schliessen

Filtern

 

Bibliotheken

Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study

There are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1—98, 9... Full description

Journal Title: European journal of epidemiology 2012, Vol.27 (10), p.815-822
Main Author: Strandberg, Timo E
Other Authors: Strandberg, Arto Y , Saijonmaa, Outi , Tilvis, Reijo S , Pitkälä, Kaisu H , Fyhrquist, Frej
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Men
Publisher: Dordrecht: Springer
ID: ISSN: 0393-2990
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1758239828
title: Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study
format: Article
creator:
  • Strandberg, Timo E
  • Strandberg, Arto Y
  • Saijonmaa, Outi
  • Tilvis, Reijo S
  • Pitkälä, Kaisu H
  • Fyhrquist, Frej
subjects:
  • Age
  • Age Factors
  • Aged
  • AGEING
  • Aging
  • Alcohol drinking
  • Alcohol Drinking - adverse effects
  • Alcohol Drinking - epidemiology
  • Alcohol use
  • Alcoholic beverages
  • Alcohols
  • Biological and medical sciences
  • Businesspeople
  • Cancer
  • Cardiology
  • Chromosomes
  • Epidemiology
  • Finland - epidemiology
  • General aspects
  • Health Status
  • Humans
  • Infectious Diseases
  • Leukocytes
  • Male
  • Medical sciences
  • Medicine
  • Medicine & Public Health
  • Men
  • Middle Aged
  • Miscellaneous
  • Mortality
  • Oncology
  • Prospective Studies
  • Public Health
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Statistical median
  • Telomere Shortening - drug effects
  • Telomeres
ispartof: European journal of epidemiology, 2012, Vol.27 (10), p.815-822
description: There are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1—98, 99—196, 197—490, >490 g/week) has been repeatedly assessed until old age. In 2002/2003, leukocyte telomere length (LTL) and the proportion of short telomeres (less than 5 kilobases) were measured in a random subcohort of 499 men (mean age 76 years) using the Southern blot. Age-adjusted mean LTL in the 5 midlife alcohol consumption groups were 8.33, 8.24, 8.12, 8.13, and 7.87 kilobases, respectively (P < 0.001). The respective proportions (%) for short telomeres were 11.24, 11.52, 11.89, 12.08, and 13.47 (P = 0.004). The differences remained after further adjustments (ever smoking, body mass index, cholesterol, perceived fitness) for LTL (P = 0.03) and tended to remain for proportion of short telomeres (P = 0.07). Neither LTL, nor proportion of short telomeres, were associated with contemporary alcohol consumption groups in old age. Even minor alcohol consumption in midlife was significantly associated with shorter telomere length in old age. The differences represent an up to 10 year gap in biological age between zero and highest consumption.
language: eng
source:
identifier: ISSN: 0393-2990
fulltext: no_fulltext
issn:
  • 0393-2990
  • 1573-7284
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.5209954
LOCALfalse
PrimoNMBib
record
control
sourceidjstor_opena
recordidTN_cdi_proquest_miscellaneous_1758239828
sourceformatXML
sourcesystemPC
jstor_id23272517
sourcerecordid23272517
originalsourceidFETCH-LOGICAL-1571t-2ef41f621f0b74f14f95a165ff537490757edbc904246dc27bc7957eb9b705da0
addsrcrecordideNp9UsFuFSEUnRiNrdUPcKEhMSZupgIDw7CsjVpNExfWNWHgTh9PBp7AxLz48_L6nq3poqsbuOecey6HpnlJ8CnBWLzPBPectZjQVgo6tPhRc0y46Np6YI-bY9zJrqVS4qPmWc5rjPGAJX_aHFE6CM6wOG7-nOUcjdPFxYBGKL8BAtLexFX0yMSQl3lz03MBrUD7stqi2VnvJkA6WFTAxxkSIA_huqx2sOgtJDRDOEVXK0AX4LMLPx36sNQKOdcO-l4Wu33ePJm0z_DiUE-aH58-Xp1ftJffPn85P7ts6y6ktBQmRqaekgmPgk2ETZJr0vNp4p1gEgsuwI5GYkZZbw0VoxGy3o1yFJhbjU-ar3vduIGgXQK1SW7WaauidsoGKMrqoo0roCzpmAY8MCp0T4wE4J1mZCDUsqEbSBV7txfbpPhrgVzU7LIB73WAuGRFBB9oJwc6VOibe9B1XFKoqypCWDdgwehOkOxRJsWcE0y37ghWu5jVPmZVY1a7mBWunNcH5WWcwd4y_uVaAW8PAJ2N9lPSwbh8h-u5HFi_syjuDa-vcPMZStLOP2iB7pm5ioZrSP8t9wDp1Z60ziWmOzsdFZQTgf8CT5naHA
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1143807421
display
typearticle
titleAssociation between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study
creatorStrandberg, Timo E ; Strandberg, Arto Y ; Saijonmaa, Outi ; Tilvis, Reijo S ; Pitkälä, Kaisu H ; Fyhrquist, Frej
