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Cystatin C- and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing Highly Active Antiretroviral Therapy

Background We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured glomerular filtration rate in an antiretroviral-naive human immunodeficiency virus population. Methods The study population consi... Full description

Journal Title: Annals of clinical biochemistry 2016, Vol.53 (1), p.58-66
Main Author: Seape, Tebogo
Other Authors: Gounden, Verena , van Deventer, Hendrick E , Candy, Geoffrey P , George, Jaya A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: London, England: SAGE Publications
ID: ISSN: 0004-5632
Link: https://www.ncbi.nlm.nih.gov/pubmed/25766385
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title: Cystatin C- and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing Highly Active Antiretroviral Therapy
format: Article
creator:
  • Seape, Tebogo
  • Gounden, Verena
  • van Deventer, Hendrick E
  • Candy, Geoffrey P
  • George, Jaya A
subjects:
  • Adult
  • Antiretroviral Therapy, Highly Active
  • Creatinine - blood
  • Cross-Sectional Studies
  • Cystatin C - blood
  • Female
  • Glomerular Filtration Rate
  • HIV Infections - blood
  • HIV Infections - drug therapy
  • HIV Infections - physiopathology
  • Human immunodeficiency virus
  • Humans
  • Kidney Function Tests - methods
  • Kidney Function Tests - standards
  • Male
  • Reference Standards
ispartof: Annals of clinical biochemistry, 2016, Vol.53 (1), p.58-66
description: Background We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured glomerular filtration rate in an antiretroviral-naive human immunodeficiency virus population. Methods The study population consisted of 100 treatment-naive HIV patients. Glomerular filtration rate was estimated using the Cockcroft–Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, as well as cystatin C-based equations (CKD-EPIcystatin C, cystatin Cvan Deventer and CKD-EPIcombined)) compared to 51Cr-EDTA plasma clearance-measured glomerular filtration rate. We calculated percentage bias, standard deviation of the differences, accuracy within 15 and 30% of measured glomerular filtration rate and sensitivity and specificity for predicting measured glomerular filtration rate
language: eng
source:
identifier: ISSN: 0004-5632
fulltext: no_fulltext
issn:
  • 0004-5632
  • 1758-1001
url: Link


