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Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway

Highlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.

Journal Title: Cancer epidemiology 2014, Vol.38 (6), p.765-772
Main Author: Khan, Arif
Other Authors: Aljarbou, Ahmad N , Aldebasi, Yousef H , Faisal, Syed M , Khan, Masood A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Akt
Publisher: Amsterdam: Elsevier Ltd
ID: ISSN: 1877-7821
Zum Text:
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title: Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway
format: Article
creator:
  • Khan, Arif
  • Aljarbou, Ahmad N
  • Aldebasi, Yousef H
  • Faisal, Syed M
  • Khan, Masood A
subjects:
  • Akt
  • Analysis. Health state
  • Anticarcinogenic Agents - administration & dosage
  • Anticarcinogenic Agents - therapeutic use
  • Apoptosis
  • Biological and medical sciences
  • Breast cancer
  • Breast Neoplasms - drug therapy
  • Breast Neoplasms - genetics
  • Cell cycle
  • Cell growth
  • Cell Line, Tumor
  • Cell Proliferation
  • Epidemiology
  • FASN
  • Female
  • General aspects
  • Hematology, Oncology and Palliative Medicine
  • Her2
  • Humans
  • Internal Medicine
  • Kinases
  • Medical sciences
  • PI3K
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Receptor, ErbB-2 - metabolism
  • Resveratrol
  • Signal Transduction
  • SKBR-3
  • Stilbenes - administration & dosage
  • Stilbenes - therapeutic use
  • Tumors
ispartof: Cancer epidemiology, 2014, Vol.38 (6), p.765-772
description: Highlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.
language: eng
source:
identifier: ISSN: 1877-7821
fulltext: no_fulltext
issn:
  • 1877-7821
  • 1877-783X
url: Link


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descriptionHighlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.
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subjectAkt ; Analysis. Health state ; Anticarcinogenic Agents - administration & dosage ; Anticarcinogenic Agents - therapeutic use ; Apoptosis ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation ; Epidemiology ; FASN ; Female ; General aspects ; Hematology, Oncology and Palliative Medicine ; Her2 ; Humans ; Internal Medicine ; Kinases ; Medical sciences ; PI3K ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Receptor, ErbB-2 - metabolism ; Resveratrol ; Signal Transduction ; SKBR-3 ; Stilbenes - administration & dosage ; Stilbenes - therapeutic use ; Tumors
ispartofCancer epidemiology, 2014, Vol.38 (6), p.765-772
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abstractHighlights • The molecular connection between HER2 and FASN. • Resveratrol inhibit FASN. • Down-regulate Her2. • Up-regulates the expression of Ets factor, PEA3. • Sustained resveratrol induced-PI3K/Akt/mTOR signaling.
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pmid25448084
doi10.1016/j.canep.2014.09.006