schliessen

Filtern

 

Bibliotheken

Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes

Context: Betatrophin is a secreted protein recently involved in β-cell replication with a potential role in type 2 diabetes mellitus (T2D). Objective: The aim of the present study was to compare the circulating concentrations of betatrophin in human obesity and T2D. Design, Setting, and Participants... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2014, Vol.99 (10), p.E2004-E2009
Main Author: Gómez-Ambrosi, Javier
Other Authors: Pascual, Eider , Catalán, Victoria , Rodríguez, Amaia , Ramírez, Beatriz , Silva, Camilo , Gil, María J , Salvador, Javier , Frühbeck, Gema
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25050901
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1586100871
title: Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes
format: Article
creator:
  • Gómez-Ambrosi, Javier
  • Pascual, Eider
  • Catalán, Victoria
  • Rodríguez, Amaia
  • Ramírez, Beatriz
  • Silva, Camilo
  • Gil, María J
  • Salvador, Javier
  • Frühbeck, Gema
subjects:
  • Abridged Index Medicus
  • Adiposity - physiology
  • Adult
  • Angiopoietin-like Proteins
  • Biomarkers - blood
  • Blood Glucose - metabolism
  • Diabetes Mellitus, Type 2 - epidemiology
  • Diabetes Mellitus, Type 2 - metabolism
  • Female
  • Glucose Intolerance - epidemiology
  • Glucose Intolerance - metabolism
  • Humans
  • Insulin Resistance - physiology
  • Insulin-Secreting Cells - cytology
  • Insulin-Secreting Cells - metabolism
  • Male
  • Middle Aged
  • Obesity - epidemiology
  • Obesity - metabolism
  • Peptide Hormones - blood
  • Peptide Hormones - deficiency
  • Risk Factors
ispartof: The journal of clinical endocrinology and metabolism, 2014, Vol.99 (10), p.E2004-E2009
description: Context: Betatrophin is a secreted protein recently involved in β-cell replication with a potential role in type 2 diabetes mellitus (T2D). Objective: The aim of the present study was to compare the circulating concentrations of betatrophin in human obesity and T2D. Design, Setting, and Participants: Serum concentrations of betatrophin were measured by ELISA in 153 subjects: 75 obese normoglycemic subjects (OB-NG), 30 obese subjects with impaired glucose tolerance (OB-IGT), and 15 obese subjects with T2D (OB-T2D) matched by sex, age, and body adiposity, in comparison with 33 lean normoglycemic individuals (LN-NG). Results: Circulating levels of betatrophin were significantly decreased in obese individuals and further diminished in IGT and T2D participants (LN-NG, 45.1 ± 24.4 ng/mL; OB-NG, 26.9 ± 15.4 ng/mL; OB-IGT, 18.3 ± 10.7 ng/mL; OB-T2D, 13.5 ± 8.8 ng/mL; P < .001). A marked sexual dimorphism was found, with betatrophin levels being significantly higher in women than in men (males, 21.1 ± 16.0 ng/mL; females, 34.1 ± 20.1 ng/mL; P < .001). Interestingly, betatrophin levels were positively correlated with the quantitative insulin sensitivity check index (r = 0.46; P < .001) and with high-density lipoprotein-cholesterol concentrations (r = 0.51; P < .001). Conclusions: We conclude that serum betatrophin is decreased in human obesity, being further reduced in obesity-associated insulin resistance. Betatrophin levels are closely related to obesity-associated cardiometabolic risk factors, emerging as a potential biomarker of insulin resistance and T2D.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.742922
