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Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility

Abstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combi... Full description

Journal Title: Immunobiology (1979) 2014, Vol.220 (1), p.20-25
Main Author: Ben Chaaben, Arij
Other Authors: Mariaselvam, Christina , Salah, Sofiane , Busson, Marc , Dulphy, Nicolas , Douik, Hayet , Ghanem, Abderraouf , Boukaouci, Wahid , Al Daccak, Reem , Mamoghli, Tesnim , Harzallah, Latifa , Bouassida, Jihene , Fortier, Catherine , Gritli, Said , Hamida, Jeannette Ben , Charron, Dominique , Krishnamoorthy, Rajagopal , Guemira, Fethi , Tamouza, Ryad
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adolescent
Adult
Advanced Basic Science
Aged
Aged, 80 and over
Alleles
Allergy and Immunology
Antioxidants
Cancer
Carcinoma
Case-Control Studies
Child
Disease susceptibility
Female
Gene Frequency
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Genotype
Glutathione S-transferases
Glutathione transferase
Glutathione Transferase - genetics
Goods and services tax
Humans
Male
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - genetics
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - pathology
Nitric oxide
Nitric oxide synthase
Nitric Oxide Synthase Type II - genetics
Nitric Oxide Synthase Type III - metabolism
Odds Ratio
Oxidative stress
Oxidative Stress - genetics
Polymorphism
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Tunisia
Young Adult
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier GmbH
ID: ISSN: 0171-2985
Link: https://www.ncbi.nlm.nih.gov/pubmed/25446398
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title: Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
format: Article
creator:
  • Ben Chaaben, Arij
  • Mariaselvam, Christina
  • Salah, Sofiane
  • Busson, Marc
  • Dulphy, Nicolas
  • Douik, Hayet
  • Ghanem, Abderraouf
  • Boukaouci, Wahid
  • Al Daccak, Reem
  • Mamoghli, Tesnim
  • Harzallah, Latifa
  • Bouassida, Jihene
  • Fortier, Catherine
  • Gritli, Said
  • Hamida, Jeannette Ben
  • Charron, Dominique
  • Krishnamoorthy, Rajagopal
  • Guemira, Fethi
  • Tamouza, Ryad
subjects:
  • Adolescent
  • Adult
  • Advanced Basic Science
  • Aged
  • Aged, 80 and over
  • Alleles
  • Allergy and Immunology
  • Antioxidants
  • Cancer
  • Carcinoma
  • Case-Control Studies
  • Child
  • Disease susceptibility
  • Female
  • Gene Frequency
  • Genes
  • Genetic aspects
  • Genetic polymorphisms
  • Genetic Predisposition to Disease
  • Genotype
  • Glutathione S-transferases
  • Glutathione transferase
  • Glutathione Transferase - genetics
  • Goods and services tax
  • Humans
  • Male
  • Middle Aged
  • Nasopharyngeal Carcinoma
  • Nasopharyngeal Neoplasms - genetics
  • Nasopharyngeal Neoplasms - metabolism
  • Nasopharyngeal Neoplasms - pathology
  • Nitric oxide
  • Nitric oxide synthase
  • Nitric Oxide Synthase Type II - genetics
  • Nitric Oxide Synthase Type III - metabolism
  • Odds Ratio
  • Oxidative stress
  • Oxidative Stress - genetics
  • Polymorphism
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Tunisia
  • Young Adult
ispartof: Immunobiology (1979), 2014, Vol.220 (1), p.20-25
description: Abstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0171-2985
fulltext: fulltext
issn:
  • 0171-2985
  • 1878-3279
url: Link


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titlePolymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
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creatorBen Chaaben, Arij ; Mariaselvam, Christina ; Salah, Sofiane ; Busson, Marc ; Dulphy, Nicolas ; Douik, Hayet ; Ghanem, Abderraouf ; Boukaouci, Wahid ; Al Daccak, Reem ; Mamoghli, Tesnim ; Harzallah, Latifa ; Bouassida, Jihene ; Fortier, Catherine ; Gritli, Said ; Hamida, Jeannette Ben ; Charron, Dominique ; Krishnamoorthy, Rajagopal ; Guemira, Fethi ; Tamouza, Ryad
creatorcontribBen Chaaben, Arij ; Mariaselvam, Christina ; Salah, Sofiane ; Busson, Marc ; Dulphy, Nicolas ; Douik, Hayet ; Ghanem, Abderraouf ; Boukaouci, Wahid ; Al Daccak, Reem ; Mamoghli, Tesnim ; Harzallah, Latifa ; Bouassida, Jihene ; Fortier, Catherine ; Gritli, Said ; Hamida, Jeannette Ben ; Charron, Dominique ; Krishnamoorthy, Rajagopal ; Guemira, Fethi ; Tamouza, Ryad
descriptionAbstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
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languageeng
publisherNetherlands: Elsevier GmbH
subjectAdolescent ; Adult ; Advanced Basic Science ; Aged ; Aged, 80 and over ; Alleles ; Allergy and Immunology ; Antioxidants ; Cancer ; Carcinoma ; Case-Control Studies ; Child ; Disease susceptibility ; Female ; Gene Frequency ; Genes ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-transferases ; Glutathione transferase ; Glutathione Transferase - genetics ; Goods and services tax ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms - genetics ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - pathology ; Nitric oxide ; Nitric oxide synthase ; Nitric Oxide Synthase Type II - genetics ; Nitric Oxide Synthase Type III - metabolism ; Odds Ratio ; Oxidative stress ; Oxidative Stress - genetics ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Tunisia ; Young Adult
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1Mariaselvam, Christina
2Salah, Sofiane
3Busson, Marc
4Dulphy, Nicolas
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7Boukaouci, Wahid
8Al Daccak, Reem
9Mamoghli, Tesnim
10Harzallah, Latifa
11Bouassida, Jihene
12Fortier, Catherine
13Gritli, Said
14Hamida, Jeannette Ben
15Charron, Dominique
16Krishnamoorthy, Rajagopal
17Guemira, Fethi
18Tamouza, Ryad
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descriptionAbstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
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4Aged, 80 and over
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8Cancer
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10Case-Control Studies
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33Nitric Oxide Synthase Type II - genetics
34Nitric Oxide Synthase Type III - metabolism
35Odds Ratio
36Oxidative stress
37Oxidative Stress - genetics
38Polymorphism
39Polymorphism, Genetic
40Polymorphism, Single Nucleotide
41Tunisia
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titlePolymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility
authorBen Chaaben, Arij ; Mariaselvam, Christina ; Salah, Sofiane ; Busson, Marc ; Dulphy, Nicolas ; Douik, Hayet ; Ghanem, Abderraouf ; Boukaouci, Wahid ; Al Daccak, Reem ; Mamoghli, Tesnim ; Harzallah, Latifa ; Bouassida, Jihene ; Fortier, Catherine ; Gritli, Said ; Hamida, Jeannette Ben ; Charron, Dominique ; Krishnamoorthy, Rajagopal ; Guemira, Fethi ; Tamouza, Ryad
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4Aged, 80 and over
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10Case-Control Studies
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abstractAbstract Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.
copNetherlands
pubElsevier GmbH
pmid25446398
doi10.1016/j.imbio.2014.09.021
orcididhttps://orcid.org/0000-0001-5323-137X