schliessen

Filtern

 

Bibliotheken

Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility

Abstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combi... Full description

Journal Title: Immunobiology (1979) 2014, Vol.220 (1), p.20-25
Main Author: Ben Chaaben, Arij
Other Authors: Mariaselvam, Christina , Salah, Sofiane , Busson, Marc , Dulphy, Nicolas , Douik, Hayet , Ghanem, Abderraouf , Boukaouci, Wahid , Al Daccak, Reem , Mamoghli, Tesnim , Harzallah, Latifa , Bouassida, Jihene , Fortier, Catherine , Gritli, Said , Hamida, Jeannette Ben , Charron, Dominique , Krishnamoorthy, Rajagopal , Guemira, Fethi , Tamouza, Ryad
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier GmbH
ID: ISSN: 0171-2985
Link: https://www.ncbi.nlm.nih.gov/pubmed/25446398
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1652408694
title: Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
format: Article
creator:
  • Ben Chaaben, Arij
  • Mariaselvam, Christina
  • Salah, Sofiane
  • Busson, Marc
  • Dulphy, Nicolas
  • Douik, Hayet
  • Ghanem, Abderraouf
  • Boukaouci, Wahid
  • Al Daccak, Reem
  • Mamoghli, Tesnim
  • Harzallah, Latifa
  • Bouassida, Jihene
  • Fortier, Catherine
  • Gritli, Said
  • Hamida, Jeannette Ben
  • Charron, Dominique
  • Krishnamoorthy, Rajagopal
  • Guemira, Fethi
  • Tamouza, Ryad
subjects:
  • Adolescent
  • Adult
  • Advanced Basic Science
  • Aged
  • Aged, 80 and over
  • Alleles
  • Allergy and Immunology
  • Antioxidants
  • Cancer
  • Carcinoma
  • Case-Control Studies
  • Child
  • Disease susceptibility
  • Female
  • Gene Frequency
  • Genes
  • Genetic aspects
  • Genetic polymorphisms
  • Genetic Predisposition to Disease
  • Genotype
  • Glutathione S-transferases
  • Glutathione transferase
  • Glutathione Transferase - genetics
  • Goods and services tax
  • Humans
  • Male
  • Middle Aged
  • Nasopharyngeal Carcinoma
  • Nasopharyngeal Neoplasms - genetics
  • Nasopharyngeal Neoplasms - metabolism
  • Nasopharyngeal Neoplasms - pathology
  • Nitric oxide
  • Nitric oxide synthase
  • Nitric Oxide Synthase Type II - genetics
  • Nitric Oxide Synthase Type III - metabolism
  • Odds Ratio
  • Oxidative stress
  • Oxidative Stress - genetics
  • Polymorphism
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Tunisia
  • Young Adult
ispartof: Immunobiology (1979), 2014, Vol.220 (1), p.20-25
description: Abstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0171-2985
fulltext: fulltext
issn:
  • 0171-2985
  • 1878-3279
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.354843
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1652408694
sourceformatXML
sourcesystemPC
galeidA394882451
sourcerecordidA394882451
originalsourceidFETCH-LOGICAL-c488t-cb5d077f3360579c8eb46d81b7d49d91b3e00d6ea620536e8be72bab557e70653
addsrcrecordideNqNkk9v1DAQxSMEokvhEyChHLkk2I7jPweQqgoKUiWQgLPl2LO7s03sxU4K--3r7RYOXEA-WBq9Z8-831TVS0paSqh4s2txGjC2jFDeEt0SRh9VK6qkajom9eNqRaikDdOqP6ue5bwjhGom1dPqjPWci06rVXXzJY6HKab9FvOUawx1_IXezngLdZ4T5NwkGO0Mvt5AgFzbBLXNOTq8L_7EeVsHm-N-a9MhbMCOtbPJYYiTrfOSHexnHHDE-fC8erK2Y4YXD_d59f3D-2-XH5vrz1efLi-uG8eVmhs39J5Iue46QXqpnYKBC6_oID3XXtOhA0K8ACsY6TsBagDJBjv0vQRJRN-dV69P7-5T_LFAns2EpY9xtAHikg0VPeNECc3_Q8pliY0KVaTtSbqxIxgM6zgn68rxMKGLAdZY6hedLkMw3tNi6E4Gl2LOCdZmn3AqKRlKzJGg2Zl7guZI0BBtCsHievXQ0TJM4P94fiMrgrcnAZQIbxGSyQ4hOPCYwM3GR_zHB-_-8rsRAzo73sAB8i4uKRQ6hprMDDFfj0t03CHKj_tDdHcHh7TECg
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1647001168
display
typearticle
titlePolymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
sourceAlma/SFX Local Collection
creatorBen Chaaben, Arij ; Mariaselvam, Christina ; Salah, Sofiane ; Busson, Marc ; Dulphy, Nicolas ; Douik, Hayet ; Ghanem, Abderraouf ; Boukaouci, Wahid ; Al Daccak, Reem ; Mamoghli, Tesnim ; Harzallah, Latifa ; Bouassida, Jihene ; Fortier, Catherine ; Gritli, Said ; Hamida, Jeannette Ben ; Charron, Dominique ; Krishnamoorthy, Rajagopal ; Guemira, Fethi ; Tamouza, Ryad