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_1586100871
sourceformatXML
sourcesystemPC
sourcerecordid1586100871
originalsourceidFETCH-LOGICAL-14288-f9c892bba0caed95d0af631204b3e94fec32136200234aa2defe6f32aac17d4e0
addsrcrecordideNp1kE1v1DAURS0EokNhxxp5yYKU9xzna1mmQJEqdVMkWFmO88J4yNjBdlTNv8dhCgsElizLeudey4exlwgXKBDe7s2FAJQFVnX7iG2wk1XRYNc8ZhsAgUXXiC9n7FmMe8iYrMqn7ExUUEEHuGFftzaYZdLJum_8HSWdgp931vGtd4ZcCnniXeSXgfgVmUA60sDz_Ho5aMdve4o2Hbl2A787zsQFv7K6p0TxOXsy6inSi4fznH3-8P5ue13c3H78tL28KVCKti3GzrSd6HsNRtPQVQPosS5RgOxL6uRIphRY1iL_pZRai4FGqsdSaG2wGSTBOXt96p2D_7FQTOpgo6Fp0o78EhVWbY0AbYMZfXNCTfAxBhrVHOxBh6NCUKtMtTdqlalWmRl_9dC89Aca_sC_7WVA_NVnbPolLHuz0_9a5Sl076dEIX6flnsKakd6SjsFecm6aYs1gOutyLtZY-UpRm7wJlhHc6AY1d4vwWW__37sJ2r2oJg
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1586100871
display
typearticle
titleCirculating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes
creatorGómez-Ambrosi, Javier ; Pascual, Eider ; Catalán, Victoria ; Rodríguez, Amaia ; Ramírez, Beatriz ; Silva, Camilo ; Gil, María J ; Salvador, Javier ; Frühbeck, Gema
creatorcontribGómez-Ambrosi, Javier ; Pascual, Eider ; Catalán, Victoria ; Rodríguez, Amaia ; Ramírez, Beatriz ; Silva, Camilo ; Gil, María J ; Salvador, Javier ; Frühbeck, Gema
descriptionContext: Betatrophin is a secreted protein recently involved in β-cell replication with a potential role in type 2 diabetes mellitus (T2D). Objective: The aim of the present study was to compare the circulating concentrations of betatrophin in human obesity and T2D. Design, Setting, and Participants: Serum concentrations of betatrophin were measured by ELISA in 153 subjects: 75 obese normoglycemic subjects (OB-NG), 30 obese subjects with impaired glucose tolerance (OB-IGT), and 15 obese subjects with T2D (OB-T2D) matched by sex, age, and body adiposity, in comparison with 33 lean normoglycemic individuals (LN-NG). Results: Circulating levels of betatrophin were significantly decreased in obese individuals and further diminished in IGT and T2D participants (LN-NG, 45.1 ± 24.4 ng/mL; OB-NG, 26.9 ± 15.4 ng/mL; OB-IGT, 18.3 ± 10.7 ng/mL; OB-T2D, 13.5 ± 8.8 ng/mL; P < .001). A marked sexual dimorphism was found, with betatrophin levels being significantly higher in women than in men (males, 21.1 ± 16.0 ng/mL; females, 34.1 ± 20.1 ng/mL; P < .001). Interestingly, betatrophin levels were positively correlated with the quantitative insulin sensitivity check index (r = 0.46; P < .001) and with high-density lipoprotein-cholesterol concentrations (r = 0.51; P < .001). Conclusions: We conclude that serum betatrophin is decreased in human obesity, being further reduced in obesity-associated insulin resistance. Betatrophin levels are closely related to obesity-associated cardiometabolic risk factors, emerging as a potential biomarker of insulin resistance and T2D.
