schliessen

Filtern

 

Bibliotheken

Cover Image

Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma

The LASS2 gene has been identified as a new tumor metastasis suppressor gene and has been seen to correlate with the degree of invasion and recurrence in carcinomas of prostate, breast, liver, ovarian, and pancreas. However, expression and prognostic significance of LASS2 in human bladder carcinoma... Full description

Journal Title: Medical oncology (Northwood London, England), 2011, Vol.29 (3), p.1921-1927
Main Author: Wang, Haifeng
Other Authors: Wang, Jiansong , Zuo, Yigang , Ding, Mingxia , Yan, Ruping , Yang, Delin , Ke, Changxin
Format: Electronic Article Electronic Article
Language: English
Subjects:
Carcinoma, Transitional Cell - genetics
Carcinoma, Transitional Cell - pathology
Female
Genes, Tumor Suppressor
Hematology
Humans
Immunohistochemistry
Internal Medicine
Kaplan-Meier Estimate
Male
Medicine
Medicine & Public Health
Membrane Proteins - genetics
Middle Aged
Neoplasm Invasiveness - genetics
Neoplasm Staging
Oncology
Original Paper
Pathology
Prognosis
Real-Time Polymerase Chain Reaction
Sphingosine N-Acyltransferase - genetics
Tumor Suppressor Proteins - genetics
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Publisher: Boston: Springer US
ID: ISSN: 1357-0560
Link: https://www.ncbi.nlm.nih.gov/pubmed/21755371
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1753480374
title: Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
format: Article
creator:
  • Wang, Haifeng
  • Wang, Jiansong
  • Zuo, Yigang
  • Ding, Mingxia
  • Yan, Ruping
  • Yang, Delin
  • Ke, Changxin
subjects:
  • Carcinoma, Transitional Cell - genetics
  • Carcinoma, Transitional Cell - pathology
  • Female
  • Genes, Tumor Suppressor
  • Hematology
  • Humans
  • Immunohistochemistry
  • Internal Medicine
  • Kaplan-Meier Estimate
  • Male
  • Medicine
  • Medicine & Public Health
  • Membrane Proteins - genetics
  • Middle Aged
  • Neoplasm Invasiveness - genetics
  • Neoplasm Staging
  • Oncology
  • Original Paper
  • Pathology
  • Prognosis
  • Real-Time Polymerase Chain Reaction
  • Sphingosine N-Acyltransferase - genetics
  • Tumor Suppressor Proteins - genetics
  • Urinary Bladder Neoplasms - genetics
  • Urinary Bladder Neoplasms - pathology
ispartof: Medical oncology (Northwood, London, England), 2011, Vol.29 (3), p.1921-1927
description: The LASS2 gene has been identified as a new tumor metastasis suppressor gene and has been seen to correlate with the degree of invasion and recurrence in carcinomas of prostate, breast, liver, ovarian, and pancreas. However, expression and prognostic significance of LASS2 in human bladder carcinoma are largely unknown. In this study, the protein expression of LASS2 in 80 patients with different stages was detected by immunohistochemical staining. The prognostic value of LASS2 in bladder cancers can also be assessed by a long-term follow-up investigation. The mRNA expression level of the LASS2 gene was examined using real-time quantitative PCR (qPCR) in human bladder carcinoma and paired non-tumor bladder tissues, which were obtained from 30 patients who underwent total cystectomy. We found that patients with LASS2-negative bladder cancer were linked to poor clinical prognosis. The expression of LASS2 mRNA was significantly correlated with clinical stage ( P  
language: eng
source:
identifier: ISSN: 1357-0560
fulltext: no_fulltext
issn:
  • 1357-0560
  • 1559-131X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.389217
