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Vasculogenic mimicry: a new prognostic sign of human osteosarcoma

Summary Vasculogenic mimicry (VM), a formation of nonendothelial microvascular channels, has been generally recognized as a new pattern of neovascularization in aggressive malignancies. However, whether VM is present and clinically significant in osteosarcoma remains unknown. We identified VM by CD3... Full description

Journal Title: Human pathology 2014, Vol.45 (10), p.2120-2129
Main Author: Ren, Ke, MD
Other Authors: Yao, Nan, MS , Wang, Guangye, MD , Tian, Lei, MS , Ma, Jie, PhD , Shi, Xin, MS , Zhang, Lei, MD , Zhang, Jian, PhD , Zhou, Xing, MD , Zhou, Guangxin, MD , Wu, Sujia, MS , Sun, Xiaoliang, MB
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0046-8177
Link: https://www.ncbi.nlm.nih.gov/pubmed/25123071
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title: Vasculogenic mimicry: a new prognostic sign of human osteosarcoma
format: Article
creator:
  • Ren, Ke, MD
  • Yao, Nan, MS
  • Wang, Guangye, MD
  • Tian, Lei, MS
  • Ma, Jie, PhD
  • Shi, Xin, MS
  • Zhang, Lei, MD
  • Zhang, Jian, PhD
  • Zhou, Xing, MD
  • Zhou, Guangxin, MD
  • Wu, Sujia, MS
  • Sun, Xiaoliang, MB
subjects:
  • Adolescent
  • Adult
  • Amputation
  • Analysis
  • Antigens
  • Binding sites
  • Bone Neoplasms - mortality
  • Bone Neoplasms - pathology
  • Cancer
  • Chemotherapy
  • Child
  • Child, Preschool
  • Confidence intervals
  • Diagnosis, Differential
  • Female
  • Focal adhesion kinase
  • Gene expression
  • Humans
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Male
  • Medical prognosis
  • Melanoma
  • Metastasis
  • Middle Aged
  • Migration inducting gene-7
  • Multivariate analysis
  • Neovascularization
  • Neovascularization, Pathologic - mortality
  • Neovascularization, Pathologic - pathology
  • Osteosarcoma
  • Osteosarcoma - mortality
  • Osteosarcoma - pathology
  • Pathology
  • Patients
  • Prognosis
  • Proportional Hazards Models
  • Studies
  • Surgery
  • Survival
  • Survival analysis
  • Tumors
  • Vasculogenic mimicry
  • Young Adult
ispartof: Human pathology, 2014, Vol.45 (10), p.2120-2129
description: Summary Vasculogenic mimicry (VM), a formation of nonendothelial microvascular channels, has been generally recognized as a new pattern of neovascularization in aggressive malignancies. However, whether VM is present and clinically significant in osteosarcoma remains unknown. We identified VM by CD34/periodic acid–Schiff double staining of osteosarcoma specimens before chemotherapy and investigated its prognostic implications. Tumors were also immunohistochemically stained for focal adhesion kinase (FAK) and migration inducing gene 7 (Mig-7) to determine whether these markers are associated with the occurrence of VM. VM was found in 15 of 66 osteoblastic-type osteosarcoma samples (22.7%), and the incidence of VM did not differ with respect to patient sex, age, tumor size, tumor site, surgical type, or histologic response to preoperative chemotherapy. However, Kaplan-Meier survival analysis determined that the presence of VM and the tumor necrosis rate after preoperative chemotherapy are associated with both the overall survival ( P = .011 and P = .040, respectively) and metastasis-free survival ( P = .002 and P = .045, respectively). Furthermore, Cox proportional hazards analysis showed that the presence of VM and the histologic response to preoperative chemotherapy were independent indicators for both poor overall survival ( P = .007 and P = .024, respectively) and poor metastasis-free survival ( P = .002 and P = .027, respectively). The expression level of FAK and Mig-7 were higher in the VM group than the non-VM group ( P = .017 and P = .021, respectively). These results demonstrate the presence of VM in osteoblastic osteosarcoma and suggest that VM is an unfavorable prognostic factor with FAK and Mig-7 expressions as a potential mechanism of VM formation in osteosarcoma.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0046-8177
fulltext: fulltext
issn:
  • 0046-8177
  • 1532-8392
url: Link


