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Anti-rheumatoid arthritic activity of flavonoids from Daphne genkwa

The aim of the study was to investigate the anti-rheumatoid arthritic activity of four flavonoids from Daphne genkwa (FFD) in vivo and in vitro. Flavonoids of D. genkwa were extracted by refluxing with ethanol and purified by polyamide resin. An in vivo carrageenan-induced paw edema model, tampon-gr... Full description

Journal Title: Phytomedicine (Stuttgart) 2014-05-15, Vol.21 (6), p.830-837
Main Author: Jiang, Cui-Ping
Other Authors: He, Xin , Yang, Xiao-Lin , Zhang, Su-Li , Li, Hui , Song, Zi-Jing , Zhang, Chun-Feng , Yang, Zhong-Lin , Li, Ping , Wang, Chong-Zhi , Yuan, Chun-Su
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/24561028
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recordid: cdi_proquest_miscellaneous_1526736814
title: Anti-rheumatoid arthritic activity of flavonoids from Daphne genkwa
format: Article
creator:
  • Jiang, Cui-Ping
  • He, Xin
  • Yang, Xiao-Lin
  • Zhang, Su-Li
  • Li, Hui
  • Song, Zi-Jing
  • Zhang, Chun-Feng
  • Yang, Zhong-Lin
  • Li, Ping
  • Wang, Chong-Zhi
  • Yuan, Chun-Su
subjects:
  • Adjuvant-induced arthritis
  • Animals
  • Anti-Inflammatory Agents - isolation & purification
  • Anti-Inflammatory Agents - pharmacology
  • Anti-Inflammatory Agents - therapeutic use
  • Antioxidants - pharmacology
  • Antioxidants - therapeutic use
  • Antirheumatic Agents - pharmacology
  • Antirheumatic Agents - therapeutic use
  • Arthritis, Experimental - drug therapy
  • Arthritis, Experimental - metabolism
  • Arthritis, Rheumatoid - drug therapy
  • Bioflavonoids
  • Biphenyl Compounds
  • Care and treatment
  • Carrageenan
  • Daphne - chemistry
  • Daphne genkwa
  • Dose-Response Relationship, Drug
  • Edema
  • Female
  • Flavones
  • Flavonoids
  • Flavonoids - isolation & purification
  • Flavonoids - pharmacology
  • Flavonoids - therapeutic use
  • Freund's Adjuvant
  • Health aspects
  • Inflammation - chemically induced
  • Inflammation - drug therapy
  • Inflammation - metabolism
  • Lipopolysaccharides
  • Macrophages - drug effects
  • Macrophages - metabolism
  • Male
  • Materia medica, Vegetable
  • Medical research
  • Medicine, Botanic
  • Medicine, Experimental
  • Medicine, Herbal
  • Mice
  • Nitric Oxide - metabolism
  • Phytotherapy
  • Picrates
  • Plant extracts
  • Plant Extracts - pharmacology
  • Plant Extracts - therapeutic use
  • Rats
  • RAW264.7 cells
  • Research
  • Rheumatoid arthritis
ispartof: Phytomedicine (Stuttgart), 2014-05-15, Vol.21 (6), p.830-837
description: The aim of the study was to investigate the anti-rheumatoid arthritic activity of four flavonoids from Daphne genkwa (FFD) in vivo and in vitro. Flavonoids of D. genkwa were extracted by refluxing with ethanol and purified by polyamide resin. An in vivo carrageenan-induced paw edema model, tampon-granuloma model and Freund's complete adjuvant (FCA)-induced arthritis mouse model were used to evaluate the anti-rheumatoid arthritic activities of FFD. Moreover, nitric oxide (NO) release and neutral red uptake (NRU) in lipopolysaccharide (LPS)-induced murine macrophage RAW264.7 cells were used to evaluate the anti-inflammatory effect in vitro. In addition, antioxidant effect of FFD was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. A high dose of FFD significantly reduced the degree of acute inflammatory paw edema in mice as a response to carrageenan administration (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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titleAnti-rheumatoid arthritic activity of flavonoids from Daphne genkwa
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creatorJiang, Cui-Ping ; He, Xin ; Yang, Xiao-Lin ; Zhang, Su-Li ; Li, Hui ; Song, Zi-Jing ; Zhang, Chun-Feng ; Yang, Zhong-Lin ; Li, Ping ; Wang, Chong-Zhi ; Yuan, Chun-Su
