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Impact of Sex on Insulin Secretion in Cystic Fibrosis

Context: Cystic fibrosis-related diabetes is primarily due to a defect in insulin secretion. Women with cystic fibrosis (CF) are at higher risk of developing CF-related diabetes. Objective: The objective of the study was to examine sex differences in insulin and glucose homeostasis. We hypothesized... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2014-05, Vol.99 (5), p.1767-1773
Main Author: Coriati, Adèle
Other Authors: Belson, Linda , Ziai, Sophie , Haberer, Eleonore , Gauthier, Marie-Soleil , Mailhot, Geneviève , Coderre, Lise , Berthiaume, Yves , Rabasa-Lhoret, Rémi
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/24446654
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recordid: cdi_proquest_miscellaneous_1522682846
title: Impact of Sex on Insulin Secretion in Cystic Fibrosis
format: Article
creator:
  • Coriati, Adèle
  • Belson, Linda
  • Ziai, Sophie
  • Haberer, Eleonore
  • Gauthier, Marie-Soleil
  • Mailhot, Geneviève
  • Coderre, Lise
  • Berthiaume, Yves
  • Rabasa-Lhoret, Rémi
subjects:
  • Abridged Index Medicus
  • Adult
  • Blood Glucose
  • Cystic Fibrosis - blood
  • Cystic Fibrosis - physiopathology
  • Female
  • Glucose Intolerance - blood
  • Glucose Intolerance - physiopathology
  • Humans
  • Insulin - blood
  • Insulin - metabolism
  • Insulin Secretion
  • Male
  • Sex Factors
ispartof: The journal of clinical endocrinology and metabolism, 2014-05, Vol.99 (5), p.1767-1773
description: Context: Cystic fibrosis-related diabetes is primarily due to a defect in insulin secretion. Women with cystic fibrosis (CF) are at higher risk of developing CF-related diabetes. Objective: The objective of the study was to examine sex differences in insulin and glucose homeostasis. We hypothesized that in CF, women would display lower insulin secretion than men. Design: This was a study based on an ongoing observational CF cohort with a mean follow-up of 19.9 ± 5.2 months. Setting: The study was conducted at the CF clinic of the Centre Hospitalier de l'Université de Montréal (Québec, Canada). Patients: From 230 adults with CF (123 men, 107 women) of similar age and functional pulmonary status, 104 retested after the follow-up. Age-matched healthy individuals (25 men, 19 women) were included in the study. Interventions: Participants underwent a 2-hour oral glucose tolerance test with 30-minute interval sample measurements. Main Outcome Measure: Plasma insulin and glucose levels were measured. Results: Women with CF had higher overall insulin secretion as compared with men with CF (P ≤ .05) but similar to healthy women (P = .606). Men with CF had lower overall insulin secretion than healthy men (P = .020) and higher insulin sensitivity (P = .009) than women with CF. Patients with CF displayed higher overall glucose excursions than healthy patients. Sex-related differences were still observed in the CF cohort after follow-up. Conclusions: Surprisingly, in CF, adult women presented higher insulin secretion than adult men at a comparable level with what is observed in healthy individuals. Potential implications of this sex dimorphism in CF remain to be established.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleImpact of Sex on Insulin Secretion in Cystic Fibrosis
creatorCoriati, Adèle ; Belson, Linda ; Ziai, Sophie ; Haberer, Eleonore ; Gauthier, Marie-Soleil ; Mailhot, Geneviève ; Coderre, Lise ; Berthiaume, Yves ; Rabasa-Lhoret, Rémi
creatorcontribCoriati, Adèle ; Belson, Linda ; Ziai, Sophie ; Haberer, Eleonore ; Gauthier, Marie-Soleil ; Mailhot, Geneviève ; Coderre, Lise ; Berthiaume, Yves ; Rabasa-Lhoret, Rémi
descriptionContext: Cystic fibrosis-related diabetes is primarily due to a defect in insulin secretion. Women with cystic fibrosis (CF) are at higher risk of developing CF-related diabetes. Objective: The objective of the study was to examine sex differences in insulin and glucose homeostasis. We hypothesized that in CF, women would display lower insulin secretion than men. Design: This was a study based on an ongoing observational CF cohort with a mean follow-up of 19.9 ± 5.2 months. Setting: The study was conducted at the CF clinic of the Centre Hospitalier de l'Université de Montréal (Québec, Canada). Patients: From 230 adults with CF (123 men, 107 women) of similar age and functional pulmonary status, 104 retested after the follow-up. Age-matched healthy individuals (25 men, 19 women) were included in the study. Interventions: Participants underwent a 2-hour oral glucose tolerance test with 30-minute interval sample measurements. Main Outcome Measure: Plasma insulin and glucose levels were measured. Results: Women with CF had higher overall insulin secretion as compared with men with CF (P ≤ .05) but similar to healthy women (P = .606). Men with CF had lower overall insulin secretion than healthy men (P = .020) and higher insulin sensitivity (P = .009) than women with CF. Patients with CF displayed higher overall glucose excursions than healthy patients. Sex-related differences were still observed in the CF cohort after follow-up. Conclusions: Surprisingly, in CF, adult women presented higher insulin secretion than adult men at a comparable level with what is observed in healthy individuals. Potential implications of this sex dimorphism in CF remain to be established.
