Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review
Journal Title: | Gerontology (Basel) 2015-08, Vol.61 (5), p.427-434 |
Main Author: | Quan, Taihao |
Other Authors: | Fisher, Gary J |
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English |
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Quelle: | Alma/SFX Local Collection |
Publisher: | Basel, Switzerland: S. Karger AG |
ID: | ISSN: 0304-324X |
Link: | https://www.ncbi.nlm.nih.gov/pubmed/25660807 |
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recordid: | cdi_proquest_miscellaneous_1707554159 |
title: | Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review |
format: | Article |
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ispartof: | Gerontology (Basel), 2015-08, Vol.61 (5), p.427-434 |
description: | Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function. |
language: | eng |
source: | Alma/SFX Local Collection |
identifier: | ISSN: 0304-324X |
fulltext: | fulltext |
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url: | Link |
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