schliessen

Filtern

 

Bibliotheken

Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group

Neurocognitive function, neurological symptoms, functional independence, and health-related quality of life are major concerns for patients with brain metastases. The inclusion of these endpoints in trials of brain metastases and the methods by which these measures are assessed vary substantially. I... Full description

Journal Title: The lancet oncology 2013, Vol.14 (10), p.e407-e416
Main Author: Lin, Nancy U, Dr
Other Authors: Wefel, Jeffrey S, PhD , Lee, Eudocia Q, MD , Schiff, David, Prof , van den Bent, Martin J, Prof , Soffietti, Riccardo, Prof , Suh, John H, Prof , Vogelbaum, Michael A, Prof , Mehta, Minesh P, MD , Dancey, Janet, Prof , Linskey, Mark E, Prof , Camidge, D Ross, MD , Aoyama, Hidefumi, Prof , Brown, Paul D, Prof , Chang, Susan M, Prof , Kalkanis, Steven N, MD , Barani, Igor J, MD , Baumert, Brigitta G, Prof , Gaspar, Laurie E, Prof , Hodi, F Stephen, MD , Macdonald, David R, MD , Wen, Patrick Y, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 1470-2045
Link: https://www.ncbi.nlm.nih.gov/pubmed/23993385
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1751210294
title: Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
format: Article
creator:
  • Lin, Nancy U, Dr
  • Wefel, Jeffrey S, PhD
  • Lee, Eudocia Q, MD
  • Schiff, David, Prof
  • van den Bent, Martin J, Prof
  • Soffietti, Riccardo, Prof
  • Suh, John H, Prof
  • Vogelbaum, Michael A, Prof
  • Mehta, Minesh P, MD
  • Dancey, Janet, Prof
  • Linskey, Mark E, Prof
  • Camidge, D Ross, MD
  • Aoyama, Hidefumi, Prof
  • Brown, Paul D, Prof
  • Chang, Susan M, Prof
  • Kalkanis, Steven N, MD
  • Barani, Igor J, MD
  • Baumert, Brigitta G, Prof
  • Gaspar, Laurie E, Prof
  • Hodi, F Stephen, MD
  • Macdonald, David R, MD
  • Wen, Patrick Y, Prof
subjects:
  • Brain Neoplasms - psychology
  • Brain Neoplasms - secondary
  • Brain tumors
  • Clinical trials
  • Clinical Trials as Topic
  • Cognition
  • Hematology, Oncology and Palliative Medicine
  • Humans
  • Metastasis
  • Quality of Life
  • Reports
  • Research Design
ispartof: The lancet oncology, 2013, Vol.14 (10), p.e407-e416
description: Neurocognitive function, neurological symptoms, functional independence, and health-related quality of life are major concerns for patients with brain metastases. The inclusion of these endpoints in trials of brain metastases and the methods by which these measures are assessed vary substantially. If functional independence or health-related quality of life are planned as key study outcomes, then the reliability and validity of these endpoints can be crucial because methodological issues might affect the interpretation and acceptance of findings. The Response Assessment in Neuro-Oncology (RANO) working group is an independent, international, and collaborative effort to improve the design of clinical trials in patients with brain tumours. In this report, the second in a two-part series, we review clinical trials of brain metastases in relation to measures of clinical benefit and provide a framework for the design and conduct of future trials.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1470-2045
fulltext: fulltext
issn:
  • 1470-2045
  • 1474-5488
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6595256
