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Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients

Background The prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome have been increasing worldwide. The associations between metabolic factors and the histologic severity of NAFLD have not yet been clarified. Therefore, we studied the relationships between relevant metabolic... Full description

Journal Title: Journal of gastroenterology 2013-11-26, Vol.49 (11), p.1477-1484
Main Author: Nakahara, Takashi
Other Authors: Hyogo, Hideyuki , Yoneda, Masato , Sumida, Yoshio , Eguchi, Yuichiro , Fujii, Hideki , Ono, Masafumi , Kawaguchi, Takumi , Imajo, Kento , Aikata, Hiroshi , Tanaka, Saiyu , Kanemasa, Kazuyuki , Fujimoto, Kazuma , Anzai, Keizo , Saibara, Toshiji , Sata, Michio , Nakajima, Atushi , Itoh, Yoshito , Chayama, Kazuaki , Okanoue, Takeshi
Format: Electronic Article Electronic Article
Language: English
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Publisher: Tokyo: Springer Japan
ID: ISSN: 0944-1174
Link: https://www.ncbi.nlm.nih.gov/pubmed/24277052
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title: Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients
format: Article
creator:
  • Nakahara, Takashi
  • Hyogo, Hideyuki
  • Yoneda, Masato
  • Sumida, Yoshio
  • Eguchi, Yuichiro
  • Fujii, Hideki
  • Ono, Masafumi
  • Kawaguchi, Takumi
  • Imajo, Kento
  • Aikata, Hiroshi
  • Tanaka, Saiyu
  • Kanemasa, Kazuyuki
  • Fujimoto, Kazuma
  • Anzai, Keizo
  • Saibara, Toshiji
  • Sata, Michio
  • Nakajima, Atushi
  • Itoh, Yoshito
  • Chayama, Kazuaki
  • Okanoue, Takeshi
subjects:
  • Abdominal Surgery
  • Adult
  • Age Factors
  • Aged
  • Analysis
  • Asian Continental Ancestry Group
  • Biliary Tract
  • Biopsy
  • Care and treatment
  • Colorectal Surgery
  • Cross-Sectional Studies
  • Dextrose
  • Diabetes Mellitus, Type 2 - complications
  • Diabetes Mellitus, Type 2 - epidemiology
  • Dyslipidemias - complications
  • Dyslipidemias - epidemiology
  • Fatty liver
  • Female
  • Fibrosis
  • Gastroenterology
  • Glucose
  • Glucose metabolism
  • Hepatology
  • Humans
  • Hypertension
  • Hypertension - complications
  • Hypertension - epidemiology
  • Japan
  • Liver - pathology
  • Liver Cirrhosis - ethnology
  • Liver Cirrhosis - etiology
  • Liver Cirrhosis - pathology
  • Logistic Models
  • Low density lipoproteins
  • Male
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease - complications
  • Non-alcoholic Fatty Liver Disease - ethnology
  • Non-alcoholic Fatty Liver Disease - pathology
  • Obesity - complications
  • Obesity - epidemiology
  • Original Article—Liver
  • Pancreas
  • Postmenopausal women
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Surgical Oncology
  • Type 2 diabetes
ispartof: Journal of gastroenterology, 2013-11-26, Vol.49 (11), p.1477-1484
description: Background The prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome have been increasing worldwide. The associations between metabolic factors and the histologic severity of NAFLD have not yet been clarified. Therefore, we studied the relationships between relevant metabolic factors and the histological severity of NAFLD. Methods In a cross-sectional multicenter study conducted in Japan, we examined 1,365 biopsy-proven NAFLD patients. The frequencies of underlying lifestyle-related diseases and their relationships to the NAFLD histology were investigated. Results The hepatic fibrosis stages (Stage 0/1/2/3/4) were 22.6/34.1/26.7/14.5/2.1 (%) in the male patients, and 16.2/31.7/23.9/21.6/6.6 (%) in the female patients. Dyslipidemia was present in 65.7 % (hypertriglyceridemia, 45.3 %; increased low-density lipoprotein cholesterol, 37.5 %; decreased high density lipoprotein cholesterol, 19.5 %) of patients. Hypertension was present in 30.2 %, and diabetes mellitus (DM) in 47.3 %. The fibrosis stage increased with age, especially in postmenopausal females. The body mass index was positively correlated with the fibrosis stage. Deterioration of glucose control was positively correlated with the fibrosis stage, this correlation being more prominent in females. Multivariate analysis identified age and DM as significant risk factors for advanced fibrosis. No significant correlation of the fibrosis stage was observed with hypertension. There was a negative correlation between the serum triglyceride levels and the fibrosis stage. Conclusions DM appeared to be a significant risk factor for advanced fibrosis in patients with NAFLD, and would therefore need to be properly managed to prevent the progression of NAFLD.
