schliessen

Filtern

 

Bibliotheken

Clinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience

Background Food protein–induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergy. FPIES diagnosis is frequently delayed because of the absence of classic allergic symptoms and lack of biomarkers. Objective We sought to characterize the clinical features and resolution of FPIES in pa... Full description

Journal Title: Journal of allergy and clinical immunology 2014, Vol.134 (2), p.382-389.e4
Main Author: Caubet, Jean Christoph, MD
Other Authors: Ford, Lara Simone, MD, MPH , Sickles, Laura, BA , Järvinen, Kirsi M., MD, PhD , Sicherer, Scott H., MD , Sampson, Hugh A., MD , Nowak-Węgrzyn, Anna, MD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: United States: Mosby, Inc
ID: ISSN: 0091-6749
Link: https://www.ncbi.nlm.nih.gov/pubmed/24880634
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1554944524
title: Clinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience
format: Article
creator:
  • Caubet, Jean Christoph, MD
  • Ford, Lara Simone, MD, MPH
  • Sickles, Laura, BA
  • Järvinen, Kirsi M., MD, PhD
  • Sicherer, Scott H., MD
  • Sampson, Hugh A., MD
  • Nowak-Węgrzyn, Anna, MD
subjects:
  • Abridged Index Medicus
  • Adolescent
  • Adult
  • Age
  • allergic enterocolitis
  • Allergies
  • Allergy and Immunology
  • Animals
  • Cattle
  • Child
  • Child, Preschool
  • Children
  • Diarrhea
  • Enterocolitis
  • Enterocolitis - complications
  • Enterocolitis - immunology
  • Enterocolitis - physiopathology
  • Family medical history
  • Female
  • Food
  • Food allergies
  • Food allergy
  • Food Hypersensitivity - complications
  • Food Hypersensitivity - immunology
  • Food Hypersensitivity - physiopathology
  • food protein–induced enterocolitis
  • Food protein–induced enterocolitis syndrome
  • Health aspects
  • Hospitals
  • Humans
  • Immune Tolerance
  • Immunoglobulin E
  • Immunoglobulin E - blood
  • Infant
  • Male
  • Medical colleges
  • Middle Aged
  • Milk
  • milk allergy
  • Milk Proteins - immunology
  • natural history
  • oat allergy
  • Oryza sativa
  • Patients
  • Prospective Studies
  • Proteins
  • rice allergy
  • soy allergy
  • Soybean Proteins - immunology
  • Studies
  • Syndrome
  • Time Factors
ispartof: Journal of allergy and clinical immunology, 2014, Vol.134 (2), p.382-389.e4
description: Background Food protein–induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergy. FPIES diagnosis is frequently delayed because of the absence of classic allergic symptoms and lack of biomarkers. Objective We sought to characterize the clinical features and resolution of FPIES in patients evaluated in our practice. Methods Subjects 6 months to 45 years of age with FPIES were prospectively recruited for oral food challenges (OFCs). Medical records were searched to identify the subjects who did not participate in OFCs. Results Among 160 subjects, 54% were male; median age at diagnosis was 15 months. We performed 180 OFCs to 15 foods in 82 subjects; 30% of the study population had FPIES confirmed based on OFC results. The most common foods were cow's milk (44%), soy (41%), rice (22.5%), and oat (16%). The majority (65%) reacted to 1 food, 26% reacted to 2 foods, and 9% reacted to 3 or more foods. The majority were atopic, and 39% had IgE sensitization to another food. Thirty-nine (24%) subjects had positive specific IgE levels to the food inducing FPIES. Among children with specific IgE to cow's milk, 41% changed from a milk FPIES to an IgE-mediated phenotype over time. The median age when tolerance was established was 4.7 years for rice, 4 years for oat, and 6.7 years for soy. Median age when milk tolerance was established for subjects with undetectable milk-specific IgE levels was 5.1 years, whereas none of the subjects with detectable milk-specific IgE became tolerant to milk during the study ( P  = .003). Conclusion FPIES typically resolves by age 5 years. Milk FPIES, especially with detectable food-specific IgE, can have a protracted course and eventually transition to acute reactions.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0091-6749
