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Reference Range of Serum Calcitonin in Pediatric Population

Background: Children belonging to the multiple endocrine neoplasia type 2 (MEN 2) pedigree and carrying germline RET mutations are candidates for prophylactic thyroidectomy, the timing of which is based on the mutation-associated risk and the calcitonin (CT) levels. Design: The aim of this study was... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2015, Vol.100 (5), p.1780-1784
Main Author: Castagna, Maria G
Other Authors: Fugazzola, Laura , Maino, Fabio , Covelli, Danila , Memmo, Silvia , Sestini, Fausta , Fioravanti, Carla , Ferraris Fusarini, Chiara , Scapellato, Carlo , Macchini, Francesco , Cevenini, Gabriele , Pacini, Furio
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25955324
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recordid: cdi_proquest_miscellaneous_1680179859
title: Reference Range of Serum Calcitonin in Pediatric Population
format: Article
creator:
  • Castagna, Maria G
  • Fugazzola, Laura
  • Maino, Fabio
  • Covelli, Danila
  • Memmo, Silvia
  • Sestini, Fausta
  • Fioravanti, Carla
  • Ferraris Fusarini, Chiara
  • Scapellato, Carlo
  • Macchini, Francesco
  • Cevenini, Gabriele
  • Pacini, Furio
subjects:
  • Abridged Index Medicus
  • Adolescent
  • Calcitonin - blood
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Reference Values
ispartof: The journal of clinical endocrinology and metabolism, 2015, Vol.100 (5), p.1780-1784
description: Background: Children belonging to the multiple endocrine neoplasia type 2 (MEN 2) pedigree and carrying germline RET mutations are candidates for prophylactic thyroidectomy, the timing of which is based on the mutation-associated risk and the calcitonin (CT) levels. Design: The aim of this study was to establish the reference range for serum CT in a pediatric population. The study included 2740 subjects (1339 females and 1401 males) ranging in age from 1 day to 16 years and undergoing blood testing for any medical condition not affecting serum CT. Results: Overall, serum CT was undetectable in 61.5% of the samples and detectable in 38.5%. Detectable samples were more frequent in the first 2 years of life. Thereafter, undetectable samples became more frequent, particularly in females. Mean serum CT concentrations were higher in the first year of life (9.81 ± 8.8 pg/mL; range, 2.0–48.9 pg/mL) and the second year of life (4.56 ± 2.64 pg/mL; range, 2.0–14.7 pg/mL). A significant decrease of serum CT levels was observed thereafter (P < .001), and starting from the third year of life serum CT levels were similar to those found in adults. No gender difference was found in any age group. Based on these results, age-specific CT reference ranges are needed in the pediatric population, and especially in the first 2 years of life. Conclusions: This is the first study defining the reference range for serum CT in the pediatric population and large enough to be statistically meaningful. Our proposal may facilitate the process of decision making when dealing with gene carriers of MEN 2.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleReference Range of Serum Calcitonin in Pediatric Population
creatorCastagna, Maria G ; Fugazzola, Laura ; Maino, Fabio ; Covelli, Danila ; Memmo, Silvia ; Sestini, Fausta ; Fioravanti, Carla ; Ferraris Fusarini, Chiara ; Scapellato, Carlo ; Macchini, Francesco ; Cevenini, Gabriele ; Pacini, Furio
creatorcontribCastagna, Maria G ; Fugazzola, Laura ; Maino, Fabio ; Covelli, Danila ; Memmo, Silvia ; Sestini, Fausta ; Fioravanti, Carla ; Ferraris Fusarini, Chiara ; Scapellato, Carlo ; Macchini, Francesco ; Cevenini, Gabriele ; Pacini, Furio
descriptionBackground: Children belonging to the multiple endocrine neoplasia type 2 (MEN 2) pedigree and carrying germline RET mutations are candidates for prophylactic thyroidectomy, the timing of which is based on the mutation-associated risk and the calcitonin (CT) levels. Design: The aim of this study was to establish the reference range for serum CT in a pediatric population. The study included 2740 subjects (1339 females and 1401 males) ranging in age from 1 day to 16 years and undergoing blood testing for any medical condition not affecting serum CT. Results: Overall, serum CT was undetectable in 61.5% of the samples and detectable in 38.5%. Detectable samples were more frequent in the first 2 years of life. Thereafter, undetectable samples became more frequent, particularly in females. Mean serum CT concentrations were higher in the first year of life (9.81 ± 8.8 pg/mL; range, 2.0–48.9 pg/mL) and the second year of life (4.56 ± 2.64 pg/mL; range, 2.0–14.7 pg/mL). A significant decrease of serum CT levels was observed thereafter (P < .001), and starting from the third year of life serum CT levels were similar to those found in adults. No gender difference was found in any age group. Based on these results, age-specific CT reference ranges are needed in the pediatric population, and especially in the first 2 years of life. Conclusions: This is the first study defining the reference range for serum CT in the pediatric population and large enough to be statistically meaningful. Our proposal may facilitate the process of decision making when dealing with gene carriers of MEN 2.
