schliessen

Filtern

 

Bibliotheken

Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study

Summary Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associatio... Full description

Journal Title: The Lancet (British edition) 2015, Vol.386 (10007), p.1945-1954
Main Author: Smyth, Andrew, Dr
Other Authors: Teo, Koon K, Prof , Rangarajan, Sumathy, MSc , O'Donnell, Martin, PhD , Zhang, Xiaohe, MSc , Rana, Punam, MD , Leong, Darryl P, PhD , Dagenais, Gilles, Prof , Seron, Pamela, MSc , Rosengren, Annika, Prof , Schutte, Aletta E, Prof , Lopez-Jaramillo, Patricio, Prof , Oguz, Ayetkin, Prof , Chifamba, Jephat, MPhil , Diaz, Rafael, MD , Lear, Scott, Prof , Avezum, Alvaro, PhD , Kumar, Rajesh, MD , Mohan, Viswanathan, MD , Szuba, Andrzej, Prof , Wei, Li, PhD , Yang, Wang, MD , Jian, Bo, BSc , McKee, Martin, Prof , Yusuf, Salim, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Link: https://www.ncbi.nlm.nih.gov/pubmed/26386538
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1762961960
title: Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
format: Article
creator:
  • Smyth, Andrew, Dr
  • Teo, Koon K, Prof
  • Rangarajan, Sumathy, MSc
  • O'Donnell, Martin, PhD
  • Zhang, Xiaohe, MSc
  • Rana, Punam, MD
  • Leong, Darryl P, PhD
  • Dagenais, Gilles, Prof
  • Seron, Pamela, MSc
  • Rosengren, Annika, Prof
  • Schutte, Aletta E, Prof
  • Lopez-Jaramillo, Patricio, Prof
  • Oguz, Ayetkin, Prof
  • Chifamba, Jephat, MPhil
  • Diaz, Rafael, MD
  • Lear, Scott, Prof
  • Avezum, Alvaro, PhD
  • Kumar, Rajesh, MD
  • Mohan, Viswanathan, MD
  • Szuba, Andrzej, Prof
  • Wei, Li, PhD
  • Yang, Wang, MD
  • Jian, Bo, BSc
  • McKee, Martin, Prof
  • Yusuf, Salim, Prof
subjects:
  • Abridged Index Medicus
  • Admission and discharge
  • Adult
  • Aged
  • Alcohol Drinking - epidemiology
  • Alcohol use
  • Alcoholic beverages
  • Alcohols
  • Analysis
  • Blood pressure
  • Canada
  • Cancer
  • Cardiovascular disease
  • Cardiovascular diseases
  • Cardiovascular Diseases - epidemiology
  • Cerebral infarction
  • Cohort Studies
  • Consumption
  • Developed Countries
  • Developing Countries
  • Drinking behavior
  • Drinking of alcoholic beverages
  • Epidemiology
  • Female
  • Hazard identification
  • Health aspects
  • Health hazards
  • Health risk assessment
  • Heart attack
  • Heart attacks
  • Hospitalization
  • Hospitalization - statistics & numerical data
  • Hospitals
  • Humans
  • Hypertension
  • Income
  • India
  • Injuries
  • Internal Medicine
  • Male
  • Middle Aged
  • Mortality
  • Myocardial infarction
  • Neoplasms - epidemiology
  • Oncology, Experimental
  • Pharmaceuticals
  • Proportional Hazards Models
  • Public health
  • Risk analysis
  • Risk factors
  • Smoking
  • Stroke
  • Variables
  • Womens health
  • Wounds and Injuries - epidemiology
ispartof: The Lancet (British edition), 2015, Vol.386 (10007), p.1945-1954