fulltext: fulltext
issn:
  • 0091-6749
  • 1097-6825
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.7626677
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1554944524
sourceformatXML
sourcesystemPC
galeidA378201478
sourcerecordidA378201478
originalsourceidFETCH-LOGICAL-1558t-98763572e7c653f3e69986778a91c927e98f635d56f2953f13f47bca695672523
addsrcrecordideNqNksuKFDEUhgtRnJ7RF3AhBW7cVJn7RUQYmvECAy7UdcikTiRtddImVWLvfAff0CcxZbcKvRgkBw4J339ykv80zSOMeoyweLbpN9aFniDMelQDqTvNCiMtO6EIv9usENK4E5Lps-a8lA2qe6r0_eaMMKWQoGzVwHoMMTg7th7sNGcorY1DW3Ma5ymk2Cbf-pSGdpfTBCH-_P4jxGF2MLQQJ8jJpTFMobRlH4ectvC8xajbg80tfNtBDhAdPGjueTsWeHjMF83HV1cf1m-663ev364vrzvMuZo6raSgXBKQTnDqKQitlZBSWY2dJhK08hUYuPBEVwBTz-SNs0JzIQkn9KJ5eqhbm_0yQ5nMNhQH42gjpLmYeg3TjHHC_gfFlGJCUEWfnKCbNOdYH1IppmsnWvFK9Qfqkx3BhOjTlK2ra4BtcCmCD_X8kkq1GCZVFZCDwOVUSgZvdjlsbd4bjMxisNmYxWCz8AbVQIvo8bGX-WYLw1_JH0croE6qujDZxcnaThhvr_3iIIVq0dcA2RT3274hZHCTGVK4Xf7yRO6Os_UZ9lD-_ZkpxCDzfpnOZTgxQ4gLLekvHQndBg
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1549953985
display
typearticle
titleClinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience
sourceAlma/SFX Local Collection
creatorCaubet, Jean Christoph, MD ; Ford, Lara Simone, MD, MPH ; Sickles, Laura, BA ; Järvinen, Kirsi M., MD, PhD ; Sicherer, Scott H., MD ; Sampson, Hugh A., MD ; Nowak-Węgrzyn, Anna, MD
creatorcontribCaubet, Jean Christoph, MD ; Ford, Lara Simone, MD, MPH ; Sickles, Laura, BA ; Järvinen, Kirsi M., MD, PhD ; Sicherer, Scott H., MD ; Sampson, Hugh A., MD ; Nowak-Węgrzyn, Anna, MD
descriptionBackground Food protein–induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergy. FPIES diagnosis is frequently delayed because of the absence of classic allergic symptoms and lack of biomarkers. Objective We sought to characterize the clinical features and resolution of FPIES in patients evaluated in our practice. Methods Subjects 6 months to 45 years of age with FPIES were prospectively recruited for oral food challenges (OFCs). Medical records were searched to identify the subjects who did not participate in OFCs. Results Among 160 subjects, 54% were male; median age at diagnosis was 15 months. We performed 180 OFCs to 15 foods in 82 subjects; 30% of the study population had FPIES confirmed based on OFC results. The most common foods were cow's milk (44%), soy (41%), rice (22.5%), and oat (16%). The majority (65%) reacted to 1 food, 26% reacted to 2 foods, and 9% reacted to 3 or more foods. The majority were atopic, and 39% had IgE sensitization to another food. Thirty-nine (24%) subjects had positive specific IgE levels to the food inducing FPIES. Among children with specific IgE to cow's milk, 41% changed from a milk FPIES to an IgE-mediated phenotype over time. The median age when tolerance was established was 4.7 years for rice, 4 years for oat, and 6.7 years for soy. Median age when milk tolerance was established for subjects with undetectable milk-specific IgE levels was 5.1 years, whereas none of the subjects with detectable milk-specific IgE became tolerant to milk during the study ( P  = .003). Conclusion FPIES typically resolves by age 5 years. Milk FPIES, especially with detectable food-specific IgE, can have a protracted course and eventually transition to acute reactions.
