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Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)

It has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is avail... Full description

Journal Title: European child & adolescent psychiatry 2013-06-28, Vol.23 (3), p.173-177
Main Author: Scassellati, Catia
Other Authors: Zanardini, Roberta , Tiberti, Alessandra , Pezzani, Marco , Valenti, Vera , Effedri, Paola , Filippini, Elena , Conte, Stefano , Ottolini, Alberto , Gennarelli, Massimo , Bocchio-Chiavetto, Luisella
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1018-8827
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recordid: cdi_proquest_miscellaneous_1520316857
title: Serum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
format: Article
creator:
  • Scassellati, Catia
  • Zanardini, Roberta
  • Tiberti, Alessandra
  • Pezzani, Marco
  • Valenti, Vera
  • Effedri, Paola
  • Filippini, Elena
  • Conte, Stefano
  • Ottolini, Alberto
  • Gennarelli, Massimo
  • Bocchio-Chiavetto, Luisella
subjects:
  • Adolescent
  • Attention Deficit Disorder with Hyperactivity - blood
  • Attention Deficit Disorder with Hyperactivity - diagnosis
  • Attention deficit disorders. Hyperactivity
  • Attention deficit hyperactivity disorder
  • Biological and medical sciences
  • Body Mass Index
  • Brain-Derived Neurotrophic Factor - blood
  • Case-Control Studies
  • Child
  • Child and Adolescent Psychiatry
  • Child clinical studies
  • Enzyme-linked immunosorbent assay
  • Female
  • Humans
  • Life course
  • Male
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Nervous system
  • Original Contribution
  • Pathology
  • Psychiatry
  • Psychology. Psychoanalysis. Psychiatry
  • Psychopathology. Psychiatry
  • Serum
  • Socioeconomic Factors
  • Stratification
ispartof: European child & adolescent psychiatry, 2013-06-28, Vol.23 (3), p.173-177
description: It has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
language: eng
source:
identifier: ISSN: 1018-8827
fulltext: no_fulltext
issn:
  • 1018-8827
  • 1435-165X
url: Link


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titleSerum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
creatorScassellati, Catia ; Zanardini, Roberta ; Tiberti, Alessandra ; Pezzani, Marco ; Valenti, Vera ; Effedri, Paola ; Filippini, Elena ; Conte, Stefano ; Ottolini, Alberto ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella
creatorcontribScassellati, Catia ; Zanardini, Roberta ; Tiberti, Alessandra ; Pezzani, Marco ; Valenti, Vera ; Effedri, Paola ; Filippini, Elena ; Conte, Stefano ; Ottolini, Alberto ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella
descriptionIt has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
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subjectAdolescent ; Attention Deficit Disorder with Hyperactivity - blood ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention deficit disorders. Hyperactivity ; Attention deficit hyperactivity disorder ; Biological and medical sciences ; Body Mass Index ; Brain-Derived Neurotrophic Factor - blood ; Case-Control Studies ; Child ; Child and Adolescent Psychiatry ; Child clinical studies ; Enzyme-linked immunosorbent assay ; Female ; Humans ; Life course ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Nervous system ; Original Contribution ; Pathology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Serum ; Socioeconomic Factors ; Stratification
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descriptionIt has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
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titleSerum brain-derived neurotrophic factor (BDNF) levels in attention deficit–hyperactivity disorder (ADHD)
authorScassellati, Catia ; Zanardini, Roberta ; Tiberti, Alessandra ; Pezzani, Marco ; Valenti, Vera ; Effedri, Paola ; Filippini, Elena ; Conte, Stefano ; Ottolini, Alberto ; Gennarelli, Massimo ; Bocchio-Chiavetto, Luisella
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1Attention Deficit Disorder with Hyperactivity - blood
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abstractIt has been proposed that the neurotrophin brain-derived neurotrophic factor (BDNF) may be involved in attention deficit–hyperactivity disorder (ADHD) etiopathogenesis. Alterations in BDNF serum levels have been observed in childhood/adulthood neurodevelopmental pathologies, but no evidence is available for BDNF serum concentrations in ADHD. The study includes 45 drug-naïve ADHD children and 45 age–sex matched healthy subjects. Concentration of serum BDNF was determined by the ELISA method. BDNF serum levels in patients with ADHD were not different from those of controls (mean ± SD; ADHD: 39.33 ± 10.41 ng/ml; controls: 38.82 ± 8.29 ng/ml, t  = −0.26, p  = 0.80). Our findings indicate no alteration of serum BDNF levels in untreated patients with ADHD. A further stratification for cognitive, neuropsychological and psychopathological assessment in a larger sample could be useful to clarify the role of BDNF in the endophenotype characterization of ADHD.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid23812866
doi10.1007/s00787-013-0447-1