schliessen

Filtern

 

Bibliotheken

Cover Image

Basic study design influences the results of orthodontic clinical investigations

Abstract Objectives Meta-analysis is the gold standard for synthesizing evidence on the effectiveness of health care interventions. However, its validity is dependent on the quality of included studies. Here, we investigated whether basic study design (i.e., randomization and timing of data collecti... Full description

Journal Title: Journal of clinical epidemiology 2015, Vol.68 (12), p.1512-1522
Main Author: Papageorgiou, Spyridon N
Other Authors: Xavier, Guilherme M , Cobourne, Martyn T
Format: Electronic Article Electronic Article
Language: English
Subjects:
analysis
asjc
atira
Bias
Clinical trials
Confidence intervals
Data Collection
Data entry
Databases
Dental Research
Epidemiology
Humans
Internal Medicine
Medical care
Meta
Meta-analysis
omized controlled trial
Orthodontics
Patient Outcome Assessment
Prospective clinical study
Prospective Studies
pure
Quality management
Randomized controlled trial
Randomized Controlled Trials as Topic
Research Design
Research methodology
Retrospective clinical study
Retrospective Studies
Studies
subjectarea
Systematic review
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0895-4356
Link: https://www.ncbi.nlm.nih.gov/pubmed/25910911
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1735908269
title: Basic study design influences the results of orthodontic clinical investigations
format: Article
creator:
  • Papageorgiou, Spyridon N
  • Xavier, Guilherme M
  • Cobourne, Martyn T
subjects:
  • analysis
  • asjc
  • atira
  • Bias
  • Clinical trials
  • Confidence intervals
  • Data Collection
  • Data entry
  • Databases
  • Dental Research
  • Epidemiology
  • Humans
  • Internal Medicine
  • Medical care
  • Meta
  • Meta-analysis
  • omized controlled trial
  • Orthodontics
  • Patient Outcome Assessment
  • Prospective clinical study
  • Prospective Studies
  • pure
  • Quality management
  • Randomized controlled trial
  • Randomized Controlled Trials as Topic
  • Research Design
  • Research methodology
  • Retrospective clinical study
  • Retrospective Studies
  • Studies
  • subjectarea
  • Systematic review
ispartof: Journal of clinical epidemiology, 2015, Vol.68 (12), p.1512-1522
description: Abstract Objectives Meta-analysis is the gold standard for synthesizing evidence on the effectiveness of health care interventions. However, its validity is dependent on the quality of included studies. Here, we investigated whether basic study design (i.e., randomization and timing of data collection) in orthodontic research influences the results of clinical trials. Study Design and Setting This meta-epidemiologic study used unrestricted electronic and manual searching for meta-analyses in orthodontics. Differences in standardized mean differences (ΔSMD) between interventions and their 95% confidence intervals (CIs) were calculated according to study design through random-effects meta-regression. Effects were then pooled with random-effects meta-analyses. Results No difference was found between randomized and nonrandomized trials (25 meta-analyses; ΔSMD = 0.07; 95% CI = −0.21, 0.34; P  = 0.630). However, retrospective nonrandomized trials reported inflated treatment effects compared with prospective (40 meta-analyses; ΔSMD = −0.30; 95% CI = −0.53, −0.06; P  = 0.018). No difference was found between randomized trials with adequate and those with unclear/inadequate generation (25 meta-analyses; ΔSMD = 0.01; 95% CI = −0.25, 0.26; P  = 0.957). Finally, subgroup analyses indicated that the results of randomized and nonrandomized trials differed significantly according to scope of the trial (effectiveness or adverse effects; P  = 0.005). Conclusion Caution is warranted when interpreting systematic reviews investigating clinical orthodontic interventions when nonrandomized and especially retrospective nonrandomized studies are included in the meta-analysis.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0895-4356
fulltext: fulltext
issn:
  • 0895-4356
  • 1878-5921
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6744604
LOCALfalse
PrimoNMBib
record
control
sourceidgale_opena
recordidTN_cdi_proquest_miscellaneous_1735908269
sourceformatXML
sourcesystemPC
galeidA435802798