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_cross
recordidTN_cdi_proquest_miscellaneous_1753480374
sourceformatXML
sourcesystemPC
sourcerecordid1753480374
originalsourceidFETCH-LOGICAL-c395t-a288072c661e766dd7ae06d5d7066462bcedce04e75a5a4cd4c24aec58c20df90
addsrcrecordideNqFkU1rFTEUhoMotlZ_gBsJuHEzepJMkpllKfUDLriogrvh3OTMNWUmuU1mqP57c71VpKBCQkJ43ockL2PPBbwWAPZNERKUbECIBkCaxjxgp0LrvhFKfHlY90rbBrSBE_aklOvKCC37x-xECqu1suKU3Vx-22cqJaTIMXq-z2kXU1mC4yXsYhiDw-iIp5Ejj3TLl3VOmc-0YKkjFF7W_U9DPd1RJL45v7qSPET-dZ0x8u2E3lPmDrMLMc34lD0acSr07G49Y5_fXn66eN9sPr77cHG-aZzq9dKg7Dqw0hkjyBrjvUUC47W3YExr5NaRdwQtWY0aW-dbJ1skpzsnwY89nLFXR2990s1KZRnmUBxNE0ZKaxnqF6i2A2Xb_6OgdJ3QiYq-vIdepzXH-pADZaU1ba8qJY6Uy6mUTOOwz2HG_L1Cw6G64VjdUKsbDtUNpmZe3JnX7Uz-d-JXVxWw96QuLLjU5paMYfqnWh6TpUrjjvKfl_5b6Ae-cLWX
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1037276493
display
typearticle
titleExpression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
creatorWang, Haifeng ; Wang, Jiansong ; Zuo, Yigang ; Ding, Mingxia ; Yan, Ruping ; Yang, Delin ; Ke, Changxin
creatorcontribWang, Haifeng ; Wang, Jiansong ; Zuo, Yigang ; Ding, Mingxia ; Yan, Ruping ; Yang, Delin ; Ke, Changxin
descriptionThe LASS2 gene has been identified as a new tumor metastasis suppressor gene and has been seen to correlate with the degree of invasion and recurrence in carcinomas of prostate, breast, liver, ovarian, and pancreas. However, expression and prognostic significance of LASS2 in human bladder carcinoma are largely unknown. In this study, the protein expression of LASS2 in 80 patients with different stages was detected by immunohistochemical staining. The prognostic value of LASS2 in bladder cancers can also be assessed by a long-term follow-up investigation. The mRNA expression level of the LASS2 gene was examined using real-time quantitative PCR (qPCR) in human bladder carcinoma and paired non-tumor bladder tissues, which were obtained from 30 patients who underwent total cystectomy. We found that patients with LASS2-negative bladder cancer were linked to poor clinical prognosis. The expression of LASS2 mRNA was significantly correlated with clinical stage ( P  < 0.001), depth of tumor invasion ( P  < 0.001), and recurrence ( P  < 0.001). Thus, LASS2 expression may be correlated with the development and progression of human bladder carcinoma and may be a prognostic indicator for this carcinoma.
identifier
0ISSN: 1357-0560
1EISSN: 1559-131X
2DOI: 10.1007/s12032-011-0026-6
3PMID: 21755371
4CODEN: MONCEZ
languageeng
publisherBoston: Springer US
subjectCarcinoma, Transitional Cell - genetics ; Carcinoma, Transitional Cell - pathology ; Female ; Genes, Tumor Suppressor ; Hematology ; Humans ; Immunohistochemistry ; Internal Medicine ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Membrane Proteins - genetics ; Middle Aged ; Neoplasm Invasiveness - genetics ; Neoplasm Staging ; Oncology ; Original Paper ; Pathology ; Prognosis ; Real-Time Polymerase Chain Reaction ; Sphingosine N-Acyltransferase - genetics ; Tumor Suppressor Proteins - genetics ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - pathology
ispartofMedical oncology (Northwood, London, England), 2011, Vol.29 (3), p.1921-1927
rights
0Springer Science+Business Media, LLC 2011
1Springer Science+Business Media, LLC 2012
lds50peer_reviewed
citedbyFETCH-LOGICAL-c395t-a288072c661e766dd7ae06d5d7066462bcedce04e75a5a4cd4c24aec58c20df90
citesFETCH-LOGICAL-c395t-a288072c661e766dd7ae06d5d7066462bcedce04e75a5a4cd4c24aec58c20df90
