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Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study

Aims/hypothesis We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers. Methods During 1993–1999, pregnancies of women with type 1 diabetes in Denmark were prosp... Full description

Journal Title: Diabetologia 2015, Vol.58 (7), p.1454-1463
Main Author: Vlachová, Zuzana
Other Authors: Bytoft, Birgitte , Knorr, Sine , Clausen, Tine D , Jensen, Rikke Beck , Mathiesen, Elisabeth R , Højlund, Kurt , Ovesen, Per , Beck-Nielsen, Henning , Gravholt, Claus H , Damm, Peter , Jensen, Dorte M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25924986
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title: Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study
format: Article
creator:
  • Vlachová, Zuzana
  • Bytoft, Birgitte
  • Knorr, Sine
  • Clausen, Tine D
  • Jensen, Rikke Beck
  • Mathiesen, Elisabeth R
  • Højlund, Kurt
  • Ovesen, Per
  • Beck-Nielsen, Henning
  • Gravholt, Claus H
  • Damm, Peter
  • Jensen, Dorte M
subjects:
  • Adolescent
  • Adult
  • Anthropometry
  • Article
  • Blood
  • Denmark - epidemiology
  • Dextrose
  • Diabetes Mellitus, Type 1 - epidemiology
  • Diabetics
  • European Continental Ancestry Group
  • Female
  • Glucose
  • Glucose Tolerance Test
  • Glucose tolerance tests
  • Glycated Hemoglobin A - analysis
  • Human Physiology
  • Humans
  • Hyperglycemia
  • Insulin - blood
  • Insulin Resistance
  • Internal Medicine
  • Male
  • Medical examination
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Metabolic Diseases - epidemiology
  • Mothers
  • Pregnancy
  • Pregnancy in Diabetics
  • Pregnancy Outcome
  • Pregnant women
  • Risk Factors
  • Type 1 diabetes
  • Young Adult
ispartof: Diabetologia, 2015, Vol.58 (7), p.1454-1463
description: Aims/hypothesis We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers. Methods During 1993–1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed. Results We examined 278 index offspring (mean age 16.7 years; range 13.0–19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5–20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA 1c levels in pregnancy were not directly associated with offspring metabolic outcomes. Conclusions/interpretation Adolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA 1c levels in pregnancy could not be demonstrated. Trial registration : ClinicalTrials.gov NCT01559181
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleIncreased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study
creatorVlachová, Zuzana ; Bytoft, Birgitte ; Knorr, Sine ; Clausen, Tine D ; Jensen, Rikke Beck ; Mathiesen, Elisabeth R ; Højlund, Kurt ; Ovesen, Per ; Beck-Nielsen, Henning ; Gravholt, Claus H ; Damm, Peter ; Jensen, Dorte M
creatorcontribVlachová, Zuzana ; Bytoft, Birgitte ; Knorr, Sine ; Clausen, Tine D ; Jensen, Rikke Beck ; Mathiesen, Elisabeth R ; Højlund, Kurt ; Ovesen, Per ; Beck-Nielsen, Henning ; Gravholt, Claus H ; Damm, Peter ; Jensen, Dorte M
descriptionAims/hypothesis We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers. Methods During 1993–1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed. Results We examined 278 index offspring (mean age 16.7 years; range 13.0–19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5–20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA 1c levels in pregnancy were not directly associated with offspring metabolic outcomes. Conclusions/interpretation Adolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA 1c levels in pregnancy could not be demonstrated. Trial registration : ClinicalTrials.gov NCT01559181
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subjectAdolescent ; Adult ; Anthropometry ; Article ; Blood ; Denmark - epidemiology ; Dextrose ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetics ; European Continental Ancestry Group ; Female ; Glucose ; Glucose Tolerance Test ; Glucose tolerance tests ; Glycated Hemoglobin A - analysis ; Human Physiology ; Humans ; Hyperglycemia ; Insulin - blood ; Insulin Resistance ; Internal Medicine ; Male ; Medical examination ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic Diseases - epidemiology ; Mothers ; Pregnancy ; Pregnancy in Diabetics ; Pregnancy Outcome ; Pregnant women ; Risk Factors ; Type 1 diabetes ; Young Adult
ispartofDiabetologia, 2015, Vol.58 (7), p.1454-1463
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1Bytoft, Birgitte
2Knorr, Sine
3Clausen, Tine D
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5Mathiesen, Elisabeth R
6Højlund, Kurt
7Ovesen, Per
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10Damm, Peter
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descriptionAims/hypothesis We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers. Methods During 1993–1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed. Results We examined 278 index offspring (mean age 16.7 years; range 13.0–19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5–20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA 1c levels in pregnancy were not directly associated with offspring metabolic outcomes. Conclusions/interpretation Adolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA 1c levels in pregnancy could not be demonstrated. Trial registration : ClinicalTrials.gov NCT01559181
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titleIncreased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study
authorVlachová, Zuzana ; Bytoft, Birgitte ; Knorr, Sine ; Clausen, Tine D ; Jensen, Rikke Beck ; Mathiesen, Elisabeth R ; Højlund, Kurt ; Ovesen, Per ; Beck-Nielsen, Henning ; Gravholt, Claus H ; Damm, Peter ; Jensen, Dorte M
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abstractAims/hypothesis We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers. Methods During 1993–1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed. Results We examined 278 index offspring (mean age 16.7 years; range 13.0–19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5–20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA 1c levels in pregnancy were not directly associated with offspring metabolic outcomes. Conclusions/interpretation Adolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA 1c levels in pregnancy could not be demonstrated. Trial registration : ClinicalTrials.gov NCT01559181
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pmid25924986
doi10.1007/s00125-015-3589-5
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