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Primary intravascular large B cell lymphoma of the endometrium

Primary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, a... Full description

Journal Title: Acta histochemica 2014, Vol.116 (5), p.993-996
Main Author: Xia, Yan
Other Authors: Wang, Yuewei , Jiang, Yanxia , Yu, Wenjuan , Li, Yujun , Xiang, Fenggang , Wang, Chengqin
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0065-1281
Link: https://www.ncbi.nlm.nih.gov/pubmed/24418320
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title: Primary intravascular large B cell lymphoma of the endometrium
format: Article
creator:
  • Xia, Yan
  • Wang, Yuewei
  • Jiang, Yanxia
  • Yu, Wenjuan
  • Li, Yujun
  • Xiang, Fenggang
  • Wang, Chengqin
subjects:
  • Aged
  • Endometrial Neoplasms - diagnosis
  • Endometrial Neoplasms - pathology
  • Endometrium
  • Endometrium - pathology
  • Female
  • Humans
  • Intravascular large B cell lymphoma
  • Lymphoma, B-Cell - diagnosis
  • Lymphoma, B-Cell - pathology
ispartof: Acta histochemica, 2014, Vol.116 (5), p.993-996
description: Primary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old woman showed symptoms of chronic cough and choking sensation for 4 months. Following three days of vaginal bleeding she presented for examination and diagnosis. The percentage of monocytes in the blood was double that of normal levels. There was a polyp in the endometrium, which showed a number of medium–large lymphoid cells in dilated capillaries. Immunohistochemically, the lymphoid cells were immunoreactive to CD20, CD79a, Mum-1 and Foxp-1 with 85% cells immunoreactive to Ki-67. IVLBCL of the endometrium is rare and the clinical diagnosis is very difficult. Unexplained fever of old people and abnormal laboratory tests such as obvious abnormal monocyte distribution in the blood should alert the clinical doctor to the possibility of IVLBCL. A correct diagnosis mainly depends on pathological tests and immunohistochemical labeling. The prognosis of IVLBCL is poor and few patients survive longer than one year.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0065-1281
fulltext: fulltext
issn:
  • 0065-1281
  • 1618-0372
url: Link


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descriptionPrimary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old woman showed symptoms of chronic cough and choking sensation for 4 months. Following three days of vaginal bleeding she presented for examination and diagnosis. The percentage of monocytes in the blood was double that of normal levels. There was a polyp in the endometrium, which showed a number of medium–large lymphoid cells in dilated capillaries. Immunohistochemically, the lymphoid cells were immunoreactive to CD20, CD79a, Mum-1 and Foxp-1 with 85% cells immunoreactive to Ki-67. IVLBCL of the endometrium is rare and the clinical diagnosis is very difficult. Unexplained fever of old people and abnormal laboratory tests such as obvious abnormal monocyte distribution in the blood should alert the clinical doctor to the possibility of IVLBCL. A correct diagnosis mainly depends on pathological tests and immunohistochemical labeling. The prognosis of IVLBCL is poor and few patients survive longer than one year.
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subjectAged ; Endometrial Neoplasms - diagnosis ; Endometrial Neoplasms - pathology ; Endometrium ; Endometrium - pathology ; Female ; Humans ; Intravascular large B cell lymphoma ; Lymphoma, B-Cell - diagnosis ; Lymphoma, B-Cell - pathology
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abstractPrimary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old woman showed symptoms of chronic cough and choking sensation for 4 months. Following three days of vaginal bleeding she presented for examination and diagnosis. The percentage of monocytes in the blood was double that of normal levels. There was a polyp in the endometrium, which showed a number of medium–large lymphoid cells in dilated capillaries. Immunohistochemically, the lymphoid cells were immunoreactive to CD20, CD79a, Mum-1 and Foxp-1 with 85% cells immunoreactive to Ki-67. IVLBCL of the endometrium is rare and the clinical diagnosis is very difficult. Unexplained fever of old people and abnormal laboratory tests such as obvious abnormal monocyte distribution in the blood should alert the clinical doctor to the possibility of IVLBCL. A correct diagnosis mainly depends on pathological tests and immunohistochemical labeling. The prognosis of IVLBCL is poor and few patients survive longer than one year.
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