creatorcontribBen Chaaben, Arij ; Mariaselvam, Christina ; Salah, Sofiane ; Busson, Marc ; Dulphy, Nicolas ; Douik, Hayet ; Ghanem, Abderraouf ; Boukaouci, Wahid ; Al Daccak, Reem ; Mamoghli, Tesnim ; Harzallah, Latifa ; Bouassida, Jihene ; Fortier, Catherine ; Gritli, Said ; Hamida, Jeannette Ben ; Charron, Dominique ; Krishnamoorthy, Rajagopal ; Guemira, Fethi ; Tamouza, Ryad
descriptionAbstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
identifier
0ISSN: 0171-2985
1EISSN: 1878-3279
2DOI: 10.1016/j.imbio.2014.09.021
3PMID: 25446398
languageeng
publisherNetherlands: Elsevier GmbH
subjectAdolescent ; Adult ; Advanced Basic Science ; Aged ; Aged, 80 and over ; Alleles ; Allergy and Immunology ; Antioxidants ; Cancer ; Carcinoma ; Case-Control Studies ; Child ; Disease susceptibility ; Female ; Gene Frequency ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-transferases ; Glutathione transferase ; Glutathione Transferase - genetics ; Goods and services tax ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms - genetics ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - pathology ; Nitric oxide ; Nitric oxide synthase ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type III - metabolism ; Odds Ratio ; Oxidative stress ; Oxidative Stress - genetics ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Tunisia ; Young Adult
ispartofImmunobiology (1979), 2014, Vol.220 (1), p.20-25
rights
0Elsevier GmbH
12014 Elsevier GmbH
2COPYRIGHT 2015 Elsevier B.V.
lds50peer_reviewed
orcidid0000-0001-5323-137X
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25446398$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Ben Chaaben, Arij
1Mariaselvam, Christina
2Salah, Sofiane
3Busson, Marc
4Dulphy, Nicolas
5Douik, Hayet
6Ghanem, Abderraouf
7Boukaouci, Wahid
8Al Daccak, Reem
9Mamoghli, Tesnim
10Harzallah, Latifa
11Bouassida, Jihene
12Fortier, Catherine
13Gritli, Said
14Hamida, Jeannette Ben
15Charron, Dominique
16Krishnamoorthy, Rajagopal
17Guemira, Fethi
18Tamouza, Ryad
title
0Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
1Immunobiology (1979)
addtitleImmunobiology
descriptionAbstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
subject
0Adolescent
1Adult
2Advanced Basic Science
3Aged
4Aged, 80 and over
5Alleles
6Allergy and Immunology
7Antioxidants
8Cancer
9Carcinoma
10Case-Control Studies
11Child
12Disease susceptibility
13Female
14Gene Frequency
15Genes
16Genetic aspects
17Genetic polymorphisms
18Genetic Predisposition to Disease
19Genotype
20Glutathione S-transferases
21Glutathione transferase
22Glutathione Transferase - genetics
23Goods and services tax
24Humans
25Male
26Middle Aged
27Nasopharyngeal Carcinoma
28Nasopharyngeal Neoplasms - genetics
29Nasopharyngeal Neoplasms - metabolism
30Nasopharyngeal Neoplasms - pathology
31Nitric oxide
32Nitric oxide synthase
33Nitric Oxide Synthase Type II - genetics
34Nitric Oxide Synthase Type III - metabolism
35Odds Ratio
36Oxidative stress
37Oxidative Stress - genetics
38Polymorphism
39Polymorphism, Genetic
40Polymorphism, Single Nucleotide
41Tunisia
42Young Adult
issn
00171-2985
11878-3279
fulltexttrue
rsrctypearticle
creationdate2014
recordtypearticle
recordideNqNkk9v1DAQxSMEokvhEyChHLkk2I7jPweQqgoKUiWQgLPl2LO7s03sxU4K--3r7RYOXEA-WBq9Z8-831TVS0paSqh4s2txGjC2jFDeEt0SRh9VK6qkajom9eNqRaikDdOqP6ue5bwjhGom1dPqjPWci06rVXXzJY6HKab9FvOUawx1_IXezngLdZ4T5NwkGO0Mvt5AgFzbBLXNOTq8L_7EeVsHm-N-a9MhbMCOtbPJYYiTrfOSHexnHHDE-fC8erK2Y4YXD_d59f3D-2-XH5vrz1efLi-uG8eVmhs39J5Iue46QXqpnYKBC6_oID3XXtOhA0K8ACsY6TsBagDJBjv0vQRJRN-dV69P7-5T_LFAns2EpY9xtAHikg0VPeNECc3_Q8pliY0KVaTtSbqxIxgM6zgn68rxMKGLAdZY6hedLkMw3tNi6E4Gl2LOCdZmn3AqKRlKzJGg2Zl7guZI0BBtCsHievXQ0TJM4P94fiMrgrcnAZQIbxGSyQ4hOPCYwM3GR_zHB-_-8rsRAzo73sAB8i4uKRQ6hprMDDFfj0t03CHKj_tDdHcHh7TECg