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1751210294
sourceformatXML
sourcesystemPC
galeidA345977867
sourcerecordidA345977867
originalsourceidFETCH-LOGICAL-c571t-23bef602d02f818c4f7d10255b6753101f2d40a90b775dbbc0cfa4ebecead70e3
addsrcrecordideNqFkl1rFTEQhhdRbK3-BCXgTYVuTTbJyW4vlEPxC4oFP668CNlk9jQ1m5wm2UJ_kv_S7Dlt1SKULCQTnnk3M_NW1XOCDwkmi9dfCRO4bjDj-4S-EpjituYPqt1yzWrO2vbh5rxFdqonKZ1jTATB_HG109Cuo7Tlu9Wv4zPlHPgVJBTBqWz9CuWAUnDWoDyNYYqoj8p6NEJWqXyFLJF21lutHMrRKpcO0FrFjJoj5GGKQYeVt9lewsE2dmE1wwdIeYMuJuVsvqrDUDs7AApT1mGEdIiW5Q3rUHSGGEaUzwB9WX4-RasYpvXT6tFQfgTPrve96vv7d9-OP9Ynpx8-HS9Pas0FyXVDexgWuDG4GVrSajYIQ3DDeb8QnJbWDY1hWHW4F4KbvtdYD4pBDxqUERjoXrW_1V3HcDFBynK0SYNzykOYkiSCk6Yodux-lDXdgnYNmdGXd9Dz0llfCpmpllLc8b-olXIgrR9CjkrPonJJGe-EaBeiUIf_ocoyMFodPAy23P-TwLcJOoaUIgxyHe2o4pUkWM5ukhs3ydkqklC5cZPkJe_F9aOnfgRzm3VjnwL82AJeRW3TLVBGLoOycj1F2ATelXPvigeyDX6uWRgm1EIyA1wyzZhsFxxKcwfd0tbwpjdF_e1WHcq4Ly1EmbQFr8HYCDpLE-y9Bby5o3Bj259wBenPCGRqJN6KzBqEbhQ4_Q02oA57
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1428330954
display
typearticle
titleChallenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
sourceAlma/SFX Local Collection
creatorLin, Nancy U, Dr ; Wefel, Jeffrey S, PhD ; Lee, Eudocia Q, MD ; Schiff, David, Prof ; van den Bent, Martin J, Prof ; Soffietti, Riccardo, Prof ; Suh, John H, Prof ; Vogelbaum, Michael A, Prof ; Mehta, Minesh P, MD ; Dancey, Janet, Prof ; Linskey, Mark E, Prof ; Camidge, D Ross, MD ; Aoyama, Hidefumi, Prof ; Brown, Paul D, Prof ; Chang, Susan M, Prof ; Kalkanis, Steven N, MD ; Barani, Igor J, MD ; Baumert, Brigitta G, Prof ; Gaspar, Laurie E, Prof ; Hodi, F Stephen, MD ; Macdonald, David R, MD ; Wen, Patrick Y, Prof
creatorcontribLin, Nancy U, Dr ; Wefel, Jeffrey S, PhD ; Lee, Eudocia Q, MD ; Schiff, David, Prof ; van den Bent, Martin J, Prof ; Soffietti, Riccardo, Prof ; Suh, John H, Prof ; Vogelbaum, Michael A, Prof ; Mehta, Minesh P, MD ; Dancey, Janet, Prof ; Linskey, Mark E, Prof ; Camidge, D Ross, MD ; Aoyama, Hidefumi, Prof ; Brown, Paul D, Prof ; Chang, Susan M, Prof ; Kalkanis, Steven N, MD ; Barani, Igor J, MD ; Baumert, Brigitta G, Prof ; Gaspar, Laurie E, Prof ; Hodi, F Stephen, MD ; Macdonald, David R, MD ; Wen, Patrick Y, Prof ; for the Response Assessment in Neuro-Oncology (RANO) group ; Response Assessment in Neuro-Oncology (RANO) group
descriptionNeurocognitive function, neurological symptoms, functional independence, and health-related quality of life are major concerns for patients with brain metastases. The inclusion of these endpoints in trials of brain metastases and the methods by which these measures are assessed vary substantially. If functional independence or health-related quality of life are planned as key study outcomes, then the reliability and validity of these endpoints can be crucial because methodological issues might affect the interpretation and acceptance of findings. The Response Assessment in Neuro-Oncology (RANO) working group is an independent, international, and collaborative effort to improve the design of clinical trials in patients with brain tumours. In this report, the second in a two-part series, we review clinical trials of brain metastases in relation to measures of clinical benefit and provide a framework for the design and conduct of future trials.
