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Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation

Abstract Objective The use of cardiopulmonary bypass (CPB) is suggested to induce oxidative stress, reflected by an imbalance between prooxidant and antioxidant substances. The majority of studies published have either focused on only one aspect (prooxidant or antioxidant side) or covered only a sho... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2014, Vol.30 (6), p.673-678
Main Author: Rodemeister, Sandra
Other Authors: Duquesne, Mathieu, M.D , Adolph, Michael, M.D , Nohr, Donatus, Ph.D , Biesalski, Hans K., M.D , Unertl, Klaus, M.D
Format: Electronic Article Electronic Article
Language: English
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Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0899-9007
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title: Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation
format: Article
creator:
  • Rodemeister, Sandra
  • Duquesne, Mathieu, M.D
  • Adolph, Michael, M.D
  • Nohr, Donatus, Ph.D
  • Biesalski, Hans K., M.D
  • Unertl, Klaus, M.D
subjects:
  • Acids
  • Adult
  • Aged
  • Antioxidants
  • Antioxidants - metabolism
  • Ascorbic acid
  • Ascorbic Acid - blood
  • Ascorbyl free radical
  • Biological and medical sciences
  • Cardiopulmonary bypass
  • Cardiopulmonary Bypass - adverse effects
  • Cardiopulmonary Bypass - methods
  • Cardiovascular Diseases - surgery
  • Cardiovascular surgery
  • Chromatography, High Pressure Liquid
  • Coronary artery bypass
  • Dehydroascorbic Acid - analogs & derivatives
  • Dehydroascorbic Acid - blood
  • Electron Spin Resonance Spectroscopy
  • Feeding. Feeding behavior
  • Female
  • Free radicals
  • Fundamental and applied biological sciences. Psychology
  • Gastroenterology and Hepatology
  • Heart surgery
  • Humans
  • Kinases
  • Lipids
  • Male
  • Malondialdehyde - blood
  • Middle Aged
  • Multiple organ dysfunction syndrome
  • Oxidative stress
  • Oxidative Stress - drug effects
  • Plasma
  • Reactive Oxygen Species - metabolism
  • Studies
  • Time Factors
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vitamin C
  • Vitamin E
  • Vitamin E - blood
  • Vitamins
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2014, Vol.30 (6), p.673-678
description: Abstract Objective The use of cardiopulmonary bypass (CPB) is suggested to induce oxidative stress, reflected by an imbalance between prooxidant and antioxidant substances. The majority of studies published have either focused on only one aspect (prooxidant or antioxidant side) or covered only a short observation period. Therefore, the aim of this study was to investigate the long-term effects of CPB on the balance of prooxidative markers and antioxidant substances in one single group of patients, being able to estimate the degree of oxidative stress. Methods Blood samples were taken from 29 patients undergoing cardiovascular surgery beginning the day before surgery through postoperative day 6 (discharge). Plasma concentrations of vitamins C (total ascorbic acid) and E and malondialdehyde were measured by high-performance liquid chromatography. Plasma levels of ascorbyl free radical were determined using electron paramagnetic resonance spectroscopy. Results The study showed a significant decrease in vitamin C plasma levels during CPB without any recovery of vitamin C up to the time of discharge. Furthermore, CPB induced a significant increase in malondialdehyde plasma concentrations immediately after unclamping, accompanied by a significant increase in the ascorbyl free radical to total ascorbic acid ratio. The latter stayed elevated until the end of observation. Conclusions Our findings indicate that the oxidative stress event after CPB can be divided into two phases: Immediately after reperfusion, a massive oxidative stress occurs, reflected by the increase in malondialdehyde. During convalescence, there must be an ongoing situation of oxidative stress, especially in the water-soluble compartment, leading to the consumption of vitamin C. Because the main antioxidant substance, vitamin C, did not increase again over the entire observation period, supplementation should be given consideration.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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titleMassive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation
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creatorRodemeister, Sandra ; Duquesne, Mathieu, M.D ; Adolph, Michael, M.D ; Nohr, Donatus, Ph.D ; Biesalski, Hans K., M.D ; Unertl, Klaus, M.D
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descriptionAbstract Objective The use of cardiopulmonary bypass (CPB) is suggested to induce oxidative stress, reflected by an imbalance between prooxidant and antioxidant substances. The majority of studies published have either focused on only one aspect (prooxidant or antioxidant side) or covered only a short observation period. Therefore, the aim of this study was to investigate the long-term effects of CPB on the balance of prooxidative markers and antioxidant substances in one single group of patients, being able to estimate the degree of oxidative stress. Methods Blood samples were taken from 29 patients undergoing cardiovascular surgery beginning the day before surgery through postoperative day 6 (discharge). Plasma concentrations of vitamins C (total ascorbic acid) and E and malondialdehyde were measured by high-performance liquid chromatography. Plasma levels of ascorbyl free radical were determined using electron paramagnetic resonance spectroscopy. Results The study showed a significant decrease in vitamin C plasma levels during CPB without any recovery of vitamin C up to the time of discharge. Furthermore, CPB induced a significant increase in malondialdehyde plasma concentrations immediately after unclamping, accompanied by a significant increase in the ascorbyl free radical to total ascorbic acid ratio. The latter stayed elevated until the end of observation. Conclusions Our findings indicate that the oxidative stress event after CPB can be divided into two phases: Immediately after reperfusion, a massive oxidative stress occurs, reflected by the increase in malondialdehyde. During convalescence, there must be an ongoing situation of oxidative stress, especially in the water-soluble compartment, leading to the consumption of vitamin C. Because the main antioxidant substance, vitamin C, did not increase again over the entire observation period, supplementation should be given consideration.
