Nox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia
Journal Title: | Thorax 2015-10, Vol.70 (10), p.961-966 |
Main Author: | Violi, Francesco |
Other Authors: | Carnevale, Roberto , Calvieri, Camilla , Nocella, Cristina , Falcone, Marco , Farcomeni, Alessio , Taliani, Gloria , Cangemi, Roberto |
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English |
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Quelle: | Alma/SFX Local Collection |
Publisher: | England: BMJ Publishing Group Ltd |
ID: | ISSN: 0040-6376 |
Link: | https://www.ncbi.nlm.nih.gov/pubmed/26123660 |
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recordid: | cdi_proquest_miscellaneous_1712779710 |
title: | Nox2 up-regulation is associated with an enhanced risk of atrial fibrillation in patients with pneumonia |
format: | Article |
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ispartof: | Thorax, 2015-10, Vol.70 (10), p.961-966 |
description: | BackgroundCommunity-acquired pneumonia (CAP) may be complicated by atrial fibrillation (AF) but the underlying mechanism is still unclear. Nox2-derived oxidative stress has been suggested to favour AF.MethodsWe consecutively enrolled 432 patients hospitalised for CAP. Nox2 activity, as assessed by serum levels of soluble Nox2 (sNox2-dp), was evaluated in each CAP patient. A 12-lead electrocardiography was repeated every 24 h. All patients were followed up until discharge.ResultsForty-one patients with CAP (9.5%) experienced a new episode of AF within 24–72 h after hospital admission. Patients who experienced AF showed higher blood levels of sNox2-dp compared to those who did not (35.2±15.1 vs 27.0±12.5 pg/mL; p |
language: | eng |
source: | Alma/SFX Local Collection |
identifier: | ISSN: 0040-6376 |
fulltext: | fulltext |
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url: | Link |
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