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The efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study

Essential oils of many plants have been previously tested in the treatment of oral diseases and other infections. This study was a randomized, double-blind, in parallel with an active control study, which aimed to evaluate the efficacy of three formulations of the Lippia sidoides Cham. essential oil... Full description

Journal Title: Phytomedicine (Stuttgart) 2014, Vol.21 (8-9), p.1043-1047
Main Author: Lobo, Patrícia Leal Dantas
Other Authors: Fonteles, Cristiane Sá Roriz , Marques, Lídia Audrey Rocha Valadas , Jamacaru, Francisco Vagnaldo Fechine , Fonseca, Said Gonçalves da Cruz , de Carvalho, Cibele Barreto Mano , de Moraes, Maria Elisabete Amaral
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/24863037
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title: The efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study
format: Article
creator:
  • Lobo, Patrícia Leal Dantas
  • Fonteles, Cristiane Sá Roriz
  • Marques, Lídia Audrey Rocha Valadas
  • Jamacaru, Francisco Vagnaldo Fechine
  • Fonseca, Said Gonçalves da Cruz
  • de Carvalho, Cibele Barreto Mano
  • de Moraes, Maria Elisabete Amaral
subjects:
  • Anti-Infective Agents, Local - pharmacology
  • Brazil
  • Care and treatment
  • Chemistry, Pharmaceutical
  • Child
  • Chlorhexidine - pharmacology
  • Dental caries
  • Dental Caries - drug therapy
  • Double-Blind Method
  • Essences and essential oils
  • Female
  • Health aspects
  • Humans
  • Lippia
  • Lippia - chemistry
  • Lippia sidoides Cham. essential oil
  • Male
  • Mouthwashes - pharmacology
  • Oils, Volatile - chemistry
  • Oils, Volatile - isolation & purification
  • Oils, Volatile - pharmacology
  • Pilot Projects
  • Plant Oils - chemistry
  • Plant Oils - isolation & purification
  • Plant Oils - pharmacology
  • Saliva - drug effects
  • Saliva - microbiology
  • Streptococcal infections
  • Streptococcus mutans
  • Streptococcus mutans - drug effects
  • Toothpastes
  • Treatment Outcome
  • Usage
  • Verbena
ispartof: Phytomedicine (Stuttgart), 2014, Vol.21 (8-9), p.1043-1047
description: Essential oils of many plants have been previously tested in the treatment of oral diseases and other infections. This study was a randomized, double-blind, in parallel with an active control study, which aimed to evaluate the efficacy of three formulations of the Lippia sidoides Cham. essential oil (LSO) in the reduction of salivary Streptococcus mutans in children with caries. 81 volunteers, aged 6–12 years, both genders, with caries, were recruited to participate in this study, and randomly assigned to either one of five different groups. Each group received topical treatment with either 1.4% LSO toothpaste, 1.4% LSO gel, 0.8% LSO mouthwash, 1% chlorhexidine gel, or 0.12% chlorhexidine mouthwash. A 5-ml volume of each gel was placed inside disposable trays, and applied for 1min, every 24h, for 5 consecutive days. The mouthwash groups used 5-ml volume of a mouthwash inside disposable syringes. In the toothpaste group, children brushed their teeth for 1min, once a day for 5 days. Saliva was collected before and after treatment. MS colonies were counted, isolated and confirmed through biochemical tests. Differences in MS levels measured in different days within the same treatment group was only verified with LSO toothpaste, chlorhexidine gel and chlorhexidine mouthwash. Comparison between groups of LSO mouthwash, toothpaste and gel showed that the toothpaste group expressed significantly lower MS levels than the mouthwash and gel groups at day-30. Chlorhexidine significantly reduced MS levels after 5 days of treatment, but these levels returned to baseline in other periods of the study. LSO toothpaste reduced MS levels after 5 days of treatment, and MS levels remained low and did not return to baseline during subsequent analysis. Hence, LSO toothpaste demonstrated the most long-lasting MS reduction in saliva, whereas other LSO formulations did not effectively reduce MS levels in children with dental caries.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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titleThe efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study
sourceAlma/SFX Local Collection
creatorLobo, Patrícia Leal Dantas ; Fonteles, Cristiane Sá Roriz ; Marques, Lídia Audrey Rocha Valadas ; Jamacaru, Francisco Vagnaldo Fechine ; Fonseca, Said Gonçalves da Cruz ; de Carvalho, Cibele Barreto Mano ; de Moraes, Maria Elisabete Amaral
creatorcontribLobo, Patrícia Leal Dantas ; Fonteles, Cristiane Sá Roriz ; Marques, Lídia Audrey Rocha Valadas ; Jamacaru, Francisco Vagnaldo Fechine ; Fonseca, Said Gonçalves da Cruz ; de Carvalho, Cibele Barreto Mano ; de Moraes, Maria Elisabete Amaral
