology. Vascular system
  • Endothelium, Vascular - metabolism
  • Humans
  • Medical sciences
  • Nitric Oxide - metabolism
  • Regional Blood Flow - physiology
  • Stress, Mechanical
  • Vasodilation - physiology
ispartof: Hypertension (Dallas, Tex. 1979), 2014, Vol.63 (2), p.376-82
description: Flow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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titleIs flow-mediated dilation nitric oxide mediated?: A meta-analysis
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descriptionFlow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P<0.001). Stage 2 analysis focused on studies that used the most commonly adopted approach in healthy volunteers (ie, distal cuff placement, approximately 5-minute occlusion), which similarly revealed a significant NO contribution to FMD (FMD(saline), 6.5% [95% CI, 5.7%-7.3%]; FMD(L-NMMA), 0.9% [95% CI, 0.5%-1.3%]; P<0.001). Stage 3 meta-analyzed the studies that adopted the commonly adopted approach and automated, continuous method of analysis, which also revealed a significant contribution of NO to the FMD (FMD(saline), 6.9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO.
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subjectArterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Brachial Artery - physiology ; Cardiology. Vascular system ; Endothelium, Vascular - metabolism ; Humans ; Medical sciences ; Nitric Oxide - metabolism ; Regional Blood Flow - physiology ; Stress, Mechanical ; Vasodilation - physiology
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descriptionFlow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P<0.001). Stage 2 analysis focused on studies that used the most commonly adopted approach in healthy volunteers (ie, distal cuff placement, approximately 5-minute occlusion), which similarly revealed a significant NO contribution to FMD (FMD(saline), 6.5% [95% CI, 5.7%-7.3%]; FMD(L-NMMA), 0.9% [95% CI, 0.5%-1.3%]; P<0.001). Stage 3 meta-analyzed the studies that adopted the commonly adopted approach and automated, continuous method of analysis, which also revealed a significant contribution of NO to the FMD (FMD(saline), 6.9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO.
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abstractFlow-mediated dilation (FMD) is a noninvasive index of endothelial function and vascular health in humans. Studies examining the role of nitric oxide (NO) are not conclusive. In this article, we quantified the contribution of NO in FMD of conduit arteries and explored the effect of the protocol (ie, distal cuff, approximately 5-minute ischemia) and method of analysis (ie, automated and continuous edge detection) on the NO dependency of this test. A systematic review and 3-stage meta-analysis of published crossover studies that measured FMD under local infusion of saline or the NO synthase blocker N(G)monomethyl-L-arginine (L-NMMA) was undertaken. Twenty studies met the inclusion criteria for stage 1 (374 individual comparisons). The meta-analyzed outcome was the difference in FMD between infusion of saline (ie, FMD(saline)) and NO synthase blocker (ie, FMD(L-NMMA)). Overall, FMD(saline) was 8.2% (95% confidence interval [CI], 6.8%-9.6%) compared with FMD(L-NMMA) of 3.7% (95% CI, 3.1%-4.3%; P<0.001). Stage 2 analysis focused on studies that used the most commonly adopted approach in healthy volunteers (ie, distal cuff placement, approximately 5-minute occlusion), which similarly revealed a significant NO contribution to FMD (FMD(saline), 6.5% [95% CI, 5.7%-7.3%]; FMD(L-NMMA), 0.9% [95% CI, 0.5%-1.3%]; P<0.001). Stage 3 meta-analyzed the studies that adopted the commonly adopted approach and automated, continuous method of analysis, which also revealed a significant contribution of NO to the FMD (FMD(saline), 6.9% [95% CI, 6.0%-7.8%]; FMD(L-NMMA), 2.4% [95% CI, 1.1%-3.7%]; P<0.001). This comprehensive analysis demonstrates that FMD of conduit arteries in humans is, at least in part, mediated by NO.
copHagerstown, MD
pubAmerican Heart Association, Inc
pmid24277765
doi10.1161/HYPERTENSIONAHA.113.02044
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