description: Summary Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents. Methods We included information from 12 countries participating in the Prospective Urban Rural Epidemiological (PURE) study, a prospective cohort study of individuals aged 35–70 years. We used Cox proportional hazards regression to study associations with mortality (n=2723), cardiovascular disease (n=2742), myocardial infarction (n=979), stroke (n=817), alcohol-related cancer (n=764), injury (n=824), admission to hospital (n=8786), and for a composite of these outcomes (n=11 963). Findings We included 114 970 adults, of whom 12 904 (11%) were from high-income countries (HICs), 24 408 (21%) were from upper-middle-income countries (UMICs), 48 845 (43%) were from lower-middle-income countries (LMICs), and 28 813 (25%) were from low-income countries (LICs). Median follow-up was 4·3 years (IQR 3·0–6·0). Current drinking was reported by 36 030 (31%) individuals, and was associated with reduced myocardial infarction (hazard ratio [HR] 0·76 [95% CI 0·63–0·93]), but increased alcohol-related cancers (HR 1·51 [1·22–1·89]) and injury (HR 1·29 [1·04–1·61]). High intake was associated with increased mortality (HR 1·31 [1·04–1·66]). Compared with never drinkers, we identified significantly reduced hazards for the composite outcome for current drinkers in HICs and UMICs (HR 0·84 [0·77–0·92]), but not in LMICs and LICs, for which we identified no reductions in this outcome (HR 1·07 [0·95–1·21]; pinteraction
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.7349052
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1762961960
sourceformatXML
sourcesystemPC
galeidA435957359
sourcerecordidA435957359
originalsourceidFETCH-LOGICAL-c752t-1c6ce7421551857f96b52312a22132126a214b36616b2327c2dff139fad84d643
addsrcrecordideNqVk--L0zAYx4so3jz9E5SCICesZ353VVDG4S848IUKvgtZkm6ZabNL0sHe-aebbnrrjXGnFNqQfp7v86T9frPsKQTnEED26iuABBSsxOwM0pcAIEwLci8bQVKSgpLyx_1sdI2cZI9CWAIACAP0YXaCGJ4wiiej7NfUSrdwNpeuDV2zisa1uWhVLoVXxq1FkJ0VPlcmaBH0OO23Uvtxbtpl5zfjXKjGhNBXRZcvXFiZKOx4K9E4n9Ymbl7nIl_59E7LaNY67zv6mIfYqc3j7EEtbNBP_jxPs-8f3n-7-FRcfvn4-WJ6WciSolhAyaQuCYKUwgkt64rNKMIQCYQgRhAxgSCZYcYgmyGMSolUXUNc1UJNiGIEn2ZnO900yFWnQ-RpbqmtFa12XeCwZKhisGIgoc8P0KXrfJum44hUFaYVK6vbKFhiNKG4JJM9NRdWc9PWLnoh-9Z8yighJCneTpHUj5bplqjzI1S6lG5M-n-6Nmn_huw_FQw7PDtSwIeKR4GhwosBsNDCxkVwtut9FW7ONh6Asy6YVicftcHMFzHMRRf-Hx-OQXe4TLYLXtd85U0j_IZDwPv88G1-eB8ODinf5oeT_flW3azR6rrqb2AS8OZAWCbD96dLH8LYO-Xf7ap1cvraaM-DNDoFShmfssGVM3cqvD1QkNa0Rgr7U2902FuQB8TBTqTXgHSrQPBv43FI_Q
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1732853748
display
typearticle
titleAlcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
sourceAlma/SFX Local Collection
creatorSmyth, Andrew, Dr ; Teo, Koon K, Prof ; Rangarajan, Sumathy, MSc ; O'Donnell, Martin, PhD ; Zhang, Xiaohe, MSc ; Rana, Punam, MD ; Leong, Darryl P, PhD ; Dagenais, Gilles, Prof ; Seron, Pamela, MSc ; Rosengren, Annika, Prof ; Schutte, Aletta E, Prof ; Lopez-Jaramillo, Patricio, Prof ; Oguz, Ayetkin, Prof ; Chifamba, Jephat, MPhil ; Diaz, Rafael, MD ; Lear, Scott, Prof ; Avezum, Alvaro, PhD ; Kumar, Rajesh, MD ; Mohan, Viswanathan, MD ; Szuba, Andrzej, Prof ; Wei, Li, PhD ; Yang, Wang, MD ; Jian, Bo, BSc ; McKee, Martin, Prof ; Yusuf, Salim, Prof
creatorcontribSmyth, Andrew, Dr ; Teo, Koon K, Prof ; Rangarajan, Sumathy, MSc ; O'Donnell, Martin, PhD ; Zhang, Xiaohe, MSc ; Rana, Punam, MD ; Leong, Darryl P, PhD ; Dagenais, Gilles, Prof ; Seron, Pamela, MSc ; Rosengren, Annika, Prof ; Schutte, Aletta E, Prof ; Lopez-Jaramillo, Patricio, Prof ; Oguz, Ayetkin, Prof ; Chifamba, Jephat, MPhil ; Diaz, Rafael, MD ; Lear, Scott, Prof ; Avezum, Alvaro, PhD ; Kumar, Rajesh, MD ; Mohan, Viswanathan, MD ; Szuba, Andrzej, Prof ; Wei, Li, PhD ; Yang, Wang, MD ; Jian, Bo, BSc ; McKee, Martin, Prof ; Yusuf, Salim, Prof ; PURE Investigators
