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Homocysteine, antioxidant micronutrients and late onset dementia

Purpose To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients. Methods This is a follow-up study of a sample reported in 2002. Homocysteine was measured at baseline in 201 individuals born in 1921 and without dementia at age 77 years and fo... Full description

Journal Title: European journal of nutrition 2013-04-27, Vol.53 (1), p.277-285
Main Author: Whalley, Lawrence J
Other Authors: Duthie, Susan J , Collins, Andrew R , Starr, John M , Deary, Ian J , Lemmon, Helen , Duthie, Ashleigh C , Murray, Alison D , Staff, Roger T
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1436-6207
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title: Homocysteine, antioxidant micronutrients and late onset dementia
format: Article
creator:
  • Whalley, Lawrence J
  • Duthie, Susan J
  • Collins, Andrew R
  • Starr, John M
  • Deary, Ian J
  • Lemmon, Helen
  • Duthie, Ashleigh C
  • Murray, Alison D
  • Staff, Roger T
subjects:
  • Aged
  • Aged, 80 and over
  • Analysis
  • Antioxidants
  • Antioxidants - metabolism
  • Biological and medical sciences
  • Body Mass Index
  • Chemistry
  • Chemistry and Materials Science
  • Cognition - physiology
  • Dementia
  • Dementia - blood
  • Dementia - diagnosis
  • Dementia - etiology
  • Feeding. Feeding behavior
  • Female
  • Folic acid
  • Folic Acid - blood
  • Follow-Up Studies
  • Fundamental and applied biological sciences. Psychology
  • Heart diseases
  • Homocysteine
  • Homocysteine - blood
  • Humans
  • Hyperhomocysteinemia - complications
  • Hypertension
  • Male
  • Micronutrients - blood
  • Nutrition
  • Nutrition Assessment
  • Original Contribution
  • Proportional Hazards Models
  • Risk Factors
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vitamin B 12 - blood
ispartof: European journal of nutrition, 2013-04-27, Vol.53 (1), p.277-285
description: Purpose To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients. Methods This is a follow-up study of a sample reported in 2002. Homocysteine was measured at baseline in 201 individuals born in 1921 and without dementia at age 77 years and followed up to age 88 years. Baseline macro- and micronutrient status was estimated from BMI, the MONICA food frequency questionnaire, plasma folate, B12 and, in a subgroup ( N  = 173), plasma antioxidant micronutrients. Time to dementia onset during follow-up was compared between participants grouped by homocysteine concentration using Cox regression. Model 1 adjusted for age, sex, childhood IQ, education, socioeconomic deprivation, presence of heart disease, hypertension, plasma folate and B12. In model 2 plasma, antioxidants were added to these covariables. Results During a mean follow-up of about 5 years, there were 39 incident dementia cases among 201 participants. In model 1, being in the highest homocysteine group (>14 μmol/L) was associated with a 234 % increased risk (HR 3.34, 95 % CI 1.16–9.57) of any dementia. After inclusion of plasma antioxidants in model 2, there were 32 incident dementia cases from a subsample ( N  = 173). Homocysteine >14 μmol was associated with a 272 % increased dementia risk (HR = 3.72, 95 % CI 1.06–13.08). Conclusions High homocysteine increases the risk of dementia. The association between tHcy and dementia is independent of plasma folate, B12 and antioxidant micronutrient status.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleHomocysteine, antioxidant micronutrients and late onset dementia
creatorWhalley, Lawrence J ; Duthie, Susan J ; Collins, Andrew R ; Starr, John M ; Deary, Ian J ; Lemmon, Helen ; Duthie, Ashleigh C ; Murray, Alison D ; Staff, Roger T
creatorcontribWhalley, Lawrence J ; Duthie, Susan J ; Collins, Andrew R ; Starr, John M ; Deary, Ian J ; Lemmon, Helen ; Duthie, Ashleigh C ; Murray, Alison D ; Staff, Roger T
descriptionPurpose To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients. Methods This is a follow-up study of a sample reported in 2002. Homocysteine was measured at baseline in 201 individuals born in 1921 and without dementia at age 77 years and followed up to age 88 years. Baseline macro- and micronutrient status was estimated from BMI, the MONICA food frequency questionnaire, plasma folate, B12 and, in a subgroup ( N  = 173), plasma antioxidant micronutrients. Time to dementia onset during follow-up was compared between participants grouped by homocysteine concentration using Cox regression. Model 1 adjusted for age, sex, childhood IQ, education, socioeconomic deprivation, presence of heart disease, hypertension, plasma folate and B12. In model 2 plasma, antioxidants were added to these covariables. Results During a mean follow-up of about 5 years, there were 39 incident dementia cases among 201 participants. In model 1, being in the highest homocysteine group (>14 μmol/L) was associated with a 234 % increased risk (HR 3.34, 95 % CI 1.16–9.57) of any dementia. After inclusion of plasma antioxidants in model 2, there were 32 incident dementia cases from a subsample ( N  = 173). Homocysteine >14 μmol was associated with a 272 % increased dementia risk (HR = 3.72, 95 % CI 1.06–13.08). Conclusions High homocysteine increases the risk of dementia. The association between tHcy and dementia is independent of plasma folate, B12 and antioxidant micronutrient status.
