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Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial

Aim/hypothesis Dietary polyphenols and long chain n -3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine o... Full description

Journal Title: Diabetologia 2015, Vol.58 (7), p.1551-1560
Main Author: Bozzetto, Lutgarda
Other Authors: Annuzzi, Giovanni , Pacini, Giovanni , Costabile, Giuseppina , Vetrani, Claudia , Vitale, Marilena , Griffo, Ettore , Giacco, Angela , De Natale, Claudia , Cocozza, Sara , Della Pepa, Giuseppe , Tura, Andrea , Riccardi, Gabriele , Rivellese, Angela A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25906754
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title: Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial
format: Article
creator:
  • Bozzetto, Lutgarda
  • Annuzzi, Giovanni
  • Pacini, Giovanni
  • Costabile, Giuseppina
  • Vetrani, Claudia
  • Vitale, Marilena
  • Griffo, Ettore
  • Giacco, Angela
  • De Natale, Claudia
  • Cocozza, Sara
  • Della Pepa, Giuseppe
  • Tura, Andrea
  • Riccardi, Gabriele
  • Rivellese, Angela A
subjects:
  • Adult
  • Aged
  • Article
  • Blood Glucose - metabolism
  • Blood sugar
  • Cardiovascular Diseases - diet therapy
  • Cardiovascular Diseases - prevention & control
  • Diet
  • Evaluation
  • Fatty Acids, Omega-3 - pharmacology
  • Female
  • Glucagon-Like Peptide 1 - blood
  • Glucose - metabolism
  • Glucose Tolerance Test
  • Glucose tolerance tests
  • Human Physiology
  • Humans
  • Insulin - blood
  • Insulin Resistance
  • Insulin-Secreting Cells - metabolism
  • Internal Medicine
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Metabolic Diseases - diet therapy
  • Metabolic Diseases - prevention & control
  • Middle Aged
  • Obesity - diet therapy
  • Patient Compliance
  • Physiological aspects
  • Polyphenols
  • Polyphenols - pharmacology
  • Unsaturated fatty acids
  • Waist Circumference
ispartof: Diabetologia, 2015, Vol.58 (7), p.1551-1560
description: Aim/hypothesis Dietary polyphenols and long chain n -3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine origin on glucose metabolism in people at high cardiometabolic risk. Methods According to a 2 × 2 factorial design, individuals with high waist circumference and at least one more component of the metabolic syndrome were recruited at the obesity outpatient clinic. Eighty-six participants were randomly assigned by MINIM software to an isoenergetic diet: (1) control, low in LCn3 and polyphenol (analysed n  = 20); (2) rich in LCn3 ( n  = 19); (3) rich in polyphenols ( n  = 19); or (4) rich in LCn3 and polyphenols ( n  = 19). The assigned diets were known for the participants and blinded for people doing measurements. Before and after the 8 week intervention, participants underwent a 3 h OGTT and a test meal with a similar composition as the assigned diet for the evaluation of plasma glucose, insulin and glucagon-like peptide 1 (GLP-1) concentrations, and indices of insulin sensitivity and beta cell function. Results During OGTT, polyphenols significantly reduced plasma glucose total AUC ( p  = 0.038) and increased early insulin secretion ( p  = 0.048), while LCn3 significantly reduced beta cell function ( p  = 0.031) (two-factor ANOVA). Moreover, polyphenols improved post-challenge oral glucose insulin sensitivity (OGIS; p  = 0.05 vs control diet by post hoc ANOVA). At test meal, LCn3 significantly reduced GLP-1 total postprandial AUC ( p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titlePolyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial
creatorBozzetto, Lutgarda ; Annuzzi, Giovanni ; Pacini, Giovanni ; Costabile, Giuseppina ; Vetrani, Claudia ; Vitale, Marilena ; Griffo, Ettore ; Giacco, Angela ; De Natale, Claudia ; Cocozza, Sara ; Della Pepa, Giuseppe ; Tura, Andrea ; Riccardi, Gabriele ; Rivellese, Angela A
creatorcontribBozzetto, Lutgarda ; Annuzzi, Giovanni ; Pacini, Giovanni ; Costabile, Giuseppina ; Vetrani, Claudia ; Vitale, Marilena ; Griffo, Ettore ; Giacco, Angela ; De Natale, Claudia ; Cocozza, Sara ; Della Pepa, Giuseppe ; Tura, Andrea ; Riccardi, Gabriele ; Rivellese, Angela A
