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Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)

It has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is avail... Full description

Journal Title: European child & adolescent psychiatry 2013-06-28, Vol.23 (3), p.173-177
Main Author: Scassellati, Catia
Other Authors: Zanardini, Roberta , Tiberti, Alessandra , Pezzani, Marco , Valenti, Vera , Effedri, Paola , Filippini, Elena , Conte, Stefano , Ottolini, Alberto , Gennarelli, Massimo , Bocchio-Chiavetto, Luisella
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adolescent
Attention Deficit Disorder with Hyperactivity - blood
Attention Deficit Disorder with Hyperactivity - diagnosis
Attention deficit disorders. Hyperactivity
Attention deficit hyperactivity disorder
Biological and medical sciences
Body Mass Index
Brain-Derived Neurotrophic Factor - blood
Case-Control Studies
Child
Child and Adolescent Psychiatry
Child clinical studies
Enzyme-linked immunosorbent assay
Female
Humans
Life course
Male
Medical sciences
Medicine
Medicine & Public Health
Nervous system
Original Contribution
Pathology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serum
Socioeconomic Factors
Stratification
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1018-8827
Zum Text:
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recordid: cdi_proquest_miscellaneous_1520316857
title: Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
format: Article
creator:
  • Scassellati, Catia
  • Zanardini, Roberta
  • Tiberti, Alessandra
  • Pezzani, Marco
  • Valenti, Vera
  • Effedri, Paola
  • Filippini, Elena
  • Conte, Stefano
  • Ottolini, Alberto
  • Gennarelli, Massimo
  • Bocchio-Chiavetto, Luisella
subjects:
  • Adolescent
  • Attention Deficit Disorder with Hyperactivity - blood
  • Attention Deficit Disorder with Hyperactivity - diagnosis
  • Attention deficit disorders. Hyperactivity
  • Attention deficit hyperactivity disorder
  • Biological and medical sciences
  • Body Mass Index
  • Brain-Derived Neurotrophic Factor - blood
  • Case-Control Studies
  • Child
  • Child and Adolescent Psychiatry
  • Child clinical studies
  • Enzyme-linked immunosorbent assay
  • Female
  • Humans
  • Life course
  • Male
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Nervous system
  • Original Contribution
  • Pathology
  • Psychiatry
  • Psychology. Psychoanalysis. Psychiatry
  • Psychopathology. Psychiatry
  • Serum
  • Socioeconomic Factors
  • Stratification
ispartof: European child & adolescent psychiatry, 2013-06-28, Vol.23 (3), p.173-177
description: It has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
language: eng
source:
identifier: ISSN: 1018-8827
fulltext: no_fulltext
issn:
  • 1018-8827
  • 1435-165X
url: Link


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titleSerum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
creatorScassellati, Catia ; Zanardini, Roberta ; Tiberti, Alessandra ; Pezzani, Marco ; Valenti, Vera ; Effedri, Paola ; Filippini, Elena ; Conte, Stefano ; Ottolini, Alberto ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella
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descriptionIt has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
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publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAdolescent ; Attention Deficit Disorder with Hyperactivity - blood ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention deficit disorders. Hyperactivity ; Attention deficit hyperactivity disorder ; Biological and medical sciences ; Body Mass Index ; Brain-Derived Neurotrophic Factor - blood ; Case-Control Studies ; Child ; Child and Adolescent Psychiatry ; Child clinical studies ; Enzyme-linked immunosorbent assay ; Female ; Humans ; Life course ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Nervous system ; Original Contribution ; Pathology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Serum ; Socioeconomic Factors ; Stratification
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descriptionIt has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
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1Attention Deficit Disorder with Hyperactivity - blood
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5Biological and medical sciences
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10Child and Adolescent Psychiatry
11Child clinical studies
12Enzyme-linked immunosorbent assay
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titleSerum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
authorScassellati, Catia ; Zanardini, Roberta ; Tiberti, Alessandra ; Pezzani, Marco ; Valenti, Vera ; Effedri, Paola ; Filippini, Elena ; Conte, Stefano ; Ottolini, Alberto ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella
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0Adolescent
1Attention Deficit Disorder with Hyperactivity - blood
2Attention Deficit Disorder with Hyperactivity - diagnosis
3Attention deficit disorders. Hyperactivity
4Attention deficit hyperactivity disorder
5Biological and medical sciences
6Body Mass Index
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10Child and Adolescent Psychiatry
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12Enzyme-linked immunosorbent assay
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14Humans
15Life course
16Male
17Medical sciences
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19Medicine & Public Health
20Nervous system
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23Psychiatry
24Psychology. Psychoanalysis. Psychiatry
25Psychopathology. Psychiatry
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27Socioeconomic Factors
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4Valenti, Vera
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7Conte, Stefano
8Ottolini, Alberto
9Gennarelli, Massimo
10Bocchio-Chiavetto, Luisella
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atitleSerum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
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date2013-06-28
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issn1018-8827
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abstractIt has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid23812866
doi10.1007/s00787-013-0447-1