identifier
0ISSN: 1470-2045
1EISSN: 1474-5488
2DOI: 10.1016/S1470-2045(13)70308-5
3PMID: 23993385
4CODEN: LANCAO
languageeng
publisherEngland: Elsevier Ltd
subjectBrain Neoplasms - psychology ; Brain Neoplasms - secondary ; Brain tumors ; Clinical trials ; Clinical Trials as Topic ; Cognition ; Hematology, Oncology and Palliative Medicine ; Humans ; Metastasis ; Quality of Life ; Reports ; Research Design
ispartofThe lancet oncology, 2013, Vol.14 (10), p.e407-e416
rights
0Elsevier Ltd
12013 Elsevier Ltd
2info:eu-repo/semantics/restrictedAccess
3Copyright © 2013 Elsevier Ltd. All rights reserved.
4COPYRIGHT 2013 Elsevier B.V.
5Copyright Elsevier Limited Sep 2013
lds50peer_reviewed
citesFETCH-LOGICAL-c571t-23bef602d02f818c4f7d10255b6753101f2d40a90b775dbbc0cfa4ebecead70e3
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23993385$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Lin, Nancy U, Dr
1Wefel, Jeffrey S, PhD
2Lee, Eudocia Q, MD
3Schiff, David, Prof
4van den Bent, Martin J, Prof
5Soffietti, Riccardo, Prof
6Suh, John H, Prof
7Vogelbaum, Michael A, Prof
8Mehta, Minesh P, MD
9Dancey, Janet, Prof
10Linskey, Mark E, Prof
11Camidge, D Ross, MD
12Aoyama, Hidefumi, Prof
13Brown, Paul D, Prof
14Chang, Susan M, Prof
15Kalkanis, Steven N, MD
16Barani, Igor J, MD
17Baumert, Brigitta G, Prof
18Gaspar, Laurie E, Prof
19Hodi, F Stephen, MD
20Macdonald, David R, MD
21Wen, Patrick Y, Prof
22for the Response Assessment in Neuro-Oncology (RANO) group
23Response Assessment in Neuro-Oncology (RANO) group
title
0Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
1The lancet oncology
addtitleLancet Oncol
descriptionNeurocognitive function, neurological symptoms, functional independence, and health-related quality of life are major concerns for patients with brain metastases. The inclusion of these endpoints in trials of brain metastases and the methods by which these measures are assessed vary substantially. If functional independence or health-related quality of life are planned as key study outcomes, then the reliability and validity of these endpoints can be crucial because methodological issues might affect the interpretation and acceptance of findings. The Response Assessment in Neuro-Oncology (RANO) working group is an independent, international, and collaborative effort to improve the design of clinical trials in patients with brain tumours. In this report, the second in a two-part series, we review clinical trials of brain metastases in relation to measures of clinical benefit and provide a framework for the design and conduct of future trials.
subject
0Brain Neoplasms - psychology
1Brain Neoplasms - secondary
2Brain tumors
3Clinical trials
4Clinical Trials as Topic
5Cognition
6Hematology, Oncology and Palliative Medicine
7Humans
8Metastasis
9Quality of Life
10Reports
11Research Design
issn
01470-2045
11474-5488
fulltexttrue
rsrctypearticle
creationdate2013
recordtypearticle
