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Green tea catechins: a fresh flavor to anticancer therapy

Green tea catechins have been extensively studied for their cancer preventive effects. Accumulating evidence has shown that green tea catechins, like (−)-epigallocatechin-3-gallate, have strong anti-oxidant activity and affect several signal transduction pathways relevant to cancer development. Here... Full description

Journal Title: Apoptosis (London) 2013-10-01, Vol.19 (1), p.1-18
Main Author: Yu, Yang
Other Authors: Deng, Yuan , Lu, Bang-min , Liu, Yong-xi , Li, Jian , Bao, Jin-ku
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Boston: Springer US
ID: ISSN: 1360-8185
Link: https://www.ncbi.nlm.nih.gov/pubmed/24081390
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title: Green tea catechins: a fresh flavor to anticancer therapy
format: Article
creator:
  • Yu, Yang
  • Deng, Yuan
  • Lu, Bang-min
  • Liu, Yong-xi
  • Li, Jian
  • Bao, Jin-ku
subjects:
  • Angiogenesis
  • Animals
  • Antimitotic agents
  • Antineoplastic agents
  • Antineoplastic Agents - administration & dosage
  • Apoptosis - drug effects
  • Biochemistry
  • Biomedical and Life Sciences
  • Biomedicine
  • Camellia sinensis - chemistry
  • Cancer
  • Cancer Research
  • Care and treatment
  • Catechin
  • Catechin - administration & dosage
  • Cell Biology
  • general
  • Green tea
  • Humans
  • Neoplasms - drug therapy
  • Neoplasms - genetics
  • Neoplasms - metabolism
  • Neoplasms - physiopathology
  • Oncology
  • Original Paper
  • Plant Extracts - administration & dosage
  • Virology
ispartof: Apoptosis (London), 2013-10-01, Vol.19 (1), p.1-18
description: Green tea catechins have been extensively studied for their cancer preventive effects. Accumulating evidence has shown that green tea catechins, like (−)-epigallocatechin-3-gallate, have strong anti-oxidant activity and affect several signal transduction pathways relevant to cancer development. Here, we review the biological properties of green tea catechins and the molecular mechanisms of their anticancer effects, including the suppression of cancer cell proliferation, induction of apoptosis, and inhibition of tumor metastasis and angiogenesis. We summarize the efficacy of a single catechin and the synergetic effects of multiple catechins. We also discuss the enhanced anticancer effects of green tea catechins when they are combined with anticancer drugs. The information present in this review might promote the development of strategy for the co-administration of green tea catechins with other anticancer drugs to increase the potency of currently available anticancer medicine. This new strategy should in turn lower the cytotoxicity and cost of anticancer treatment.
language: eng
source:
identifier: ISSN: 1360-8185
fulltext: no_fulltext
issn:
  • 1360-8185
  • 1573-675X
url: Link


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descriptionGreen tea catechins have been extensively studied for their cancer preventive effects. Accumulating evidence has shown that green tea catechins, like (−)-epigallocatechin-3-gallate, have strong anti-oxidant activity and affect several signal transduction pathways relevant to cancer development. Here, we review the biological properties of green tea catechins and the molecular mechanisms of their anticancer effects, including the suppression of cancer cell proliferation, induction of apoptosis, and inhibition of tumor metastasis and angiogenesis. We summarize the efficacy of a single catechin and the synergetic effects of multiple catechins. We also discuss the enhanced anticancer effects of green tea catechins when they are combined with anticancer drugs. The information present in this review might promote the development of strategy for the co-administration of green tea catechins with other anticancer drugs to increase the potency of currently available anticancer medicine. This new strategy should in turn lower the cytotoxicity and cost of anticancer treatment.
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subjectAngiogenesis ; Animals ; Antimitotic agents ; Antineoplastic agents ; Antineoplastic Agents - administration & dosage ; Apoptosis - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Camellia sinensis - chemistry ; Cancer ; Cancer Research ; Care and treatment ; Catechin ; Catechin - administration & dosage ; Cell Biology ; general ; Green tea ; Humans ; Neoplasms - drug therapy ; Neoplasms - genetics ; Neoplasms - metabolism ; Neoplasms - physiopathology ; Oncology ; Original Paper ; Plant Extracts - administration & dosage ; Virology
ispartofApoptosis (London), 2013-10-01, Vol.19 (1), p.1-18
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abstractGreen tea catechins have been extensively studied for their cancer preventive effects. Accumulating evidence has shown that green tea catechins, like (−)-epigallocatechin-3-gallate, have strong anti-oxidant activity and affect several signal transduction pathways relevant to cancer development. Here, we review the biological properties of green tea catechins and the molecular mechanisms of their anticancer effects, including the suppression of cancer cell proliferation, induction of apoptosis, and inhibition of tumor metastasis and angiogenesis. We summarize the efficacy of a single catechin and the synergetic effects of multiple catechins. We also discuss the enhanced anticancer effects of green tea catechins when they are combined with anticancer drugs. The information present in this review might promote the development of strategy for the co-administration of green tea catechins with other anticancer drugs to increase the potency of currently available anticancer medicine. This new strategy should in turn lower the cytotoxicity and cost of anticancer treatment.
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pmid24081390
doi10.1007/s10495-013-0908-5