descriptionEssential oils of many plants have been previously tested in the treatment of oral diseases and other infections. This study was a randomized, double-blind, in parallel with an active control study, which aimed to evaluate the efficacy of three formulations of the Lippia sidoides Cham. essential oil (LSO) in the reduction of salivary Streptococcus mutans in children with caries. 81 volunteers, aged 6–12 years, both genders, with caries, were recruited to participate in this study, and randomly assigned to either one of five different groups. Each group received topical treatment with either 1.4% LSO toothpaste, 1.4% LSO gel, 0.8% LSO mouthwash, 1% chlorhexidine gel, or 0.12% chlorhexidine mouthwash. A 5-ml volume of each gel was placed inside disposable trays, and applied for 1min, every 24h, for 5 consecutive days. The mouthwash groups used 5-ml volume of a mouthwash inside disposable syringes. In the toothpaste group, children brushed their teeth for 1min, once a day for 5 days. Saliva was collected before and after treatment. MS colonies were counted, isolated and confirmed through biochemical tests. Differences in MS levels measured in different days within the same treatment group was only verified with LSO toothpaste, chlorhexidine gel and chlorhexidine mouthwash. Comparison between groups of LSO mouthwash, toothpaste and gel showed that the toothpaste group expressed significantly lower MS levels than the mouthwash and gel groups at day-30. Chlorhexidine significantly reduced MS levels after 5 days of treatment, but these levels returned to baseline in other periods of the study. LSO toothpaste reduced MS levels after 5 days of treatment, and MS levels remained low and did not return to baseline during subsequent analysis. Hence, LSO toothpaste demonstrated the most long-lasting MS reduction in saliva, whereas other LSO formulations did not effectively reduce MS levels in children with dental caries.
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languageeng
publisherGermany: Elsevier GmbH
subjectAnti-Infective Agents, Local - pharmacology ; Brazil ; Care and treatment ; Chemistry, Pharmaceutical ; Child ; Chlorhexidine - pharmacology ; Dental caries ; Dental Caries - drug therapy ; Double-Blind Method ; Essences and essential oils ; Female ; Health aspects ; Humans ; Lippia ; Lippia - chemistry ; Lippia sidoides Cham. essential oil ; Male ; Mouthwashes - pharmacology ; Oils, Volatile - chemistry ; Oils, Volatile - isolation & purification ; Oils, Volatile - pharmacology ; Pilot Projects ; Plant Oils - chemistry ; Plant Oils - isolation & purification ; Plant Oils - pharmacology ; Saliva - drug effects ; Saliva - microbiology ; Streptococcal infections ; Streptococcus mutans ; Streptococcus mutans - drug effects ; Toothpastes ; Treatment Outcome ; Usage ; Verbena
ispartofPhytomedicine (Stuttgart), 2014, Vol.21 (8-9), p.1043-1047
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1Fonteles, Cristiane Sá Roriz
2Marques, Lídia Audrey Rocha Valadas
3Jamacaru, Francisco Vagnaldo Fechine
4Fonseca, Said Gonçalves da Cruz
5de Carvalho, Cibele Barreto Mano
6de Moraes, Maria Elisabete Amaral
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0The efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study
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descriptionEssential oils of many plants have been previously tested in the treatment of oral diseases and other infections. This study was a randomized, double-blind, in parallel with an active control study, which aimed to evaluate the efficacy of three formulations of the Lippia sidoides Cham. essential oil (LSO) in the reduction of salivary Streptococcus mutans in children with caries. 81 volunteers, aged 6–12 years, both genders, with caries, were recruited to participate in this study, and randomly assigned to either one of five different groups. Each group received topical treatment with either 1.4% LSO toothpaste, 1.4% LSO gel, 0.8% LSO mouthwash, 1% chlorhexidine gel, or 0.12% chlorhexidine mouthwash. A 5-ml volume of each gel was placed inside disposable trays, and applied for 1min, every 24h, for 5 consecutive days. The mouthwash groups used 5-ml volume of a mouthwash inside disposable syringes. In the toothpaste group, children brushed their teeth for 1min, once a day for 5 days. Saliva was collected before and after treatment. MS colonies were counted, isolated and confirmed through biochemical tests. Differences in MS levels measured in different days within the same treatment group was only verified with LSO toothpaste, chlorhexidine gel and chlorhexidine mouthwash. Comparison between groups of LSO mouthwash, toothpaste and gel showed that the toothpaste group expressed significantly lower MS levels than the mouthwash and gel groups at day-30. Chlorhexidine significantly reduced MS levels after 5 days of treatment, but these levels returned to baseline in other periods of the study. LSO toothpaste reduced MS levels after 5 days of treatment, and MS levels remained low and did not return to baseline during subsequent analysis. Hence, LSO toothpaste demonstrated the most long-lasting MS reduction in saliva, whereas other LSO formulations did not effectively reduce MS levels in children with dental caries.