creatorcontribStrandberg, Timo E ; Strandberg, Arto Y ; Saijonmaa, Outi ; Tilvis, Reijo S ; Pitkälä, Kaisu H ; Fyhrquist, Frej
descriptionThere are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1—98, 99—196, 197—490, >490 g/week) has been repeatedly assessed until old age. In 2002/2003, leukocyte telomere length (LTL) and the proportion of short telomeres (less than 5 kilobases) were measured in a random subcohort of 499 men (mean age 76 years) using the Southern blot. Age-adjusted mean LTL in the 5 midlife alcohol consumption groups were 8.33, 8.24, 8.12, 8.13, and 7.87 kilobases, respectively (P < 0.001). The respective proportions (%) for short telomeres were 11.24, 11.52, 11.89, 12.08, and 13.47 (P = 0.004). The differences remained after further adjustments (ever smoking, body mass index, cholesterol, perceived fitness) for LTL (P = 0.03) and tended to remain for proportion of short telomeres (P = 0.07). Neither LTL, nor proportion of short telomeres, were associated with contemporary alcohol consumption groups in old age. Even minor alcohol consumption in midlife was significantly associated with shorter telomere length in old age. The differences represent an up to 10 year gap in biological age between zero and highest consumption.
identifier
0ISSN: 0393-2990
1EISSN: 1573-7284
2DOI: 10.1007/s10654-012-9728-0
3PMID: 22875407
4CODEN: EJEPE8
languageeng
publisherDordrecht: Springer
subjectAge ; Age Factors ; Aged ; AGEING ; Aging ; Alcohol drinking ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Alcoholic beverages ; Alcohols ; Biological and medical sciences ; Businesspeople ; Cancer ; Cardiology ; Chromosomes ; Epidemiology ; Finland - epidemiology ; General aspects ; Health Status ; Humans ; Infectious Diseases ; Leukocytes ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Men ; Middle Aged ; Miscellaneous ; Mortality ; Oncology ; Prospective Studies ; Public Health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Statistical median ; Telomere Shortening - drug effects ; Telomeres
ispartofEuropean journal of epidemiology, 2012, Vol.27 (10), p.815-822
rights
0Springer Science+Business Media Dordrecht 2012
1Springer Science+Business Media B.V. 2012
22015 INIST-CNRS
lds50peer_reviewed
citedbyFETCH-LOGICAL-1571t-2ef41f621f0b74f14f95a165ff537490757edbc904246dc27bc7957eb9b705da0
citesFETCH-LOGICAL-1571t-2ef41f621f0b74f14f95a165ff537490757edbc904246dc27bc7957eb9b705da0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26598468$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22875407$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Strandberg, Timo E
1Strandberg, Arto Y
2Saijonmaa, Outi
3Tilvis, Reijo S
4Pitkälä, Kaisu H
5Fyhrquist, Frej
title
0Association between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study
1European journal of epidemiology
addtitle
0Eur J Epidemiol
1Eur J Epidemiol
descriptionThere are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1—98, 99—196, 197—490, >490 g/week) has been repeatedly assessed until old age. In 2002/2003, leukocyte telomere length (LTL) and the proportion of short telomeres (less than 5 kilobases) were measured in a random subcohort of 499 men (mean age 76 years) using the Southern blot. Age-adjusted mean LTL in the 5 midlife alcohol consumption groups were 8.33, 8.24, 8.12, 8.13, and 7.87 kilobases, respectively (P < 0.001). The respective proportions (%) for short telomeres were 11.24, 11.52, 11.89, 12.08, and 13.47 (P = 0.004). The differences remained after further adjustments (ever smoking, body mass index, cholesterol, perceived fitness) for LTL (P = 0.03) and tended to remain for proportion of short telomeres (P = 0.07). Neither LTL, nor proportion of short telomeres, were associated with contemporary alcohol consumption groups in old age. Even minor alcohol consumption in midlife was significantly associated with shorter telomere length in old age. The differences represent an up to 10 year gap in biological age between zero and highest consumption.