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subjectAbridged Index Medicus ; Adult ; Blood Glucose ; Cystic Fibrosis - blood ; Cystic Fibrosis - physiopathology ; Female ; Glucose Intolerance - blood ; Glucose Intolerance - physiopathology ; Humans ; Insulin - blood ; Insulin - metabolism ; Insulin Secretion ; Male ; Sex Factors
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descriptionContext: Cystic fibrosis-related diabetes is primarily due to a defect in insulin secretion. Women with cystic fibrosis (CF) are at higher risk of developing CF-related diabetes. Objective: The objective of the study was to examine sex differences in insulin and glucose homeostasis. We hypothesized that in CF, women would display lower insulin secretion than men. Design: This was a study based on an ongoing observational CF cohort with a mean follow-up of 19.9 ± 5.2 months. Setting: The study was conducted at the CF clinic of the Centre Hospitalier de l'Université de Montréal (Québec, Canada). Patients: From 230 adults with CF (123 men, 107 women) of similar age and functional pulmonary status, 104 retested after the follow-up. Age-matched healthy individuals (25 men, 19 women) were included in the study. Interventions: Participants underwent a 2-hour oral glucose tolerance test with 30-minute interval sample measurements. Main Outcome Measure: Plasma insulin and glucose levels were measured. Results: Women with CF had higher overall insulin secretion as compared with men with CF (P ≤ .05) but similar to healthy women (P = .606). Men with CF had lower overall insulin secretion than healthy men (P = .020) and higher insulin sensitivity (P = .009) than women with CF. Patients with CF displayed higher overall glucose excursions than healthy patients. Sex-related differences were still observed in the CF cohort after follow-up. Conclusions: Surprisingly, in CF, adult women presented higher insulin secretion than adult men at a comparable level with what is observed in healthy individuals. Potential implications of this sex dimorphism in CF remain to be established.
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notesThis work was supported by the J.-A. DeSève Chair for Clinical Research (to R.R.-L.) and by Operating Team Grant 18636 from the Canadian Cystic Fibrosis Foundation (to R.R.-L. and Y.B.). A.C. holds the Michel Bélanger PhD scholarship from the Institut de Recherches Cliniques de Montréal. R.R.-L. holds a scholarship from the Fonds de Recherche en Santé du Québec, and S.Z. has a doctoral Banting and Best scholarship from the Canadian Institutes of Health Research.
abstractContext: Cystic fibrosis-related diabetes is primarily due to a defect in insulin secretion. Women with cystic fibrosis (CF) are at higher risk of developing CF-related diabetes. Objective: The objective of the study was to examine sex differences in insulin and glucose homeostasis. We hypothesized that in CF, women would display lower insulin secretion than men. Design: This was a study based on an ongoing observational CF cohort with a mean follow-up of 19.9 ± 5.2 months. Setting: The study was conducted at the CF clinic of the Centre Hospitalier de l'Université de Montréal (Québec, Canada). Patients: From 230 adults with CF (123 men, 107 women) of similar age and functional pulmonary status, 104 retested after the follow-up. Age-matched healthy individuals (25 men, 19 women) were included in the study. Interventions: Participants underwent a 2-hour oral glucose tolerance test with 30-minute interval sample measurements. Main Outcome Measure: Plasma insulin and glucose levels were measured. Results: Women with CF had higher overall insulin secretion as compared with men with CF (P ≤ .05) but similar to healthy women (P = .606). Men with CF had lower overall insulin secretion than healthy men (P = .020) and higher insulin sensitivity (P = .009) than women with CF. Patients with CF displayed higher overall glucose excursions than healthy patients. Sex-related differences were still observed in the CF cohort after follow-up. Conclusions: Surprisingly, in CF, adult women presented higher insulin secretion than adult men at a comparable level with what is observed in healthy individuals. Potential implications of this sex dimorphism in CF remain to be established.
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