sourcerecordidA435802798
originalsourceidFETCH-LOGICAL-c547t-d89f274bba3228517dd0c59f17931334a1c918fd6353a244971f3e23a39524c43
addsrcrecordideNqFkl1rFDEYhQdR7Fr9C2XAG292zMdkkoCItfhRKCio1yGbvNlmnU3WJFPYf2_G7VbYmzIXgeGck7zvc5rmAqMOIzy83XQbM_oAO98RhFmHaIeQeNIssOBiySTBT5sFEpIte8qGs-ZFzhuEMEecPW_OCJMYSYwXzfePOnvT5jLZfWsh-3VofXDjBMFAbssttAnyNJbcRtfGVG6jjaFUy3y9N3qs8jvIxa918THkl80zp8cMr-7P8-bX508_r74ub759ub66vFka1vOytEI6wvvVSlNCBMPcWmSYdJhLiintNTYSC2cHyqgmfS85dhQI1VQy0puenjfXh9y4g6B9ArVLfqvTXkXtlQ1QVLSK8AErBysrhWDDSvABSaQdxxQ521twEjOoWW8OWbsU_0x1GLX12cA46gBxygpzyiQSZJBV-vpEuolTCnXSquoHNl9Dq6o7qNZ6BFX3GUvSpn4Wtt7EAM7X_5cVjUCES1ENw8FgUsw5gXuYBiM1A1cbdQSuZuAKUVWBV-PF_Xum1Rbsg-1IuArenSQbX_6hqk_y4-P5Hw52qCzvPCSVjZ-7YevKTVE2-scj3p9EHKvzG_aQ_-9PZaKQ-jG3di4tZrWwrPL_C_D_5pg
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1746588563
display
typearticle
titleBasic study design influences the results of orthodontic clinical investigations
sourceAlma/SFX Local Collection
creatorPapageorgiou, Spyridon N ; Xavier, Guilherme M ; Cobourne, Martyn T
creatorcontribPapageorgiou, Spyridon N ; Xavier, Guilherme M ; Cobourne, Martyn T
descriptionAbstract Objectives Meta-analysis is the gold standard for synthesizing evidence on the effectiveness of health care interventions. However, its validity is dependent on the quality of included studies. Here, we investigated whether basic study design (i.e., randomization and timing of data collection) in orthodontic research influences the results of clinical trials. Study Design and Setting This meta-epidemiologic study used unrestricted electronic and manual searching for meta-analyses in orthodontics. Differences in standardized mean differences (ΔSMD) between interventions and their 95% confidence intervals (CIs) were calculated according to study design through random-effects meta-regression. Effects were then pooled with random-effects meta-analyses. Results No difference was found between randomized and nonrandomized trials (25 meta-analyses; ΔSMD = 0.07; 95% CI = −0.21, 0.34; P  = 0.630). However, retrospective nonrandomized trials reported inflated treatment effects compared with prospective (40 meta-analyses; ΔSMD = −0.30; 95% CI = −0.53, −0.06; P  = 0.018). No difference was found between randomized trials with adequate and those with unclear/inadequate generation (25 meta-analyses; ΔSMD = 0.01; 95% CI = −0.25, 0.26; P  = 0.957). Finally, subgroup analyses indicated that the results of randomized and nonrandomized trials differed significantly according to scope of the trial (effectiveness or adverse effects; P  = 0.005). Conclusion Caution is warranted when interpreting systematic reviews investigating clinical orthodontic interventions when nonrandomized and especially retrospective nonrandomized studies are included in the meta-analysis.
identifier
0ISSN: 0895-4356
1EISSN: 1878-5921
2DOI: 10.1016/j.jclinepi.2015.03.008
3PMID: 25910911
languageeng
publisherUnited States: Elsevier Inc
subjectanalysis ; asjc ; atira ; Bias ; Clinical trials ; Confidence intervals ; Data Collection ; Data entry ; Databases ; Dental Research ; Epidemiology ; Humans ; Internal Medicine ; Medical care ; Meta ; Meta-analysis ; omized controlled trial ; Orthodontics ; Patient Outcome Assessment ; Prospective clinical study ; Prospective Studies ; pure ; Quality management ; Randomized controlled trial ; Randomized Controlled Trials as Topic ; Research Design ; Research methodology ; Retrospective clinical study ; Retrospective Studies ; Studies ; subjectarea ; Systematic review
ispartofJournal of clinical epidemiology, 2015, Vol.68 (12), p.1512-1522
rights
0Elsevier Inc.
12015 Elsevier Inc.
2Copyright © 2015 Elsevier Inc. All rights reserved.
3COPYRIGHT 2015 Elsevier B.V.
4Copyright Elsevier Limited Dec 2015
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-c547t-d89f274bba3228517dd0c59f17931334a1c918fd6353a244971f3e23a39524c43
orcidid0000-0003-1968-3326
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25910911$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Papageorgiou, Spyridon N
1Xavier, Guilherme M
2Cobourne, Martyn T
title
0Basic study design influences the results of orthodontic clinical investigations
1Journal of clinical epidemiology
addtitleJ Clin Epidemiol
