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Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans

Aims/hypothesis This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function. Methods Fifty-six participants (normal glucose tolerance [NGT] ( n  = 28), impaired fasting glucose (IF... Full description

Journal Title: Diabetologia 2015, Vol.58 (7), p.1646-1655
Main Author: Begovatz, Paul
Other Authors: Koliaki, Chrysi , Weber, Katharina , Strassburger, Klaus , Nowotny, Bettina , Nowotny, Peter , Müssig, Karsten , Bunke, Jürgen , Pacini, Giovanni , Szendrödi, Julia , Roden, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25740696
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title: Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans
format: Article
creator:
  • Begovatz, Paul
  • Koliaki, Chrysi
  • Weber, Katharina
  • Strassburger, Klaus
  • Nowotny, Bettina
  • Nowotny, Peter
  • Müssig, Karsten
  • Bunke, Jürgen
  • Pacini, Giovanni
  • Szendrödi, Julia
  • Roden, Michael
subjects:
  • Adipose Tissue - diagnostic imaging
  • Adipose Tissue - pathology
  • Adipose tissues
  • Adult
  • Aging - metabolism
  • Article
  • Biomedical engineering
  • Blood Glucose - metabolism
  • Body Mass Index
  • Dextrose
  • Fatty Liver - diagnostic imaging
  • Fatty Liver - metabolism
  • Fatty Liver - pathology
  • Female
  • Glucose
  • Glucose Intolerance - metabolism
  • Glucose tolerance tests
  • Human Physiology
  • Humans
  • Insulin - metabolism
  • Insulin-Secreting Cells - metabolism
  • Insulin-Secreting Cells - pathology
  • Internal Medicine
  • Lipid Metabolism
  • Lipids
  • Liver
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Middle Aged
  • Nuclear magnetic resonance spectroscopy
  • Pancreas - diagnostic imaging
  • Pancreas - metabolism
  • Pancreas - pathology
  • Pancreatic beta cells
  • Pancreatic Diseases - diagnostic imaging
  • Pancreatic Diseases - pathology
  • Type 2 diabetes
  • Ultrasonography
ispartof: Diabetologia, 2015, Vol.58 (7), p.1646-1655
description: Aims/hypothesis This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function. Methods Fifty-six participants (normal glucose tolerance [NGT] ( n  = 28), impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) ( n  = 14) and patients with type 2 diabetes ( n  = 14)) underwent a frequent-sampling OGTT and non-invasive magnetic resonance imaging (MRI; whole-body and pancreatic) and proton magnetic resonance spectroscopy ( 1 H-MRS; liver and pancreatic fat). Total pancreatic fat was assessed by a standard 2 cm 3 1 H-MRS method, intralobular fat by 1 cm 3 1 H-MRS that avoided interlobular fat within modified DIXON (mDIXON) water images, and parenchymal fat by a validated mDIXON-MRI fat-fraction method. Results Comparison of 1 H-MRS techniques revealed an inhomogeneous distribution of interlobular and intralobular adipose tissue, which increased with decreasing glucose tolerance. mDIXON-MRI measurements provided evidence against uniform steatosis, revealing regions of parenchymal tissue void of lipid accumulation in all participants. Total ( r  = 0.385, p   0.2). Conclusions/interpretation The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage. No relationship was found between pancreatic adipose tissue infiltration and beta cell function, regardless of glucose tolerance status.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titlePancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans
creatorBegovatz, Paul ; Koliaki, Chrysi ; Weber, Katharina ; Strassburger, Klaus ; Nowotny, Bettina ; Nowotny, Peter ; Müssig, Karsten ; Bunke, Jürgen ; Pacini, Giovanni ; Szendrödi, Julia ; Roden, Michael
creatorcontribBegovatz, Paul ; Koliaki, Chrysi ; Weber, Katharina ; Strassburger, Klaus ; Nowotny, Bettina ; Nowotny, Peter ; Müssig, Karsten ; Bunke, Jürgen ; Pacini, Giovanni ; Szendrödi, Julia ; Roden, Michael
