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Inhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats

Purpose This study explored the in vitro antioxidant and anti-platelet activities of hydroxytyrosol, hydroxytyrosol acetate, 3,4-dihydroxyphenylglycol and two phenolic olive extracts. These compounds and extracts were obtained from a new industrial process to hydrothermally treat the alperujo (160 °... Full description

Journal Title: European journal of nutrition 2014, Vol.54 (8), p.1287-1295
Main Author: Rubio-Senent, Fátima
Other Authors: de Roos, Baukje , Duthie, Garry , Fernández-Bolaños, Juan , Rodríguez-Gutiérrez, Guillermo
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1436-6207
Link: https://www.ncbi.nlm.nih.gov/pubmed/25504445
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title: Inhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats
format: Article
creator:
  • Rubio-Senent, Fátima
  • de Roos, Baukje
  • Duthie, Garry
  • Fernández-Bolaños, Juan
  • Rodríguez-Gutiérrez, Guillermo
subjects:
  • Adult
  • Alperujo
  • Animals
  • Antioxidants - pharmacology
  • Chemistry
  • Chemistry and Materials Science
  • Disease Models, Animal
  • Female
  • Humans
  • Lipid peroxidation
  • Lipid Peroxidation - drug effects
  • Liver
  • Male
  • Methoxyhydroxyphenylglycol - analogs & derivatives
  • Methoxyhydroxyphenylglycol - pharmacology
  • Microsomes - drug effects
  • Middle Aged
  • Nutrition
  • Olea - chemistry
  • Olive Oil - chemistry
  • Olive oil wastes
  • Original Contribution
  • Phenols
  • Phenols - pharmacology
  • Phenylethyl Alcohol - analogs & derivatives
  • Phenylethyl Alcohol - pharmacology
  • Plant Extracts - pharmacology
  • Platelet Aggregation - drug effects
  • Platelet function
  • Rats
  • Resveratrol
  • Vitamin E
  • Vitamin E - blood
  • Vitamin E Deficiency - blood
ispartof: European journal of nutrition, 2014, Vol.54 (8), p.1287-1295
description: Purpose This study explored the in vitro antioxidant and anti-platelet activities of hydroxytyrosol, hydroxytyrosol acetate, 3,4-dihydroxyphenylglycol and two phenolic olive extracts. These compounds and extracts were obtained from a new industrial process to hydrothermally treat the alperujo (160 °C/60 min), a by-product of olive oil extraction. Methods The extracts and the purified compounds were obtained chromatographically using both ionic and adsorbent resins. The antioxidant activity was determined by measuring inhibition of human platelet aggregation and inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats. Results The positive effect of the extracts on the inhibition of platelet aggregation is showed, being higher in the case of hydroxytyrosol acetate up to 38 %, and for the first time, its synergist effect with hydroxytyrosol has been proved, obtaining more than double of inhibition. The phenolic extracts and the isolated phenols showed good results for inhibiting the lipid oxidation, up to 62 and 25 %, respectively. A synergistic effect occurred when the hydroxytyrosol acetate and the 3,4-dihydroxyphenylglycol were supplemented by hydroxytyrosol. Conclusion These results suggest the extract and these compounds obtained from a novel industrial process could be natural alternatives for the prevention of diseases related to cardiovascular disorder or oxidative damage.
language: eng
source:
identifier: ISSN: 1436-6207
fulltext: no_fulltext
issn:
  • 1436-6207
  • 1436-6215
url: Link


