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Increased Serum Level of Growth Differentiation Factor 15 (GDF‐15) is Associated with Coronary Artery Disease

Aim There is evidence suggesting that inflammatory responses play a critical role in the development of coronary artery disease (CAD). Growth differentiation factor 15 (GDF‐15) is a stress‐responsive cytokine. It increases during inflammatory processes and is associated with cardiometabolic risk. Ho... Full description

Journal Title: Cardiovascular therapeutics 2016-06, Vol.34 (3), p.138-143
Main Author: Wang, Xia
Other Authors: Chen, Lei‐Lei , Zhang, Qing
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: Wiley Subscription Services, Inc
ID: ISSN: 1755-5914
Link: https://www.ncbi.nlm.nih.gov/pubmed/26996787
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recordid: cdi_proquest_miscellaneous_1790454341
title: Increased Serum Level of Growth Differentiation Factor 15 (GDF‐15) is Associated with Coronary Artery Disease
format: Article
creator:
  • Wang, Xia
  • Chen, Lei‐Lei
  • Zhang, Qing
subjects:
  • Aged
  • Analysis
  • Biomarkers - blood
  • Case-Control Studies
  • Coronary Angiography
  • Coronary artery disease
  • Coronary Artery Disease - blood
  • Coronary Artery Disease - diagnostic imaging
  • Coronary heart disease
  • Coronary Stenosis - blood
  • Coronary Stenosis - diagnostic imaging
  • Cross-Sectional Studies
  • Enzyme-linked immunosorbent assay
  • Enzymes
  • Female
  • Growth
  • Growth differentiation factor 15
  • Growth Differentiation Factor 15 - blood
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • ROC Curve
  • Serum
  • Severity of Illness Index
  • Statistics
  • Up-Regulation
ispartof: Cardiovascular therapeutics, 2016-06, Vol.34 (3), p.138-143
description: Aim There is evidence suggesting that inflammatory responses play a critical role in the development of coronary artery disease (CAD). Growth differentiation factor 15 (GDF‐15) is a stress‐responsive cytokine. It increases during inflammatory processes and is associated with cardiometabolic risk. However, the relation between GDF‐15 and CAD remains largely unknown. Herein, we aimed to evaluate serum GDF‐15 levels and predictive values in patients with CAD. Methods Serum levels of GDF‐15 in 105 patients with CAD and 96 healthy controls were measured by the enzyme‐linked immunosorbent assay. Gensini scores were used to assess severity of CAD. The correlations between the serum GDF‐15 levels and Gensini scores were examined using Spearman's correlation. Receivers operating characteristic (ROC) curve analysis was performed to determine the predictive values of GDF‐15 levels. Results We found that serum GDF‐15 levels were significantly increased in CAD group compared with healthy controls group (P 
language: eng
source:
identifier: ISSN: 1755-5914
fulltext: no_fulltext
issn:
  • 1755-5914
  • 1755-5922
url: Link


