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Lactate, glucose and the neonatal brain: it’s time to challenge the paradigm

[...]the affinity of glial cells in the brain is higher for lactate (and ketones) than it is for glucose, so lactate is actually the preferential fuel, an effect sometimes described as 'glucose sparing'. [...]the tipping point for the neonatal brain comes when there is not enough glucose available t... Full description

Journal Title: Archives of disease in childhood. Fetal and neonatal edition 2015-03, Vol.100 (2), p.F96-F97
Main Author: Platt, Martin Ward
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group LTD
ID: ISSN: 1359-2998
Link: https://www.ncbi.nlm.nih.gov/pubmed/25260360
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title: Lactate, glucose and the neonatal brain: it’s time to challenge the paradigm
format: Article
creator:
  • Platt, Martin Ward
subjects:
  • Abridged Index Medicus
  • Amino acids
  • Carbon
  • Female
  • Glucose
  • Humans
  • Hypoglycemia - blood
  • Ketones - blood
  • Lactic Acid - blood
  • Male
  • Metabolism
  • Pregnancy
ispartof: Archives of disease in childhood. Fetal and neonatal edition, 2015-03, Vol.100 (2), p.F96-F97
description: [...]the affinity of glial cells in the brain is higher for lactate (and ketones) than it is for glucose, so lactate is actually the preferential fuel, an effect sometimes described as 'glucose sparing'. [...]the tipping point for the neonatal brain comes when there is not enough glucose available to provide, via glycolysis, enough pyruvate to saturate the Krebs cycle.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1359-2998
fulltext: fulltext
issn:
  • 1359-2998
  • 1468-2052
url: Link


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description[...]the affinity of glial cells in the brain is higher for lactate (and ketones) than it is for glucose, so lactate is actually the preferential fuel, an effect sometimes described as 'glucose sparing'. [...]the tipping point for the neonatal brain comes when there is not enough glucose available to provide, via glycolysis, enough pyruvate to saturate the Krebs cycle.
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subjectAbridged Index Medicus ; Amino acids ; Carbon ; Female ; Glucose ; Humans ; Hypoglycemia - blood ; Ketones - blood ; Lactic Acid - blood ; Male ; Metabolism ; Pregnancy
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abstract[...]the affinity of glial cells in the brain is higher for lactate (and ketones) than it is for glucose, so lactate is actually the preferential fuel, an effect sometimes described as 'glucose sparing'. [...]the tipping point for the neonatal brain comes when there is not enough glucose available to provide, via glycolysis, enough pyruvate to saturate the Krebs cycle.
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