subject
0Age
1Age Factors
2Aged
3AGEING
4Aging
5Alcohol drinking
6Alcohol Drinking - adverse effects
7Alcohol Drinking - epidemiology
8Alcohol use
9Alcoholic beverages
10Alcohols
11Biological and medical sciences
12Businesspeople
13Cancer
14Cardiology
15Chromosomes
16Epidemiology
17Finland - epidemiology
18General aspects
19Health Status
20Humans
21Infectious Diseases
22Leukocytes
23Male
24Medical sciences
25Medicine
26Medicine & Public Health
27Men
28Middle Aged
29Miscellaneous
30Mortality
31Oncology
32Prospective Studies
33Public Health
34Public health. Hygiene
35Public health. Hygiene-occupational medicine
36Statistical median
37Telomere Shortening - drug effects
38Telomeres
issn
00393-2990
11573-7284
fulltextfalse
rsrctypearticle
creationdate2012
recordtypearticle
recordideNp9UsFuFSEUnRiNrdUPcKEhMSZupgIDw7CsjVpNExfWNWHgTh9PBp7AxLz48_L6nq3poqsbuOecey6HpnlJ8CnBWLzPBPectZjQVgo6tPhRc0y46Np6YI-bY9zJrqVS4qPmWc5rjPGAJX_aHFE6CM6wOG7-nOUcjdPFxYBGKL8BAtLexFX0yMSQl3lz03MBrUD7stqi2VnvJkA6WFTAxxkSIA_huqx2sOgtJDRDOEVXK0AX4LMLPx36sNQKOdcO-l4Wu33ePJm0z_DiUE-aH58-Xp1ftJffPn85P7ts6y6ktBQmRqaekgmPgk2ETZJr0vNp4p1gEgsuwI5GYkZZbw0VoxGy3o1yFJhbjU-ar3vduIGgXQK1SW7WaauidsoGKMrqoo0roCzpmAY8MCp0T4wE4J1mZCDUsqEbSBV7txfbpPhrgVzU7LIB73WAuGRFBB9oJwc6VOibe9B1XFKoqypCWDdgwehOkOxRJsWcE0y37ghWu5jVPmZVY1a7mBWunNcH5WWcwd4y_uVaAW8PAJ2N9lPSwbh8h-u5HFi_syjuDa-vcPMZStLOP2iB7pm5ioZrSP8t9wDp1Z60ziWmOzsdFZQTgf8CT5naHA
startdate20120101
enddate20120101
creator
0Strandberg, Timo E
1Strandberg, Arto Y
2Saijonmaa, Outi
3Tilvis, Reijo S
4Pitkälä, Kaisu H
5Fyhrquist, Frej
general
0Springer
1Springer Netherlands
2Springer Nature B.V
3Springer Science and Business Media LLC
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
93V.
107QL
117T2
127TK
137TS
147U7
157U9
167X7
177XB
1888C
1988E
208AO
218C1
228FI
238FJ
248FK
258G5
26ABUWG
27AZQEC
28BENPR
29C1K
30DWQXO
31FYUFA
32GHDGH
33GNUQQ
34GUQSH
35H94
36K9.
