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Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants

Background Ninety-five percent positive predictive values (PPVs) provide an invaluable tool for clinicians to avoid unnecessary oral food challenges. However, 95% PPVs specific to infants, the age group most likely to present for diagnosis of food allergy, are limited. Objective We sought to develop... Full description

Journal Title: Journal of allergy and clinical immunology 2013, Vol.132 (4), p.874-880
Main Author: Peters, Rachel L., MPH
Other Authors: Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD , Dharmage, Shyamali C., MBBS, MSc, MD, PhD , Tang, Mimi L.K., MBBS, FRACP, FRCPA, PhD , Koplin, Jennifer J., PhD , Ponsonby, Anne-Louise, BMedSci, MBBS, PhD , Lowe, Adrian J., PhD , Hill, David, MBBD, FRACP , Gurrin, Lyle C., PhD
Format: Electronic Article Electronic Article
Language: English
Subjects:
egg
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Mosby, Inc
ID: ISSN: 0091-6749
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title: Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants
format: Article
creator:
  • Peters, Rachel L., MPH
  • Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD
  • Dharmage, Shyamali C., MBBS, MSc, MD, PhD
  • Tang, Mimi L.K., MBBS, FRACP, FRCPA, PhD
  • Koplin, Jennifer J., PhD
  • Ponsonby, Anne-Louise, BMedSci, MBBS, PhD
  • Lowe, Adrian J., PhD
  • Hill, David, MBBD, FRACP
  • Gurrin, Lyle C., PhD
subjects:
  • Abridged Index Medicus
  • Allergens
  • Allergens - immunology
  • Allergic diseases
  • Allergies
  • Allergy and Immunology
  • Antibody Specificity
  • Arachis - immunology
  • Arachis hypogaea
  • Babies
  • baked egg
  • Biological and medical sciences
  • Digestive allergic diseases
  • egg
  • Egg Hypersensitivity
  • Eggs - adverse effects
  • Ethics
  • Families & family life
  • Family medical history
  • Female
  • Food
  • Food allergies
  • Food allergy
  • Food Hypersensitivity - diagnosis
  • Food Hypersensitivity - etiology
  • Food Hypersensitivity - immunology
  • Fundamental and applied biological sciences. Psychology
  • Fundamental immunology
  • Humans
  • Immunization
  • Immunoglobulin E
  • Immunoglobulin E - blood
  • Immunology
  • Immunopathology
  • Infant
  • Infants
  • Male
  • Medical sciences
  • Medical tests
  • oral food challenge
  • peanut
  • Population
  • Predictive Value of Tests
  • Recruitment
  • Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
  • serum-specific IgE
  • sesame
  • Sesamum - immunology
  • Skin
  • skin prick test
  • Skin Tests - methods
  • Skin Tests - standards
  • State government
  • Statistical methods
ispartof: Journal of allergy and clinical immunology, 2013, Vol.132 (4), p.874-880
description: Background Ninety-five percent positive predictive values (PPVs) provide an invaluable tool for clinicians to avoid unnecessary oral food challenges. However, 95% PPVs specific to infants, the age group most likely to present for diagnosis of food allergy, are limited. Objective We sought to develop skin prick test (SPT) and allergen-specific IgE (sIgE) thresholds with 95% PPVs for challenge-confirmed food allergy in a large population-based cohort of 1-year-old infants with challenges undertaken irrespective of SPT wheal size or previous history of ingestion. Methods HealthNuts is a population-based, longitudinal food allergy study with baseline recruitment of 1-year-old infants. Infants were recruited from council-run immunization sessions during which they underwent SPTs to 4 allergens: egg, peanut, sesame, and cow’s milk/shrimp. Any infant with a detectable SPT response was invited to undergo oral food challenge and sIgE testing. Results Five thousand two hundred seventy-six infants participated in the study. Peanut SPT responses of 8 mm or greater (95% CI, 7-9 mm), egg SPT responses of 4 mm or greater (95% CI, 3-5 mm), and sesame SPT responses of 8 mm or greater (95% CI, 5-9 mm) had 95% PPVs for challenge-proved food allergy. Peanut sIgE levels of 34 kUA /L or greater (95% CI, 14-48 kUA /L) and egg sIgE levels of 1.7 kUA /L or greater (95% CI, 1-3 kUA /L) had 95% PPVs for challenge-proved food allergy. Results were robust when stratified on established risk factors for food allergy. Egg SPT responses and sIgE levels were poor predictors of allergy to egg in baked goods. Conclusion These 95% PPVs, which were generated from a unique dataset, are valuable for the diagnosis of food allergy in young infants and were robust when stratified across a number of different risk factors.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0091-6749