descriptionSummary Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents. Methods We included information from 12 countries participating in the Prospective Urban Rural Epidemiological (PURE) study, a prospective cohort study of individuals aged 35–70 years. We used Cox proportional hazards regression to study associations with mortality (n=2723), cardiovascular disease (n=2742), myocardial infarction (n=979), stroke (n=817), alcohol-related cancer (n=764), injury (n=824), admission to hospital (n=8786), and for a composite of these outcomes (n=11 963). Findings We included 114 970 adults, of whom 12 904 (11%) were from high-income countries (HICs), 24 408 (21%) were from upper-middle-income countries (UMICs), 48 845 (43%) were from lower-middle-income countries (LMICs), and 28 813 (25%) were from low-income countries (LICs). Median follow-up was 4·3 years (IQR 3·0–6·0). Current drinking was reported by 36 030 (31%) individuals, and was associated with reduced myocardial infarction (hazard ratio [HR] 0·76 [95% CI 0·63–0·93]), but increased alcohol-related cancers (HR 1·51 [1·22–1·89]) and injury (HR 1·29 [1·04–1·61]). High intake was associated with increased mortality (HR 1·31 [1·04–1·66]). Compared with never drinkers, we identified significantly reduced hazards for the composite outcome for current drinkers in HICs and UMICs (HR 0·84 [0·77–0·92]), but not in LMICs and LICs, for which we identified no reductions in this outcome (HR 1·07 [0·95–1·21]; pinteraction <0·0001). Interpretation Current alcohol consumption had differing associations by clinical outcome, and differing associations by income region. However, we identified sufficient commonalities to support global health strategies and national initiatives to reduce harmful alcohol use. Funding Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, AstraZeneca (Canada), Sanofi-Aventis (France and Canada), Boehringer Ingelheim (Germany and Canada), Servier, GlaxoSmithKline, Novartis, King Pharma, and national or local organisations in participating countries.
identifier
0ISSN: 0140-6736
1EISSN: 1474-547X
2DOI: 10.1016/S0140-6736(15)00235-4
3PMID: 26386538
4CODEN: LANCAO
languageeng
publisherEngland: Elsevier Ltd
subjectAbridged Index Medicus ; Admission and discharge ; Adult ; Aged ; Alcohol Drinking - epidemiology ; Alcohol use ; Alcoholic beverages ; Alcohols ; Analysis ; Blood pressure ; Canada ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cerebral infarction ; Cohort Studies ; Consumption ; Developed Countries ; Developing Countries ; Drinking behavior ; Drinking of alcoholic beverages ; Epidemiology ; Female ; Hazard identification ; Health aspects ; Health hazards ; Health risk assessment ; Heart attack ; Heart attacks ; Hospitalization ; Hospitalization - statistics & numerical data ; Hospitals ; Humans ; Hypertension ; Income ; India ; Injuries ; Internal Medicine ; Male ; Middle Aged ; Mortality ; Myocardial infarction ; Neoplasms - epidemiology ; Oncology, Experimental ; Pharmaceuticals ; Proportional Hazards Models ; Public health ; Risk analysis ; Risk factors ; Smoking ; Stroke ; Variables ; Womens health ; Wounds and Injuries - epidemiology
ispartofThe Lancet (British edition), 2015, Vol.386 (10007), p.1945-1954
rights
0Elsevier Ltd
12015 Elsevier Ltd
2Copyright © 2015 Elsevier Ltd. All rights reserved.
3COPYRIGHT 2015 Elsevier B.V.