recordideNqFkl1rFTEQhhdRbK3-BCXgTYVuTTbJyW4vlEPxC4oFP668CNlk9jQ1m5wm2UJ_kv_S7Dlt1SKULCQTnnk3M_NW1XOCDwkmi9dfCRO4bjDj-4S-EpjituYPqt1yzWrO2vbh5rxFdqonKZ1jTATB_HG109Cuo7Tlu9Wv4zPlHPgVJBTBqWz9CuWAUnDWoDyNYYqoj8p6NEJWqXyFLJF21lutHMrRKpcO0FrFjJoj5GGKQYeVt9lewsE2dmE1wwdIeYMuJuVsvqrDUDs7AApT1mGEdIiW5Q3rUHSGGEaUzwB9WX4-RasYpvXT6tFQfgTPrve96vv7d9-OP9Ynpx8-HS9Pas0FyXVDexgWuDG4GVrSajYIQ3DDeb8QnJbWDY1hWHW4F4KbvtdYD4pBDxqUERjoXrW_1V3HcDFBynK0SYNzykOYkiSCk6Yodux-lDXdgnYNmdGXd9Dz0llfCpmpllLc8b-olXIgrR9CjkrPonJJGe-EaBeiUIf_ocoyMFodPAy23P-TwLcJOoaUIgxyHe2o4pUkWM5ukhs3ydkqklC5cZPkJe_F9aOnfgRzm3VjnwL82AJeRW3TLVBGLoOycj1F2ATelXPvigeyDX6uWRgm1EIyA1wyzZhsFxxKcwfd0tbwpjdF_e1WHcq4Ly1EmbQFr8HYCDpLE-y9Bby5o3Bj259wBenPCGRqJN6KzBqEbhQ4_Q02oA57
startdate2013
enddate2013
creator
0Lin, Nancy U, Dr
1Wefel, Jeffrey S, PhD
2Lee, Eudocia Q, MD
3Schiff, David, Prof
4van den Bent, Martin J, Prof
5Soffietti, Riccardo, Prof
6Suh, John H, Prof
7Vogelbaum, Michael A, Prof
8Mehta, Minesh P, MD
9Dancey, Janet, Prof
10Linskey, Mark E, Prof
11Camidge, D Ross, MD
12Aoyama, Hidefumi, Prof
13Brown, Paul D, Prof
14Chang, Susan M, Prof
15Kalkanis, Steven N, MD
16Barani, Igor J, MD
17Baumert, Brigitta G, Prof
18Gaspar, Laurie E, Prof
19Hodi, F Stephen, MD
20Macdonald, David R, MD
21Wen, Patrick Y, Prof
general
0Elsevier Ltd
1Elsevier B.V
2Elsevier Limited
scope
05DI
15DJ
2QVL
3CGR
4CUY
5CVF
6ECM
7EIF
8NPM
9AAYXX
10CITATION
11BSHEE
120TZ
133V.
147RV
157TO
167X7
177XB
1888E
198AO
208C1
218C2
228FI
238FJ
248FK
25ABUWG
26BENPR
27FYUFA
28GHDGH
29H94
30K9.
31KB0
32M0S
33M1P
34NAPCQ
35PQEST
36PQQKQ
37PQUKI
38PRINS
397X8
sort
creationdate2013
titleChallenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
authorLin, Nancy U, Dr ; Wefel, Jeffrey S, PhD ; Lee, Eudocia Q, MD ; Schiff, David, Prof ; van den Bent, Martin J, Prof ; Soffietti, Riccardo, Prof ; Suh, John H, Prof ; Vogelbaum, Michael A, Prof ; Mehta, Minesh P, MD ; Dancey, Janet, Prof ; Linskey, Mark E, Prof ; Camidge, D Ross, MD ; Aoyama, Hidefumi, Prof ; Brown, Paul D, Prof ; Chang, Susan M, Prof ; Kalkanis, Steven N, MD ; Barani, Igor J, MD ; Baumert, Brigitta G, Prof ; Gaspar, Laurie E, Prof ; Hodi, F Stephen, MD ; Macdonald, David R, MD ; Wen, Patrick Y, Prof
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c571t-23bef602d02f818c4f7d10255b6753101f2d40a90b775dbbc0cfa4ebecead70e3
rsrctypearticles
prefilterarticles
languageeng
creationdate2013
topic
0Brain Neoplasms - psychology
1Brain Neoplasms - secondary
2Brain tumors
3Clinical trials
4Clinical Trials as Topic
5Cognition
6Hematology, Oncology and Palliative Medicine
7Humans
8Metastasis
9Quality of Life
10Reports
11Research Design
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Lin, Nancy U, Dr
1Wefel, Jeffrey S, PhD
2Lee, Eudocia Q, MD
3Schiff, David, Prof
4van den Bent, Martin J, Prof
5Soffietti, Riccardo, Prof
6Suh, John H, Prof
7Vogelbaum, Michael A, Prof
8Mehta, Minesh P, MD
9Dancey, Janet, Prof
10Linskey, Mark E, Prof
11Camidge, D Ross, MD
12Aoyama, Hidefumi, Prof
13Brown, Paul D, Prof
14Chang, Susan M, Prof
15Kalkanis, Steven N, MD
16Barani, Igor J, MD
17Baumert, Brigitta G, Prof
18Gaspar, Laurie E, Prof
19Hodi, F Stephen, MD
20Macdonald, David R, MD
21Wen, Patrick Y, Prof
22for the Response Assessment in Neuro-Oncology (RANO) group
23Response Assessment in Neuro-Oncology (RANO) group
collection