descriptionAbstract Objectives Meta-analysis is the gold standard for synthesizing evidence on the effectiveness of health care interventions. However, its validity is dependent on the quality of included studies. Here, we investigated whether basic study design (i.e., randomization and timing of data collection) in orthodontic research influences the results of clinical trials. Study Design and Setting This meta-epidemiologic study used unrestricted electronic and manual searching for meta-analyses in orthodontics. Differences in standardized mean differences (ΔSMD) between interventions and their 95% confidence intervals (CIs) were calculated according to study design through random-effects meta-regression. Effects were then pooled with random-effects meta-analyses. Results No difference was found between randomized and nonrandomized trials (25 meta-analyses; ΔSMD = 0.07; 95% CI = −0.21, 0.34; P  = 0.630). However, retrospective nonrandomized trials reported inflated treatment effects compared with prospective (40 meta-analyses; ΔSMD = −0.30; 95% CI = −0.53, −0.06; P  = 0.018). No difference was found between randomized trials with adequate and those with unclear/inadequate generation (25 meta-analyses; ΔSMD = 0.01; 95% CI = −0.25, 0.26; P  = 0.957). Finally, subgroup analyses indicated that the results of randomized and nonrandomized trials differed significantly according to scope of the trial (effectiveness or adverse effects; P  = 0.005). Conclusion Caution is warranted when interpreting systematic reviews investigating clinical orthodontic interventions when nonrandomized and especially retrospective nonrandomized studies are included in the meta-analysis.
subject
0analysis
1asjc
2atira
3Bias
4Clinical trials
5Confidence intervals
6Data Collection
7Data entry
8Databases
9Dental Research
10Epidemiology
11Humans
12Internal Medicine
13Medical care
14Meta
15Meta-analysis
16omized controlled trial
17Orthodontics
18Patient Outcome Assessment
19Prospective clinical study
20Prospective Studies
21pure
22Quality management
23Randomized controlled trial
24Randomized Controlled Trials as Topic
25Research Design
26Research methodology
27Retrospective clinical study
28Retrospective Studies
29Studies
30subjectarea
31Systematic review
issn
00895-4356
11878-5921
fulltexttrue
rsrctypearticle
creationdate2015
recordtypearticle
recordideNqFkl1rFDEYhQdR7Fr9C2XAG292zMdkkoCItfhRKCio1yGbvNlmnU3WJFPYf2_G7VbYmzIXgeGck7zvc5rmAqMOIzy83XQbM_oAO98RhFmHaIeQeNIssOBiySTBT5sFEpIte8qGs-ZFzhuEMEecPW_OCJMYSYwXzfePOnvT5jLZfWsh-3VofXDjBMFAbssttAnyNJbcRtfGVG6jjaFUy3y9N3qs8jvIxa918THkl80zp8cMr-7P8-bX508_r74ub759ub66vFka1vOytEI6wvvVSlNCBMPcWmSYdJhLiintNTYSC2cHyqgmfS85dhQI1VQy0puenjfXh9y4g6B9ArVLfqvTXkXtlQ1QVLSK8AErBysrhWDDSvABSaQdxxQ521twEjOoWW8OWbsU_0x1GLX12cA46gBxygpzyiQSZJBV-vpEuolTCnXSquoHNl9Dq6o7qNZ6BFX3GUvSpn4Wtt7EAM7X_5cVjUCES1ENw8FgUsw5gXuYBiM1A1cbdQSuZuAKUVWBV-PF_Xum1Rbsg-1IuArenSQbX_6hqk_y4-P5Hw52qCzvPCSVjZ-7YevKTVE2-scj3p9EHKvzG_aQ_-9PZaKQ-jG3di4tZrWwrPL_C_D_5pg
startdate2015
enddate2015
creator
0Papageorgiou, Spyridon N
1Xavier, Guilherme M
2Cobourne, Martyn T
general
0Elsevier Inc
1Elsevier B.V
2Elsevier Limited
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8BSHEE
93V.
107QL
117QP
127RV
137T2
147T7
157TK
167U7
177U9
187X7
197XB
2088C
2188E
228AO
238C1
248FD
258FI
268FJ
278FK
288G5
29ABUWG
30AZQEC
31BENPR
32C1K
33DWQXO
34FR3
35FYUFA
36GHDGH
37GNUQQ
38GUQSH
39H94
40K9.
41KB0
42M0S
43M0T
44M1P
45M2O
46M7N
47MBDVC
48NAPCQ
49P64
50PADUT
51PQEST
52PQQKQ
53PQUKI
54PRINS
55Q9U
567X8
57BOBZL
58CLFQK
orcididhttps://orcid.org/0000-0003-1968-3326
sort
creationdate2015
titleBasic study design influences the results of orthodontic clinical investigations
authorPapageorgiou, Spyridon N ; Xavier, Guilherme M ; Cobourne, Martyn T
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c547t-d89f274bba3228517dd0c59f17931334a1c918fd6353a244971f3e23a39524c43
rsrctypearticles
prefilterarticles
languageeng
creationdate2015
topic
0analysis
1asjc
2atira
3Bias
4Clinical trials
5Confidence intervals
6Data Collection
7Data entry
8Databases
9Dental Research
10Epidemiology
11Humans
12Internal Medicine
13Medical care
14Meta
15Meta-analysis
16omized controlled trial
17Orthodontics
18Patient Outcome Assessment
19Prospective clinical study
20Prospective Studies
21pure
22Quality management
23Randomized controlled trial
24Randomized Controlled Trials as Topic
25Research Design