4Copyright Elsevier Limited Nov 14, 2015
52015. Elsevier Ltd
lds50peer_reviewed
citedbyFETCH-LOGICAL-c752t-1c6ce7421551857f96b52312a22132126a214b36616b2327c2dff139fad84d643
citesFETCH-LOGICAL-c752t-1c6ce7421551857f96b52312a22132126a214b36616b2327c2dff139fad84d643
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26386538$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Smyth, Andrew, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3O'Donnell, Martin, PhD
4Zhang, Xiaohe, MSc
5Rana, Punam, MD
6Leong, Darryl P, PhD
7Dagenais, Gilles, Prof
8Seron, Pamela, MSc
9Rosengren, Annika, Prof
10Schutte, Aletta E, Prof
11Lopez-Jaramillo, Patricio, Prof
12Oguz, Ayetkin, Prof
13Chifamba, Jephat, MPhil
14Diaz, Rafael, MD
15Lear, Scott, Prof
16Avezum, Alvaro, PhD
17Kumar, Rajesh, MD
18Mohan, Viswanathan, MD
19Szuba, Andrzej, Prof
20Wei, Li, PhD
21Yang, Wang, MD
22Jian, Bo, BSc
23McKee, Martin, Prof
24Yusuf, Salim, Prof
25PURE Investigators
title
0Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
1The Lancet (British edition)
addtitleLancet
descriptionSummary Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents. Methods We included information from 12 countries participating in the Prospective Urban Rural Epidemiological (PURE) study, a prospective cohort study of individuals aged 35–70 years. We used Cox proportional hazards regression to study associations with mortality (n=2723), cardiovascular disease (n=2742), myocardial infarction (n=979), stroke (n=817), alcohol-related cancer (n=764), injury (n=824), admission to hospital (n=8786), and for a composite of these outcomes (n=11 963). Findings We included 114 970 adults, of whom 12 904 (11%) were from high-income countries (HICs), 24 408 (21%) were from upper-middle-income countries (UMICs), 48 845 (43%) were from lower-middle-income countries (LMICs), and 28 813 (25%) were from low-income countries (LICs). Median follow-up was 4·3 years (IQR 3·0–6·0). Current drinking was reported by 36 030 (31%) individuals, and was associated with reduced myocardial infarction (hazard ratio [HR] 0·76 [95% CI 0·63–0·93]), but increased alcohol-related cancers (HR 1·51 [1·22–1·89]) and injury (HR 1·29 [1·04–1·61]). High intake was associated with increased mortality (HR 1·31 [1·04–1·66]). Compared with never drinkers, we identified significantly reduced hazards for the composite outcome for current drinkers in HICs and UMICs (HR 0·84 [0·77–0·92]), but not in LMICs and LICs, for which we identified no reductions in this outcome (HR 1·07 [0·95–1·21]; pinteraction <0·0001). Interpretation Current alcohol consumption had differing associations by clinical outcome, and differing associations by income region. However, we identified sufficient commonalities to support global health strategies and national initiatives to reduce harmful alcohol use. Funding Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, AstraZeneca (Canada), Sanofi-Aventis (France and Canada), Boehringer Ingelheim (Germany and Canada), Servier, GlaxoSmithKline, Novartis, King Pharma, and national or local organisations in participating countries.