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0Anti-Infective Agents, Local - pharmacology
1Brazil
2Care and treatment
3Chemistry, Pharmaceutical
4Child
5Chlorhexidine - pharmacology
6Dental caries
7Dental Caries - drug therapy
8Double-Blind Method
9Essences and essential oils
10Female
11Health aspects
12Humans
13Lippia
14Lippia - chemistry
15Lippia sidoides Cham. essential oil
16Male
17Mouthwashes - pharmacology
18Oils, Volatile - chemistry
19Oils, Volatile - isolation & purification
20Oils, Volatile - pharmacology
21Pilot Projects
22Plant Oils - chemistry
23Plant Oils - isolation & purification
24Plant Oils - pharmacology
25Saliva - drug effects
26Saliva - microbiology
27Streptococcal infections
28Streptococcus mutans
29Streptococcus mutans - drug effects
30Toothpastes
31Treatment Outcome
32Usage
33Verbena
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titleThe efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study
authorLobo, Patrícia Leal Dantas ; Fonteles, Cristiane Sá Roriz ; Marques, Lídia Audrey Rocha Valadas ; Jamacaru, Francisco Vagnaldo Fechine ; Fonseca, Said Gonçalves da Cruz ; de Carvalho, Cibele Barreto Mano ; de Moraes, Maria Elisabete Amaral
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8Double-Blind Method
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19Oils, Volatile - isolation & purification
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24Plant Oils - pharmacology
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31Treatment Outcome
32Usage
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1Fonteles, Cristiane Sá Roriz
2Marques, Lídia Audrey Rocha Valadas
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atitleThe efficacy of three formulations of Lippia sidoides Cham. essential oil in the reduction of salivary Streptococcus mutans in children with caries: A randomized, double-blind, controlled study
jtitlePhytomedicine (Stuttgart)
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date2014-07
risdate2014
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issue8-9
spage1043
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pages1043-1047
issn0944-7113
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abstractEssential oils of many plants have been previously tested in the treatment of oral diseases and other infections. This study was a randomized, double-blind, in parallel with an active control study, which aimed to evaluate the efficacy of three formulations of the Lippia sidoides Cham. essential oil (LSO) in the reduction of salivary Streptococcus mutans in children with caries. 81 volunteers, aged 6–12 years, both genders, with caries, were recruited to participate in this study, and randomly assigned to either one of five different groups. Each group received topical treatment with either 1.4% LSO toothpaste, 1.4% LSO gel, 0.8% LSO mouthwash, 1% chlorhexidine gel, or 0.12% chlorhexidine mouthwash. A 5-ml volume of each gel was placed inside disposable trays, and applied for 1min, every 24h, for 5 consecutive days. The mouthwash groups used 5-ml volume of a mouthwash inside disposable syringes. In the toothpaste group, children brushed their teeth for 1min, once a day for 5 days. Saliva was collected before and after treatment. MS colonies were counted, isolated and confirmed through biochemical tests. Differences in MS levels measured in different days within the same treatment group was only verified with LSO toothpaste, chlorhexidine gel and chlorhexidine mouthwash. Comparison between groups of LSO mouthwash, toothpaste and gel showed that the toothpaste group expressed significantly lower MS levels than the mouthwash and gel groups at day-30. Chlorhexidine significantly reduced MS levels after 5 days of treatment, but these levels returned to baseline in other periods of the study. LSO toothpaste reduced MS levels after 5 days of treatment, and MS levels remained low and did not return to baseline during subsequent analysis. Hence, LSO toothpaste demonstrated the most long-lasting MS reduction in saliva, whereas other LSO formulations did not effectively reduce MS levels in children with dental caries.
copGermany
pubElsevier GmbH
pmid24863037
doi10.1016/j.phymed.2014.04.021
tpages5
orcididhttps://orcid.org/0000-0001-6773-9836