schliessen

Filtern

 

Bibliotheken

Testosterone to Dihydrotestosterone Ratio as a New Biomarker for an Adverse Metabolic Phenotype in the Polycystic Ovary Syndrome

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous disease with many different aspects, including hyperandrogenism and metabolic disturbances. Clinical phenotypes show different patterns of steroid hormones that have been investigated to some extent. Objective: This study intended to deter... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2015-02, Vol.100 (2), p.653-660
Main Author: Münzker, J
Other Authors: Hofer, D , Trummer, C , Ulbing, M , Harger, A , Pieber, T , Owen, L , Keevil, B , Brabant, G , Lerchbaum, E , Obermayer-Pietsch, B
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25387259
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1653124786
title: Testosterone to Dihydrotestosterone Ratio as a New Biomarker for an Adverse Metabolic Phenotype in the Polycystic Ovary Syndrome
format: Article
creator:
  • Münzker, J
  • Hofer, D
  • Trummer, C
  • Ulbing, M
  • Harger, A
  • Pieber, T
  • Owen, L
  • Keevil, B
  • Brabant, G
  • Lerchbaum, E
  • Obermayer-Pietsch, B
subjects:
  • Abridged Index Medicus
  • Adolescent
  • Adult
  • Biomarkers - blood
  • Dihydrotestosterone - blood
  • Female
  • Glucose Intolerance - blood
  • Glucose Intolerance - complications
  • Glucose Intolerance - diagnosis
  • Humans
  • Insulin - blood
  • Insulin Resistance - physiology
  • Metabolic Syndrome - blood
  • Metabolic Syndrome - complications
  • Metabolic Syndrome - diagnosis
  • Middle Aged
  • Polycystic Ovary Syndrome - blood
  • Polycystic Ovary Syndrome - complications
  • Testosterone - blood
  • Young Adult
ispartof: The journal of clinical endocrinology and metabolism, 2015-02, Vol.100 (2), p.653-660
description: Context: Polycystic ovary syndrome (PCOS) is a heterogeneous disease with many different aspects, including hyperandrogenism and metabolic disturbances. Clinical phenotypes show different patterns of steroid hormones that have been investigated to some extent. Objective: This study intended to determine the role of the testosterone (TT) to dihydrotestosterone (DHT) ratio (TT/DHT ratio) in PCOS patients and to further assess the correlation of this ratio with hormonal, anthropometric, and metabolic parameters. Design and Setting: Serum samples of 275 premenopausal PCOS patients fulfilling Rotterdam criteria and 35 BMI-matched, premenopausal, healthy controls were analyzed for testosterone, DHT, dehydroepiandrosterone (DHEA), and androstenedione using liquid chromatography/mass spectrometry. Main Outcome Measures: We measured total levels of testosterone and DHT and calculated unbound hormone levels as well as the ratio of testosterone to DHT. Further, impaired glucose tolerance, basal and stimulated serum insulin levels, metabolic syndrome and insulin resistance according to the homeostatic model assessment (HOMA-IR) were assessed. Results: PCOS patients showed significantly higher levels of TT (P < .001), free testosterone (P < .001), and free DHT (P < .001) compared to healthy controls. The TT/DHT ratio was significantly higher in PCOS patients (P < .001). No difference was found for total DHT levels (P = .072). In PCOS patients alone, the TT/DHT ratio was significantly higher in obese patients (P < .001) and patients with metabolic syndrome (P < .001), impaired glucose tolerance (IGT) (P < .001) or insulin resistance (P < .001). Significant correlations of the TT/DHT ratio with various adverse anthropometric, hormonal, lipid and liver parameters and parameters of glucose metabolism were found. Conclusion: Our data provide evidence for a strong link between a high TT/DHT ratio and an adverse metabolic phenotype in PCOS patients. This correlation was only found in PCOS patients, suggesting the TT/DHT ratio to be a new biomarker for an adverse metabolic phenotype in PCOS patients.