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Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis

The cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5- f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of t... Full description

Journal Title: Cancer letters 1999, Vol.143 (2), p.179-183
Main Author: Xu, Meirong
Other Authors: Dashwood, Roderick H
Format: Electronic Article Electronic Article
Language: English
Subjects:
IQ
Quelle: Alma/SFX Local Collection
Publisher: Shannon: Elsevier Ireland Ltd
ID: ISSN: 0304-3835
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recordid: cdi_proquest_miscellaneous_17557162
title: Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis
format: Article
creator:
  • Xu, Meirong
  • Dashwood, Roderick H
subjects:
  • 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • 2-amino-3-methylimidazo(4,5-f)quinoline
  • Animals
  • Anticarcinogenic Agents - pharmacology
  • Anticarcinogenic Agents - therapeutic use
  • Biological and medical sciences
  • Carcinogenesis, carcinogens and anticarcinogens
  • Carcinogens - administration & dosage
  • Carcinogens - toxicity
  • Catechin - pharmacology
  • Catechin - therapeutic use
  • Chemoprevention
  • Chlorophyllides - pharmacology
  • Chlorophyllides - therapeutic use
  • Colon - drug effects
  • Colon - pathology
  • Colonic Neoplasms - chemically induced
  • Colonic Neoplasms - prevention & control
  • Drug Antagonism
  • Foods and miscellaneous
  • heterocyclic amines
  • Imidazoles - administration & dosage
  • Imidazoles - toxicity
  • Indoles - pharmacology
  • Indoles - therapeutic use
  • IQ
  • Linoleic Acid - pharmacology
  • Linoleic Acid - therapeutic use
  • Medical sciences
  • PhIP
  • Precancerous Conditions - chemically induced
  • Precancerous Conditions - prevention & control
  • Quinolines - administration & dosage
  • Quinolines - toxicity
  • Rats
  • Rats, Inbred F344
  • Tumors
ispartof: Cancer letters, 1999, Vol.143 (2), p.179-183
description: The cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5- f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF). We have used these end-points to identify potential chemopreventive agents that might be effective against heterocyclic amine colon carcinogens. Typically, IQ or PhIP were administered to groups of 10–15 rats by oral gavage on alternating days in weeks 3 and 4, and ACF were scored after 8, 12, or 16 weeks or tumors were detected at 52 weeks. To distinguish between ‘blocking’ and ‘suppressing’ agents, potential inhibitors were administered during the initiation or post-initiation phases, respectively, and subsequent studies focused on the inhibitory mechanisms. Among the most effective inhibitors identified to date, and their major mechanisms, were the following: chlorophyllin (molecular complex formation); indole-3-carbinol (inhibition and induction of cytochromes P450 and phase II enzymes); green and black tea catechins (induction of UDP-glucuronosyl transferase, inhibition of NADPH-cytochrome P450 reductase, scavenging of reactive intermediates); and conjugated linoleic acids (inhibition of cytochrome P450 and prostaglandin H synthase).
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0304-3835
fulltext: fulltext
issn:
  • 0304-3835
  • 1872-7980
url: Link