0NARCIS
1NARCIS: Datasets
2NARCIS:Publications
3Medline
4MEDLINE
5MEDLINE (Ovid)
6MEDLINE
7MEDLINE
8PubMed
9CrossRef
10Academic OneFile (A&I only)
11Pharma and Biotech Premium PRO
12ProQuest Central (Corporate)
13Nursing & Allied Health Database
14Oncogenes and Growth Factors Abstracts
15Health & Medical Collection
16ProQuest Central (purchase pre-March 2016)
17Medical Database (Alumni Edition)
18ProQuest Pharma Collection
19Public Health Database
20Lancet Titles
21Hospital Premium Collection
22Hospital Premium Collection (Alumni Edition)
23ProQuest Central (Alumni) (purchase pre-March 2016)
24ProQuest Central (Alumni Edition)
25ProQuest Central
26Health Research Premium Collection
27Health Research Premium Collection (Alumni)
28AIDS and Cancer Research Abstracts
29ProQuest Health & Medical Complete (Alumni)
30Nursing & Allied Health Database (Alumni Edition)
31Health & Medical Collection (Alumni Edition)
32Medical Database
33Nursing & Allied Health Premium
34ProQuest One Academic Eastern Edition
35ProQuest One Academic
36ProQuest One Academic UKI Edition
37ProQuest Central China
38MEDLINE - Academic
jtitleThe lancet oncology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Lin, Nancy U, Dr
1Wefel, Jeffrey S, PhD
2Lee, Eudocia Q, MD
3Schiff, David, Prof
4van den Bent, Martin J, Prof
5Soffietti, Riccardo, Prof
6Suh, John H, Prof
7Vogelbaum, Michael A, Prof
8Mehta, Minesh P, MD
9Dancey, Janet, Prof
10Linskey, Mark E, Prof
11Camidge, D Ross, MD
12Aoyama, Hidefumi, Prof
13Brown, Paul D, Prof
14Chang, Susan M, Prof
15Kalkanis, Steven N, MD
16Barani, Igor J, MD
17Baumert, Brigitta G, Prof
18Gaspar, Laurie E, Prof
19Hodi, F Stephen, MD
20Macdonald, David R, MD
21Wen, Patrick Y, Prof
aucorp
0for the Response Assessment in Neuro-Oncology (RANO) group
1Response Assessment in Neuro-Oncology (RANO) group
formatjournal
genrearticle
ristypeJOUR
atitleChallenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
jtitleThe lancet oncology
addtitleLancet Oncol
date2013
risdate2013
volume14
issue10
spagee407
epagee416
pagese407-e416
issn1470-2045
eissn1474-5488
codenLANCAO
abstractNeurocognitive function, neurological symptoms, functional independence, and health-related quality of life are major concerns for patients with brain metastases. The inclusion of these endpoints in trials of brain metastases and the methods by which these measures are assessed vary substantially. If functional independence or health-related quality of life are planned as key study outcomes, then the reliability and validity of these endpoints can be crucial because methodological issues might affect the interpretation and acceptance of findings. The Response Assessment in Neuro-Oncology (RANO) working group is an independent, international, and collaborative effort to improve the design of clinical trials in patients with brain tumours. In this report, the second in a two-part series, we review clinical trials of brain metastases in relation to measures of clinical benefit and provide a framework for the design and conduct of future trials.
copEngland
pubElsevier Ltd
pmid23993385
doi10.1016/S1470-2045(13)70308-5