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descriptionThe aim of the study was to investigate the anti-rheumatoid arthritic activity of four flavonoids from Daphne genkwa (FFD) in vivo and in vitro. Flavonoids of D. genkwa were extracted by refluxing with ethanol and purified by polyamide resin. An in vivo carrageenan-induced paw edema model, tampon-granuloma model and Freund's complete adjuvant (FCA)-induced arthritis mouse model were used to evaluate the anti-rheumatoid arthritic activities of FFD. Moreover, nitric oxide (NO) release and neutral red uptake (NRU) in lipopolysaccharide (LPS)-induced murine macrophage RAW264.7 cells were used to evaluate the anti-inflammatory effect in vitro. In addition, antioxidant effect of FFD was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. A high dose of FFD significantly reduced the degree of acute inflammatory paw edema in mice as a response to carrageenan administration (p<0.01). FFD displayed a dose-dependent inhibition of granuloma formation in mice (p<0.05). FFD also inhibited chronic inflammation in adjuvant-induced arthritis rats when administered orally at the dose of 50mg/kg/day (p<0.001). In addition, FFD suppressed the production of NO and exhibited immunoregulatory function in LPS-activated RAW264.7 cells in a dose-related manner. Simultaneously, FFD revealed conspicuous antioxidant activity with IC50 values of 18.20μg/ml. FFD possesses significant anti-inflammatory and antioxidant activity, which could be a potential therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis.
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languageeng
publisherGermany: Elsevier GmbH
subjectAdjuvant-induced arthritis ; Animals ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Antirheumatic Agents - pharmacology ; Antirheumatic Agents - therapeutic use ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - metabolism ; Arthritis, Rheumatoid - drug therapy ; Bioflavonoids ; Biphenyl Compounds ; Care and treatment ; Carrageenan ; Daphne - chemistry ; Daphne genkwa ; Dose-Response Relationship, Drug ; Edema ; Female ; Flavones ; Flavonoids ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Freund's Adjuvant ; Health aspects ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - metabolism ; Lipopolysaccharides ; Macrophages - drug effects ; Macrophages - metabolism ; Male ; Materia medica, Vegetable ; Medical research ; Medicine, Botanic ; Medicine, Experimental ; Medicine, Herbal ; Mice ; Nitric Oxide - metabolism ; Phytotherapy ; Picrates ; Plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; RAW264.7 cells ; Research ; Rheumatoid arthritis
ispartofPhytomedicine (Stuttgart), 2014-05-15, Vol.21 (6), p.830-837
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1He, Xin
2Yang, Xiao-Lin
3Zhang, Su-Li
4Li, Hui
5Song, Zi-Jing
6Zhang, Chun-Feng
7Yang, Zhong-Lin
8Li, Ping
9Wang, Chong-Zhi
10Yuan, Chun-Su
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descriptionThe aim of the study was to investigate the anti-rheumatoid arthritic activity of four flavonoids from Daphne genkwa (FFD) in vivo and in vitro. Flavonoids of D. genkwa were extracted by refluxing with ethanol and purified by polyamide resin. An in vivo carrageenan-induced paw edema model, tampon-granuloma model and Freund's complete adjuvant (FCA)-induced arthritis mouse model were used to evaluate the anti-rheumatoid arthritic activities of FFD. Moreover, nitric oxide (NO) release and neutral red uptake (NRU) in lipopolysaccharide (LPS)-induced murine macrophage RAW264.7 cells were used to evaluate the anti-inflammatory effect in vitro. In addition, antioxidant effect of FFD was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. A high dose of FFD significantly reduced the degree of acute inflammatory paw edema in mice as a response to carrageenan administration (p<0.01). FFD displayed a dose-dependent inhibition of granuloma formation in mice (p<0.05). FFD also inhibited chronic inflammation in adjuvant-induced arthritis rats when administered orally at the dose of 50mg/kg/day (p<0.001). In addition, FFD suppressed the production of NO and exhibited immunoregulatory function in LPS-activated RAW264.7 cells in a dose-related manner. Simultaneously, FFD revealed conspicuous antioxidant activity with IC50 values of 18.20μg/ml. FFD possesses significant anti-inflammatory and antioxidant activity, which could be a potential therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis.
