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Alcohol consumption and risk of coronary artery disease: A dose-response meta-analysis of prospective studies

Abstract Objectives To investigate and quantify the potential dose-response association between alcohol consumption and risk of coronary artery disease (CAD). Methods We searched the PubMed database from inception to March 2015 and reviewed the reference list of relevant articles to identify prospec... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2016, Vol.32 (6), p.637-644
Main Author: Yang, Yang, M.D
Other Authors: Liu, Dong-Chen, M.D , Wang, Qi-Ming, Ph.D , Long, Qing-Qing, M.D , Zhao, Shan, M.D , Zhang, Zhen, M.D , Ma, Yao, M.D , Wang, Ze-Mu, Ph.D , Chen, Lei-Lei, M.D., Ph.D , Wang, Lian-Sheng, M.D., Ph.D
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0899-9007
Link: https://www.ncbi.nlm.nih.gov/pubmed/26916878
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title: Alcohol consumption and risk of coronary artery disease: A dose-response meta-analysis of prospective studies
format: Article
creator:
  • Yang, Yang, M.D
  • Liu, Dong-Chen, M.D
  • Wang, Qi-Ming, Ph.D
  • Long, Qing-Qing, M.D
  • Zhao, Shan, M.D
  • Zhang, Zhen, M.D
  • Ma, Yao, M.D
  • Wang, Ze-Mu, Ph.D
  • Chen, Lei-Lei, M.D., Ph.D
  • Wang, Lian-Sheng, M.D., Ph.D
subjects:
  • Alcohol consumption
  • Alcohol Drinking - epidemiology
  • Cardiology
  • Causality
  • Comorbidity
  • Coronary artery disease
  • Coronary Artery Disease - epidemiology
  • Coronary heart disease
  • Dose-Response Relationship, Drug
  • Drinking of alcoholic beverages
  • Gastroenterology and Hepatology
  • Humans
  • Medical research
  • Medicine, Experimental
  • Meta-analysis
  • Prospective studies
  • Risk Assessment
  • Risk Factors
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2016, Vol.32 (6), p.637-644
description: Abstract Objectives To investigate and quantify the potential dose-response association between alcohol consumption and risk of coronary artery disease (CAD). Methods We searched the PubMed database from inception to March 2015 and reviewed the reference list of relevant articles to identify prospective studies assessing the association between alcohol consumption and risk of CAD. Study-specific relative risk (RR) estimates were combined using a random-effects model. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test. The meta-analysis included 18 prospective studies, with a total of 214 340 participants and 7756 CAD cases. The pooled adjusted RRs were 0.62 (95% confidence interval [CI] 0.56–0.68) for highest alcohol consumption amount versus lowest amount. Begg's and Egger's regression tests provided no evidence of substantial publication bias ( P  = 0.762 for Begg's test and 0.172 for Egger's test). Results In a dose response analysis, we observed a nonlinear association between alcohol consumption and risk of CAD ( P for nonlinearity
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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titleAlcohol consumption and risk of coronary artery disease: A dose-response meta-analysis of prospective studies
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creatorYang, Yang, M.D ; Liu, Dong-Chen, M.D ; Wang, Qi-Ming, Ph.D ; Long, Qing-Qing, M.D ; Zhao, Shan, M.D ; Zhang, Zhen, M.D ; Ma, Yao, M.D ; Wang, Ze-Mu, Ph.D ; Chen, Lei-Lei, M.D., Ph.D ; Wang, Lian-Sheng, M.D., Ph.D
creatorcontribYang, Yang, M.D ; Liu, Dong-Chen, M.D ; Wang, Qi-Ming, Ph.D ; Long, Qing-Qing, M.D ; Zhao, Shan, M.D ; Zhang, Zhen, M.D ; Ma, Yao, M.D ; Wang, Ze-Mu, Ph.D ; Chen, Lei-Lei, M.D., Ph.D ; Wang, Lian-Sheng, M.D., Ph.D
descriptionAbstract Objectives To investigate and quantify the potential dose-response association between alcohol consumption and risk of coronary artery disease (CAD). Methods We searched the PubMed database from inception to March 2015 and reviewed the reference list of relevant articles to identify prospective studies assessing the association between alcohol consumption and risk of CAD. Study-specific relative risk (RR) estimates were combined using a random-effects model. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test. The meta-analysis included 18 prospective studies, with a total of 214 340 participants and 7756 CAD cases. The pooled adjusted RRs were 0.62 (95% confidence interval [CI] 0.56–0.68) for highest alcohol consumption amount versus lowest amount. Begg's and Egger's regression tests provided no evidence of substantial publication bias ( P  = 0.762 for Begg's test and 0.172 for Egger's test). Results In a dose response analysis, we observed a nonlinear association between alcohol consumption and risk of CAD ( P for nonlinearity <0.00). Compared with non-drinkers, the RRs (95% CI) of CAD across levels of alcohol consumption were 0.75 (0.70–0.80) for 12 g/d, 0.70 (0.66–0.75) for 24 g/d, 0.69 (0.64–0.75) for 36 g/d, 0.70 (0.64–0.77) for 60 g/d, 0.74 (0.67–0.83) for 90 g/d, and 0.83 (0.67–1.04) for 135 g/d. Conclusions Alcohol consumption in moderation is associated with a reduced risk of CAD with 36 grams/d of alcohol conferring a lower risk than other levels.
