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Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke

Abstract Purpose High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods Plasma HMGB1 levels of 338 patients we... Full description

Journal Title: Journal of critical care 2013, Vol.28 (5), p.792-797
Main Author: Huang, Ju-Ming, MD
Other Authors: Hu, Jin, MD , Chen, Ning, MD , Hu, Min-Lei, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Elsevier Inc
ID: ISSN: 0883-9441
Link: https://www.ncbi.nlm.nih.gov/pubmed/23137435
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title: Relationship between plasma high-mobility group box-1 levels and clinical outcomes of ischemic stroke
format: Article
creator:
  • Huang, Ju-Ming, MD
  • Hu, Jin, MD
  • Chen, Ning, MD
  • Hu, Min-Lei, MD
subjects:
  • Aged
  • Biomarkers - blood
  • Brain Ischemia - blood
  • Brain Ischemia - mortality
  • Brain Ischemia - therapy
  • Cardiovascular disease
  • Cholesterol
  • Chromosomal proteins
  • Critical Care
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • High mobility group box-1
  • HMGB1 Protein - blood
  • Humans
  • Inflammation Mediators - blood
  • Ischemia
  • Ischemic stroke
  • Magnetic Resonance Imaging
  • Male
  • Medical research
  • Mortality
  • Outcome
  • Patient outcomes
  • Plasma
  • Prognosis
  • Risk Factors
  • Severity of Illness Index
  • Stroke (Disease)
  • Stroke - blood
  • Stroke - mortality
  • Stroke - therapy
  • Treatment Outcome
ispartof: Journal of critical care, 2013, Vol.28 (5), p.792-797
description: Abstract Purpose High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year. Results Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score. Conclusion Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke.
language: eng
source:
identifier: ISSN: 0883-9441
fulltext: no_fulltext
issn:
  • 0883-9441
  • 1557-8615
url: Link


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descriptionAbstract Purpose High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year. Results Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score. Conclusion Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke.
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subjectAged ; Biomarkers - blood ; Brain Ischemia - blood ; Brain Ischemia - mortality ; Brain Ischemia - therapy ; Cardiovascular disease ; Cholesterol ; Chromosomal proteins ; Critical Care ; Enzyme-Linked Immunosorbent Assay ; Female ; High mobility group box-1 ; HMGB1 Protein - blood ; Humans ; Inflammation Mediators - blood ; Ischemia ; Ischemic stroke ; Magnetic Resonance Imaging ; Male ; Medical research ; Mortality ; Outcome ; Patient outcomes ; Plasma ; Prognosis ; Risk Factors ; Severity of Illness Index ; Stroke (Disease) ; Stroke - blood ; Stroke - mortality ; Stroke - therapy ; Treatment Outcome
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descriptionAbstract Purpose High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year. Results Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score. Conclusion Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke.
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abstractAbstract Purpose High-mobility group box-1 (HMGB1) is regarded as a central mediator of inflammation and involved in many inflammatory diseases. This study aimed to investigate impact of plasma HMGB1 level on 1-year clinical outcomes of ischemic stroke. Methods Plasma HMGB1 levels of 338 patients were quantified by enzyme-linked immunosorbent assay. The end points were mortality and unfavorable outcome (modified Rankin Scale score>2) after 1 year. Results Plasma HMGB1 level emerged as an independent predictor of 1-year clinical outcomes. Its prognostic value was similar to National Institutes of Health Stroke Scale score's. It improved prognostic value of National Institutes of Health Stroke Scale score. Conclusion Plasma HMGB1 level represents a novel biomarker for predicting 1-year clinical outcomes of ischemic stroke.
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pmid23137435
doi10.1016/j.jcrc.2012.10.003