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Optimal approaches to diabetic patients with multivessel disease

Abstract The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population remains a subject of an ongoing discu... Full description

Journal Title: Trends in cardiovascular medicine 2015, Vol.25 (7), p.625-631
Main Author: Razzouk, Louai, MD, MPH
Other Authors: Farkouh, Michael E., MD, MSc
Format: Electronic Article Electronic Article
Language: English
Subjects:
Arteriosclerosis
Atherosclerosis
Biomarkers - blood
Blood Glucose - metabolism
Cardiovascular
Cardiovascular Agents - therapeutic use
Care and treatment
Clinical trials
Coronary artery
Coronary Artery Bypass - adverse effects
Coronary Artery Bypass - economics
Coronary Artery Bypass - mortality
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - economics
Coronary Artery Disease - mortality
Coronary Artery Disease - therapy
Coronary heart disease
Cost-Benefit Analysis
Diabetes
Diabetes mellitus
Diabetic Angiopathies - blood
Diabetic Angiopathies - diagnosis
Diabetic Angiopathies - economics
Diabetic Angiopathies - mortality
Diabetic Angiopathies - therapy
Diabetics
Health Care Costs
Heart attacks
Heart diseases
Humans
Insulin
Insulin Resistance
Mortality
Patient Selection
Patients
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - economics
Percutaneous Coronary Intervention - instrumentation
Percutaneous Coronary Intervention - mortality
Quality of Life
Risk Factors
Risk Reduction Behavior
Stents
Time Factors
Treatment Outcome
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 1050-1738
Link: https://www.ncbi.nlm.nih.gov/pubmed/26398271
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recordid: cdi_proquest_miscellaneous_1716939809
title: Optimal approaches to diabetic patients with multivessel disease
format: Article
creator:
  • Razzouk, Louai, MD, MPH
  • Farkouh, Michael E., MD, MSc
subjects:
  • Arteriosclerosis
  • Atherosclerosis
  • Biomarkers - blood
  • Blood Glucose - metabolism
  • Cardiovascular
  • Cardiovascular Agents - therapeutic use
  • Care and treatment
  • Clinical trials
  • Coronary artery
  • Coronary Artery Bypass - adverse effects
  • Coronary Artery Bypass - economics
  • Coronary Artery Bypass - mortality
  • Coronary Artery Disease - blood
  • Coronary Artery Disease - diagnosis
  • Coronary Artery Disease - economics
  • Coronary Artery Disease - mortality
  • Coronary Artery Disease - therapy
  • Coronary heart disease
  • Cost-Benefit Analysis
  • Diabetes
  • Diabetes mellitus
  • Diabetic Angiopathies - blood
  • Diabetic Angiopathies - diagnosis
  • Diabetic Angiopathies - economics
  • Diabetic Angiopathies - mortality
  • Diabetic Angiopathies - therapy
  • Diabetics
  • Health Care Costs
  • Heart attacks
  • Heart diseases
  • Humans
  • Insulin
  • Insulin Resistance
  • Mortality
  • Patient Selection
  • Patients
  • Percutaneous Coronary Intervention - adverse effects
  • Percutaneous Coronary Intervention - economics
  • Percutaneous Coronary Intervention - instrumentation
  • Percutaneous Coronary Intervention - mortality
  • Quality of Life
  • Risk Factors
  • Risk Reduction Behavior
  • Stents
  • Time Factors
  • Treatment Outcome
ispartof: Trends in cardiovascular medicine, 2015, Vol.25 (7), p.625-631
description: Abstract The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population remains a subject of an ongoing discussion. In this review, we give an overview of the unique pathophysiology of CAD in patients with diabetes, summarize the current state of therapies available, and compare modalities of revascularization that have been investigated in recent clinical trials. We conclude by highlighting the importance of a comprehensive heart team approach to every patient while accommodating both patient preference and quality-of-life decisions.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1050-1738
fulltext: fulltext
issn:
  • 1050-1738
  • 1873-2615
url: Link