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subjectAlcohol consumption ; Alcohol Drinking - epidemiology ; Cardiology ; Causality ; Comorbidity ; Coronary artery disease ; Coronary Artery Disease - epidemiology ; Coronary heart disease ; Dose-Response Relationship, Drug ; Drinking of alcoholic beverages ; Gastroenterology and Hepatology ; Humans ; Medical research ; Medicine, Experimental ; Meta-analysis ; Prospective studies ; Risk Assessment ; Risk Factors
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descriptionAbstract Objectives To investigate and quantify the potential dose-response association between alcohol consumption and risk of coronary artery disease (CAD). Methods We searched the PubMed database from inception to March 2015 and reviewed the reference list of relevant articles to identify prospective studies assessing the association between alcohol consumption and risk of CAD. Study-specific relative risk (RR) estimates were combined using a random-effects model. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test. The meta-analysis included 18 prospective studies, with a total of 214 340 participants and 7756 CAD cases. The pooled adjusted RRs were 0.62 (95% confidence interval [CI] 0.56–0.68) for highest alcohol consumption amount versus lowest amount. Begg's and Egger's regression tests provided no evidence of substantial publication bias ( P  = 0.762 for Begg's test and 0.172 for Egger's test). Results In a dose response analysis, we observed a nonlinear association between alcohol consumption and risk of CAD ( P for nonlinearity <0.00). Compared with non-drinkers, the RRs (95% CI) of CAD across levels of alcohol consumption were 0.75 (0.70–0.80) for 12 g/d, 0.70 (0.66–0.75) for 24 g/d, 0.69 (0.64–0.75) for 36 g/d, 0.70 (0.64–0.77) for 60 g/d, 0.74 (0.67–0.83) for 90 g/d, and 0.83 (0.67–1.04) for 135 g/d. Conclusions Alcohol consumption in moderation is associated with a reduced risk of CAD with 36 grams/d of alcohol conferring a lower risk than other levels.
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16Risk Assessment
17Risk Factors
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titleAlcohol consumption and risk of coronary artery disease: A dose-response meta-analysis of prospective studies
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8Dose-Response Relationship, Drug
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abstractAbstract Objectives To investigate and quantify the potential dose-response association between alcohol consumption and risk of coronary artery disease (CAD). Methods We searched the PubMed database from inception to March 2015 and reviewed the reference list of relevant articles to identify prospective studies assessing the association between alcohol consumption and risk of CAD. Study-specific relative risk (RR) estimates were combined using a random-effects model. Publication bias was estimated using Begg's funnel plot and Egger's regression asymmetry test. The meta-analysis included 18 prospective studies, with a total of 214 340 participants and 7756 CAD cases. The pooled adjusted RRs were 0.62 (95% confidence interval [CI] 0.56–0.68) for highest alcohol consumption amount versus lowest amount. Begg's and Egger's regression tests provided no evidence of substantial publication bias ( P  = 0.762 for Begg's test and 0.172 for Egger's test). Results In a dose response analysis, we observed a nonlinear association between alcohol consumption and risk of CAD ( P for nonlinearity <0.00). Compared with non-drinkers, the RRs (95% CI) of CAD across levels of alcohol consumption were 0.75 (0.70–0.80) for 12 g/d, 0.70 (0.66–0.75) for 24 g/d, 0.69 (0.64–0.75) for 36 g/d, 0.70 (0.64–0.77) for 60 g/d, 0.74 (0.67–0.83) for 90 g/d, and 0.83 (0.67–1.04) for 135 g/d. Conclusions Alcohol consumption in moderation is associated with a reduced risk of CAD with 36 grams/d of alcohol conferring a lower risk than other levels.
copUnited States
pubElsevier Inc
pmid26916878
doi10.1016/j.nut.2015.11.013