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titleChemoprevention studies of heterocyclic amine-induced colon carcinogenesis
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creatorXu, Meirong ; Dashwood, Roderick H
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descriptionThe cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5- f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF). We have used these end-points to identify potential chemopreventive agents that might be effective against heterocyclic amine colon carcinogens. Typically, IQ or PhIP were administered to groups of 10–15 rats by oral gavage on alternating days in weeks 3 and 4, and ACF were scored after 8, 12, or 16 weeks or tumors were detected at 52 weeks. To distinguish between ‘blocking’ and ‘suppressing’ agents, potential inhibitors were administered during the initiation or post-initiation phases, respectively, and subsequent studies focused on the inhibitory mechanisms. Among the most effective inhibitors identified to date, and their major mechanisms, were the following: chlorophyllin (molecular complex formation); indole-3-carbinol (inhibition and induction of cytochromes P450 and phase II enzymes); green and black tea catechins (induction of UDP-glucuronosyl transferase, inhibition of NADPH-cytochrome P450 reductase, scavenging of reactive intermediates); and conjugated linoleic acids (inhibition of cytochrome P450 and prostaglandin H synthase).
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languageeng
publisherShannon: Elsevier Ireland Ltd
subject2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine ; 2-amino-3-methylimidazo(4,5-f)quinoline ; Animals ; Anticarcinogenic Agents - pharmacology ; Anticarcinogenic Agents - therapeutic use ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogens - administration & dosage ; Carcinogens - toxicity ; Catechin - pharmacology ; Catechin - therapeutic use ; Chemoprevention ; Chlorophyllides - pharmacology ; Chlorophyllides - therapeutic use ; Colon - drug effects ; Colon - pathology ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - prevention & control ; Drug Antagonism ; Foods and miscellaneous ; heterocyclic amines ; Imidazoles - administration & dosage ; Imidazoles - toxicity ; Indoles - pharmacology ; Indoles - therapeutic use ; IQ ; Linoleic Acid - pharmacology ; Linoleic Acid - therapeutic use ; Medical sciences ; PhIP ; Precancerous Conditions - chemically induced ; Precancerous Conditions - prevention & control ; Quinolines - administration & dosage ; Quinolines - toxicity ; Rats ; Rats, Inbred F344 ; Tumors
ispartofCancer letters, 1999, Vol.143 (2), p.179-183
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addtitleCancer Lett
descriptionThe cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5- f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF). We have used these end-points to identify potential chemopreventive agents that might be effective against heterocyclic amine colon carcinogens. Typically, IQ or PhIP were administered to groups of 10–15 rats by oral gavage on alternating days in weeks 3 and 4, and ACF were scored after 8, 12, or 16 weeks or tumors were detected at 52 weeks. To distinguish between ‘blocking’ and ‘suppressing’ agents, potential inhibitors were administered during the initiation or post-initiation phases, respectively, and subsequent studies focused on the inhibitory mechanisms. Among the most effective inhibitors identified to date, and their major mechanisms, were the following: chlorophyllin (molecular complex formation); indole-3-carbinol (inhibition and induction of cytochromes P450 and phase II enzymes); green and black tea catechins (induction of UDP-glucuronosyl transferase, inhibition of NADPH-cytochrome P450 reductase, scavenging of reactive intermediates); and conjugated linoleic acids (inhibition of cytochrome P450 and prostaglandin H synthase).
subject
02-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
12-amino-3-methylimidazo(4,5-f)quinoline
2Animals
3Anticarcinogenic Agents - pharmacology
4Anticarcinogenic Agents - therapeutic use
5Biological and medical sciences
6Carcinogenesis, carcinogens and anticarcinogens
7Carcinogens - administration & dosage
8Carcinogens - toxicity
9Catechin - pharmacology
10Catechin - therapeutic use
11Chemoprevention
12Chlorophyllides - pharmacology
13Chlorophyllides - therapeutic use
14Colon - drug effects
15Colon - pathology
16Colonic Neoplasms - chemically induced
17Colonic Neoplasms - prevention & control
18Drug Antagonism
19Foods and miscellaneous
20heterocyclic amines
21Imidazoles - administration & dosage
22Imidazoles - toxicity
23Indoles - pharmacology
24Indoles - therapeutic use
25IQ
26Linoleic Acid - pharmacology
27Linoleic Acid - therapeutic use
28Medical sciences
29PhIP
30Precancerous Conditions - chemically induced
31Precancerous Conditions - prevention & control
32Quinolines - administration & dosage
33Quinolines - toxicity
34Rats
35Rats, Inbred F344
36Tumors
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titleChemoprevention studies of heterocyclic amine-induced colon carcinogenesis
authorXu, Meirong ; Dashwood, Roderick H
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02-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
12-amino-3-methylimidazo(4,5-f)quinoline
2Animals
3Anticarcinogenic Agents - pharmacology
4Anticarcinogenic Agents - therapeutic use
5Biological and medical sciences
6Carcinogenesis, carcinogens and anticarcinogens
7Carcinogens - administration & dosage
8Carcinogens - toxicity
9Catechin - pharmacology
10Catechin - therapeutic use
11Chemoprevention
12Chlorophyllides - pharmacology
13Chlorophyllides - therapeutic use
14Colon - drug effects
15Colon - pathology
16Colonic Neoplasms - chemically induced
17Colonic Neoplasms - prevention & control
18Drug Antagonism
19Foods and miscellaneous
20heterocyclic amines
21Imidazoles - administration & dosage
22Imidazoles - toxicity
23Indoles - pharmacology
24Indoles - therapeutic use
25IQ
26Linoleic Acid - pharmacology
27Linoleic Acid - therapeutic use
28Medical sciences
29PhIP
30Precancerous Conditions - chemically induced
31Precancerous Conditions - prevention & control
32Quinolines - administration & dosage
33Quinolines - toxicity
34Rats
35Rats, Inbred F344
36Tumors
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abstractThe cooking of meat and fish produces heterocyclic amine mutagens, including 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5- f]quinoline (IQ). Chronic administration of PhIP or IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of the colon, and short-term treatment leads to the formation of colonic aberrant crypt foci (ACF). We have used these end-points to identify potential chemopreventive agents that might be effective against heterocyclic amine colon carcinogens. Typically, IQ or PhIP were administered to groups of 10–15 rats by oral gavage on alternating days in weeks 3 and 4, and ACF were scored after 8, 12, or 16 weeks or tumors were detected at 52 weeks. To distinguish between ‘blocking’ and ‘suppressing’ agents, potential inhibitors were administered during the initiation or post-initiation phases, respectively, and subsequent studies focused on the inhibitory mechanisms. Among the most effective inhibitors identified to date, and their major mechanisms, were the following: chlorophyllin (molecular complex formation); indole-3-carbinol (inhibition and induction of cytochromes P450 and phase II enzymes); green and black tea catechins (induction of UDP-glucuronosyl transferase, inhibition of NADPH-cytochrome P450 reductase, scavenging of reactive intermediates); and conjugated linoleic acids (inhibition of cytochrome P450 and prostaglandin H synthase).
copShannon
pubElsevier Ireland Ltd
pmid10503900
doi10.1016/S0304-3835(99)00121-4