identifier
0ISSN: 0091-6749
1EISSN: 1097-6825
2DOI: 10.1016/j.jaci.2014.04.008
3PMID: 24880634
languageeng
publisherUnited States: Mosby, Inc
subjectAbridged Index Medicus ; Adolescent ; Adult ; Age ; allergic enterocolitis ; Allergies ; Allergy and Immunology ; Animals ; Cattle ; Child ; Child, Preschool ; Children ; Diarrhea ; Enterocolitis ; Enterocolitis - complications ; Enterocolitis - immunology ; Enterocolitis - physiopathology ; Family medical history ; Female ; Food ; Food allergies ; Food allergy ; Food Hypersensitivity - complications ; Food Hypersensitivity - immunology ; Food Hypersensitivity - physiopathology ; food protein–induced enterocolitis ; Food protein–induced enterocolitis syndrome ; Health aspects ; Hospitals ; Humans ; Immune Tolerance ; Immunoglobulin E ; Immunoglobulin E - blood ; Infant ; Male ; Medical colleges ; Middle Aged ; Milk ; milk allergy ; Milk Proteins - immunology ; natural history ; oat allergy ; Oryza sativa ; Patients ; Prospective Studies ; Proteins ; rice allergy ; soy allergy ; Soybean Proteins - immunology ; Studies ; Syndrome ; Time Factors
ispartofJournal of allergy and clinical immunology, 2014, Vol.134 (2), p.382-389.e4
rights
02014
1Copyright © 2014. Published by Mosby, Inc.
2COPYRIGHT 2014 Elsevier B.V.
3Copyright Elsevier Limited Aug 2014
lds50peer_reviewed
citedbyFETCH-LOGICAL-1558t-98763572e7c653f3e69986778a91c927e98f635d56f2953f13f47bca695672523
citesFETCH-LOGICAL-1558t-98763572e7c653f3e69986778a91c927e98f635d56f2953f13f47bca695672523
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24880634$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Caubet, Jean Christoph, MD
1Ford, Lara Simone, MD, MPH
2Sickles, Laura, BA
3Järvinen, Kirsi M., MD, PhD
4Sicherer, Scott H., MD
5Sampson, Hugh A., MD
6Nowak-Węgrzyn, Anna, MD
title
0Clinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience
1Journal of allergy and clinical immunology
addtitleJ Allergy Clin Immunol
descriptionBackground Food protein–induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergy. FPIES diagnosis is frequently delayed because of the absence of classic allergic symptoms and lack of biomarkers. Objective We sought to characterize the clinical features and resolution of FPIES in patients evaluated in our practice. Methods Subjects 6 months to 45 years of age with FPIES were prospectively recruited for oral food challenges (OFCs). Medical records were searched to identify the subjects who did not participate in OFCs. Results Among 160 subjects, 54% were male; median age at diagnosis was 15 months. We performed 180 OFCs to 15 foods in 82 subjects; 30% of the study population had FPIES confirmed based on OFC results. The most common foods were cow's milk (44%), soy (41%), rice (22.5%), and oat (16%). The majority (65%) reacted to 1 food, 26% reacted to 2 foods, and 9% reacted to 3 or more foods. The majority were atopic, and 39% had IgE sensitization to another food. Thirty-nine (24%) subjects had positive specific IgE levels to the food inducing FPIES. Among children with specific IgE to cow's milk, 41% changed from a milk FPIES to an IgE-mediated phenotype over time. The median age when tolerance was established was 4.7 years for rice, 4 years for oat, and 6.7 years for soy. Median age when milk tolerance was established for subjects with undetectable milk-specific IgE levels was 5.1 years, whereas none of the subjects with detectable milk-specific IgE became tolerant to milk during the study ( P  = .003). Conclusion FPIES typically resolves by age 5 years. Milk FPIES, especially with detectable food-specific IgE, can have a protracted course and eventually transition to acute reactions.