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21755371$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Wang, Haifeng
1Wang, Jiansong
2Zuo, Yigang
3Ding, Mingxia
4Yan, Ruping
5Yang, Delin
6Ke, Changxin
title
0Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
1Medical oncology (Northwood, London, England)
addtitle
0Med Oncol
1Med Oncol
descriptionThe LASS2 gene has been identified as a new tumor metastasis suppressor gene and has been seen to correlate with the degree of invasion and recurrence in carcinomas of prostate, breast, liver, ovarian, and pancreas. However, expression and prognostic significance of LASS2 in human bladder carcinoma are largely unknown. In this study, the protein expression of LASS2 in 80 patients with different stages was detected by immunohistochemical staining. The prognostic value of LASS2 in bladder cancers can also be assessed by a long-term follow-up investigation. The mRNA expression level of the LASS2 gene was examined using real-time quantitative PCR (qPCR) in human bladder carcinoma and paired non-tumor bladder tissues, which were obtained from 30 patients who underwent total cystectomy. We found that patients with LASS2-negative bladder cancer were linked to poor clinical prognosis. The expression of LASS2 mRNA was significantly correlated with clinical stage ( P  < 0.001), depth of tumor invasion ( P  < 0.001), and recurrence ( P  < 0.001). Thus, LASS2 expression may be correlated with the development and progression of human bladder carcinoma and may be a prognostic indicator for this carcinoma.
subject
0Carcinoma, Transitional Cell - genetics
1Carcinoma, Transitional Cell - pathology
2Female
3Genes, Tumor Suppressor
4Hematology
5Humans
6Immunohistochemistry
7Internal Medicine
8Kaplan-Meier Estimate
9Male
10Medicine
11Medicine & Public Health
12Membrane Proteins - genetics
13Middle Aged
14Neoplasm Invasiveness - genetics
15Neoplasm Staging
16Oncology
17Original Paper
18Pathology
19Prognosis
20Real-Time Polymerase Chain Reaction
21Sphingosine N-Acyltransferase - genetics
22Tumor Suppressor Proteins - genetics
23Urinary Bladder Neoplasms - genetics
24Urinary Bladder Neoplasms - pathology
issn
01357-0560
11559-131X
fulltextfalse
rsrctypearticle
creationdate2011
recordtypearticle
recordideNqFkU1rFTEUhoMotlZ_gBsJuHEzepJMkpllKfUDLriogrvh3OTMNWUmuU1mqP57c71VpKBCQkJ43ockL2PPBbwWAPZNERKUbECIBkCaxjxgp0LrvhFKfHlY90rbBrSBE_aklOvKCC37x-xECqu1suKU3Vx-22cqJaTIMXq-z2kXU1mC4yXsYhiDw-iIp5Ejj3TLl3VOmc-0YKkjFF7W_U9DPd1RJL45v7qSPET-dZ0x8u2E3lPmDrMLMc34lD0acSr07G49Y5_fXn66eN9sPr77cHG-aZzq9dKg7Dqw0hkjyBrjvUUC47W3YExr5NaRdwQtWY0aW-dbJ1skpzsnwY89nLFXR2990s1KZRnmUBxNE0ZKaxnqF6i2A2Xb_6OgdJ3QiYq-vIdepzXH-pADZaU1ba8qJY6Uy6mUTOOwz2HG_L1Cw6G64VjdUKsbDtUNpmZe3JnX7Uz-d-JXVxWw96QuLLjU5paMYfqnWh6TpUrjjvKfl_5b6Ae-cLWX
startdate20110714
enddate20110714
creator
0Wang, Haifeng
1Wang, Jiansong
2Zuo, Yigang
3Ding, Mingxia
4Yan, Ruping
5Yang, Delin
6Ke, Changxin
general
0Springer US
1Springer Nature B.V
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
83V.
97X7
107XB
1188E
128AO
138FI
148FJ
158FK
16ABUWG
17BENPR
18FYUFA
19GHDGH
20K9.
21M0S
22M1P
23PQEST
24PQQKQ
25PQUKI
26PRINS
277X8
288FD
29FR3
30P64
31RC3
sort
creationdate20110714
titleExpression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
authorWang, Haifeng ; Wang, Jiansong ; Zuo, Yigang ; Ding, Mingxia ; Yan, Ruping ; Yang, Delin ; Ke, Changxin
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c395t-a288072c661e766dd7ae06d5d7066462bcedce04e75a5a4cd4c24aec58c20df90