26Research methodology
27Retrospective clinical study
28Retrospective Studies
29Studies
30subjectarea
31Systematic review
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Papageorgiou, Spyridon N
1Xavier, Guilherme M
2Cobourne, Martyn T
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Academic OneFile (A&I only)
8ProQuest Central (Corporate)
9Bacteriology Abstracts (Microbiology B)
10Calcium & Calcified Tissue Abstracts
11Nursing & Allied Health Database
12Health and Safety Science Abstracts (Full archive)
13Industrial and Applied Microbiology Abstracts (Microbiology A)
14Neurosciences Abstracts
15Toxicology Abstracts
16Virology and AIDS Abstracts
17Health & Medical Collection
18ProQuest Central (purchase pre-March 2016)
19Healthcare Administration Database (Alumni)
20Medical Database (Alumni Edition)
21ProQuest Pharma Collection
22Public Health Database
23Technology Research Database
24Hospital Premium Collection
25Hospital Premium Collection (Alumni Edition)
26ProQuest Central (Alumni) (purchase pre-March 2016)
27Research Library (Alumni Edition)
28ProQuest Central (Alumni Edition)
29ProQuest Central Essentials
30ProQuest Central
31Environmental Sciences and Pollution Management
32ProQuest Central Korea
33Engineering Research Database
34Health Research Premium Collection
35Health Research Premium Collection (Alumni)
36ProQuest Central Student
37Research Library Prep
38AIDS and Cancer Research Abstracts
39ProQuest Health & Medical Complete (Alumni)
40Nursing & Allied Health Database (Alumni Edition)
41Health & Medical Collection (Alumni Edition)
42Healthcare Administration Database
43Medical Database
44Research Library
45Algology Mycology and Protozoology Abstracts (Microbiology C)
46Research Library (Corporate)
47Nursing & Allied Health Premium
48Biotechnology and BioEngineering Abstracts
49Research Library China
50ProQuest One Academic Eastern Edition
51ProQuest One Academic
52ProQuest One Academic UKI Edition
53ProQuest Central China
54ProQuest Central Basic
55MEDLINE - Academic
56OpenAIRE (Open Access)
57OpenAIRE
jtitleJournal of clinical epidemiology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Papageorgiou, Spyridon N
1Xavier, Guilherme M
2Cobourne, Martyn T
formatjournal
genrearticle
ristypeJOUR
atitleBasic study design influences the results of orthodontic clinical investigations
jtitleJournal of clinical epidemiology
addtitleJ Clin Epidemiol
date2015
risdate2015
volume68
issue12
spage1512
epage1522
pages1512-1522
issn0895-4356
eissn1878-5921
abstractAbstract Objectives Meta-analysis is the gold standard for synthesizing evidence on the effectiveness of health care interventions. However, its validity is dependent on the quality of included studies. Here, we investigated whether basic study design (i.e., randomization and timing of data collection) in orthodontic research influences the results of clinical trials. Study Design and Setting This meta-epidemiologic study used unrestricted electronic and manual searching for meta-analyses in orthodontics. Differences in standardized mean differences (ΔSMD) between interventions and their 95% confidence intervals (CIs) were calculated according to study design through random-effects meta-regression. Effects were then pooled with random-effects meta-analyses. Results No difference was found between randomized and nonrandomized trials (25 meta-analyses; ΔSMD = 0.07; 95% CI = −0.21, 0.34; P  = 0.630). However, retrospective nonrandomized trials reported inflated treatment effects compared with prospective (40 meta-analyses; ΔSMD = −0.30; 95% CI = −0.53, −0.06; P  = 0.018). No difference was found between randomized trials with adequate and those with unclear/inadequate generation (25 meta-analyses; ΔSMD = 0.01; 95% CI = −0.25, 0.26; P  = 0.957). Finally, subgroup analyses indicated that the results of randomized and nonrandomized trials differed significantly according to scope of the trial (effectiveness or adverse effects; P  = 0.005). Conclusion Caution is warranted when interpreting systematic reviews investigating clinical orthodontic interventions when nonrandomized and especially retrospective nonrandomized studies are included in the meta-analysis.
copUnited States
pubElsevier Inc
pmid25910911
doi10.1016/j.jclinepi.2015.03.008
orcididhttps://orcid.org/0000-0003-1968-3326
oafree_for_read