identifier
0ISSN: 0021-972X
1EISSN: 1945-7197
2DOI: 10.1210/jc.2014-1568
3PMID: 25050901
languageeng
publisherUnited States: Endocrine Society
subjectAbridged Index Medicus ; Adiposity - physiology ; Adult ; Angiopoietin-like Proteins ; Biomarkers - blood ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - metabolism ; Female ; Glucose Intolerance - epidemiology ; Glucose Intolerance - metabolism ; Humans ; Insulin Resistance - physiology ; Insulin-Secreting Cells - cytology ; Insulin-Secreting Cells - metabolism ; Male ; Middle Aged ; Obesity - epidemiology ; Obesity - metabolism ; Peptide Hormones - blood ; Peptide Hormones - deficiency ; Risk Factors
ispartofThe journal of clinical endocrinology and metabolism, 2014, Vol.99 (10), p.E2004-E2009
rights
0Copyright © 2014 by the Endocrine Society
1Copyright © 2014 by The Endocrine Society
lds50peer_reviewed
citedbyFETCH-LOGICAL-14288-f9c892bba0caed95d0af631204b3e94fec32136200234aa2defe6f32aac17d4e0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25050901$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Gómez-Ambrosi, Javier
1Pascual, Eider
2Catalán, Victoria
3Rodríguez, Amaia
4Ramírez, Beatriz
5Silva, Camilo
6Gil, María J
7Salvador, Javier
8Frühbeck, Gema
title
0Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
descriptionContext: Betatrophin is a secreted protein recently involved in β-cell replication with a potential role in type 2 diabetes mellitus (T2D). Objective: The aim of the present study was to compare the circulating concentrations of betatrophin in human obesity and T2D. Design, Setting, and Participants: Serum concentrations of betatrophin were measured by ELISA in 153 subjects: 75 obese normoglycemic subjects (OB-NG), 30 obese subjects with impaired glucose tolerance (OB-IGT), and 15 obese subjects with T2D (OB-T2D) matched by sex, age, and body adiposity, in comparison with 33 lean normoglycemic individuals (LN-NG). Results: Circulating levels of betatrophin were significantly decreased in obese individuals and further diminished in IGT and T2D participants (LN-NG, 45.1 ± 24.4 ng/mL; OB-NG, 26.9 ± 15.4 ng/mL; OB-IGT, 18.3 ± 10.7 ng/mL; OB-T2D, 13.5 ± 8.8 ng/mL; P < .001). A marked sexual dimorphism was found, with betatrophin levels being significantly higher in women than in men (males, 21.1 ± 16.0 ng/mL; females, 34.1 ± 20.1 ng/mL; P < .001). Interestingly, betatrophin levels were positively correlated with the quantitative insulin sensitivity check index (r = 0.46; P < .001) and with high-density lipoprotein-cholesterol concentrations (r = 0.51; P < .001). Conclusions: We conclude that serum betatrophin is decreased in human obesity, being further reduced in obesity-associated insulin resistance. Betatrophin levels are closely related to obesity-associated cardiometabolic risk factors, emerging as a potential biomarker of insulin resistance and T2D.
subject
0Abridged Index Medicus
1Adiposity - physiology
2Adult
3Angiopoietin-like Proteins
4Biomarkers - blood
5Blood Glucose - metabolism
6Diabetes Mellitus, Type 2 - epidemiology
7Diabetes Mellitus, Type 2 - metabolism
8Female
9Glucose Intolerance - epidemiology
10Glucose Intolerance - metabolism
11Humans
12Insulin Resistance - physiology
13Insulin-Secreting Cells - cytology
14Insulin-Secreting Cells - metabolism
15Male
16Middle Aged
17Obesity - epidemiology
18Obesity - metabolism
19Peptide Hormones - blood
20Peptide Hormones - deficiency
21Risk Factors
issn
00021-972X
11945-7197
fulltextfalse
rsrctypearticle
creationdate2014
recordtypearticle
recordideNp1kE1v1DAURS0EokNhxxp5yYKU9xzna1mmQJEqdVMkWFmO88J4yNjBdlTNv8dhCgsElizLeudey4exlwgXKBDe7s2FAJQFVnX7iG2wk1XRYNc8ZhsAgUXXiC9n7FmMe8iYrMqn7ExUUEEHuGFftzaYZdLJum_8HSWdgp931vGtd4ZcCnniXeSXgfgVmUA60sDz_Ho5aMdve4o2Hbl2A787zsQFv7K6p0TxOXsy6inSi4fznH3-8P5ue13c3H78tL28KVCKti3GzrSd6HsNRtPQVQPosS5RgOxL6uRIphRY1iL_pZRai4FGqsdSaG2wGSTBOXt96p2D_7FQTOpgo6Fp0o78EhVWbY0AbYMZfXNCTfAxBhrVHOxBh6NCUKtMtTdqlalWmRl_9dC89Aca_sC_7WVA_NVnbPolLHuz0_9a5Sl076dEIX6flnsKakd6SjsFecm6aYs1gOutyLtZY-UpRm7wJlhHc6AY1d4vwWW__37sJ2r2oJg
startdate201410
enddate201410