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6489527
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_1653124786
sourceformatXML
sourcesystemPC
sourcerecordid1653124786
originalsourceidFETCH-LOGICAL-14281-bdd6c0daa0093ff87490aa271207d6c631ed3a67f1a326b544c135cbffe7a08d0
addsrcrecordideNp1kc1v1DAQxS0EotvCjTPykUNT_JU4OZbSAlJLKygSN8txJoq3WXuxna5y40_H0RaEUPHF8sx7bzQ_I_SKkhPKKHm7NieMUFGwkvEnaEUbURaSNvIpWhHCaNFI9v0AHca4JlkmSv4cHbCS15KVzQr9vIWYfEwQvAOcPH5vh7kLPv1d_qKT9VhHrPFn2OF31m90uIOAex-wdvi0u4cQAV9B0q0frcE3Azif5i1g63AaAN_4cTZzTLl3fa_DjL_OLo_ZwAv0rNdjhJcP9xH6dnF-e_axuLz-8Ons9LKggtW0aLuuMqTTmpCG930tRUO0ZpIyInOn4hQ6rivZU81Z1ZZCGMpL0_Y9SE3qjhyhN_vcbfA_pryd2thoYBy1Az9FRauSUyZkXWXp8V5qgo8xQK-2weaNZ0WJWpirtVELc7Uwz_LXD8lTu4Huj_g35Cxg_-QZmxakLgVtx_-lir1p58f8DfFunHYQ1AB6TIMi-YhK1kU2lITlV7FUaLbxvQ1c502wDrYBYlRrPwWX-T4-7Bfw-K--
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1653124786
display
typearticle
titleTestosterone to Dihydrotestosterone Ratio as a New Biomarker for an Adverse Metabolic Phenotype in the Polycystic Ovary Syndrome
creatorMünzker, J ; Hofer, D ; Trummer, C ; Ulbing, M ; Harger, A ; Pieber, T ; Owen, L ; Keevil, B ; Brabant, G ; Lerchbaum, E ; Obermayer-Pietsch, B
creatorcontribMünzker, J ; Hofer, D ; Trummer, C ; Ulbing, M ; Harger, A ; Pieber, T ; Owen, L ; Keevil, B ; Brabant, G ; Lerchbaum, E ; Obermayer-Pietsch, B
description
identifier
0ISSN: 0021-972X
1EISSN: 1945-7197
2DOI: 10.1210/jc.2014-2523
3PMID: 25387259
languageeng
publisherUnited States: Endocrine Society
subjectAbridged Index Medicus ; Adolescent ; Adult ; Biomarkers - blood ; Dihydrotestosterone - blood ; Female ; Glucose Intolerance - blood ; Glucose Intolerance - complications ; Glucose Intolerance - diagnosis ; Humans ; Insulin - blood ; Insulin Resistance - physiology ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - diagnosis ; Middle Aged ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Testosterone - blood ; Young Adult
ispartofThe journal of clinical endocrinology and metabolism, 2015-02, Vol.100 (2), p.653-660
rights
0Copyright © 2015 by the Endocrine Society
1Copyright © 2015 by The Endocrine Society
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-14281-bdd6c0daa0093ff87490aa271207d6c631ed3a67f1a326b544c135cbffe7a08d0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25387259$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Münzker, J
1Hofer, D
2Trummer, C
3Ulbing, M
4Harger, A
5Pieber, T
6Owen, L
7Keevil, B
8Brabant, G
9Lerchbaum, E
10Obermayer-Pietsch, B
title
0Testosterone to Dihydrotestosterone Ratio as a New Biomarker for an Adverse Metabolic Phenotype in the Polycystic Ovary Syndrome
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
description
subject
0Abridged Index Medicus
1Adolescent
2Adult
3Biomarkers - blood
4Dihydrotestosterone - blood
5Female
6Glucose Intolerance - blood
7Glucose Intolerance - complications
8Glucose Intolerance - diagnosis
9Humans
10Insulin - blood
11Insulin Resistance - physiology
12Metabolic Syndrome - blood