fulltext: fulltext
issn:
  • 0091-6749
  • 1097-6825
url: Link


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titleSkin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants
sourceAlma/SFX Local Collection
creatorPeters, Rachel L., MPH ; Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD ; Dharmage, Shyamali C., MBBS, MSc, MD, PhD ; Tang, Mimi L.K., MBBS, FRACP, FRCPA, PhD ; Koplin, Jennifer J., PhD ; Ponsonby, Anne-Louise, BMedSci, MBBS, PhD ; Lowe, Adrian J., PhD ; Hill, David, MBBD, FRACP ; Gurrin, Lyle C., PhD
creatorcontribPeters, Rachel L., MPH ; Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD ; Dharmage, Shyamali C., MBBS, MSc, MD, PhD ; Tang, Mimi L.K., MBBS, FRACP, FRCPA, PhD ; Koplin, Jennifer J., PhD ; Ponsonby, Anne-Louise, BMedSci, MBBS, PhD ; Lowe, Adrian J., PhD ; Hill, David, MBBD, FRACP ; Gurrin, Lyle C., PhD ; HealthNuts study ; HealthNuts Study
descriptionBackground Ninety-five percent positive predictive values (PPVs) provide an invaluable tool for clinicians to avoid unnecessary oral food challenges. However, 95% PPVs specific to infants, the age group most likely to present for diagnosis of food allergy, are limited. Objective We sought to develop skin prick test (SPT) and allergen-specific IgE (sIgE) thresholds with 95% PPVs for challenge-confirmed food allergy in a large population-based cohort of 1-year-old infants with challenges undertaken irrespective of SPT wheal size or previous history of ingestion. Methods HealthNuts is a population-based, longitudinal food allergy study with baseline recruitment of 1-year-old infants. Infants were recruited from council-run immunization sessions during which they underwent SPTs to 4 allergens: egg, peanut, sesame, and cow’s milk/shrimp. Any infant with a detectable SPT response was invited to undergo oral food challenge and sIgE testing. Results Five thousand two hundred seventy-six infants participated in the study. Peanut SPT responses of 8 mm or greater (95% CI, 7-9 mm), egg SPT responses of 4 mm or greater (95% CI, 3-5 mm), and sesame SPT responses of 8 mm or greater (95% CI, 5-9 mm) had 95% PPVs for challenge-proved food allergy. Peanut sIgE levels of 34 kUA /L or greater (95% CI, 14-48 kUA /L) and egg sIgE levels of 1.7 kUA /L or greater (95% CI, 1-3 kUA /L) had 95% PPVs for challenge-proved food allergy. Results were robust when stratified on established risk factors for food allergy. Egg SPT responses and sIgE levels were poor predictors of allergy to egg in baked goods. Conclusion These 95% PPVs, which were generated from a unique dataset, are valuable for the diagnosis of food allergy in young infants and were robust when stratified across a number of different risk factors.
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languageeng
publisherNew York, NY: Mosby, Inc
subjectAbridged Index Medicus ; Allergens ; Allergens - immunology ; Allergic diseases ; Allergies ; Allergy and Immunology ; Antibody Specificity ; Arachis - immunology ; Arachis hypogaea ; Babies ; baked egg ; Biological and medical sciences ; Digestive allergic diseases ; egg ; Egg Hypersensitivity ; Eggs - adverse effects ; Ethics ; Families & family life ; Family medical history ; Female ; Food ; Food allergies ; Food allergy ; Food Hypersensitivity - diagnosis ; Food Hypersensitivity - etiology ; Food Hypersensitivity - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunization ; Immunoglobulin E ; Immunoglobulin E - blood ; Immunology ; Immunopathology ; Infant ; Infants ; Male ; Medical sciences ; Medical tests ; oral food challenge ; peanut ; Population ; Predictive Value of Tests ; Recruitment ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; serum-specific IgE ; sesame ; Sesamum - immunology ; Skin ; skin prick test ; Skin Tests - methods ; Skin Tests - standards ; State government ; Statistical methods
ispartofJournal of allergy and clinical immunology, 2013, Vol.132 (4), p.874-880
rights
0American Academy of Allergy, Asthma & Immunology
12013 American Academy of Allergy, Asthma & Immunology
22014 INIST-CNRS
3Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
4COPYRIGHT 2013 Elsevier B.V.