language: eng
source:
identifier: ISSN: 0944-1174
fulltext: no_fulltext
issn:
  • 0944-1174
  • 1435-5922
url: Link


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titleType 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients
creatorNakahara, Takashi ; Hyogo, Hideyuki ; Yoneda, Masato ; Sumida, Yoshio ; Eguchi, Yuichiro ; Fujii, Hideki ; Ono, Masafumi ; Kawaguchi, Takumi ; Imajo, Kento ; Aikata, Hiroshi ; Tanaka, Saiyu ; Kanemasa, Kazuyuki ; Fujimoto, Kazuma ; Anzai, Keizo ; Saibara, Toshiji ; Sata, Michio ; Nakajima, Atushi ; Itoh, Yoshito ; Chayama, Kazuaki ; Okanoue, Takeshi
creatorcontribNakahara, Takashi ; Hyogo, Hideyuki ; Yoneda, Masato ; Sumida, Yoshio ; Eguchi, Yuichiro ; Fujii, Hideki ; Ono, Masafumi ; Kawaguchi, Takumi ; Imajo, Kento ; Aikata, Hiroshi ; Tanaka, Saiyu ; Kanemasa, Kazuyuki ; Fujimoto, Kazuma ; Anzai, Keizo ; Saibara, Toshiji ; Sata, Michio ; Nakajima, Atushi ; Itoh, Yoshito ; Chayama, Kazuaki ; Okanoue, Takeshi ; Japan Study Group of Nonalcoholic Fatty Liver Disease ; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)
descriptionBackground The prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome have been increasing worldwide. The associations between metabolic factors and the histologic severity of NAFLD have not yet been clarified. Therefore, we studied the relationships between relevant metabolic factors and the histological severity of NAFLD. Methods In a cross-sectional multicenter study conducted in Japan, we examined 1,365 biopsy-proven NAFLD patients. The frequencies of underlying lifestyle-related diseases and their relationships to the NAFLD histology were investigated. Results The hepatic fibrosis stages (Stage 0/1/2/3/4) were 22.6/34.1/26.7/14.5/2.1 (%) in the male patients, and 16.2/31.7/23.9/21.6/6.6 (%) in the female patients. Dyslipidemia was present in 65.7 % (hypertriglyceridemia, 45.3 %; increased low-density lipoprotein cholesterol, 37.5 %; decreased high density lipoprotein cholesterol, 19.5 %) of patients. Hypertension was present in 30.2 %, and diabetes mellitus (DM) in 47.3 %. The fibrosis stage increased with age, especially in postmenopausal females. The body mass index was positively correlated with the fibrosis stage. Deterioration of glucose control was positively correlated with the fibrosis stage, this correlation being more prominent in females. Multivariate analysis identified age and DM as significant risk factors for advanced fibrosis. No significant correlation of the fibrosis stage was observed with hypertension. There was a negative correlation between the serum triglyceride levels and the fibrosis stage. Conclusions DM appeared to be a significant risk factor for advanced fibrosis in patients with NAFLD, and would therefore need to be properly managed to prevent the progression of NAFLD.