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subjectAcids ; Adult ; Aged ; Antioxidants ; Antioxidants - metabolism ; Ascorbic acid ; Ascorbic Acid - blood ; Ascorbyl free radical ; Biological and medical sciences ; Cardiopulmonary bypass ; Cardiopulmonary Bypass - adverse effects ; Cardiopulmonary Bypass - methods ; Cardiovascular Diseases - surgery ; Cardiovascular surgery ; Chromatography, High Pressure Liquid ; Coronary artery bypass ; Dehydroascorbic Acid - analogs & derivatives ; Dehydroascorbic Acid - blood ; Electron Spin Resonance Spectroscopy ; Feeding. Feeding behavior ; Female ; Free radicals ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Heart surgery ; Humans ; Kinases ; Lipids ; Male ; Malondialdehyde - blood ; Middle Aged ; Multiple organ dysfunction syndrome ; Oxidative stress ; Oxidative Stress - drug effects ; Plasma ; Reactive Oxygen Species - metabolism ; Studies ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin C ; Vitamin E ; Vitamin E - blood ; Vitamins
ispartofNutrition (Burbank, Los Angeles County, Calif.), 2014, Vol.30 (6), p.673-678
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descriptionAbstract Objective The use of cardiopulmonary bypass (CPB) is suggested to induce oxidative stress, reflected by an imbalance between prooxidant and antioxidant substances. The majority of studies published have either focused on only one aspect (prooxidant or antioxidant side) or covered only a short observation period. Therefore, the aim of this study was to investigate the long-term effects of CPB on the balance of prooxidative markers and antioxidant substances in one single group of patients, being able to estimate the degree of oxidative stress. Methods Blood samples were taken from 29 patients undergoing cardiovascular surgery beginning the day before surgery through postoperative day 6 (discharge). Plasma concentrations of vitamins C (total ascorbic acid) and E and malondialdehyde were measured by high-performance liquid chromatography. Plasma levels of ascorbyl free radical were determined using electron paramagnetic resonance spectroscopy. Results The study showed a significant decrease in vitamin C plasma levels during CPB without any recovery of vitamin C up to the time of discharge. Furthermore, CPB induced a significant increase in malondialdehyde plasma concentrations immediately after unclamping, accompanied by a significant increase in the ascorbyl free radical to total ascorbic acid ratio. The latter stayed elevated until the end of observation. Conclusions Our findings indicate that the oxidative stress event after CPB can be divided into two phases: Immediately after reperfusion, a massive oxidative stress occurs, reflected by the increase in malondialdehyde. During convalescence, there must be an ongoing situation of oxidative stress, especially in the water-soluble compartment, leading to the consumption of vitamin C. Because the main antioxidant substance, vitamin C, did not increase again over the entire observation period, supplementation should be given consideration.
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19Feeding. Feeding behavior
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21Free radicals
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23Gastroenterology and Hepatology
24Heart surgery
25Humans
26Kinases
27Lipids
28Male
29Malondialdehyde - blood
30Middle Aged
31Multiple organ dysfunction syndrome
32Oxidative stress
33Oxidative Stress - drug effects
34Plasma
35Reactive Oxygen Species - metabolism
36Studies
37Time Factors
38Vertebrates: anatomy and physiology, studies on body, several organs or systems
39Vitamin C
40Vitamin E
41Vitamin E - blood
42Vitamins
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titleMassive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation
authorRodemeister, Sandra ; Duquesne, Mathieu, M.D ; Adolph, Michael, M.D ; Nohr, Donatus, Ph.D ; Biesalski, Hans K., M.D ; Unertl, Klaus, M.D
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4Antioxidants - metabolism
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7Ascorbyl free radical
8Biological and medical sciences
9Cardiopulmonary bypass
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11Cardiopulmonary Bypass - methods
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atitleMassive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation
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abstractAbstract Objective The use of cardiopulmonary bypass (CPB) is suggested to induce oxidative stress, reflected by an imbalance between prooxidant and antioxidant substances. The majority of studies published have either focused on only one aspect (prooxidant or antioxidant side) or covered only a short observation period. Therefore, the aim of this study was to investigate the long-term effects of CPB on the balance of prooxidative markers and antioxidant substances in one single group of patients, being able to estimate the degree of oxidative stress. Methods Blood samples were taken from 29 patients undergoing cardiovascular surgery beginning the day before surgery through postoperative day 6 (discharge). Plasma concentrations of vitamins C (total ascorbic acid) and E and malondialdehyde were measured by high-performance liquid chromatography. Plasma levels of ascorbyl free radical were determined using electron paramagnetic resonance spectroscopy. Results The study showed a significant decrease in vitamin C plasma levels during CPB without any recovery of vitamin C up to the time of discharge. Furthermore, CPB induced a significant increase in malondialdehyde plasma concentrations immediately after unclamping, accompanied by a significant increase in the ascorbyl free radical to total ascorbic acid ratio. The latter stayed elevated until the end of observation. Conclusions Our findings indicate that the oxidative stress event after CPB can be divided into two phases: Immediately after reperfusion, a massive oxidative stress occurs, reflected by the increase in malondialdehyde. During convalescence, there must be an ongoing situation of oxidative stress, especially in the water-soluble compartment, leading to the consumption of vitamin C. Because the main antioxidant substance, vitamin C, did not increase again over the entire observation period, supplementation should be given consideration.
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pubElsevier Inc
pmid24631388
doi10.1016/j.nut.2013.10.026