subject
0Abridged Index Medicus
1Admission and discharge
2Adult
3Aged
4Alcohol Drinking - epidemiology
5Alcohol use
6Alcoholic beverages
7Alcohols
8Analysis
9Blood pressure
10Canada
11Cancer
12Cardiovascular disease
13Cardiovascular diseases
14Cardiovascular Diseases - epidemiology
15Cerebral infarction
16Cohort Studies
17Consumption
18Developed Countries
19Developing Countries
20Drinking behavior
21Drinking of alcoholic beverages
22Epidemiology
23Female
24Hazard identification
25Health aspects
26Health hazards
27Health risk assessment
28Heart attack
29Heart attacks
30Hospitalization
31Hospitalization - statistics & numerical data
32Hospitals
33Humans
34Hypertension
35Income
36India
37Injuries
38Internal Medicine
39Male
40Middle Aged
41Mortality
42Myocardial infarction
43Neoplasms - epidemiology
44Oncology, Experimental
45Pharmaceuticals
46Proportional Hazards Models
47Public health
48Risk analysis
49Risk factors
50Smoking
51Stroke
52Variables
53Womens health
54Wounds and Injuries - epidemiology
issn
00140-6736
11474-547X
fulltexttrue
rsrctypearticle
creationdate2015
recordtypearticle
recordideNqVk--L0zAYx4so3jz9E5SCICesZ353VVDG4S848IUKvgtZkm6ZabNL0sHe-aebbnrrjXGnFNqQfp7v86T9frPsKQTnEED26iuABBSsxOwM0pcAIEwLci8bQVKSgpLyx_1sdI2cZI9CWAIACAP0YXaCGJ4wiiej7NfUSrdwNpeuDV2zisa1uWhVLoVXxq1FkJ0VPlcmaBH0OO23Uvtxbtpl5zfjXKjGhNBXRZcvXFiZKOx4K9E4n9Ymbl7nIl_59E7LaNY67zv6mIfYqc3j7EEtbNBP_jxPs-8f3n-7-FRcfvn4-WJ6WciSolhAyaQuCYKUwgkt64rNKMIQCYQgRhAxgSCZYcYgmyGMSolUXUNc1UJNiGIEn2ZnO900yFWnQ-RpbqmtFa12XeCwZKhisGIgoc8P0KXrfJum44hUFaYVK6vbKFhiNKG4JJM9NRdWc9PWLnoh-9Z8yighJCneTpHUj5bplqjzI1S6lG5M-n-6Nmn_huw_FQw7PDtSwIeKR4GhwosBsNDCxkVwtut9FW7ONh6Asy6YVicftcHMFzHMRRf-Hx-OQXe4TLYLXtd85U0j_IZDwPv88G1-eB8ODinf5oeT_flW3azR6rrqb2AS8OZAWCbD96dLH8LYO-Xf7ap1cvraaM-DNDoFShmfssGVM3cqvD1QkNa0Rgr7U2902FuQB8TBTqTXgHSrQPBv43FI_Q
startdate2015
enddate2015
creator
0Smyth, Andrew, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3O'Donnell, Martin, PhD
4Zhang, Xiaohe, MSc
5Rana, Punam, MD
6Leong, Darryl P, PhD
7Dagenais, Gilles, Prof
8Seron, Pamela, MSc
9Rosengren, Annika, Prof
10Schutte, Aletta E, Prof
11Lopez-Jaramillo, Patricio, Prof
12Oguz, Ayetkin, Prof
13Chifamba, Jephat, MPhil
14Diaz, Rafael, MD
15Lear, Scott, Prof
16Avezum, Alvaro, PhD
17Kumar, Rajesh, MD
18Mohan, Viswanathan, MD
19Szuba, Andrzej, Prof
20Wei, Li, PhD
21Yang, Wang, MD
22Jian, Bo, BSc
23McKee, Martin, Prof
24Yusuf, Salim, Prof
general
0Elsevier Ltd
1Elsevier B.V
2Elsevier Limited
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8BKMMT
9BSHEE
100TT
110TZ
120U~
133V.
147QL
157QP
167RV
177TK
187U7
197U9
207X7
217XB
2288A
2388C
2488E
2588G
2688I
278AF
288AO
298C1
308C2
318FE
328FH
338FI
348FJ
358FK
368G5
37ABUWG
38AN0
39ASE
40AZQEC
41BBNVY
42BEC
43BENPR
44BHPHI
45C1K
46DWQXO
47FPQ
48FYUFA
49GHDGH
50GNUQQ
51GUQSH
52H94
53HCIFZ
54K6X
55K9-
56K9.