descriptionAim/hypothesis Dietary polyphenols and long chain n -3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine origin on glucose metabolism in people at high cardiometabolic risk. Methods According to a 2 × 2 factorial design, individuals with high waist circumference and at least one more component of the metabolic syndrome were recruited at the obesity outpatient clinic. Eighty-six participants were randomly assigned by MINIM software to an isoenergetic diet: (1) control, low in LCn3 and polyphenol (analysed n  = 20); (2) rich in LCn3 ( n  = 19); (3) rich in polyphenols ( n  = 19); or (4) rich in LCn3 and polyphenols ( n  = 19). The assigned diets were known for the participants and blinded for people doing measurements. Before and after the 8 week intervention, participants underwent a 3 h OGTT and a test meal with a similar composition as the assigned diet for the evaluation of plasma glucose, insulin and glucagon-like peptide 1 (GLP-1) concentrations, and indices of insulin sensitivity and beta cell function. Results During OGTT, polyphenols significantly reduced plasma glucose total AUC ( p  = 0.038) and increased early insulin secretion ( p  = 0.048), while LCn3 significantly reduced beta cell function ( p  = 0.031) (two-factor ANOVA). Moreover, polyphenols improved post-challenge oral glucose insulin sensitivity (OGIS; p  = 0.05 vs control diet by post hoc ANOVA). At test meal, LCn3 significantly reduced GLP-1 total postprandial AUC ( p  < 0.001; two-factor ANOVA). Conclusion/interpretation Diets naturally rich in polyphenols reduce blood glucose response, likely by increasing early insulin secretion and insulin sensitivity. These effects may favourably influence diabetes and cardiovascular risk. The implications of the decrease in insulin secretion and postprandial GLP-1 observed with diets rich in marine LCn3 need further clarification. Trial registration: ClinicalTrials.gov NCT01154478 Funding: The trial was funded by European Community’s Seventh Framework Programme FP7/2009-2012 under grant agreement FP7-KBBE-222639, Etherpaths Project and ‘Ministero Istruzione Università e Ricerca’ PRIN 2010-2011 - 2010JCWWKM.
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publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAdult ; Aged ; Article ; Blood Glucose - metabolism ; Blood sugar ; Cardiovascular Diseases - diet therapy ; Cardiovascular Diseases - prevention & control ; Diet ; Evaluation ; Fatty Acids, Omega-3 - pharmacology ; Female ; Glucagon-Like Peptide 1 - blood ; Glucose - metabolism ; Glucose Tolerance Test ; Glucose tolerance tests ; Human Physiology ; Humans ; Insulin - blood ; Insulin Resistance ; Insulin-Secreting Cells - metabolism ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic Diseases - diet therapy ; Metabolic Diseases - prevention & control ; Middle Aged ; Obesity - diet therapy ; Patient Compliance ; Physiological aspects ; Polyphenols ; Polyphenols - pharmacology ; Unsaturated fatty acids ; Waist Circumference
ispartofDiabetologia, 2015, Vol.58 (7), p.1551-1560
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7Giacco, Angela
8De Natale, Claudia
9Cocozza, Sara
10Della Pepa, Giuseppe
11Tura, Andrea
12Riccardi, Gabriele
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descriptionAim/hypothesis Dietary polyphenols and long chain n -3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine origin on glucose metabolism in people at high cardiometabolic risk. Methods According to a 2 × 2 factorial design, individuals with high waist circumference and at least one more component of the metabolic syndrome were recruited at the obesity outpatient clinic. Eighty-six participants were randomly assigned by MINIM software to an isoenergetic diet: (1) control, low in LCn3 and polyphenol (analysed n  = 20); (2) rich in LCn3 ( n  = 19); (3) rich in polyphenols ( n  = 19); or (4) rich in LCn3 and polyphenols ( n  = 19). The assigned diets were known for the participants and blinded for people doing measurements. Before and after the 8 week intervention, participants underwent a 3 h OGTT and a test meal with a similar composition as the assigned diet for the evaluation of plasma glucose, insulin and glucagon-like peptide 1 (GLP-1) concentrations, and indices of insulin sensitivity and beta cell function. Results During OGTT, polyphenols significantly reduced plasma glucose total AUC ( p  = 0.038) and increased early insulin secretion ( p  = 0.048), while LCn3 significantly reduced beta cell function ( p  = 0.031) (two-factor ANOVA). Moreover, polyphenols improved post-challenge oral glucose insulin sensitivity (OGIS; p  = 0.05 vs control diet by post hoc ANOVA). At test meal, LCn3 significantly reduced GLP-1 total postprandial AUC ( p  < 0.001; two-factor ANOVA). Conclusion/interpretation Diets naturally rich in polyphenols reduce blood glucose response, likely by increasing early insulin secretion and insulin sensitivity. These effects may favourably influence diabetes and cardiovascular risk. The implications of the decrease in insulin secretion and postprandial GLP-1 observed with diets rich in marine LCn3 need further clarification. Trial registration: ClinicalTrials.gov NCT01154478 Funding: The trial was funded by European Community’s Seventh Framework Programme FP7/2009-2012 under grant agreement FP7-KBBE-222639, Etherpaths Project and ‘Ministero Istruzione Università e Ricerca’ PRIN 2010-2011 - 2010JCWWKM.