rsrctypearticles
prefilterarticles
languageeng
creationdate2011
topic
0Carcinoma, Transitional Cell - genetics
1Carcinoma, Transitional Cell - pathology
2Female
3Genes, Tumor Suppressor
4Hematology
5Humans
6Immunohistochemistry
7Internal Medicine
8Kaplan-Meier Estimate
9Male
10Medicine
11Medicine & Public Health
12Membrane Proteins - genetics
13Middle Aged
14Neoplasm Invasiveness - genetics
15Neoplasm Staging
16Oncology
17Original Paper
18Pathology
19Prognosis
20Real-Time Polymerase Chain Reaction
21Sphingosine N-Acyltransferase - genetics
22Tumor Suppressor Proteins - genetics
23Urinary Bladder Neoplasms - genetics
24Urinary Bladder Neoplasms - pathology
toplevelpeer_reviewed
creatorcontrib
0Wang, Haifeng
1Wang, Jiansong
2Zuo, Yigang
3Ding, Mingxia
4Yan, Ruping
5Yang, Delin
6Ke, Changxin
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7ProQuest Central (Corporate)
8Health & Medical Collection
9ProQuest Central (purchase pre-March 2016)
10Medical Database (Alumni Edition)
11ProQuest Pharma Collection
12Hospital Premium Collection
13Hospital Premium Collection (Alumni Edition)
14ProQuest Central (Alumni) (purchase pre-March 2016)
15ProQuest Central (Alumni Edition)
16ProQuest Central
17Health Research Premium Collection
18Health Research Premium Collection (Alumni)
19ProQuest Health & Medical Complete (Alumni)
20Health & Medical Collection (Alumni Edition)
21Medical Database
22ProQuest One Academic Eastern Edition
23ProQuest One Academic
24ProQuest One Academic UKI Edition
25ProQuest Central China
26MEDLINE - Academic
27Technology Research Database
28Engineering Research Database
29Biotechnology and BioEngineering Abstracts
30Genetics Abstracts
jtitleMedical oncology (Northwood, London, England)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Wang, Haifeng
1Wang, Jiansong
2Zuo, Yigang
3Ding, Mingxia
4Yan, Ruping
5Yang, Delin
6Ke, Changxin
formatjournal
genrearticle
ristypeJOUR
atitleExpression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
jtitleMedical oncology (Northwood, London, England)
stitleMed Oncol
addtitleMed Oncol
date2011-07-14
risdate2011
volume29
issue3
spage1921
epage1927
pages1921-1927
issn1357-0560
eissn1559-131X
codenMONCEZ
abstractThe LASS2 gene has been identified as a new tumor metastasis suppressor gene and has been seen to correlate with the degree of invasion and recurrence in carcinomas of prostate, breast, liver, ovarian, and pancreas. However, expression and prognostic significance of LASS2 in human bladder carcinoma are largely unknown. In this study, the protein expression of LASS2 in 80 patients with different stages was detected by immunohistochemical staining. The prognostic value of LASS2 in bladder cancers can also be assessed by a long-term follow-up investigation. The mRNA expression level of the LASS2 gene was examined using real-time quantitative PCR (qPCR) in human bladder carcinoma and paired non-tumor bladder tissues, which were obtained from 30 patients who underwent total cystectomy. We found that patients with LASS2-negative bladder cancer were linked to poor clinical prognosis. The expression of LASS2 mRNA was significantly correlated with clinical stage ( P  < 0.001), depth of tumor invasion ( P  < 0.001), and recurrence ( P  < 0.001). Thus, LASS2 expression may be correlated with the development and progression of human bladder carcinoma and may be a prognostic indicator for this carcinoma.
copBoston
pubSpringer US
pmid21755371
doi10.1007/s12032-011-0026-6