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1EISSN: 1435-5922
2DOI: 10.1007/s00535-013-0911-1
3PMID: 24277052
languageeng
publisherTokyo: Springer Japan
subjectAbdominal Surgery ; Adult ; Age Factors ; Aged ; Analysis ; Asian Continental Ancestry Group ; Biliary Tract ; Biopsy ; Care and treatment ; Colorectal Surgery ; Cross-Sectional Studies ; Dextrose ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Dyslipidemias - complications ; Dyslipidemias - epidemiology ; Fatty liver ; Female ; Fibrosis ; Gastroenterology ; Glucose ; Glucose metabolism ; Hepatology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - epidemiology ; Japan ; Liver - pathology ; Liver Cirrhosis - ethnology ; Liver Cirrhosis - etiology ; Liver Cirrhosis - pathology ; Logistic Models ; Low density lipoproteins ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - ethnology ; Non-alcoholic Fatty Liver Disease - pathology ; Obesity - complications ; Obesity - epidemiology ; Original Article—Liver ; Pancreas ; Postmenopausal women ; Prevalence ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Surgical Oncology ; Type 2 diabetes
ispartofJournal of gastroenterology, 2013-11-26, Vol.49 (11), p.1477-1484
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1Hyogo, Hideyuki
2Yoneda, Masato
3Sumida, Yoshio
4Eguchi, Yuichiro
5Fujii, Hideki
6Ono, Masafumi
7Kawaguchi, Takumi
8Imajo, Kento
9Aikata, Hiroshi
10Tanaka, Saiyu
11Kanemasa, Kazuyuki
12Fujimoto, Kazuma
13Anzai, Keizo
14Saibara, Toshiji
15Sata, Michio
16Nakajima, Atushi
17Itoh, Yoshito
18Chayama, Kazuaki
19Okanoue, Takeshi
20Japan Study Group of Nonalcoholic Fatty Liver Disease
21Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)
title
0Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients
1Journal of gastroenterology
addtitle
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descriptionBackground The prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome have been increasing worldwide. The associations between metabolic factors and the histologic severity of NAFLD have not yet been clarified. Therefore, we studied the relationships between relevant metabolic factors and the histological severity of NAFLD. Methods In a cross-sectional multicenter study conducted in Japan, we examined 1,365 biopsy-proven NAFLD patients. The frequencies of underlying lifestyle-related diseases and their relationships to the NAFLD histology were investigated. Results The hepatic fibrosis stages (Stage 0/1/2/3/4) were 22.6/34.1/26.7/14.5/2.1 (%) in the male patients, and 16.2/31.7/23.9/21.6/6.6 (%) in the female patients. Dyslipidemia was present in 65.7 % (hypertriglyceridemia, 45.3 %; increased low-density lipoprotein cholesterol, 37.5 %; decreased high density lipoprotein cholesterol, 19.5 %) of patients. Hypertension was present in 30.2 %, and diabetes mellitus (DM) in 47.3 %. The fibrosis stage increased with age, especially in postmenopausal females. The body mass index was positively correlated with the fibrosis stage. Deterioration of glucose control was positively correlated with the fibrosis stage, this correlation being more prominent in females. Multivariate analysis identified age and DM as significant risk factors for advanced fibrosis. No significant correlation of the fibrosis stage was observed with hypertension. There was a negative correlation between the serum triglyceride levels and the fibrosis stage. Conclusions DM appeared to be a significant risk factor for advanced fibrosis in patients with NAFLD, and would therefore need to be properly managed to prevent the progression of NAFLD.