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descriptionAbstract The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population remains a subject of an ongoing discussion. In this review, we give an overview of the unique pathophysiology of CAD in patients with diabetes, summarize the current state of therapies available, and compare modalities of revascularization that have been investigated in recent clinical trials. We conclude by highlighting the importance of a comprehensive heart team approach to every patient while accommodating both patient preference and quality-of-life decisions.
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subjectArteriosclerosis ; Atherosclerosis ; Biomarkers - blood ; Blood Glucose - metabolism ; Cardiovascular ; Cardiovascular Agents - therapeutic use ; Care and treatment ; Clinical trials ; Coronary artery ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - economics ; Coronary Artery Bypass - mortality ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - economics ; Coronary Artery Disease - mortality ; Coronary Artery Disease - therapy ; Coronary heart disease ; Cost-Benefit Analysis ; Diabetes ; Diabetes mellitus ; Diabetic Angiopathies - blood ; Diabetic Angiopathies - diagnosis ; Diabetic Angiopathies - economics ; Diabetic Angiopathies - mortality ; Diabetic Angiopathies - therapy ; Diabetics ; Health Care Costs ; Heart attacks ; Heart diseases ; Humans ; Insulin ; Insulin Resistance ; Mortality ; Patient Selection ; Patients ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - economics ; Percutaneous Coronary Intervention - instrumentation ; Percutaneous Coronary Intervention - mortality ; Quality of Life ; Risk Factors ; Risk Reduction Behavior ; Stents ; Time Factors ; Treatment Outcome
ispartofTrends in cardiovascular medicine, 2015, Vol.25 (7), p.625-631
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descriptionAbstract The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population remains a subject of an ongoing discussion. In this review, we give an overview of the unique pathophysiology of CAD in patients with diabetes, summarize the current state of therapies available, and compare modalities of revascularization that have been investigated in recent clinical trials. We conclude by highlighting the importance of a comprehensive heart team approach to every patient while accommodating both patient preference and quality-of-life decisions.
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0Arteriosclerosis
1Atherosclerosis
2Biomarkers - blood
3Blood Glucose - metabolism
4Cardiovascular
5Cardiovascular Agents - therapeutic use
6Care and treatment
7Clinical trials
8Coronary artery
9Coronary Artery Bypass - adverse effects
10Coronary Artery Bypass - economics
11Coronary Artery Bypass - mortality
12Coronary Artery Disease - blood
13Coronary Artery Disease - diagnosis
14Coronary Artery Disease - economics
15Coronary Artery Disease - mortality
16Coronary Artery Disease - therapy
17Coronary heart disease
18Cost-Benefit Analysis
19Diabetes
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23Diabetic Angiopathies - economics
24Diabetic Angiopathies - mortality
25Diabetic Angiopathies - therapy
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27Health Care Costs
28Heart attacks
29Heart diseases
30Humans
31Insulin
32Insulin Resistance
33Mortality
34Patient Selection
35Patients
36Percutaneous Coronary Intervention - adverse effects
37Percutaneous Coronary Intervention - economics
38Percutaneous Coronary Intervention - instrumentation
39Percutaneous Coronary Intervention - mortality
40Quality of Life
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43Stents
44Time Factors
45Treatment Outcome
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3Blood Glucose - metabolism
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7Clinical trials
8Coronary artery
9Coronary Artery Bypass - adverse effects
10Coronary Artery Bypass - economics
11Coronary Artery Bypass - mortality
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13Coronary Artery Disease - diagnosis
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16Coronary Artery Disease - therapy
17Coronary heart disease
18Cost-Benefit Analysis
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20Diabetes mellitus
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22Diabetic Angiopathies - diagnosis
23Diabetic Angiopathies - economics
24Diabetic Angiopathies - mortality
25Diabetic Angiopathies - therapy
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27Health Care Costs
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32Insulin Resistance
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36Percutaneous Coronary Intervention - adverse effects
37Percutaneous Coronary Intervention - economics
38Percutaneous Coronary Intervention - instrumentation
39Percutaneous Coronary Intervention - mortality
40Quality of Life
41Risk Factors
42Risk Reduction Behavior
43Stents
44Time Factors
45Treatment Outcome
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abstractAbstract The pathophysiology of diabetes and systemic insulin resistance contributes to the nature of diffuse atherosclerosis and a high prevalence of multivessel coronary artery disease (CAD) in diabetic patients. The optimal approach to this patient population remains a subject of an ongoing discussion. In this review, we give an overview of the unique pathophysiology of CAD in patients with diabetes, summarize the current state of therapies available, and compare modalities of revascularization that have been investigated in recent clinical trials. We conclude by highlighting the importance of a comprehensive heart team approach to every patient while accommodating both patient preference and quality-of-life decisions.
copUnited States
pubElsevier Inc
pmid26398271
doi10.1016/j.tcm.2015.02.004