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Spheroid culture as a tool for creating 3D complex tissues

Highlights ► Spheroids improve the relevance of in vitro results. ► Spheroids serve as biological models of native tissues or engineered solutions. ► Spheroids are used as building blocks to form tissues. ► Spheroids in concert with other aggregated cell shapes allow for complex tissue architecture... Full description

Journal Title: Trends in biotechnology (Regular ed.) 2013, Vol.31 (2), p.108-115
Main Author: Fennema, Eelco
Other Authors: Rivron, Nicolas , Rouwkema, Jeroen , van Blitterswijk, Clemens , de Boer, Jan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Cambridge, MA: Elsevier Ltd
ID: ISSN: 0167-7799
Zum Text:
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title: Spheroid culture as a tool for creating 3D complex tissues
format: Article
creator:
  • Fennema, Eelco
  • Rivron, Nicolas
  • Rouwkema, Jeroen
  • van Blitterswijk, Clemens
  • de Boer, Jan
subjects:
  • Aggregates
  • Animals
  • bioengineering
  • Biological and medical sciences
  • Biological apparatus and supplies
  • Biomimetics
  • biomimicry
  • Biotechnology
  • Cell adhesion & migration
  • Cells
  • Culture
  • Electrochemical machining
  • Extracellular Matrix
  • Fundamental and applied biological sciences. Psychology
  • high throughput screening
  • High-Throughput Screening Assays - methods
  • Humans
  • Internal Medicine
  • IR-83313
  • Methods
  • METIS-293634
  • Microfluidics - methods
  • Platforms
  • Screening
  • Skin & tissue grafts
  • spheroid
  • Spheroids
  • Spheroids, Cellular
  • Studies
  • Three dimensional
  • Tissue Culture Techniques - methods
  • Tissue Engineering - methods
  • Tools
  • Vascular endothelial growth factor
ispartof: Trends in biotechnology (Regular ed.), 2013, Vol.31 (2), p.108-115
description: Highlights ► Spheroids improve the relevance of in vitro results. ► Spheroids serve as biological models of native tissues or engineered solutions. ► Spheroids are used as building blocks to form tissues. ► Spheroids in concert with other aggregated cell shapes allow for complex tissue architecture studies.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0167-7799
fulltext: fulltext
issn:
  • 0167-7799
  • 1879-3096
url: Link


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descriptionHighlights ► Spheroids improve the relevance of in vitro results. ► Spheroids serve as biological models of native tissues or engineered solutions. ► Spheroids are used as building blocks to form tissues. ► Spheroids in concert with other aggregated cell shapes allow for complex tissue architecture studies.
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subjectAggregates ; Animals ; bioengineering ; Biological and medical sciences ; Biological apparatus and supplies ; Biomimetics ; biomimicry ; Biotechnology ; Cell adhesion & migration ; Cells ; Culture ; Electrochemical machining ; Extracellular Matrix ; Fundamental and applied biological sciences. Psychology ; high throughput screening ; High-Throughput Screening Assays - methods ; Humans ; Internal Medicine ; IR-83313 ; Methods ; METIS-293634 ; Microfluidics - methods ; Platforms ; Screening ; Skin & tissue grafts ; spheroid ; Spheroids ; Spheroids, Cellular ; Studies ; Three dimensional ; Tissue Culture Techniques - methods ; Tissue Engineering - methods ; Tools ; Vascular endothelial growth factor
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abstractHighlights ► Spheroids improve the relevance of in vitro results. ► Spheroids serve as biological models of native tissues or engineered solutions. ► Spheroids are used as building blocks to form tissues. ► Spheroids in concert with other aggregated cell shapes allow for complex tissue architecture studies.
copCambridge, MA
pubElsevier Ltd
pmid23336996
doi10.1016/j.tibtech.2012.12.003