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Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development

The molecular and genetic basis for the evolution of anatomical diversity is a major question that has inspired evolutionary and developmental biologists for decades. Because morphology takes form during development, a true comprehension of how anatomical structures evolve requires an understanding... Full description

Journal Title: Annual review of genomics and human genetics 2015-08-24, Vol.16 (1), p.103-131
Main Author: Rebeiz, Mark
Other Authors: Patel, Nipam H , Hinman, Veronica F
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Annual Reviews
ID: ISSN: 1527-8204
Link: https://www.ncbi.nlm.nih.gov/pubmed/26079281
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title: Unraveling the Tangled Skein: The Evolution of Transcriptional Regulatory Networks in Development
format: Article
creator:
  • Rebeiz, Mark
  • Patel, Nipam H
  • Hinman, Veronica F
subjects:
  • anatomical novelty
  • Animals
  • Article
  • Biological Evolution
  • Butterflies
  • Butterflies - genetics
  • Butterflies - growth & development
  • Coleoptera
  • Coleoptera - anatomy & histology
  • Coleoptera - genetics
  • Developmental
  • Drosophila
  • Drosophila - genetics
  • Drosophila - growth & development
  • Gene Expression Regulation
  • Gene Expression Regulation, Developmental
  • gene regulation
  • gene regulatory network
  • Gene Regulatory Networks
  • Genetic regulation
  • Genetic research
  • Genetic transcription
  • Genetics & Heredity
  • Humans
  • morphological evolution
  • Primates
  • Primates - genetics
  • Primates - growth & development
  • Proteins
  • Proteins - genetics
ispartof: Annual review of genomics and human genetics, 2015-08-24, Vol.16 (1), p.103-131
description: The molecular and genetic basis for the evolution of anatomical diversity is a major question that has inspired evolutionary and developmental biologists for decades. Because morphology takes form during development, a true comprehension of how anatomical structures evolve requires an understanding of the evolutionary events that alter developmental genetic programs. Vast gene regulatory networks (GRNs) that connect transcription factors to their target regulatory sequences control gene expression in time and space and therefore determine the tissue-specific genetic programs that shape morphological structures. In recent years, many new examples have greatly advanced our understanding of the genetic alterations that modify GRNs to generate newly evolved morphologies. Here, we review several aspects of GRN evolution, including their deep preservation, their mechanisms of alteration, and how they originate to generate novel developmental programs.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1527-8204
fulltext: fulltext
issn:
  • 1527-8204
  • 1545-293X
url: Link


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descriptionThe molecular and genetic basis for the evolution of anatomical diversity is a major question that has inspired evolutionary and developmental biologists for decades. Because morphology takes form during development, a true comprehension of how anatomical structures evolve requires an understanding of the evolutionary events that alter developmental genetic programs. Vast gene regulatory networks (GRNs) that connect transcription factors to their target regulatory sequences control gene expression in time and space and therefore determine the tissue-specific genetic programs that shape morphological structures. In recent years, many new examples have greatly advanced our understanding of the genetic alterations that modify GRNs to generate newly evolved morphologies. Here, we review several aspects of GRN evolution, including their deep preservation, their mechanisms of alteration, and how they originate to generate novel developmental programs.
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subjectanatomical novelty ; Animals ; Article ; Biological Evolution ; Butterflies ; Butterflies - genetics ; Butterflies - growth & development ; Coleoptera ; Coleoptera - anatomy & histology ; Coleoptera - genetics ; Developmental ; Drosophila ; Drosophila - genetics ; Drosophila - growth & development ; Gene Expression Regulation ; Gene Expression Regulation, Developmental ; gene regulation ; gene regulatory network ; Gene Regulatory Networks ; Genetic regulation ; Genetic research ; Genetic transcription ; Genetics & Heredity ; Humans ; morphological evolution ; Primates ; Primates - genetics ; Primates - growth & development ; Proteins ; Proteins - genetics
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abstractThe molecular and genetic basis for the evolution of anatomical diversity is a major question that has inspired evolutionary and developmental biologists for decades. Because morphology takes form during development, a true comprehension of how anatomical structures evolve requires an understanding of the evolutionary events that alter developmental genetic programs. Vast gene regulatory networks (GRNs) that connect transcription factors to their target regulatory sequences control gene expression in time and space and therefore determine the tissue-specific genetic programs that shape morphological structures. In recent years, many new examples have greatly advanced our understanding of the genetic alterations that modify GRNs to generate newly evolved morphologies. Here, we review several aspects of GRN evolution, including their deep preservation, their mechanisms of alteration, and how they originate to generate novel developmental programs.
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