57KB0
58KB~
59LK8
60M0R
61M0S
62M0T
63M1P
64M2M
65M2O
66M2P
67M7N
68M7P
69MBDVC
70NAPCQ
71PQEST
72PQQKQ
73PQUKI
74Q9U
75S0X
767X8
sort
creationdate2015
titleAlcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
authorSmyth, Andrew, Dr ; Teo, Koon K, Prof ; Rangarajan, Sumathy, MSc ; O'Donnell, Martin, PhD ; Zhang, Xiaohe, MSc ; Rana, Punam, MD ; Leong, Darryl P, PhD ; Dagenais, Gilles, Prof ; Seron, Pamela, MSc ; Rosengren, Annika, Prof ; Schutte, Aletta E, Prof ; Lopez-Jaramillo, Patricio, Prof ; Oguz, Ayetkin, Prof ; Chifamba, Jephat, MPhil ; Diaz, Rafael, MD ; Lear, Scott, Prof ; Avezum, Alvaro, PhD ; Kumar, Rajesh, MD ; Mohan, Viswanathan, MD ; Szuba, Andrzej, Prof ; Wei, Li, PhD ; Yang, Wang, MD ; Jian, Bo, BSc ; McKee, Martin, Prof ; Yusuf, Salim, Prof
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c752t-1c6ce7421551857f96b52312a22132126a214b36616b2327c2dff139fad84d643
rsrctypearticles
prefilterarticles
languageeng
creationdate2015
topic
0Abridged Index Medicus
1Admission and discharge
2Adult
3Aged
4Alcohol Drinking - epidemiology
5Alcohol use
6Alcoholic beverages
7Alcohols
8Analysis
9Blood pressure
10Canada
11Cancer
12Cardiovascular disease
13Cardiovascular diseases
14Cardiovascular Diseases - epidemiology
15Cerebral infarction
16Cohort Studies
17Consumption
18Developed Countries
19Developing Countries
20Drinking behavior
21Drinking of alcoholic beverages
22Epidemiology
23Female
24Hazard identification
25Health aspects
26Health hazards
27Health risk assessment
28Heart attack
29Heart attacks
30Hospitalization
31Hospitalization - statistics & numerical data
32Hospitals
33Humans
34Hypertension
35Income
36India
37Injuries
38Internal Medicine
39Male
40Middle Aged
41Mortality
42Myocardial infarction
43Neoplasms - epidemiology
44Oncology, Experimental
45Pharmaceuticals
46Proportional Hazards Models
47Public health
48Risk analysis
49Risk factors
50Smoking
51Stroke
52Variables
53Womens health
54Wounds and Injuries - epidemiology
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Smyth, Andrew, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3O'Donnell, Martin, PhD
4Zhang, Xiaohe, MSc
5Rana, Punam, MD
6Leong, Darryl P, PhD
7Dagenais, Gilles, Prof
8Seron, Pamela, MSc
9Rosengren, Annika, Prof
10Schutte, Aletta E, Prof
11Lopez-Jaramillo, Patricio, Prof
12Oguz, Ayetkin, Prof
13Chifamba, Jephat, MPhil
14Diaz, Rafael, MD
15Lear, Scott, Prof
16Avezum, Alvaro, PhD
17Kumar, Rajesh, MD
18Mohan, Viswanathan, MD
19Szuba, Andrzej, Prof
20Wei, Li, PhD
21Yang, Wang, MD
22Jian, Bo, BSc
23McKee, Martin, Prof
24Yusuf, Salim, Prof
25PURE Investigators
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Gale General OneFile (A&I only)
8Academic OneFile (A&I only)
9News PRO
10Pharma and Biotech Premium PRO
11Global News & ABI/Inform Professional
12ProQuest Central (Corporate)
13Bacteriology Abstracts (Microbiology B)
14Calcium & Calcified Tissue Abstracts
15Nursing & Allied Health Database
16Neurosciences Abstracts
17Toxicology Abstracts
18Virology and AIDS Abstracts
19Health & Medical Collection
20ProQuest Central (purchase pre-March 2016)
21Biology Database (Alumni Edition)
22Healthcare Administration Database (Alumni)
23Medical Database (Alumni Edition)
24Psychology Database (Alumni)
25Science Database (Alumni Edition)
26STEM Database
27ProQuest Pharma Collection
28Public Health Database
29Lancet Titles
30ProQuest SciTech Collection
31ProQuest Natural Science Collection
32Hospital Premium Collection
33Hospital Premium Collection (Alumni Edition)
34ProQuest Central (Alumni) (purchase pre-March 2016)
35Research Library (Alumni Edition)
36ProQuest Central (Alumni Edition)
37British Nursing Database
38British Nursing Index
39ProQuest Central Essentials
40Biological Science Collection
41eLibrary
42ProQuest Central
43Natural Science Collection
44Environmental Sciences and Pollution Management
45ProQuest Central Korea
46British Nursing Index (BNI) (1985 to Present)
47Health Research Premium Collection