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subjectAbridged Index Medicus ; Adolescent ; Calcitonin - blood ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Reference Values
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descriptionBackground: Children belonging to the multiple endocrine neoplasia type 2 (MEN 2) pedigree and carrying germline RET mutations are candidates for prophylactic thyroidectomy, the timing of which is based on the mutation-associated risk and the calcitonin (CT) levels. Design: The aim of this study was to establish the reference range for serum CT in a pediatric population. The study included 2740 subjects (1339 females and 1401 males) ranging in age from 1 day to 16 years and undergoing blood testing for any medical condition not affecting serum CT. Results: Overall, serum CT was undetectable in 61.5% of the samples and detectable in 38.5%. Detectable samples were more frequent in the first 2 years of life. Thereafter, undetectable samples became more frequent, particularly in females. Mean serum CT concentrations were higher in the first year of life (9.81 ± 8.8 pg/mL; range, 2.0–48.9 pg/mL) and the second year of life (4.56 ± 2.64 pg/mL; range, 2.0–14.7 pg/mL). A significant decrease of serum CT levels was observed thereafter (P < .001), and starting from the third year of life serum CT levels were similar to those found in adults. No gender difference was found in any age group. Based on these results, age-specific CT reference ranges are needed in the pediatric population, and especially in the first 2 years of life. Conclusions: This is the first study defining the reference range for serum CT in the pediatric population and large enough to be statistically meaningful. Our proposal may facilitate the process of decision making when dealing with gene carriers of MEN 2.
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authorCastagna, Maria G ; Fugazzola, Laura ; Maino, Fabio ; Covelli, Danila ; Memmo, Silvia ; Sestini, Fausta ; Fioravanti, Carla ; Ferraris Fusarini, Chiara ; Scapellato, Carlo ; Macchini, Francesco ; Cevenini, Gabriele ; Pacini, Furio
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notesThis work was supported in part by grants from the Ministero Italiano dell'Università e Ricerca (Grant 2012Z3F7HE) and the Ministero Italiano della Salute (Project RF–2011–02350673).
abstractBackground: Children belonging to the multiple endocrine neoplasia type 2 (MEN 2) pedigree and carrying germline RET mutations are candidates for prophylactic thyroidectomy, the timing of which is based on the mutation-associated risk and the calcitonin (CT) levels. Design: The aim of this study was to establish the reference range for serum CT in a pediatric population. The study included 2740 subjects (1339 females and 1401 males) ranging in age from 1 day to 16 years and undergoing blood testing for any medical condition not affecting serum CT. Results: Overall, serum CT was undetectable in 61.5% of the samples and detectable in 38.5%. Detectable samples were more frequent in the first 2 years of life. Thereafter, undetectable samples became more frequent, particularly in females. Mean serum CT concentrations were higher in the first year of life (9.81 ± 8.8 pg/mL; range, 2.0–48.9 pg/mL) and the second year of life (4.56 ± 2.64 pg/mL; range, 2.0–14.7 pg/mL). A significant decrease of serum CT levels was observed thereafter (P < .001), and starting from the third year of life serum CT levels were similar to those found in adults. No gender difference was found in any age group. Based on these results, age-specific CT reference ranges are needed in the pediatric population, and especially in the first 2 years of life. Conclusions: This is the first study defining the reference range for serum CT in the pediatric population and large enough to be statistically meaningful. Our proposal may facilitate the process of decision making when dealing with gene carriers of MEN 2.
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