descriptionAims/hypothesis This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function. Methods Fifty-six participants (normal glucose tolerance [NGT] ( n  = 28), impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) ( n  = 14) and patients with type 2 diabetes ( n  = 14)) underwent a frequent-sampling OGTT and non-invasive magnetic resonance imaging (MRI; whole-body and pancreatic) and proton magnetic resonance spectroscopy ( 1 H-MRS; liver and pancreatic fat). Total pancreatic fat was assessed by a standard 2 cm 3 1 H-MRS method, intralobular fat by 1 cm 3 1 H-MRS that avoided interlobular fat within modified DIXON (mDIXON) water images, and parenchymal fat by a validated mDIXON-MRI fat-fraction method. Results Comparison of 1 H-MRS techniques revealed an inhomogeneous distribution of interlobular and intralobular adipose tissue, which increased with decreasing glucose tolerance. mDIXON-MRI measurements provided evidence against uniform steatosis, revealing regions of parenchymal tissue void of lipid accumulation in all participants. Total ( r  = 0.385, p  < 0.01) and intralobular pancreas adipose tissue infiltration ( r  = 0.310, p  < 0.05) positively associated with age, but not with fasting or 2 h glucose levels, BMI or visceral fat content (all p  > 0.5). Furthermore, no associations were found between total and intralobular pancreatic adipose tissue infiltration and insulin secretion or beta cell function within NGT, IFG/IGT or patients with type 2 diabetes (all p  > 0.2). Conclusions/interpretation The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage. No relationship was found between pancreatic adipose tissue infiltration and beta cell function, regardless of glucose tolerance status.
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languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAdipose Tissue - diagnostic imaging ; Adipose Tissue - pathology ; Adipose tissues ; Adult ; Aging - metabolism ; Article ; Biomedical engineering ; Blood Glucose - metabolism ; Body Mass Index ; Dextrose ; Fatty Liver - diagnostic imaging ; Fatty Liver - metabolism ; Fatty Liver - pathology ; Female ; Glucose ; Glucose Intolerance - metabolism ; Glucose tolerance tests ; Human Physiology ; Humans ; Insulin - metabolism ; Insulin-Secreting Cells - metabolism ; Insulin-Secreting Cells - pathology ; Internal Medicine ; Lipid Metabolism ; Lipids ; Liver ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Nuclear magnetic resonance spectroscopy ; Pancreas - diagnostic imaging ; Pancreas - metabolism ; Pancreas - pathology ; Pancreatic beta cells ; Pancreatic Diseases - diagnostic imaging ; Pancreatic Diseases - pathology ; Type 2 diabetes ; Ultrasonography
ispartofDiabetologia, 2015, Vol.58 (7), p.1646-1655
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1Koliaki, Chrysi
2Weber, Katharina
3Strassburger, Klaus
4Nowotny, Bettina
5Nowotny, Peter
6Müssig, Karsten
7Bunke, Jürgen
8Pacini, Giovanni
9Szendrödi, Julia
10Roden, Michael
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descriptionAims/hypothesis This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function. Methods Fifty-six participants (normal glucose tolerance [NGT] ( n  = 28), impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) ( n  = 14) and patients with type 2 diabetes ( n  = 14)) underwent a frequent-sampling OGTT and non-invasive magnetic resonance imaging (MRI; whole-body and pancreatic) and proton magnetic resonance spectroscopy ( 1 H-MRS; liver and pancreatic fat). Total pancreatic fat was assessed by a standard 2 cm 3 1 H-MRS method, intralobular fat by 1 cm 3 1 H-MRS that avoided interlobular fat within modified DIXON (mDIXON) water images, and parenchymal fat by a validated mDIXON-MRI fat-fraction method. Results Comparison of 1 H-MRS techniques revealed an inhomogeneous distribution of interlobular and intralobular adipose tissue, which increased with decreasing glucose tolerance. mDIXON-MRI measurements provided evidence against uniform steatosis, revealing regions of parenchymal tissue void of lipid accumulation in all participants. Total ( r  = 0.385, p  < 0.01) and intralobular pancreas adipose tissue infiltration ( r  = 0.310, p  < 0.05) positively associated with age, but not with fasting or 2 h glucose levels, BMI or visceral fat content (all p  > 0.5). Furthermore, no associations were found between total and intralobular pancreatic adipose tissue infiltration and insulin secretion or beta cell function within NGT, IFG/IGT or patients with type 2 diabetes (all p  > 0.2). Conclusions/interpretation The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage. No relationship was found between pancreatic adipose tissue infiltration and beta cell function, regardless of glucose tolerance status.