48Health Research Premium Collection (Alumni)
49ProQuest Central Student
50Research Library Prep
51AIDS and Cancer Research Abstracts
52SciTech Premium Collection
53British Nursing Index
54Consumer Health Database (Alumni Edition)
55ProQuest Health & Medical Complete (Alumni)
56Nursing & Allied Health Database (Alumni Edition)
57ProQuest Newsstand Professional
58ProQuest Biological Science Collection
59Consumer Health Database
60Health & Medical Collection (Alumni Edition)
61Healthcare Administration Database
62Medical Database
63Psychology Database
64Research Library
65Science Database
66Algology Mycology and Protozoology Abstracts (Microbiology C)
67Biological Science Database
68Research Library (Corporate)
69Nursing & Allied Health Premium
70ProQuest One Academic Eastern Edition
71ProQuest One Academic
72ProQuest One Academic UKI Edition
73ProQuest Central Basic
74SIRS Editorial
75MEDLINE - Academic
jtitleThe Lancet (British edition)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Smyth, Andrew, Dr
1Teo, Koon K, Prof
2Rangarajan, Sumathy, MSc
3O'Donnell, Martin, PhD
4Zhang, Xiaohe, MSc
5Rana, Punam, MD
6Leong, Darryl P, PhD
7Dagenais, Gilles, Prof
8Seron, Pamela, MSc
9Rosengren, Annika, Prof
10Schutte, Aletta E, Prof
11Lopez-Jaramillo, Patricio, Prof
12Oguz, Ayetkin, Prof
13Chifamba, Jephat, MPhil
14Diaz, Rafael, MD
15Lear, Scott, Prof
16Avezum, Alvaro, PhD
17Kumar, Rajesh, MD
18Mohan, Viswanathan, MD
19Szuba, Andrzej, Prof
20Wei, Li, PhD
21Yang, Wang, MD
22Jian, Bo, BSc
23McKee, Martin, Prof
24Yusuf, Salim, Prof
aucorpPURE Investigators
formatjournal
genrearticle
ristypeJOUR
atitleAlcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study
jtitleThe Lancet (British edition)
addtitleLancet
date2015
risdate2015
volume386
issue10007
spage1945
epage1954
pages1945-1954
issn0140-6736
eissn1474-547X
codenLANCAO
abstractSummary Background Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents. Methods We included information from 12 countries participating in the Prospective Urban Rural Epidemiological (PURE) study, a prospective cohort study of individuals aged 35–70 years. We used Cox proportional hazards regression to study associations with mortality (n=2723), cardiovascular disease (n=2742), myocardial infarction (n=979), stroke (n=817), alcohol-related cancer (n=764), injury (n=824), admission to hospital (n=8786), and for a composite of these outcomes (n=11 963). Findings We included 114 970 adults, of whom 12 904 (11%) were from high-income countries (HICs), 24 408 (21%) were from upper-middle-income countries (UMICs), 48 845 (43%) were from lower-middle-income countries (LMICs), and 28 813 (25%) were from low-income countries (LICs). Median follow-up was 4·3 years (IQR 3·0–6·0). Current drinking was reported by 36 030 (31%) individuals, and was associated with reduced myocardial infarction (hazard ratio [HR] 0·76 [95% CI 0·63–0·93]), but increased alcohol-related cancers (HR 1·51 [1·22–1·89]) and injury (HR 1·29 [1·04–1·61]). High intake was associated with increased mortality (HR 1·31 [1·04–1·66]). Compared with never drinkers, we identified significantly reduced hazards for the composite outcome for current drinkers in HICs and UMICs (HR 0·84 [0·77–0·92]), but not in LMICs and LICs, for which we identified no reductions in this outcome (HR 1·07 [0·95–1·21]; pinteraction <0·0001). Interpretation Current alcohol consumption had differing associations by clinical outcome, and differing associations by income region. However, we identified sufficient commonalities to support global health strategies and national initiatives to reduce harmful alcohol use. Funding Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, AstraZeneca (Canada), Sanofi-Aventis (France and Canada), Boehringer Ingelheim (Germany and Canada), Servier, GlaxoSmithKline, Novartis, King Pharma, and national or local organisations in participating countries.
copEngland
pubElsevier Ltd
pmid26386538
doi10.1016/S0140-6736(15)00235-4