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Systematic review: the role of the gut microbiota in chemotherapy‐ or radiation‐induced gastrointestinal mucositis – current evidence and potential clinical applications

Summary Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy, and affects about 50% of all cancer patients. Aim To assess the role of gut microbiota in the pathogenesis of gastro... Full description

Journal Title: Alimentary pharmacology & therapeutics 2014-09, Vol.40 (5), p.409-421
Main Author: Touchefeu, Y.
Other Authors: Montassier, E. , Nieman, K. , Gastinne, T. , Potel, G. , Bruley des Varannes, S. , Le Vacon, F. , La Cochetière, M. F.
Format: Electronic Article Electronic Article
Language: English
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Publisher: Oxford: Blackwell
ID: ISSN: 0269-2813
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title: Systematic review: the role of the gut microbiota in chemotherapy‐ or radiation‐induced gastrointestinal mucositis – current evidence and potential clinical applications
format: Article
creator:
  • Touchefeu, Y.
  • Montassier, E.
  • Nieman, K.
  • Gastinne, T.
  • Potel, G.
  • Bruley des Varannes, S.
  • Le Vacon, F.
  • La Cochetière, M. F.
subjects:
  • Animals
  • Antineoplastic Agents - adverse effects
  • Bacteroides
  • Bifidobacterium
  • Biological and medical sciences
  • Cancer
  • Chemotherapy
  • Clostridium
  • Diarrhea - drug therapy
  • Diarrhea - etiology
  • Diarrhea - microbiology
  • Drug toxicity and drugs side effects treatment
  • Enterobacteriaceae
  • Faecalibacterium prausnitzii
  • Gastrointestinal system
  • Health aspects
  • Humans
  • Intestinal Diseases - drug therapy
  • Intestinal Diseases - etiology
  • Intestinal Diseases - microbiology
  • Intestines - microbiology
  • Medical sciences
  • Microbiota
  • Microbiota (Symbiotic organisms)
  • Mucositis - drug therapy
  • Mucositis - etiology
  • Mucositis - microbiology
  • Neoplasms - drug therapy
  • Neoplasms - microbiology
  • Neoplasms - radiotherapy
  • Pharmacology. Drug treatments
  • Probiotics - therapeutic use
  • Radiation
  • Radiation Injuries - drug therapy
  • Radiation Injuries - microbiology
  • Toxicity: digestive system
ispartof: Alimentary pharmacology & therapeutics, 2014-09, Vol.40 (5), p.409-421
description: Summary Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy, and affects about 50% of all cancer patients. Aim To assess the role of gut microbiota in the pathogenesis of gastrointestinal mucositis and the potential for manipulations of the microbiota to prevent and to treat mucositis. Methods Search of the literature published in English using Medline, Scopus and the Cochrane Library, with main search terms ‘intestinal microbiota’, ‘bacteremia’, ‘mucositis’, ‘chemotherapy‐induced diarrhoea’, ‘chemotherapy‐induced mucositis’, ‘radiotherapy‐induced mucositis’. Results The gut microbiota plays a major role in the maintenance of intestinal homoeostasis and integrity. Patients receiving cytotoxic and radiation therapy exhibit marked changes in intestinal microbiota, with most frequently, decrease in Bifidobacterium, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and increase in Enterobacteriaceae and Bacteroides. These modifications may contribute to the development of mucositis, particularly diarrhoea and bacteraemia. The prevention of cancer therapy‐induced mucositis by probiotics has been investigated in randomised clinical trials with some promising results. Three of six trials reported a significantly decreased incidence of diarrhoea. One trial reported a decrease in infectious complications. Conclusions The gut microbiota may play a major role in the pathogenesis of mucositis through the modification of intestinal barrier function, innate immunity and intestinal repair mechanisms. Better knowledge of these effects may lead to new therapeutic approaches and to the identification of predictive markers of mucositis.
language: eng
source:
identifier: ISSN: 0269-2813
fulltext: no_fulltext
issn:
  • 0269-2813
  • 1365-2036
url: Link


