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Individualised exercise improves endothelial function in patients with rheumatoid arthritis

Background We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exerci... Full description

Journal Title: Annals of the rheumatic diseases 2014-04, Vol.73 (4), p.748-751
Main Author: Metsios, George S
Other Authors: Stavropoulos-Kalinoglou, Antonios , Veldhuijzen van Zanten, Jet JCS , Nightingale, Peter , Sandoo, Aamer , Dimitroulas, Theodoros , Kitas, George D , Koutedakis, Yiannis
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: BMJ Publishing Group Ltd
ID: ISSN: 0003-4967
Link: https://www.ncbi.nlm.nih.gov/pubmed/23904472
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recordid: cdi_proquest_miscellaneous_1503540492
title: Individualised exercise improves endothelial function in patients with rheumatoid arthritis
format: Article
creator:
  • Metsios, George S
  • Stavropoulos-Kalinoglou, Antonios
  • Veldhuijzen van Zanten, Jet JCS
  • Nightingale, Peter
  • Sandoo, Aamer
  • Dimitroulas, Theodoros
  • Kitas, George D
  • Koutedakis, Yiannis
subjects:
  • Adult
  • Aged
  • Analysis
  • Anthropometry - methods
  • Arthritis, Rheumatoid - physiopathology
  • Arthritis, Rheumatoid - rehabilitation
  • Body mass index
  • Care and treatment
  • Endothelium, Vascular - physiopathology
  • Exercise
  • Exercise Therapy - methods
  • Female
  • Humans
  • Influence
  • Male
  • Microcirculation - physiology
  • Middle Aged
  • Oxygen Consumption - physiology
  • Resistance Training - methods
  • Rheumatoid arthritis
  • Severity of Illness Index
  • Single-Blind Method
  • Vasodilation - physiology
ispartof: Annals of the rheumatic diseases, 2014-04, Vol.73 (4), p.748-751
description: Background We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p
language: eng
source:
identifier: ISSN: 0003-4967
fulltext: no_fulltext
issn:
  • 0003-4967
  • 1468-2060
url: Link


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titleIndividualised exercise improves endothelial function in patients with rheumatoid arthritis
creatorMetsios, George S ; Stavropoulos-Kalinoglou, Antonios ; Veldhuijzen van Zanten, Jet JCS ; Nightingale, Peter ; Sandoo, Aamer ; Dimitroulas, Theodoros ; Kitas, George D ; Koutedakis, Yiannis
creatorcontribMetsios, George S ; Stavropoulos-Kalinoglou, Antonios ; Veldhuijzen van Zanten, Jet JCS ; Nightingale, Peter ; Sandoo, Aamer ; Dimitroulas, Theodoros ; Kitas, George D ; Koutedakis, Yiannis
descriptionBackground We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p<0.001) or 6 months (Ach: p=0.016, SNP: p=0.045, FMD: p=0.016) in the exercise but not in the control group. Generalised estimated equations detected that maximal oxygen uptake was a strong predictor for the observed changes in Ach (p=0.009) and GTN (p<0.001) whereas logCRP for SNP (p=0.017) and GTN (p=0.008). Conclusions An exercise programme designed to meet individual needs and physical abilities significantly improves microvascular and macrovascular function in parallel with disease-related characteristics in RA patients. The potential long-term beneficial effects of such interventions at reducing cardiovascular risk in these patients merit further exploration. Clinical Trial Registration ISRCTN50861407.
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subjectAdult ; Aged ; Analysis ; Anthropometry - methods ; Arthritis, Rheumatoid - physiopathology ; Arthritis, Rheumatoid - rehabilitation ; Body mass index ; Care and treatment ; Endothelium, Vascular - physiopathology ; Exercise ; Exercise Therapy - methods ; Female ; Humans ; Influence ; Male ; Microcirculation - physiology ; Middle Aged ; Oxygen Consumption - physiology ; Resistance Training - methods ; Rheumatoid arthritis ; Severity of Illness Index ; Single-Blind Method ; Vasodilation - physiology
ispartofAnnals of the rheumatic diseases, 2014-04, Vol.73 (4), p.748-751
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descriptionBackground We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p<0.001) or 6 months (Ach: p=0.016, SNP: p=0.045, FMD: p=0.016) in the exercise but not in the control group. Generalised estimated equations detected that maximal oxygen uptake was a strong predictor for the observed changes in Ach (p=0.009) and GTN (p<0.001) whereas logCRP for SNP (p=0.017) and GTN (p=0.008). Conclusions An exercise programme designed to meet individual needs and physical abilities significantly improves microvascular and macrovascular function in parallel with disease-related characteristics in RA patients. The potential long-term beneficial effects of such interventions at reducing cardiovascular risk in these patients merit further exploration. Clinical Trial Registration ISRCTN50861407.
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10Exercise Therapy - methods
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13Influence
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17Oxygen Consumption - physiology
18Resistance Training - methods
19Rheumatoid arthritis
20Severity of Illness Index
21Single-Blind Method
22Vasodilation - physiology
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titleIndividualised exercise improves endothelial function in patients with rheumatoid arthritis
authorMetsios, George S ; Stavropoulos-Kalinoglou, Antonios ; Veldhuijzen van Zanten, Jet JCS ; Nightingale, Peter ; Sandoo, Aamer ; Dimitroulas, Theodoros ; Kitas, George D ; Koutedakis, Yiannis
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8Endothelium, Vascular - physiopathology
9Exercise
10Exercise Therapy - methods
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13Influence
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15Microcirculation - physiology
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17Oxygen Consumption - physiology
18Resistance Training - methods
19Rheumatoid arthritis
20Severity of Illness Index
21Single-Blind Method
22Vasodilation - physiology
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1Stavropoulos-Kalinoglou, Antonios
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abstractBackground We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p<0.001) or 6 months (Ach: p=0.016, SNP: p=0.045, FMD: p=0.016) in the exercise but not in the control group. Generalised estimated equations detected that maximal oxygen uptake was a strong predictor for the observed changes in Ach (p=0.009) and GTN (p<0.001) whereas logCRP for SNP (p=0.017) and GTN (p=0.008). Conclusions An exercise programme designed to meet individual needs and physical abilities significantly improves microvascular and macrovascular function in parallel with disease-related characteristics in RA patients. The potential long-term beneficial effects of such interventions at reducing cardiovascular risk in these patients merit further exploration. Clinical Trial Registration ISRCTN50861407.
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pmid23904472
doi10.1136/annrheumdis-2013-203291