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0Adjuvant-induced arthritis
1Animals
2Anti-Inflammatory Agents - isolation & purification
3Anti-Inflammatory Agents - pharmacology
4Anti-Inflammatory Agents - therapeutic use
5Antioxidants - pharmacology
6Antioxidants - therapeutic use
7Antirheumatic Agents - pharmacology
8Antirheumatic Agents - therapeutic use
9Arthritis, Experimental - drug therapy
10Arthritis, Experimental - metabolism
11Arthritis, Rheumatoid - drug therapy
12Bioflavonoids
13Biphenyl Compounds
14Care and treatment
15Carrageenan
16Daphne - chemistry
17Daphne genkwa
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20Female
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23Flavonoids - isolation & purification
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29Inflammation - drug therapy
30Inflammation - metabolism
31Lipopolysaccharides
32Macrophages - drug effects
33Macrophages - metabolism
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35Materia medica, Vegetable
36Medical research
37Medicine, Botanic
38Medicine, Experimental
39Medicine, Herbal
40Mice
41Nitric Oxide - metabolism
42Phytotherapy
43Picrates
44Plant extracts
45Plant Extracts - pharmacology
46Plant Extracts - therapeutic use
47Rats
48RAW264.7 cells
49Research
50Rheumatoid arthritis
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titleAnti-rheumatoid arthritic activity of flavonoids from Daphne genkwa
authorJiang, Cui-Ping ; He, Xin ; Yang, Xiao-Lin ; Zhang, Su-Li ; Li, Hui ; Song, Zi-Jing ; Zhang, Chun-Feng ; Yang, Zhong-Lin ; Li, Ping ; Wang, Chong-Zhi ; Yuan, Chun-Su
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abstractThe aim of the study was to investigate the anti-rheumatoid arthritic activity of four flavonoids from Daphne genkwa (FFD) in vivo and in vitro. Flavonoids of D. genkwa were extracted by refluxing with ethanol and purified by polyamide resin. An in vivo carrageenan-induced paw edema model, tampon-granuloma model and Freund's complete adjuvant (FCA)-induced arthritis mouse model were used to evaluate the anti-rheumatoid arthritic activities of FFD. Moreover, nitric oxide (NO) release and neutral red uptake (NRU) in lipopolysaccharide (LPS)-induced murine macrophage RAW264.7 cells were used to evaluate the anti-inflammatory effect in vitro. In addition, antioxidant effect of FFD was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. A high dose of FFD significantly reduced the degree of acute inflammatory paw edema in mice as a response to carrageenan administration (p<0.01). FFD displayed a dose-dependent inhibition of granuloma formation in mice (p<0.05). FFD also inhibited chronic inflammation in adjuvant-induced arthritis rats when administered orally at the dose of 50mg/kg/day (p<0.001). In addition, FFD suppressed the production of NO and exhibited immunoregulatory function in LPS-activated RAW264.7 cells in a dose-related manner. Simultaneously, FFD revealed conspicuous antioxidant activity with IC50 values of 18.20μg/ml. FFD possesses significant anti-inflammatory and antioxidant activity, which could be a potential therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis.
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pmid24561028
doi10.1016/j.phymed.2014.01.009
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