creator
0Gómez-Ambrosi, Javier
1Pascual, Eider
2Catalán, Victoria
3Rodríguez, Amaia
4Ramírez, Beatriz
5Silva, Camilo
6Gil, María J
7Salvador, Javier
8Frühbeck, Gema
general
0Endocrine Society
1Copyright by The Endocrine Society
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
87X8
sort
creationdate201410
titleCirculating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes
authorGómez-Ambrosi, Javier ; Pascual, Eider ; Catalán, Victoria ; Rodríguez, Amaia ; Ramírez, Beatriz ; Silva, Camilo ; Gil, María J ; Salvador, Javier ; Frühbeck, Gema
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-14288-f9c892bba0caed95d0af631204b3e94fec32136200234aa2defe6f32aac17d4e0
rsrctypearticles
prefilterarticles
languageeng
creationdate2014
topic
0Abridged Index Medicus
1Adiposity - physiology
2Adult
3Angiopoietin-like Proteins
4Biomarkers - blood
5Blood Glucose - metabolism
6Diabetes Mellitus, Type 2 - epidemiology
7Diabetes Mellitus, Type 2 - metabolism
8Female
9Glucose Intolerance - epidemiology
10Glucose Intolerance - metabolism
11Humans
12Insulin Resistance - physiology
13Insulin-Secreting Cells - cytology
14Insulin-Secreting Cells - metabolism
15Male
16Middle Aged
17Obesity - epidemiology
18Obesity - metabolism
19Peptide Hormones - blood
20Peptide Hormones - deficiency
21Risk Factors
toplevelpeer_reviewed
creatorcontrib
0Gómez-Ambrosi, Javier
1Pascual, Eider
2Catalán, Victoria
3Rodríguez, Amaia
4Ramírez, Beatriz
5Silva, Camilo
6Gil, María J
7Salvador, Javier
8Frühbeck, Gema
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7MEDLINE - Academic
jtitleThe journal of clinical endocrinology and metabolism
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Gómez-Ambrosi, Javier
1Pascual, Eider
2Catalán, Victoria
3Rodríguez, Amaia
4Ramírez, Beatriz
5Silva, Camilo
6Gil, María J
7Salvador, Javier
8Frühbeck, Gema
formatjournal
genrearticle
ristypeJOUR
atitleCirculating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes
jtitleThe journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
date2014-10
risdate2014
volume99
issue10
spageE2004
epageE2009
pagesE2004-E2009
issn0021-972X
eissn1945-7197
notesThis work was supported by grants from the Fondo de Investigación Sanitaria-FEDER, Instituto de Salud Carlos III (ISCIII), (PI11/02681 and PI12/00515); and from the Department of Health (48/2011 and 58/2011) of the Gobierno de Navarra of Spain. CIBERobn is an initiative of the ISCIII, Spain.
abstractContext: Betatrophin is a secreted protein recently involved in β-cell replication with a potential role in type 2 diabetes mellitus (T2D). Objective: The aim of the present study was to compare the circulating concentrations of betatrophin in human obesity and T2D. Design, Setting, and Participants: Serum concentrations of betatrophin were measured by ELISA in 153 subjects: 75 obese normoglycemic subjects (OB-NG), 30 obese subjects with impaired glucose tolerance (OB-IGT), and 15 obese subjects with T2D (OB-T2D) matched by sex, age, and body adiposity, in comparison with 33 lean normoglycemic individuals (LN-NG). Results: Circulating levels of betatrophin were significantly decreased in obese individuals and further diminished in IGT and T2D participants (LN-NG, 45.1 ± 24.4 ng/mL; OB-NG, 26.9 ± 15.4 ng/mL; OB-IGT, 18.3 ± 10.7 ng/mL; OB-T2D, 13.5 ± 8.8 ng/mL; P < .001). A marked sexual dimorphism was found, with betatrophin levels being significantly higher in women than in men (males, 21.1 ± 16.0 ng/mL; females, 34.1 ± 20.1 ng/mL; P < .001). Interestingly, betatrophin levels were positively correlated with the quantitative insulin sensitivity check index (r = 0.46; P < .001) and with high-density lipoprotein-cholesterol concentrations (r = 0.51; P < .001). Conclusions: We conclude that serum betatrophin is decreased in human obesity, being further reduced in obesity-associated insulin resistance. Betatrophin levels are closely related to obesity-associated cardiometabolic risk factors, emerging as a potential biomarker of insulin resistance and T2D.
copUnited States
pubEndocrine Society
pmid25050901
doi10.1210/jc.2014-1568