subject
0Abridged Index Medicus
1Adolescent
2Adult
3Age
4allergic enterocolitis
5Allergies
6Allergy and Immunology
7Animals
8Cattle
9Child
10Child, Preschool
11Children
12Diarrhea
13Enterocolitis
14Enterocolitis - complications
15Enterocolitis - immunology
16Enterocolitis - physiopathology
17Family medical history
18Female
19Food
20Food allergies
21Food allergy
22Food Hypersensitivity - complications
23Food Hypersensitivity - immunology
24Food Hypersensitivity - physiopathology
25food protein–induced enterocolitis
26Food protein–induced enterocolitis syndrome
27Health aspects
28Hospitals
29Humans
30Immune Tolerance
31Immunoglobulin E
32Immunoglobulin E - blood
33Infant
34Male
35Medical colleges
36Middle Aged
37Milk
38milk allergy
39Milk Proteins - immunology
40natural history
41oat allergy
42Oryza sativa
43Patients
44Prospective Studies
45Proteins
46rice allergy
47soy allergy
48Soybean Proteins - immunology
49Studies
50Syndrome
51Time Factors
issn
00091-6749
11097-6825
fulltexttrue
rsrctypearticle
creationdate2014
recordtypearticle
recordideNqNksuKFDEUhgtRnJ7RF3AhBW7cVJn7RUQYmvECAy7UdcikTiRtddImVWLvfAff0CcxZbcKvRgkBw4J339ykv80zSOMeoyweLbpN9aFniDMelQDqTvNCiMtO6EIv9usENK4E5Lps-a8lA2qe6r0_eaMMKWQoGzVwHoMMTg7th7sNGcorY1DW3Ma5ymk2Cbf-pSGdpfTBCH-_P4jxGF2MLQQJ8jJpTFMobRlH4ectvC8xajbg80tfNtBDhAdPGjueTsWeHjMF83HV1cf1m-663ev364vrzvMuZo6raSgXBKQTnDqKQitlZBSWY2dJhK08hUYuPBEVwBTz-SNs0JzIQkn9KJ5eqhbm_0yQ5nMNhQH42gjpLmYeg3TjHHC_gfFlGJCUEWfnKCbNOdYH1IppmsnWvFK9Qfqkx3BhOjTlK2ra4BtcCmCD_X8kkq1GCZVFZCDwOVUSgZvdjlsbd4bjMxisNmYxWCz8AbVQIvo8bGX-WYLw1_JH0croE6qujDZxcnaThhvr_3iIIVq0dcA2RT3274hZHCTGVK4Xf7yRO6Os_UZ9lD-_ZkpxCDzfpnOZTgxQ4gLLekvHQndBg
startdate2014
enddate2014
creator
0Caubet, Jean Christoph, MD
1Ford, Lara Simone, MD, MPH
2Sickles, Laura, BA
3Järvinen, Kirsi M., MD, PhD
4Sicherer, Scott H., MD
5Sampson, Hugh A., MD
6Nowak-Węgrzyn, Anna, MD
general
0Mosby, Inc
1Elsevier B.V
2Elsevier Limited
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8BSHEE
97SS
107T5
11H94
12K9.