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2Age Factors
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4Analysis
5Asian Continental Ancestry Group
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13Diabetes Mellitus, Type 2 - epidemiology
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20Glucose
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29Liver Cirrhosis - ethnology
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34Male
35Medicine
36Medicine & Public Health
37Middle Aged
38Non-alcoholic Fatty Liver Disease - complications
39Non-alcoholic Fatty Liver Disease - ethnology
40Non-alcoholic Fatty Liver Disease - pathology
41Obesity - complications
42Obesity - epidemiology
43Original Article—Liver
44Pancreas
45Postmenopausal women
46Prevalence
47Retrospective Studies
48Risk Factors
49Severity of Illness Index
50Surgical Oncology
51Type 2 diabetes
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titleType 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients
authorNakahara, Takashi ; Hyogo, Hideyuki ; Yoneda, Masato ; Sumida, Yoshio ; Eguchi, Yuichiro ; Fujii, Hideki ; Ono, Masafumi ; Kawaguchi, Takumi ; Imajo, Kento ; Aikata, Hiroshi ; Tanaka, Saiyu ; Kanemasa, Kazuyuki ; Fujimoto, Kazuma ; Anzai, Keizo ; Saibara, Toshiji ; Sata, Michio ; Nakajima, Atushi ; Itoh, Yoshito ; Chayama, Kazuaki ; Okanoue, Takeshi
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1Adult
2Age Factors
3Aged
4Analysis
5Asian Continental Ancestry Group
6Biliary Tract
7Biopsy
8Care and treatment
9Colorectal Surgery
10Cross-Sectional Studies
11Dextrose
12Diabetes Mellitus, Type 2 - complications
13Diabetes Mellitus, Type 2 - epidemiology
14Dyslipidemias - complications
15Dyslipidemias - epidemiology
16Fatty liver
17Female
18Fibrosis
19Gastroenterology
20Glucose
21Glucose metabolism
22Hepatology
23Humans
24Hypertension
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29Liver Cirrhosis - ethnology
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38Non-alcoholic Fatty Liver Disease - complications
39Non-alcoholic Fatty Liver Disease - ethnology
40Non-alcoholic Fatty Liver Disease - pathology
41Obesity - complications
42Obesity - epidemiology
43Original Article—Liver
44Pancreas
45Postmenopausal women
46Prevalence
47Retrospective Studies
48Risk Factors
49Severity of Illness Index
50Surgical Oncology
51Type 2 diabetes
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9Aikata, Hiroshi
10Tanaka, Saiyu
11Kanemasa, Kazuyuki
12Fujimoto, Kazuma
13Anzai, Keizo
14Saibara, Toshiji
15Sata, Michio
16Nakajima, Atushi
17Itoh, Yoshito
18Chayama, Kazuaki
19Okanoue, Takeshi
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7Kawaguchi, Takumi
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date2013-11-26
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abstractBackground The prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome have been increasing worldwide. The associations between metabolic factors and the histologic severity of NAFLD have not yet been clarified. Therefore, we studied the relationships between relevant metabolic factors and the histological severity of NAFLD. Methods In a cross-sectional multicenter study conducted in Japan, we examined 1,365 biopsy-proven NAFLD patients. The frequencies of underlying lifestyle-related diseases and their relationships to the NAFLD histology were investigated. Results The hepatic fibrosis stages (Stage 0/1/2/3/4) were 22.6/34.1/26.7/14.5/2.1 (%) in the male patients, and 16.2/31.7/23.9/21.6/6.6 (%) in the female patients. Dyslipidemia was present in 65.7 % (hypertriglyceridemia, 45.3 %; increased low-density lipoprotein cholesterol, 37.5 %; decreased high density lipoprotein cholesterol, 19.5 %) of patients. Hypertension was present in 30.2 %, and diabetes mellitus (DM) in 47.3 %. The fibrosis stage increased with age, especially in postmenopausal females. The body mass index was positively correlated with the fibrosis stage. Deterioration of glucose control was positively correlated with the fibrosis stage, this correlation being more prominent in females. Multivariate analysis identified age and DM as significant risk factors for advanced fibrosis. No significant correlation of the fibrosis stage was observed with hypertension. There was a negative correlation between the serum triglyceride levels and the fibrosis stage. Conclusions DM appeared to be a significant risk factor for advanced fibrosis in patients with NAFLD, and would therefore need to be properly managed to prevent the progression of NAFLD.
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pmid24277052
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