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12Glucose - metabolism
13Glucose Tolerance Test
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15Human Physiology
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17Insulin - blood
18Insulin Resistance
19Insulin-Secreting Cells - metabolism
20Internal Medicine
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24Metabolic Diseases
25Metabolic Diseases - diet therapy
26Metabolic Diseases - prevention & control
27Middle Aged
28Obesity - diet therapy
29Patient Compliance
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titlePolyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial
authorBozzetto, Lutgarda ; Annuzzi, Giovanni ; Pacini, Giovanni ; Costabile, Giuseppina ; Vetrani, Claudia ; Vitale, Marilena ; Griffo, Ettore ; Giacco, Angela ; De Natale, Claudia ; Cocozza, Sara ; Della Pepa, Giuseppe ; Tura, Andrea ; Riccardi, Gabriele ; Rivellese, Angela A
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9Fatty Acids, Omega-3 - pharmacology
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11Glucagon-Like Peptide 1 - blood
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13Glucose Tolerance Test
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18Insulin Resistance
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24Metabolic Diseases
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7Giacco, Angela
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abstractAim/hypothesis Dietary polyphenols and long chain n -3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine origin on glucose metabolism in people at high cardiometabolic risk. Methods According to a 2 × 2 factorial design, individuals with high waist circumference and at least one more component of the metabolic syndrome were recruited at the obesity outpatient clinic. Eighty-six participants were randomly assigned by MINIM software to an isoenergetic diet: (1) control, low in LCn3 and polyphenol (analysed n  = 20); (2) rich in LCn3 ( n  = 19); (3) rich in polyphenols ( n  = 19); or (4) rich in LCn3 and polyphenols ( n  = 19). The assigned diets were known for the participants and blinded for people doing measurements. Before and after the 8 week intervention, participants underwent a 3 h OGTT and a test meal with a similar composition as the assigned diet for the evaluation of plasma glucose, insulin and glucagon-like peptide 1 (GLP-1) concentrations, and indices of insulin sensitivity and beta cell function. Results During OGTT, polyphenols significantly reduced plasma glucose total AUC ( p  = 0.038) and increased early insulin secretion ( p  = 0.048), while LCn3 significantly reduced beta cell function ( p  = 0.031) (two-factor ANOVA). Moreover, polyphenols improved post-challenge oral glucose insulin sensitivity (OGIS; p  = 0.05 vs control diet by post hoc ANOVA). At test meal, LCn3 significantly reduced GLP-1 total postprandial AUC ( p  < 0.001; two-factor ANOVA). Conclusion/interpretation Diets naturally rich in polyphenols reduce blood glucose response, likely by increasing early insulin secretion and insulin sensitivity. These effects may favourably influence diabetes and cardiovascular risk. The implications of the decrease in insulin secretion and postprandial GLP-1 observed with diets rich in marine LCn3 need further clarification. Trial registration: ClinicalTrials.gov NCT01154478 Funding: The trial was funded by European Community’s Seventh Framework Programme FP7/2009-2012 under grant agreement FP7-KBBE-222639, Etherpaths Project and ‘Ministero Istruzione Università e Ricerca’ PRIN 2010-2011 - 2010JCWWKM.
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