137X8
sort
creationdate2014
titleClinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience
authorCaubet, Jean Christoph, MD ; Ford, Lara Simone, MD, MPH ; Sickles, Laura, BA ; Järvinen, Kirsi M., MD, PhD ; Sicherer, Scott H., MD ; Sampson, Hugh A., MD ; Nowak-Węgrzyn, Anna, MD
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1558t-98763572e7c653f3e69986778a91c927e98f635d56f2953f13f47bca695672523
rsrctypearticles
prefilterarticles
languageeng
creationdate2014
topic
0Abridged Index Medicus
1Adolescent
2Adult
3Age
4allergic enterocolitis
5Allergies
6Allergy and Immunology
7Animals
8Cattle
9Child
10Child, Preschool
11Children
12Diarrhea
13Enterocolitis
14Enterocolitis - complications
15Enterocolitis - immunology
16Enterocolitis - physiopathology
17Family medical history
18Female
19Food
20Food allergies
21Food allergy
22Food Hypersensitivity - complications
23Food Hypersensitivity - immunology
24Food Hypersensitivity - physiopathology
25food protein–induced enterocolitis
26Food protein–induced enterocolitis syndrome
27Health aspects
28Hospitals
29Humans
30Immune Tolerance
31Immunoglobulin E
32Immunoglobulin E - blood
33Infant
34Male
35Medical colleges
36Middle Aged
37Milk
38milk allergy
39Milk Proteins - immunology
40natural history
41oat allergy
42Oryza sativa
43Patients
44Prospective Studies
45Proteins
46rice allergy
47soy allergy
48Soybean Proteins - immunology
49Studies
50Syndrome
51Time Factors
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Caubet, Jean Christoph, MD
1Ford, Lara Simone, MD, MPH
2Sickles, Laura, BA
3Järvinen, Kirsi M., MD, PhD
4Sicherer, Scott H., MD
5Sampson, Hugh A., MD
6Nowak-Węgrzyn, Anna, MD
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Academic OneFile (A&I only)
8Entomology Abstracts (Full archive)
9Immunology Abstracts
10AIDS and Cancer Research Abstracts
11ProQuest Health & Medical Complete (Alumni)
12MEDLINE - Academic
jtitleJournal of allergy and clinical immunology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Caubet, Jean Christoph, MD
1Ford, Lara Simone, MD, MPH
2Sickles, Laura, BA
3Järvinen, Kirsi M., MD, PhD
4Sicherer, Scott H., MD
5Sampson, Hugh A., MD
6Nowak-Węgrzyn, Anna, MD
formatjournal
genrearticle
ristypeJOUR
atitleClinical features and resolution of food protein–induced enterocolitis syndrome: 10-year experience
jtitleJournal of allergy and clinical immunology
addtitleJ Allergy Clin Immunol
date2014
risdate2014
volume134
issue2
spage382
epage389.e4
pages382-389.e4
issn0091-6749
eissn1097-6825
abstractBackground Food protein–induced enterocolitis syndrome (FPIES) is a non–IgE-mediated food allergy. FPIES diagnosis is frequently delayed because of the absence of classic allergic symptoms and lack of biomarkers. Objective We sought to characterize the clinical features and resolution of FPIES in patients evaluated in our practice. Methods Subjects 6 months to 45 years of age with FPIES were prospectively recruited for oral food challenges (OFCs). Medical records were searched to identify the subjects who did not participate in OFCs. Results Among 160 subjects, 54% were male; median age at diagnosis was 15 months. We performed 180 OFCs to 15 foods in 82 subjects; 30% of the study population had FPIES confirmed based on OFC results. The most common foods were cow's milk (44%), soy (41%), rice (22.5%), and oat (16%). The majority (65%) reacted to 1 food, 26% reacted to 2 foods, and 9% reacted to 3 or more foods. The majority were atopic, and 39% had IgE sensitization to another food. Thirty-nine (24%) subjects had positive specific IgE levels to the food inducing FPIES. Among children with specific IgE to cow's milk, 41% changed from a milk FPIES to an IgE-mediated phenotype over time. The median age when tolerance was established was 4.7 years for rice, 4 years for oat, and 6.7 years for soy. Median age when milk tolerance was established for subjects with undetectable milk-specific IgE levels was 5.1 years, whereas none of the subjects with detectable milk-specific IgE became tolerant to milk during the study ( P  = .003). Conclusion FPIES typically resolves by age 5 years. Milk FPIES, especially with detectable food-specific IgE, can have a protracted course and eventually transition to acute reactions.
copUnited States
pubMosby, Inc
pmid24880634
doi10.1016/j.jaci.2014.04.008