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titleInhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats
creatorRubio-Senent, Fátima ; de Roos, Baukje ; Duthie, Garry ; Fernández-Bolaños, Juan ; Rodríguez-Gutiérrez, Guillermo
creatorcontribRubio-Senent, Fátima ; de Roos, Baukje ; Duthie, Garry ; Fernández-Bolaños, Juan ; Rodríguez-Gutiérrez, Guillermo
descriptionPurpose This study explored the in vitro antioxidant and anti-platelet activities of hydroxytyrosol, hydroxytyrosol acetate, 3,4-dihydroxyphenylglycol and two phenolic olive extracts. These compounds and extracts were obtained from a new industrial process to hydrothermally treat the alperujo (160 °C/60 min), a by-product of olive oil extraction. Methods The extracts and the purified compounds were obtained chromatographically using both ionic and adsorbent resins. The antioxidant activity was determined by measuring inhibition of human platelet aggregation and inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats. Results The positive effect of the extracts on the inhibition of platelet aggregation is showed, being higher in the case of hydroxytyrosol acetate up to 38 %, and for the first time, its synergist effect with hydroxytyrosol has been proved, obtaining more than double of inhibition. The phenolic extracts and the isolated phenols showed good results for inhibiting the lipid oxidation, up to 62 and 25 %, respectively. A synergistic effect occurred when the hydroxytyrosol acetate and the 3,4-dihydroxyphenylglycol were supplemented by hydroxytyrosol. Conclusion These results suggest the extract and these compounds obtained from a novel industrial process could be natural alternatives for the prevention of diseases related to cardiovascular disorder or oxidative damage.
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subjectAdult ; Alperujo ; Animals ; Antioxidants - pharmacology ; Chemistry ; Chemistry and Materials Science ; Disease Models, Animal ; Female ; Humans ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Liver ; Male ; Methoxyhydroxyphenylglycol - analogs & derivatives ; Methoxyhydroxyphenylglycol - pharmacology ; Microsomes - drug effects ; Middle Aged ; Nutrition ; Olea - chemistry ; Olive Oil - chemistry ; Olive oil wastes ; Original Contribution ; Phenols ; Phenols - pharmacology ; Phenylethyl Alcohol - analogs & derivatives ; Phenylethyl Alcohol - pharmacology ; Plant Extracts - pharmacology ; Platelet Aggregation - drug effects ; Platelet function ; Rats ; Resveratrol ; Vitamin E ; Vitamin E - blood ; Vitamin E Deficiency - blood
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descriptionPurpose This study explored the in vitro antioxidant and anti-platelet activities of hydroxytyrosol, hydroxytyrosol acetate, 3,4-dihydroxyphenylglycol and two phenolic olive extracts. These compounds and extracts were obtained from a new industrial process to hydrothermally treat the alperujo (160 °C/60 min), a by-product of olive oil extraction. Methods The extracts and the purified compounds were obtained chromatographically using both ionic and adsorbent resins. The antioxidant activity was determined by measuring inhibition of human platelet aggregation and inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats. Results The positive effect of the extracts on the inhibition of platelet aggregation is showed, being higher in the case of hydroxytyrosol acetate up to 38 %, and for the first time, its synergist effect with hydroxytyrosol has been proved, obtaining more than double of inhibition. The phenolic extracts and the isolated phenols showed good results for inhibiting the lipid oxidation, up to 62 and 25 %, respectively. A synergistic effect occurred when the hydroxytyrosol acetate and the 3,4-dihydroxyphenylglycol were supplemented by hydroxytyrosol. Conclusion These results suggest the extract and these compounds obtained from a novel industrial process could be natural alternatives for the prevention of diseases related to cardiovascular disorder or oxidative damage.
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titleInhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats
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atitleInhibitory and synergistic effects of natural olive phenols on human platelet aggregation and lipid peroxidation of microsomes from vitamin E-deficient rats
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abstractPurpose This study explored the in vitro antioxidant and anti-platelet activities of hydroxytyrosol, hydroxytyrosol acetate, 3,4-dihydroxyphenylglycol and two phenolic olive extracts. These compounds and extracts were obtained from a new industrial process to hydrothermally treat the alperujo (160 °C/60 min), a by-product of olive oil extraction. Methods The extracts and the purified compounds were obtained chromatographically using both ionic and adsorbent resins. The antioxidant activity was determined by measuring inhibition of human platelet aggregation and inhibition of lipid peroxidation in liver microsomes of vitamin E-deficient rats. Results The positive effect of the extracts on the inhibition of platelet aggregation is showed, being higher in the case of hydroxytyrosol acetate up to 38 %, and for the first time, its synergist effect with hydroxytyrosol has been proved, obtaining more than double of inhibition. The phenolic extracts and the isolated phenols showed good results for inhibiting the lipid oxidation, up to 62 and 25 %, respectively. A synergistic effect occurred when the hydroxytyrosol acetate and the 3,4-dihydroxyphenylglycol were supplemented by hydroxytyrosol. Conclusion These results suggest the extract and these compounds obtained from a novel industrial process could be natural alternatives for the prevention of diseases related to cardiovascular disorder or oxidative damage.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid25504445
doi10.1007/s00394-014-0807-8
oafree_for_read