startdate2014
enddate2014
creator
0Ben Chaaben, Arij
1Mariaselvam, Christina
2Salah, Sofiane
3Busson, Marc
4Dulphy, Nicolas
5Douik, Hayet
6Ghanem, Abderraouf
7Boukaouci, Wahid
8Al Daccak, Reem
9Mamoghli, Tesnim
10Harzallah, Latifa
11Bouassida, Jihene
12Fortier, Catherine
13Gritli, Said
14Hamida, Jeannette Ben
15Charron, Dominique
16Krishnamoorthy, Rajagopal
17Guemira, Fethi
18Tamouza, Ryad
general
0Elsevier GmbH
1Elsevier B.V
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8BSHEE
97T5
108FD
11FR3
12H94
13P64
14RC3
157X8
orcididhttps://orcid.org/0000-0001-5323-137X
sort
creationdate2014
titlePolymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
authorBen Chaaben, Arij ; Mariaselvam, Christina ; Salah, Sofiane ; Busson, Marc ; Dulphy, Nicolas ; Douik, Hayet ; Ghanem, Abderraouf ; Boukaouci, Wahid ; Al Daccak, Reem ; Mamoghli, Tesnim ; Harzallah, Latifa ; Bouassida, Jihene ; Fortier, Catherine ; Gritli, Said ; Hamida, Jeannette Ben ; Charron, Dominique ; Krishnamoorthy, Rajagopal ; Guemira, Fethi ; Tamouza, Ryad
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c488t-cb5d077f3360579c8eb46d81b7d49d91b3e00d6ea620536e8be72bab557e70653
rsrctypearticles
prefilterarticles
languageeng
creationdate2014
topic
0Adolescent
1Adult
2Advanced Basic Science
3Aged
4Aged, 80 and over
5Alleles
6Allergy and Immunology
7Antioxidants
8Cancer
9Carcinoma
10Case-Control Studies
11Child
12Disease susceptibility
13Female
14Gene Frequency
15Genes
16Genetic aspects
17Genetic polymorphisms
18Genetic Predisposition to Disease
19Genotype
20Glutathione S-transferases
21Glutathione transferase
22Glutathione Transferase - genetics
23Goods and services tax
24Humans
25Male
26Middle Aged
27Nasopharyngeal Carcinoma
28Nasopharyngeal Neoplasms - genetics
29Nasopharyngeal Neoplasms - metabolism
30Nasopharyngeal Neoplasms - pathology
31Nitric oxide
32Nitric oxide synthase
33Nitric Oxide Synthase Type II - genetics
34Nitric Oxide Synthase Type III - metabolism
35Odds Ratio
36Oxidative stress
37Oxidative Stress - genetics
38Polymorphism
39Polymorphism, Genetic
40Polymorphism, Single Nucleotide
41Tunisia
42Young Adult
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Ben Chaaben, Arij
1Mariaselvam, Christina
2Salah, Sofiane
3Busson, Marc
4Dulphy, Nicolas
5Douik, Hayet
6Ghanem, Abderraouf
7Boukaouci, Wahid
8Al Daccak, Reem
9Mamoghli, Tesnim
10Harzallah, Latifa
11Bouassida, Jihene
12Fortier, Catherine
13Gritli, Said
14Hamida, Jeannette Ben
15Charron, Dominique
16Krishnamoorthy, Rajagopal
17Guemira, Fethi
18Tamouza, Ryad
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Academic OneFile (A&I only)
8Immunology Abstracts
9Technology Research Database
10Engineering Research Database
11AIDS and Cancer Research Abstracts
12Biotechnology and BioEngineering Abstracts
13Genetics Abstracts
14MEDLINE - Academic
jtitleImmunobiology (1979)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Ben Chaaben, Arij
1Mariaselvam, Christina
2Salah, Sofiane
3Busson, Marc
4Dulphy, Nicolas
5Douik, Hayet
6Ghanem, Abderraouf
7Boukaouci, Wahid
8Al Daccak, Reem
9Mamoghli, Tesnim
10Harzallah, Latifa
11Bouassida, Jihene
12Fortier, Catherine
13Gritli, Said
14Hamida, Jeannette Ben
15Charron, Dominique
16Krishnamoorthy, Rajagopal
17Guemira, Fethi
18Tamouza, Ryad
formatjournal
genrearticle
ristypeJOUR
atitlePolymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
jtitleImmunobiology (1979)
addtitleImmunobiology
date2014
risdate2014
volume220
issue1
spage20
epage25
pages20-25
issn0171-2985
eissn1878-3279
abstractAbstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
copNetherlands
pubElsevier GmbH
pmid25446398
doi10.1016/j.imbio.2014.09.021
orcididhttps://orcid.org/0000-0001-5323-137X