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titleCystatin C- and creatinine-based equations in the assessment of renal function in HIV-positive patients prior to commencing Highly Active Antiretroviral Therapy
creatorSeape, Tebogo ; Gounden, Verena ; van Deventer, Hendrick E ; Candy, Geoffrey P ; George, Jaya A
creatorcontribSeape, Tebogo ; Gounden, Verena ; van Deventer, Hendrick E ; Candy, Geoffrey P ; George, Jaya A
descriptionBackground We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured glomerular filtration rate in an antiretroviral-naive human immunodeficiency virus population. Methods The study population consisted of 100 treatment-naive HIV patients. Glomerular filtration rate was estimated using the Cockcroft–Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, as well as cystatin C-based equations (CKD-EPIcystatin C, cystatin Cvan Deventer and CKD-EPIcombined)) compared to 51Cr-EDTA plasma clearance-measured glomerular filtration rate. We calculated percentage bias, standard deviation of the differences, accuracy within 15 and 30% of measured glomerular filtration rate and sensitivity and specificity for predicting measured glomerular filtration rate <60 mL/min/1.73 m2. Results Bias for all estimating glomerular filtration rate equations ranged from −9.4% to 38.4%. The CKD-EPIcombined without ethnicity correction factor equation had the least bias, 2.9% (−2.9 to 8.8). Bias was higher for the Modification of Diet in Renal Disease and CKD-EPI equation with the African–American ethnicity factor (38.4 and 33.7%) than without (14.2 and 15.3%). Standard deviation of the differences ranged from 29.2% (CKD-EPIcombined without ethnicity factor) to 54.0% (Modification of Diet in Renal Disease with ethnicity factor). Accuracy within 30% of measured glomerular filtration rate ranged from 78% for CKD-EPIcombined without ethnicity factor to 56.7% for the Cockcroft–Gault equation. Sensitivity for creatinine-based equations was less than 50% and for the CKD-EPIcystatin C equation was 75%. Conclusion Sensitivity of creatinine-based equations for predicting glomerular filtration rate was poor in this group of patients. The CKD-EPIcombined equation performed better than creatinine-based equations.
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subjectAdult ; Antiretroviral Therapy, Highly Active ; Creatinine - blood ; Cross-Sectional Studies ; Cystatin C - blood ; Female ; Glomerular Filtration Rate ; HIV Infections - blood ; HIV Infections - drug therapy ; HIV Infections - physiopathology ; Human immunodeficiency virus ; Humans ; Kidney Function Tests - methods ; Kidney Function Tests - standards ; Male ; Reference Standards
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descriptionBackground We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured glomerular filtration rate in an antiretroviral-naive human immunodeficiency virus population. Methods The study population consisted of 100 treatment-naive HIV patients. Glomerular filtration rate was estimated using the Cockcroft–Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, as well as cystatin C-based equations (CKD-EPIcystatin C, cystatin Cvan Deventer and CKD-EPIcombined)) compared to 51Cr-EDTA plasma clearance-measured glomerular filtration rate. We calculated percentage bias, standard deviation of the differences, accuracy within 15 and 30% of measured glomerular filtration rate and sensitivity and specificity for predicting measured glomerular filtration rate <60 mL/min/1.73 m2. Results Bias for all estimating glomerular filtration rate equations ranged from −9.4% to 38.4%. The CKD-EPIcombined without ethnicity correction factor equation had the least bias, 2.9% (−2.9 to 8.8). Bias was higher for the Modification of Diet in Renal Disease and CKD-EPI equation with the African–American ethnicity factor (38.4 and 33.7%) than without (14.2 and 15.3%). Standard deviation of the differences ranged from 29.2% (CKD-EPIcombined without ethnicity factor) to 54.0% (Modification of Diet in Renal Disease with ethnicity factor). Accuracy within 30% of measured glomerular filtration rate ranged from 78% for CKD-EPIcombined without ethnicity factor to 56.7% for the Cockcroft–Gault equation. Sensitivity for creatinine-based equations was less than 50% and for the CKD-EPIcystatin C equation was 75%. Conclusion Sensitivity of creatinine-based equations for predicting glomerular filtration rate was poor in this group of patients. The CKD-EPIcombined equation performed better than creatinine-based equations.
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abstractBackground We evaluated the accuracy and precision of creatinine- and cystatin C-based prediction equations for estimating glomerular filtration rate compared to measured glomerular filtration rate in an antiretroviral-naive human immunodeficiency virus population. Methods The study population consisted of 100 treatment-naive HIV patients. Glomerular filtration rate was estimated using the Cockcroft–Gault, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, as well as cystatin C-based equations (CKD-EPIcystatin C, cystatin Cvan Deventer and CKD-EPIcombined)) compared to 51Cr-EDTA plasma clearance-measured glomerular filtration rate. We calculated percentage bias, standard deviation of the differences, accuracy within 15 and 30% of measured glomerular filtration rate and sensitivity and specificity for predicting measured glomerular filtration rate <60 mL/min/1.73 m2. Results Bias for all estimating glomerular filtration rate equations ranged from −9.4% to 38.4%. The CKD-EPIcombined without ethnicity correction factor equation had the least bias, 2.9% (−2.9 to 8.8). Bias was higher for the Modification of Diet in Renal Disease and CKD-EPI equation with the African–American ethnicity factor (38.4 and 33.7%) than without (14.2 and 15.3%). Standard deviation of the differences ranged from 29.2% (CKD-EPIcombined without ethnicity factor) to 54.0% (Modification of Diet in Renal Disease with ethnicity factor). Accuracy within 30% of measured glomerular filtration rate ranged from 78% for CKD-EPIcombined without ethnicity factor to 56.7% for the Cockcroft–Gault equation. Sensitivity for creatinine-based equations was less than 50% and for the CKD-EPIcystatin C equation was 75%. Conclusion Sensitivity of creatinine-based equations for predicting glomerular filtration rate was poor in this group of patients. The CKD-EPIcombined equation performed better than creatinine-based equations.
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doi10.1177/0004563215579695
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