13Metabolic Syndrome - complications
14Metabolic Syndrome - diagnosis
15Middle Aged
16Polycystic Ovary Syndrome - blood
17Polycystic Ovary Syndrome - complications
18Testosterone - blood
19Young Adult
issn
00021-972X
11945-7197
fulltextfalse
rsrctypearticle
creationdate2015
recordtypearticle
recordideNp1kc1v1DAQxS0EotvCjTPykUNT_JU4OZbSAlJLKygSN8txJoq3WXuxna5y40_H0RaEUPHF8sx7bzQ_I_SKkhPKKHm7NieMUFGwkvEnaEUbURaSNvIpWhHCaNFI9v0AHca4JlkmSv4cHbCS15KVzQr9vIWYfEwQvAOcPH5vh7kLPv1d_qKT9VhHrPFn2OF31m90uIOAex-wdvi0u4cQAV9B0q0frcE3Azif5i1g63AaAN_4cTZzTLl3fa_DjL_OLo_ZwAv0rNdjhJcP9xH6dnF-e_axuLz-8Ons9LKggtW0aLuuMqTTmpCG930tRUO0ZpIyInOn4hQ6rivZU81Z1ZZCGMpL0_Y9SE3qjhyhN_vcbfA_pryd2thoYBy1Az9FRauSUyZkXWXp8V5qgo8xQK-2weaNZ0WJWpirtVELc7Uwz_LXD8lTu4Huj_g35Cxg_-QZmxakLgVtx_-lir1p58f8DfFunHYQ1AB6TIMi-YhK1kU2lITlV7FUaLbxvQ1c502wDrYBYlRrPwWX-T4-7Bfw-K--
startdate201502
enddate201502
creator
0Münzker, J
1Hofer, D
2Trummer, C
3Ulbing, M
4Harger, A
5Pieber, T
6Owen, L
7Keevil, B
8Brabant, G
9Lerchbaum, E
10Obermayer-Pietsch, B
general
0Endocrine Society
1Copyright by The Endocrine Society
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
87X8
sort
creationdate201502
titleTestosterone to Dihydrotestosterone Ratio as a New Biomarker for an Adverse Metabolic Phenotype in the Polycystic Ovary Syndrome
authorMünzker, J ; Hofer, D ; Trummer, C ; Ulbing, M ; Harger, A ; Pieber, T ; Owen, L ; Keevil, B ; Brabant, G ; Lerchbaum, E ; Obermayer-Pietsch, B
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-14281-bdd6c0daa0093ff87490aa271207d6c631ed3a67f1a326b544c135cbffe7a08d0
rsrctypearticles
prefilterarticles
languageeng
creationdate2015
topic
0Abridged Index Medicus
1Adolescent
2Adult
3Biomarkers - blood
4Dihydrotestosterone - blood
5Female
6Glucose Intolerance - blood
7Glucose Intolerance - complications
8Glucose Intolerance - diagnosis
9Humans
10Insulin - blood
11Insulin Resistance - physiology
12Metabolic Syndrome - blood
13Metabolic Syndrome - complications
14Metabolic Syndrome - diagnosis
15Middle Aged
16Polycystic Ovary Syndrome - blood
17Polycystic Ovary Syndrome - complications
18Testosterone - blood
19Young Adult
toplevelpeer_reviewed
creatorcontrib
0Münzker, J
1Hofer, D
2Trummer, C
3Ulbing, M
4Harger, A
5Pieber, T
6Owen, L
7Keevil, B
8Brabant, G
9Lerchbaum, E
10Obermayer-Pietsch, B
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7MEDLINE - Academic
jtitleThe journal of clinical endocrinology and metabolism
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Münzker, J
1Hofer, D
2Trummer, C
3Ulbing, M
4Harger, A
5Pieber, T
6Owen, L
7Keevil, B
8Brabant, G
9Lerchbaum, E
10Obermayer-Pietsch, B
formatjournal
genrearticle
ristypeJOUR
atitleTestosterone to Dihydrotestosterone Ratio as a New Biomarker for an Adverse Metabolic Phenotype in the Polycystic Ovary Syndrome
jtitleThe journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
date2015-02
risdate2015
volume100
issue2
spage653
epage660
pages653-660
issn0021-972X
eissn1945-7197
notesThis work was supported by FEMTech project No. 826217, funded by the Austrian Research Promotion Agency (FFG), and by the Austrian BioPersMed (COMET K-project No. 825329), the Federal Ministry of Transport, Innovation and Technology (BMVIT) and the Federal Ministry of Economics and Labor, the Federal Ministry of Economy, Family and Youth (BMWA/BMWFJ), and the Styrian Business Promotion Agency (SFG).
abstract
copUnited States
pubEndocrine Society
pmid25387259
doi10.1210/jc.2014-2523
oafree_for_read