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Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review

Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, l... Full description

Journal Title: Gerontology (Basel) 2015-08, Vol.61 (5), p.427-434
Main Author: Quan, Taihao
Other Authors: Fisher, Gary J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: S. Karger AG
ID: ISSN: 0304-324X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25660807
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title: Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review
format: Article
creator:
  • Quan, Taihao
  • Fisher, Gary J
subjects:
  • Aging
  • Aging - pathology
  • Aging - physiology
  • Cellular Microenvironment
  • Collagen
  • Connective Tissue - pathology
  • Connective Tissue - physiopathology
  • Cysteine-Rich Protein 61 - metabolism
  • Dermatology
  • Experimental Section / Mini-Review
  • Extracellular matrix
  • Extracellular Matrix - pathology
  • Extracellular Matrix - physiology
  • Gerontology
  • Humans
  • Matrix Metalloproteinases - metabolism
  • Models, Biological
  • Proteins
  • Signal Transduction
  • Skin
  • Skin Aging - pathology
  • Skin Aging - physiology
  • Skin Diseases - etiology
  • Transforming Growth Factor beta - metabolism
ispartof: Gerontology (Basel), 2015-08, Vol.61 (5), p.427-434
description: Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-324X
fulltext: fulltext
issn:
  • 0304-324X
  • 1423-0003
url: Link


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descriptionHuman skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.
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subjectAging ; Aging - pathology ; Aging - physiology ; Cellular Microenvironment ; Collagen ; Connective Tissue - pathology ; Connective Tissue - physiopathology ; Cysteine-Rich Protein 61 - metabolism ; Dermatology ; Experimental Section / Mini-Review ; Extracellular matrix ; Extracellular Matrix - pathology ; Extracellular Matrix - physiology ; Gerontology ; Humans ; Matrix Metalloproteinases - metabolism ; Models, Biological ; Proteins ; Signal Transduction ; Skin ; Skin Aging - pathology ; Skin Aging - physiology ; Skin Diseases - etiology ; Transforming Growth Factor beta - metabolism
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abstractHuman skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo progressive loss and fragmentation, leading to thin and structurally weakened skin. Age-related alterations of collagen fibrils impairs skin structure and function and creates a tissue microenvironment that promotes age-related skin diseases, such as delayed wound healing and skin cancer development. This mini-review describes cellular mechanisms that give rise to self-perpetuating, collagen fibril fragmentation that creates an age-associated dermal microenvironment, which contributes to decline of human skin function.
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