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12Fatty Liver - pathology
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14Glucose
15Glucose Intolerance - metabolism
16Glucose tolerance tests
17Human Physiology
18Humans
19Insulin - metabolism
20Insulin-Secreting Cells - metabolism
21Insulin-Secreting Cells - pathology
22Internal Medicine
23Lipid Metabolism
24Lipids
25Liver
26Male
27Medicine
28Medicine & Public Health
29Metabolic Diseases
30Middle Aged
31Nuclear magnetic resonance spectroscopy
32Pancreas - diagnostic imaging
33Pancreas - metabolism
34Pancreas - pathology
35Pancreatic beta cells
36Pancreatic Diseases - diagnostic imaging
37Pancreatic Diseases - pathology
38Type 2 diabetes
39Ultrasonography
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9Szendrödi, Julia
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titlePancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans
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1Koliaki, Chrysi
2Weber, Katharina
3Strassburger, Klaus
4Nowotny, Bettina
5Nowotny, Peter
6Müssig, Karsten
7Bunke, Jürgen
8Pacini, Giovanni
9Szendrödi, Julia
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jtitleDiabetologia
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risdate2015
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issue7
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pages1646-1655
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abstractAims/hypothesis This study aimed to perform a comprehensive analysis of interlobular, intralobular and parenchymal pancreatic fat in order to assess their respective effects on beta cell function. Methods Fifty-six participants (normal glucose tolerance [NGT] ( n  = 28), impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) ( n  = 14) and patients with type 2 diabetes ( n  = 14)) underwent a frequent-sampling OGTT and non-invasive magnetic resonance imaging (MRI; whole-body and pancreatic) and proton magnetic resonance spectroscopy ( 1 H-MRS; liver and pancreatic fat). Total pancreatic fat was assessed by a standard 2 cm 3 1 H-MRS method, intralobular fat by 1 cm 3 1 H-MRS that avoided interlobular fat within modified DIXON (mDIXON) water images, and parenchymal fat by a validated mDIXON-MRI fat-fraction method. Results Comparison of 1 H-MRS techniques revealed an inhomogeneous distribution of interlobular and intralobular adipose tissue, which increased with decreasing glucose tolerance. mDIXON-MRI measurements provided evidence against uniform steatosis, revealing regions of parenchymal tissue void of lipid accumulation in all participants. Total ( r  = 0.385, p  < 0.01) and intralobular pancreas adipose tissue infiltration ( r  = 0.310, p  < 0.05) positively associated with age, but not with fasting or 2 h glucose levels, BMI or visceral fat content (all p  > 0.5). Furthermore, no associations were found between total and intralobular pancreatic adipose tissue infiltration and insulin secretion or beta cell function within NGT, IFG/IGT or patients with type 2 diabetes (all p  > 0.2). Conclusions/interpretation The pancreas does not appear to be another target organ for abnormal endocrine function because of ectopic parenchymal fat storage. No relationship was found between pancreatic adipose tissue infiltration and beta cell function, regardless of glucose tolerance status.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid25740696
doi10.1007/s00125-015-3544-5
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