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subjectAged ; Aged, 80 and over ; Analysis ; Antioxidants ; Antioxidants - metabolism ; Biological and medical sciences ; Body Mass Index ; Chemistry ; Chemistry and Materials Science ; Cognition - physiology ; Dementia ; Dementia - blood ; Dementia - diagnosis ; Dementia - etiology ; Feeding. Feeding behavior ; Female ; Folic acid ; Folic Acid - blood ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Heart diseases ; Homocysteine ; Homocysteine - blood ; Humans ; Hyperhomocysteinemia - complications ; Hypertension ; Male ; Micronutrients - blood ; Nutrition ; Nutrition Assessment ; Original Contribution ; Proportional Hazards Models ; Risk Factors ; Socioeconomic Factors ; Surveys and Questionnaires ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B 12 - blood
ispartofEuropean journal of nutrition, 2013-04-27, Vol.53 (1), p.277-285
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descriptionPurpose To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients. Methods This is a follow-up study of a sample reported in 2002. Homocysteine was measured at baseline in 201 individuals born in 1921 and without dementia at age 77 years and followed up to age 88 years. Baseline macro- and micronutrient status was estimated from BMI, the MONICA food frequency questionnaire, plasma folate, B12 and, in a subgroup ( N  = 173), plasma antioxidant micronutrients. Time to dementia onset during follow-up was compared between participants grouped by homocysteine concentration using Cox regression. Model 1 adjusted for age, sex, childhood IQ, education, socioeconomic deprivation, presence of heart disease, hypertension, plasma folate and B12. In model 2 plasma, antioxidants were added to these covariables. Results During a mean follow-up of about 5 years, there were 39 incident dementia cases among 201 participants. In model 1, being in the highest homocysteine group (>14 μmol/L) was associated with a 234 % increased risk (HR 3.34, 95 % CI 1.16–9.57) of any dementia. After inclusion of plasma antioxidants in model 2, there were 32 incident dementia cases from a subsample ( N  = 173). Homocysteine >14 μmol was associated with a 272 % increased dementia risk (HR = 3.72, 95 % CI 1.06–13.08). Conclusions High homocysteine increases the risk of dementia. The association between tHcy and dementia is independent of plasma folate, B12 and antioxidant micronutrient status.
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4Antioxidants - metabolism
5Biological and medical sciences
6Body Mass Index
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12Dementia - diagnosis
13Dementia - etiology
14Feeding. Feeding behavior
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32Risk Factors
33Socioeconomic Factors
34Surveys and Questionnaires
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36Vitamin B 12 - blood
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abstractPurpose To distinguish between contributions to dementia made by homocysteine, folate, B12 and antioxidant micronutrients. Methods This is a follow-up study of a sample reported in 2002. Homocysteine was measured at baseline in 201 individuals born in 1921 and without dementia at age 77 years and followed up to age 88 years. Baseline macro- and micronutrient status was estimated from BMI, the MONICA food frequency questionnaire, plasma folate, B12 and, in a subgroup ( N  = 173), plasma antioxidant micronutrients. Time to dementia onset during follow-up was compared between participants grouped by homocysteine concentration using Cox regression. Model 1 adjusted for age, sex, childhood IQ, education, socioeconomic deprivation, presence of heart disease, hypertension, plasma folate and B12. In model 2 plasma, antioxidants were added to these covariables. Results During a mean follow-up of about 5 years, there were 39 incident dementia cases among 201 participants. In model 1, being in the highest homocysteine group (>14 μmol/L) was associated with a 234 % increased risk (HR 3.34, 95 % CI 1.16–9.57) of any dementia. After inclusion of plasma antioxidants in model 2, there were 32 incident dementia cases from a subsample ( N  = 173). Homocysteine >14 μmol was associated with a 272 % increased dementia risk (HR = 3.72, 95 % CI 1.06–13.08). Conclusions High homocysteine increases the risk of dementia. The association between tHcy and dementia is independent of plasma folate, B12 and antioxidant micronutrient status.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid23625136
doi10.1007/s00394-013-0526-6