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Nox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia

BackgroundCommunity-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF.MethodsWe consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed by s... Full description

Journal Title: Thorax 2015-10, Vol.70 (10), p.961-966
Main Author: Violi, Francesco
Other Authors: Carnevale, Roberto , Calvieri, Camilla , Nocella, Cristina , Falcone, Marco , Farcomeni, Alessio , Taliani, Gloria , Cangemi, Roberto
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd
ID: ISSN: 0040-6376
Link: https://www.ncbi.nlm.nih.gov/pubmed/26123660
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title: Nox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia
format: Article
creator:
  • Violi, Francesco
  • Carnevale, Roberto
  • Calvieri, Camilla
  • Nocella, Cristina
  • Falcone, Marco
  • Farcomeni, Alessio
  • Taliani, Gloria
  • Cangemi, Roberto
subjects:
  • Aged
  • Aged, 80 and over
  • Atrial fibrillation
  • Atrial Fibrillation - blood
  • Atrial Fibrillation - diagnosis
  • Atrial Fibrillation - etiology
  • Bacterial pneumonia
  • Care and treatment
  • Community-Acquired Infections
  • Electrocardiogram
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Hospitalization
  • Humans
  • Influence
  • Male
  • Membrane Glycoproteins - blood
  • Middle Aged
  • NADPH Oxidase 2
  • NADPH Oxidases - blood
  • Oxidative stress
  • Oxidative Stress - physiology
  • Pneumonia
  • Pneumonia - blood
  • Pneumonia - complications
  • Pneumonia - physiopathology
  • Risk Factors
  • Usage
ispartof: Thorax, 2015-10, Vol.70 (10), p.961-966
description: BackgroundCommunity-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF.MethodsWe consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed by serum levels of soluble Nox2 (sNox2-dp), was evaluated in each CAP patient. A 12-lead electrocardiography was repeated every 24 h. All patients were followed up until discharge.ResultsForty-one patients with CAP (9.5%) experienced a new episode of AF within 24–72 h after hospital admission. Patients who experienced AF showed higher blood levels of sNox2-dp compared to those who did not (35.2±15.1 vs 27.0±12.5 pg/mL; p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0040-6376
fulltext: fulltext
issn:
  • 0040-6376
  • 1468-3296
url: Link