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titleIncreased Serum Level of Growth Differentiation Factor 15 (GDF‐15) is Associated with Coronary Artery Disease
creatorWang, Xia ; Chen, Lei‐Lei ; Zhang, Qing
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descriptionAim There is evidence suggesting that inflammatory responses play a critical role in the development of coronary artery disease (CAD). Growth differentiation factor 15 (GDF‐15) is a stress‐responsive cytokine. It increases during inflammatory processes and is associated with cardiometabolic risk. However, the relation between GDF‐15 and CAD remains largely unknown. Herein, we aimed to evaluate serum GDF‐15 levels and predictive values in patients with CAD. Methods Serum levels of GDF‐15 in 105 patients with CAD and 96 healthy controls were measured by the enzyme‐linked immunosorbent assay. Gensini scores were used to assess severity of CAD. The correlations between the serum GDF‐15 levels and Gensini scores were examined using Spearman's correlation. Receivers operating characteristic (ROC) curve analysis was performed to determine the predictive values of GDF‐15 levels. Results We found that serum GDF‐15 levels were significantly increased in CAD group compared with healthy controls group (P < 0.001). Additionally, a positive correlation was observed between GDF‐15 and the Gensini score (r = 0.85, P < 0.001). Moreover, the area under the ROC curve assay yielded a satisfactory result of 0.96 (95% confidence interval 0.94–0.98; P < 0.001), and the serum GDF‐15 level had a 80.0% sensitivity and 91.7% specificity for predicting CAD. Conclusions These data suggested that increased GDF‐15 levels were positively associated with CAD, and GDF‐15 might be a useful adjunct in discriminating CAD.
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subjectAged ; Analysis ; Biomarkers - blood ; Case-Control Studies ; Coronary Angiography ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary heart disease ; Coronary Stenosis - blood ; Coronary Stenosis - diagnostic imaging ; Cross-Sectional Studies ; Enzyme-linked immunosorbent assay ; Enzymes ; Female ; Growth ; Growth differentiation factor 15 ; Growth Differentiation Factor 15 - blood ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; ROC Curve ; Serum ; Severity of Illness Index ; Statistics ; Up-Regulation
ispartofCardiovascular therapeutics, 2016-06, Vol.34 (3), p.138-143
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descriptionAim There is evidence suggesting that inflammatory responses play a critical role in the development of coronary artery disease (CAD). Growth differentiation factor 15 (GDF‐15) is a stress‐responsive cytokine. It increases during inflammatory processes and is associated with cardiometabolic risk. However, the relation between GDF‐15 and CAD remains largely unknown. Herein, we aimed to evaluate serum GDF‐15 levels and predictive values in patients with CAD. Methods Serum levels of GDF‐15 in 105 patients with CAD and 96 healthy controls were measured by the enzyme‐linked immunosorbent assay. Gensini scores were used to assess severity of CAD. The correlations between the serum GDF‐15 levels and Gensini scores were examined using Spearman's correlation. Receivers operating characteristic (ROC) curve analysis was performed to determine the predictive values of GDF‐15 levels. Results We found that serum GDF‐15 levels were significantly increased in CAD group compared with healthy controls group (P < 0.001). Additionally, a positive correlation was observed between GDF‐15 and the Gensini score (r = 0.85, P < 0.001). Moreover, the area under the ROC curve assay yielded a satisfactory result of 0.96 (95% confidence interval 0.94–0.98; P < 0.001), and the serum GDF‐15 level had a 80.0% sensitivity and 91.7% specificity for predicting CAD. Conclusions These data suggested that increased GDF‐15 levels were positively associated with CAD, and GDF‐15 might be a useful adjunct in discriminating CAD.
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abstractAim There is evidence suggesting that inflammatory responses play a critical role in the development of coronary artery disease (CAD). Growth differentiation factor 15 (GDF‐15) is a stress‐responsive cytokine. It increases during inflammatory processes and is associated with cardiometabolic risk. However, the relation between GDF‐15 and CAD remains largely unknown. Herein, we aimed to evaluate serum GDF‐15 levels and predictive values in patients with CAD. Methods Serum levels of GDF‐15 in 105 patients with CAD and 96 healthy controls were measured by the enzyme‐linked immunosorbent assay. Gensini scores were used to assess severity of CAD. The correlations between the serum GDF‐15 levels and Gensini scores were examined using Spearman's correlation. Receivers operating characteristic (ROC) curve analysis was performed to determine the predictive values of GDF‐15 levels. Results We found that serum GDF‐15 levels were significantly increased in CAD group compared with healthy controls group (P < 0.001). Additionally, a positive correlation was observed between GDF‐15 and the Gensini score (r = 0.85, P < 0.001). Moreover, the area under the ROC curve assay yielded a satisfactory result of 0.96 (95% confidence interval 0.94–0.98; P < 0.001), and the serum GDF‐15 level had a 80.0% sensitivity and 91.7% specificity for predicting CAD. Conclusions These data suggested that increased GDF‐15 levels were positively associated with CAD, and GDF‐15 might be a useful adjunct in discriminating CAD.
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