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creatorRen, Ke, MD ; Yao, Nan, MS ; Wang, Guangye, MD ; Tian, Lei, MS ; Ma, Jie, PhD ; Shi, Xin, MS ; Zhang, Lei, MD ; Zhang, Jian, PhD ; Zhou, Xing, MD ; Zhou, Guangxin, MD ; Wu, Sujia, MS ; Sun, Xiaoliang, MB
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descriptionSummary Vasculogenic mimicry (VM), a formation of nonendothelial microvascular channels, has been generally recognized as a new pattern of neovascularization in aggressive malignancies. However, whether VM is present and clinically significant in osteosarcoma remains unknown. We identified VM by CD34/periodic acid–Schiff double staining of osteosarcoma specimens before chemotherapy and investigated its prognostic implications. Tumors were also immunohistochemically stained for focal adhesion kinase (FAK) and migration inducing gene 7 (Mig-7) to determine whether these markers are associated with the occurrence of VM. VM was found in 15 of 66 osteoblastic-type osteosarcoma samples (22.7%), and the incidence of VM did not differ with respect to patient sex, age, tumor size, tumor site, surgical type, or histologic response to preoperative chemotherapy. However, Kaplan-Meier survival analysis determined that the presence of VM and the tumor necrosis rate after preoperative chemotherapy are associated with both the overall survival ( P = .011 and P = .040, respectively) and metastasis-free survival ( P = .002 and P = .045, respectively). Furthermore, Cox proportional hazards analysis showed that the presence of VM and the histologic response to preoperative chemotherapy were independent indicators for both poor overall survival ( P = .007 and P = .024, respectively) and poor metastasis-free survival ( P = .002 and P = .027, respectively). The expression level of FAK and Mig-7 were higher in the VM group than the non-VM group ( P = .017 and P = .021, respectively). These results demonstrate the presence of VM in osteoblastic osteosarcoma and suggest that VM is an unfavorable prognostic factor with FAK and Mig-7 expressions as a potential mechanism of VM formation in osteosarcoma.
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subjectAdolescent ; Adult ; Amputation ; Analysis ; Antigens ; Binding sites ; Bone Neoplasms - mortality ; Bone Neoplasms - pathology ; Cancer ; Chemotherapy ; Child ; Child, Preschool ; Confidence intervals ; Diagnosis, Differential ; Female ; Focal adhesion kinase ; Gene expression ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Melanoma ; Metastasis ; Middle Aged ; Migration inducting gene-7 ; Multivariate analysis ; Neovascularization ; Neovascularization, Pathologic - mortality ; Neovascularization, Pathologic - pathology ; Osteosarcoma ; Osteosarcoma - mortality ; Osteosarcoma - pathology ; Pathology ; Patients ; Prognosis ; Proportional Hazards Models ; Studies ; Surgery ; Survival ; Survival analysis ; Tumors ; Vasculogenic mimicry ; Young Adult
ispartofHuman pathology, 2014, Vol.45 (10), p.2120-2129
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descriptionSummary Vasculogenic mimicry (VM), a formation of nonendothelial microvascular channels, has been generally recognized as a new pattern of neovascularization in aggressive malignancies. However, whether VM is present and clinically significant in osteosarcoma remains unknown. We identified VM by CD34/periodic acid–Schiff double staining of osteosarcoma specimens before chemotherapy and investigated its prognostic implications. Tumors were also immunohistochemically stained for focal adhesion kinase (FAK) and migration inducing gene 7 (Mig-7) to determine whether these markers are associated with the occurrence of VM. VM was found in 15 of 66 osteoblastic-type osteosarcoma samples (22.7%), and the incidence of VM did not differ with respect to patient sex, age, tumor size, tumor site, surgical type, or histologic response to preoperative chemotherapy. However, Kaplan-Meier survival analysis determined that the presence of VM and the tumor necrosis rate after preoperative chemotherapy are associated with both the overall survival ( P = .011 and P = .040, respectively) and metastasis-free survival ( P = .002 and P = .045, respectively). Furthermore, Cox proportional hazards analysis showed that the presence of VM and the histologic response to preoperative chemotherapy were independent indicators for both poor overall survival ( P = .007 and P = .024, respectively) and poor metastasis-free survival ( P = .002 and P = .027, respectively). The expression level of FAK and Mig-7 were higher in the VM group than the non-VM group ( P = .017 and P = .021, respectively). These results demonstrate the presence of VM in osteoblastic osteosarcoma and suggest that VM is an unfavorable prognostic factor with FAK and Mig-7 expressions as a potential mechanism of VM formation in osteosarcoma.
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9Chemotherapy
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13Diagnosis, Differential
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19Kaplan-Meier Estimate
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21Medical prognosis
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36Proportional Hazards Models
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abstractSummary Vasculogenic mimicry (VM), a formation of nonendothelial microvascular channels, has been generally recognized as a new pattern of neovascularization in aggressive malignancies. However, whether VM is present and clinically significant in osteosarcoma remains unknown. We identified VM by CD34/periodic acid–Schiff double staining of osteosarcoma specimens before chemotherapy and investigated its prognostic implications. Tumors were also immunohistochemically stained for focal adhesion kinase (FAK) and migration inducing gene 7 (Mig-7) to determine whether these markers are associated with the occurrence of VM. VM was found in 15 of 66 osteoblastic-type osteosarcoma samples (22.7%), and the incidence of VM did not differ with respect to patient sex, age, tumor size, tumor site, surgical type, or histologic response to preoperative chemotherapy. However, Kaplan-Meier survival analysis determined that the presence of VM and the tumor necrosis rate after preoperative chemotherapy are associated with both the overall survival ( P = .011 and P = .040, respectively) and metastasis-free survival ( P = .002 and P = .045, respectively). Furthermore, Cox proportional hazards analysis showed that the presence of VM and the histologic response to preoperative chemotherapy were independent indicators for both poor overall survival ( P = .007 and P = .024, respectively) and poor metastasis-free survival ( P = .002 and P = .027, respectively). The expression level of FAK and Mig-7 were higher in the VM group than the non-VM group ( P = .017 and P = .021, respectively). These results demonstrate the presence of VM in osteoblastic osteosarcoma and suggest that VM is an unfavorable prognostic factor with FAK and Mig-7 expressions as a potential mechanism of VM formation in osteosarcoma.
copUnited States
pubElsevier Inc
pmid25123071
doi10.1016/j.humpath.2014.06.013