5Copyright Elsevier Limited Oct 2013
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0Peters, Rachel L., MPH
1Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD
2Dharmage, Shyamali C., MBBS, MSc, MD, PhD
3Tang, Mimi L.K., MBBS, FRACP, FRCPA, PhD
4Koplin, Jennifer J., PhD
5Ponsonby, Anne-Louise, BMedSci, MBBS, PhD
6Lowe, Adrian J., PhD
7Hill, David, MBBD, FRACP
8Gurrin, Lyle C., PhD
9HealthNuts study
10HealthNuts Study
title
0Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants
1Journal of allergy and clinical immunology
addtitleJ Allergy Clin Immunol
descriptionBackground Ninety-five percent positive predictive values (PPVs) provide an invaluable tool for clinicians to avoid unnecessary oral food challenges. However, 95% PPVs specific to infants, the age group most likely to present for diagnosis of food allergy, are limited. Objective We sought to develop skin prick test (SPT) and allergen-specific IgE (sIgE) thresholds with 95% PPVs for challenge-confirmed food allergy in a large population-based cohort of 1-year-old infants with challenges undertaken irrespective of SPT wheal size or previous history of ingestion. Methods HealthNuts is a population-based, longitudinal food allergy study with baseline recruitment of 1-year-old infants. Infants were recruited from council-run immunization sessions during which they underwent SPTs to 4 allergens: egg, peanut, sesame, and cow’s milk/shrimp. Any infant with a detectable SPT response was invited to undergo oral food challenge and sIgE testing. Results Five thousand two hundred seventy-six infants participated in the study. Peanut SPT responses of 8 mm or greater (95% CI, 7-9 mm), egg SPT responses of 4 mm or greater (95% CI, 3-5 mm), and sesame SPT responses of 8 mm or greater (95% CI, 5-9 mm) had 95% PPVs for challenge-proved food allergy. Peanut sIgE levels of 34 kUA /L or greater (95% CI, 14-48 kUA /L) and egg sIgE levels of 1.7 kUA /L or greater (95% CI, 1-3 kUA /L) had 95% PPVs for challenge-proved food allergy. Results were robust when stratified on established risk factors for food allergy. Egg SPT responses and sIgE levels were poor predictors of allergy to egg in baked goods. Conclusion These 95% PPVs, which were generated from a unique dataset, are valuable for the diagnosis of food allergy in young infants and were robust when stratified across a number of different risk factors.
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1Allergens
2Allergens - immunology
3Allergic diseases
4Allergies
5Allergy and Immunology
6Antibody Specificity
7Arachis - immunology
8Arachis hypogaea
9Babies
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12Digestive allergic diseases
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14Egg Hypersensitivity
15Eggs - adverse effects
16Ethics
17Families & family life
18Family medical history
19Female
20Food
21Food allergies
22Food allergy
23Food Hypersensitivity - diagnosis
24Food Hypersensitivity - etiology
25Food Hypersensitivity - immunology
26Fundamental and applied biological sciences. Psychology
27Fundamental immunology
28Humans
29Immunization
30Immunoglobulin E
31Immunoglobulin E - blood
32Immunology
33Immunopathology
34Infant
35Infants
36Male
37Medical sciences
38Medical tests
39oral food challenge
40peanut
41Population
42Predictive Value of Tests
43Recruitment
44Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
45serum-specific IgE
46sesame
47Sesamum - immunology
48Skin
49skin prick test
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52State government
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1Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD
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4Koplin, Jennifer J., PhD
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titleSkin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants
authorPeters, Rachel L., MPH ; Allen, Katrina J., BMedSc, MBBS, FRACP, FAAAAI, PhD ; Dharmage, Shyamali C., MBBS, MSc, MD, PhD ; Tang, Mimi L.K., MBBS, FRACP, FRCPA, PhD ; Koplin, Jennifer J., PhD ; Ponsonby, Anne-Louise, BMedSci, MBBS, PhD ; Lowe, Adrian J., PhD ; Hill, David, MBBD, FRACP ; Gurrin, Lyle C., PhD
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1Allergens
2Allergens - immunology
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4Allergies
5Allergy and Immunology
6Antibody Specificity
7Arachis - immunology
8Arachis hypogaea
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10baked egg
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18Family medical history
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21Food allergies
22Food allergy
23Food Hypersensitivity - diagnosis
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abstractBackground Ninety-five percent positive predictive values (PPVs) provide an invaluable tool for clinicians to avoid unnecessary oral food challenges. However, 95% PPVs specific to infants, the age group most likely to present for diagnosis of food allergy, are limited. Objective We sought to develop skin prick test (SPT) and allergen-specific IgE (sIgE) thresholds with 95% PPVs for challenge-confirmed food allergy in a large population-based cohort of 1-year-old infants with challenges undertaken irrespective of SPT wheal size or previous history of ingestion. Methods HealthNuts is a population-based, longitudinal food allergy study with baseline recruitment of 1-year-old infants. Infants were recruited from council-run immunization sessions during which they underwent SPTs to 4 allergens: egg, peanut, sesame, and cow’s milk/shrimp. Any infant with a detectable SPT response was invited to undergo oral food challenge and sIgE testing. Results Five thousand two hundred seventy-six infants participated in the study. Peanut SPT responses of 8 mm or greater (95% CI, 7-9 mm), egg SPT responses of 4 mm or greater (95% CI, 3-5 mm), and sesame SPT responses of 8 mm or greater (95% CI, 5-9 mm) had 95% PPVs for challenge-proved food allergy. Peanut sIgE levels of 34 kUA /L or greater (95% CI, 14-48 kUA /L) and egg sIgE levels of 1.7 kUA /L or greater (95% CI, 1-3 kUA /L) had 95% PPVs for challenge-proved food allergy. Results were robust when stratified on established risk factors for food allergy. Egg SPT responses and sIgE levels were poor predictors of allergy to egg in baked goods. Conclusion These 95% PPVs, which were generated from a unique dataset, are valuable for the diagnosis of food allergy in young infants and were robust when stratified across a number of different risk factors.
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