37M0S
38M0T
39M1P
40M2O
41MBDVC
42PADUT
43PQEST
44PQQKQ
45PQUKI
46PRINS
47Q9U
488FD
49FR3
50P64
51RC3
52CLFQK
sort
creationdate20120101
titleAssociation between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study
authorStrandberg, Timo E ; Strandberg, Arto Y ; Saijonmaa, Outi ; Tilvis, Reijo S ; Pitkälä, Kaisu H ; Fyhrquist, Frej
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1571t-2ef41f621f0b74f14f95a165ff537490757edbc904246dc27bc7957eb9b705da0
rsrctypearticles
prefilterarticles
languageeng
creationdate2012
topic
0Age
1Age Factors
2Aged
3AGEING
4Aging
5Alcohol drinking
6Alcohol Drinking - adverse effects
7Alcohol Drinking - epidemiology
8Alcohol use
9Alcoholic beverages
10Alcohols
11Biological and medical sciences
12Businesspeople
13Cancer
14Cardiology
15Chromosomes
16Epidemiology
17Finland - epidemiology
18General aspects
19Health Status
20Humans
21Infectious Diseases
22Leukocytes
23Male
24Medical sciences
25Medicine
26Medicine & Public Health
27Men
28Middle Aged
29Miscellaneous
30Mortality
31Oncology
32Prospective Studies
33Public Health
34Public health. Hygiene
35Public health. Hygiene-occupational medicine
36Statistical median
37Telomere Shortening - drug effects
38Telomeres
toplevelpeer_reviewed
creatorcontrib
0Strandberg, Timo E
1Strandberg, Arto Y
2Saijonmaa, Outi
3Tilvis, Reijo S
4Pitkälä, Kaisu H
5Fyhrquist, Frej
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8ProQuest Central (Corporate)
9Bacteriology Abstracts (Microbiology B)
10Health and Safety Science Abstracts (Full archive)
11Neurosciences Abstracts
12Physical Education Index
13Toxicology Abstracts
14Virology and AIDS Abstracts
15Health & Medical Collection
16ProQuest Central (purchase pre-March 2016)
17Healthcare Administration Database (Alumni)
18Medical Database (Alumni Edition)
19ProQuest Pharma Collection
20Public Health Database
21Hospital Premium Collection
22Hospital Premium Collection (Alumni Edition)
23ProQuest Central (Alumni) (purchase pre-March 2016)
24Research Library (Alumni Edition)
25ProQuest Central (Alumni Edition)
26ProQuest Central Essentials
27ProQuest Central
28Environmental Sciences and Pollution Management
29ProQuest Central Korea
30Health Research Premium Collection
31Health Research Premium Collection (Alumni)
32ProQuest Central Student
33Research Library Prep
34AIDS and Cancer Research Abstracts
35ProQuest Health & Medical Complete (Alumni)
36Health & Medical Collection (Alumni Edition)
37Healthcare Administration Database
38Medical Database
39Research Library
40Research Library (Corporate)
41Research Library China
42ProQuest One Academic Eastern Edition
43ProQuest One Academic
44ProQuest One Academic UKI Edition
45ProQuest Central China
46ProQuest Central Basic
47Technology Research Database
48Engineering Research Database
49Biotechnology and BioEngineering Abstracts
50Genetics Abstracts
51OpenAIRE
jtitleEuropean journal of epidemiology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Strandberg, Timo E
1Strandberg, Arto Y
2Saijonmaa, Outi
3Tilvis, Reijo S
4Pitkälä, Kaisu H
5Fyhrquist, Frej
formatjournal
genrearticle
ristypeJOUR
atitleAssociation between alcohol consumption in healthy midlife and telomere length in older men. The Helsinki Businessmen Study
jtitleEuropean journal of epidemiology
stitleEur J Epidemiol
addtitleEur J Epidemiol
date2012-01-01
risdate2012
volume27
issue10
spage815
epage822
pages815-822
issn0393-2990
eissn1573-7284
codenEJEPE8
abstractThere are scarce data of alcohol consumption and telomere length, an indicator of biological age. In 1974, detailed alcohol consumption was available for a socioeconomically homogenous cohort of middle-aged men (The Helsinki Businessmen Study). Their alcohol use, divided into 5 groups (zero, 1—98, 99—196, 197—490, >490 g/week) has been repeatedly assessed until old age. In 2002/2003, leukocyte telomere length (LTL) and the proportion of short telomeres (less than 5 kilobases) were measured in a random subcohort of 499 men (mean age 76 years) using the Southern blot. Age-adjusted mean LTL in the 5 midlife alcohol consumption groups were 8.33, 8.24, 8.12, 8.13, and 7.87 kilobases, respectively (P < 0.001). The respective proportions (%) for short telomeres were 11.24, 11.52, 11.89, 12.08, and 13.47 (P = 0.004). The differences remained after further adjustments (ever smoking, body mass index, cholesterol, perceived fitness) for LTL (P = 0.03) and tended to remain for proportion of short telomeres (P = 0.07). Neither LTL, nor proportion of short telomeres, were associated with contemporary alcohol consumption groups in old age. Even minor alcohol consumption in midlife was significantly associated with shorter telomere length in old age. The differences represent an up to 10 year gap in biological age between zero and highest consumption.
copDordrecht
pubSpringer
pmid22875407
doi10.1007/s10654-012-9728-0