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titleSystematic review: the role of the gut microbiota in chemotherapy‐ or radiation‐induced gastrointestinal mucositis – current evidence and potential clinical applications
creatorTouchefeu, Y. ; Montassier, E. ; Nieman, K. ; Gastinne, T. ; Potel, G. ; Bruley des Varannes, S. ; Le Vacon, F. ; La Cochetière, M. F.
creatorcontribTouchefeu, Y. ; Montassier, E. ; Nieman, K. ; Gastinne, T. ; Potel, G. ; Bruley des Varannes, S. ; Le Vacon, F. ; La Cochetière, M. F.
descriptionSummary Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy, and affects about 50% of all cancer patients. Aim To assess the role of gut microbiota in the pathogenesis of gastrointestinal mucositis and the potential for manipulations of the microbiota to prevent and to treat mucositis. Methods Search of the literature published in English using Medline, Scopus and the Cochrane Library, with main search terms ‘intestinal microbiota’, ‘bacteremia’, ‘mucositis’, ‘chemotherapy‐induced diarrhoea’, ‘chemotherapy‐induced mucositis’, ‘radiotherapy‐induced mucositis’. Results The gut microbiota plays a major role in the maintenance of intestinal homoeostasis and integrity. Patients receiving cytotoxic and radiation therapy exhibit marked changes in intestinal microbiota, with most frequently, decrease in Bifidobacterium, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and increase in Enterobacteriaceae and Bacteroides. These modifications may contribute to the development of mucositis, particularly diarrhoea and bacteraemia. The prevention of cancer therapy‐induced mucositis by probiotics has been investigated in randomised clinical trials with some promising results. Three of six trials reported a significantly decreased incidence of diarrhoea. One trial reported a decrease in infectious complications. Conclusions The gut microbiota may play a major role in the pathogenesis of mucositis through the modification of intestinal barrier function, innate immunity and intestinal repair mechanisms. Better knowledge of these effects may lead to new therapeutic approaches and to the identification of predictive markers of mucositis.
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subjectAnimals ; Antineoplastic Agents - adverse effects ; Bacteroides ; Bifidobacterium ; Biological and medical sciences ; Cancer ; Chemotherapy ; Clostridium ; Diarrhea - drug therapy ; Diarrhea - etiology ; Diarrhea - microbiology ; Drug toxicity and drugs side effects treatment ; Enterobacteriaceae ; Faecalibacterium prausnitzii ; Gastrointestinal system ; Health aspects ; Humans ; Intestinal Diseases - drug therapy ; Intestinal Diseases - etiology ; Intestinal Diseases - microbiology ; Intestines - microbiology ; Medical sciences ; Microbiota ; Microbiota (Symbiotic organisms) ; Mucositis - drug therapy ; Mucositis - etiology ; Mucositis - microbiology ; Neoplasms - drug therapy ; Neoplasms - microbiology ; Neoplasms - radiotherapy ; Pharmacology. Drug treatments ; Probiotics - therapeutic use ; Radiation ; Radiation Injuries - drug therapy ; Radiation Injuries - microbiology ; Toxicity: digestive system
ispartofAlimentary pharmacology & therapeutics, 2014-09, Vol.40 (5), p.409-421
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02014 John Wiley & Sons Ltd
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7La Cochetière, M. F.
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descriptionSummary Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy, and affects about 50% of all cancer patients. Aim To assess the role of gut microbiota in the pathogenesis of gastrointestinal mucositis and the potential for manipulations of the microbiota to prevent and to treat mucositis. Methods Search of the literature published in English using Medline, Scopus and the Cochrane Library, with main search terms ‘intestinal microbiota’, ‘bacteremia’, ‘mucositis’, ‘chemotherapy‐induced diarrhoea’, ‘chemotherapy‐induced mucositis’, ‘radiotherapy‐induced mucositis’. Results The gut microbiota plays a major role in the maintenance of intestinal homoeostasis and integrity. Patients receiving cytotoxic and radiation therapy exhibit marked changes in intestinal microbiota, with most frequently, decrease in Bifidobacterium, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and increase in Enterobacteriaceae and Bacteroides. These modifications may contribute to the development of mucositis, particularly diarrhoea and bacteraemia. The prevention of cancer therapy‐induced mucositis by probiotics has been investigated in randomised clinical trials with some promising results. Three of six trials reported a significantly decreased incidence of diarrhoea. One trial reported a decrease in infectious complications. Conclusions The gut microbiota may play a major role in the pathogenesis of mucositis through the modification of intestinal barrier function, innate immunity and intestinal repair mechanisms. Better knowledge of these effects may lead to new therapeutic approaches and to the identification of predictive markers of mucositis.
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1Antineoplastic Agents - adverse effects
2Bacteroides
3Bifidobacterium
4Biological and medical sciences
5Cancer
6Chemotherapy
7Clostridium
8Diarrhea - drug therapy
9Diarrhea - etiology
10Diarrhea - microbiology
11Drug toxicity and drugs side effects treatment
12Enterobacteriaceae
13Faecalibacterium prausnitzii
14Gastrointestinal system
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17Intestinal Diseases - drug therapy
18Intestinal Diseases - etiology
19Intestinal Diseases - microbiology
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22Microbiota
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26Mucositis - microbiology
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28Neoplasms - microbiology
29Neoplasms - radiotherapy
30Pharmacology. Drug treatments
31Probiotics - therapeutic use
32Radiation
33Radiation Injuries - drug therapy
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35Toxicity: digestive system
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titleSystematic review: the role of the gut microbiota in chemotherapy‐ or radiation‐induced gastrointestinal mucositis – current evidence and potential clinical applications
authorTouchefeu, Y. ; Montassier, E. ; Nieman, K. ; Gastinne, T. ; Potel, G. ; Bruley des Varannes, S. ; Le Vacon, F. ; La Cochetière, M. F.
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date2014-09
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issue5
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abstractSummary Background Gastrointestinal mucositis is defined as inflammation and/or ulcers of the gastrointestinal tract occurring as a complication of chemotherapy and radiation therapy, and affects about 50% of all cancer patients. Aim To assess the role of gut microbiota in the pathogenesis of gastrointestinal mucositis and the potential for manipulations of the microbiota to prevent and to treat mucositis. Methods Search of the literature published in English using Medline, Scopus and the Cochrane Library, with main search terms ‘intestinal microbiota’, ‘bacteremia’, ‘mucositis’, ‘chemotherapy‐induced diarrhoea’, ‘chemotherapy‐induced mucositis’, ‘radiotherapy‐induced mucositis’. Results The gut microbiota plays a major role in the maintenance of intestinal homoeostasis and integrity. Patients receiving cytotoxic and radiation therapy exhibit marked changes in intestinal microbiota, with most frequently, decrease in Bifidobacterium, Clostridium cluster XIVa, Faecalibacterium prausnitzii, and increase in Enterobacteriaceae and Bacteroides. These modifications may contribute to the development of mucositis, particularly diarrhoea and bacteraemia. The prevention of cancer therapy‐induced mucositis by probiotics has been investigated in randomised clinical trials with some promising results. Three of six trials reported a significantly decreased incidence of diarrhoea. One trial reported a decrease in infectious complications. Conclusions The gut microbiota may play a major role in the pathogenesis of mucositis through the modification of intestinal barrier function, innate immunity and intestinal repair mechanisms. Better knowledge of these effects may lead to new therapeutic approaches and to the identification of predictive markers of mucositis.
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