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Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition

Highlights • CAI is confirmed to inhibit OXPHOS in cancer cells for the first time. • Anti-cancer effect of CAI is greatly improved by being combined with 2-DG. • ATP decrease and G2/M arrest are caused by the combination of CAI and 2-DG. • Combination of CAI and 2-DG is well-tolerated and effective... Full description

Journal Title: Cancer letters 2015, Vol.370 (2), p.232-241
Main Author: Ju, Rui
Other Authors: Guo, Lei , Li, Juan , Zhu, Lei , Yu, Xiaoli , Chen, Chen , Chen, Wei , Ye, Caiying , Zhang, Dechang
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Ireland: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
Link: https://www.ncbi.nlm.nih.gov/pubmed/26522259
Zum Text:
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title: Carboxyamidotriazole inhibits oxidative phosphorylation in cancer cells and exerts synergistic anti-cancer effect with glycolysis inhibition
format: Article
creator:
  • Ju, Rui
  • Guo, Lei
  • Li, Juan
  • Zhu, Lei
  • Yu, Xiaoli
  • Chen, Chen
  • Chen, Wei
  • Ye, Caiying
  • Zhang, Dechang
subjects:
  • 2-deoxyglucose
  • Analysis
  • Animals
  • Antineoplastic Agents - pharmacology
  • Apoptosis - drug effects
  • Cancer
  • Cancer cells
  • Carboxyamidotriazole
  • Care and treatment
  • Cell Line, Tumor
  • Cell Proliferation - drug effects
  • Deoxyglucose - pharmacology
  • Drug Synergism
  • G2/M arrest
  • Glucose - metabolism
  • Glycolysis
  • Glycolysis - drug effects
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Oxidative phosphorylation
  • Oxidative Phosphorylation - drug effects
  • Oxygen Consumption - drug effects
  • Prevention
  • Triazoles - pharmacology
ispartof: Cancer letters, 2015, Vol.370 (2), p.232-241
description: Highlights • CAI is confirmed to inhibit OXPHOS in cancer cells for the first time. • Anti-cancer effect of CAI is greatly improved by being combined with 2-DG. • ATP decrease and G2/M arrest are caused by the combination of CAI and 2-DG. • Combination of CAI and 2-DG is well-tolerated and effective in a xenograft model. • Combination of CAI and 2-DG may potentiate other metabolism targeting approaches.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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descriptionHighlights • CAI is confirmed to inhibit OXPHOS in cancer cells for the first time. • Anti-cancer effect of CAI is greatly improved by being combined with 2-DG. • ATP decrease and G2/M arrest are caused by the combination of CAI and 2-DG. • Combination of CAI and 2-DG is well-tolerated and effective in a xenograft model. • Combination of CAI and 2-DG may potentiate other metabolism targeting approaches.
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subject2-deoxyglucose ; Analysis ; Animals ; Antineoplastic Agents - pharmacology ; Apoptosis - drug effects ; Cancer ; Cancer cells ; Carboxyamidotriazole ; Care and treatment ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Deoxyglucose - pharmacology ; Drug Synergism ; G2/M arrest ; Glucose - metabolism ; Glycolysis ; Glycolysis - drug effects ; Hematology, Oncology and Palliative Medicine ; Humans ; Mice ; Mice, Inbred C57BL ; Oxidative phosphorylation ; Oxidative Phosphorylation - drug effects ; Oxygen Consumption - drug effects ; Prevention ; Triazoles - pharmacology
ispartofCancer letters, 2015, Vol.370 (2), p.232-241
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descriptionHighlights • CAI is confirmed to inhibit OXPHOS in cancer cells for the first time. • Anti-cancer effect of CAI is greatly improved by being combined with 2-DG. • ATP decrease and G2/M arrest are caused by the combination of CAI and 2-DG. • Combination of CAI and 2-DG is well-tolerated and effective in a xenograft model. • Combination of CAI and 2-DG may potentiate other metabolism targeting approaches.
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abstractHighlights • CAI is confirmed to inhibit OXPHOS in cancer cells for the first time. • Anti-cancer effect of CAI is greatly improved by being combined with 2-DG. • ATP decrease and G2/M arrest are caused by the combination of CAI and 2-DG. • Combination of CAI and 2-DG is well-tolerated and effective in a xenograft model. • Combination of CAI and 2-DG may potentiate other metabolism targeting approaches.
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