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titleNox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia
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creatorVioli, Francesco ; Carnevale, Roberto ; Calvieri, Camilla ; Nocella, Cristina ; Falcone, Marco ; Farcomeni, Alessio ; Taliani, Gloria ; Cangemi, Roberto
creatorcontribVioli, Francesco ; Carnevale, Roberto ; Calvieri, Camilla ; Nocella, Cristina ; Falcone, Marco ; Farcomeni, Alessio ; Taliani, Gloria ; Cangemi, Roberto ; SIXTUS study group ; in collaboration with the SIXTUS study group
descriptionBackgroundCommunity-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF.MethodsWe consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed by serum levels of soluble Nox2 (sNox2-dp), was evaluated in each CAP patient. A 12-lead electrocardiography was repeated every 24 h. All patients were followed up until discharge.ResultsForty-one patients with CAP (9.5%) experienced a new episode of AF within 24–72 h after hospital admission. Patients who experienced AF showed higher blood levels of sNox2-dp compared to those who did not (35.2±15.1 vs 27.0±12.5 pg/mL; p<0.001). Pneumonia Severity Index score (p=0.014), history of paroxysmal AF (p<0.001) and sNox2-dp (p=0.019) were independently associated with AF. At discharge, serum sNox2-dp levels were significantly decreased in the entire cohort (27.8±13.0 vs 21.9±6.8 pg/mL; p<0.001). Twenty-three out of 41 CAP patients with AF returned to sinus rhythm (56%); patients who remained in AF showed significantly higher baseline and discharge levels of sNox2-dp compared to those without AF (p<0.001) or with the 23 AF patients who returned to sinus rhythm (p<0.05). In vitro study showed that platelets or leucocytes incubated with endotoxin, at concentrations similar to those found in the circulation of CAP patients, elicited Nox2 up-regulation, suggesting endotoxin as a trigger of oxidative stress.ConclusionsAF may be detected in the early phase of CAP and is associated with Nox2 activation, suggesting a role for oxidative stress in promoting this cardiac arrhythmia.Trial registration numberNCT01773863.
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subjectAged ; Aged, 80 and over ; Atrial fibrillation ; Atrial Fibrillation - blood ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - etiology ; Bacterial pneumonia ; Care and treatment ; Community-Acquired Infections ; Electrocardiogram ; Electrocardiography ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Influence ; Male ; Membrane Glycoproteins - blood ; Middle Aged ; NADPH Oxidase 2 ; NADPH Oxidases - blood ; Oxidative stress ; Oxidative Stress - physiology ; Pneumonia ; Pneumonia - blood ; Pneumonia - complications ; Pneumonia - physiopathology ; Risk Factors ; Usage
ispartofThorax, 2015-10, Vol.70 (10), p.961-966
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descriptionBackgroundCommunity-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF.MethodsWe consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed by serum levels of soluble Nox2 (sNox2-dp), was evaluated in each CAP patient. A 12-lead electrocardiography was repeated every 24 h. All patients were followed up until discharge.ResultsForty-one patients with CAP (9.5%) experienced a new episode of AF within 24–72 h after hospital admission. Patients who experienced AF showed higher blood levels of sNox2-dp compared to those who did not (35.2±15.1 vs 27.0±12.5 pg/mL; p<0.001). Pneumonia Severity Index score (p=0.014), history of paroxysmal AF (p<0.001) and sNox2-dp (p=0.019) were independently associated with AF. At discharge, serum sNox2-dp levels were significantly decreased in the entire cohort (27.8±13.0 vs 21.9±6.8 pg/mL; p<0.001). Twenty-three out of 41 CAP patients with AF returned to sinus rhythm (56%); patients who remained in AF showed significantly higher baseline and discharge levels of sNox2-dp compared to those without AF (p<0.001) or with the 23 AF patients who returned to sinus rhythm (p<0.05). In vitro study showed that platelets or leucocytes incubated with endotoxin, at concentrations similar to those found in the circulation of CAP patients, elicited Nox2 up-regulation, suggesting endotoxin as a trigger of oxidative stress.ConclusionsAF may be detected in the early phase of CAP and is associated with Nox2 activation, suggesting a role for oxidative stress in promoting this cardiac arrhythmia.Trial registration numberNCT01773863.
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titleNox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia
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abstractBackgroundCommunity-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF.MethodsWe consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed by serum levels of soluble Nox2 (sNox2-dp), was evaluated in each CAP patient. A 12-lead electrocardiography was repeated every 24 h. All patients were followed up until discharge.ResultsForty-one patients with CAP (9.5%) experienced a new episode of AF within 24–72 h after hospital admission. Patients who experienced AF showed higher blood levels of sNox2-dp compared to those who did not (35.2±15.1 vs 27.0±12.5 pg/mL; p<0.001). Pneumonia Severity Index score (p=0.014), history of paroxysmal AF (p<0.001) and sNox2-dp (p=0.019) were independently associated with AF. At discharge, serum sNox2-dp levels were significantly decreased in the entire cohort (27.8±13.0 vs 21.9±6.8 pg/mL; p<0.001). Twenty-three out of 41 CAP patients with AF returned to sinus rhythm (56%); patients who remained in AF showed significantly higher baseline and discharge levels of sNox2-dp compared to those without AF (p<0.001) or with the 23 AF patients who returned to sinus rhythm (p<0.05). In vitro study showed that platelets or leucocytes incubated with endotoxin, at concentrations similar to those found in the circulation of CAP patients, elicited Nox2 up-regulation, suggesting endotoxin as a trigger of oxidative stress.ConclusionsAF may be detected in the early phase of CAP and is associated with Nox2 activation, suggesting a role for oxidative stress in promoting this cardiac arrhythmia.Trial registration numberNCT01773863.
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pubBMJ Publishing Group Ltd
pmid26123660
doi10.1136/thoraxjnl-2015-207178
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