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Pulmonary function as a risk factor for dementia death: an individual participant meta-analysis of six UK general population cohort studies

Background In addition to being associated with all-cause mortality and cardiovascular disease mortality, lung function has been linked with dementia. However, existing studies typically provide imprecise estimates due to small numbers of outcome events and are based on unrepresentative samples of t... Full description

Journal Title: Journal of epidemiology and community health (1979) 2015, Vol.69 (6), p.550-556
Main Author: Russ, Tom C
Other Authors: Starr, John M , Stamatakis, Emmanuel , Kivimäki, Mika , Batty, G David
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: BMJ Publishing Group Ltd
ID: ISSN: 0143-005X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25691274
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title: Pulmonary function as a risk factor for dementia death: an individual participant meta-analysis of six UK general population cohort studies
format: Article
creator:
  • Russ, Tom C
  • Starr, John M
  • Stamatakis, Emmanuel
  • Kivimäki, Mika
  • Batty, G David
subjects:
  • Adult
  • Aged
  • Alcohol
  • Analysis
  • Cohort analysis
  • Cohort Studies
  • Complications and side effects
  • Councils
  • Dementia
  • Dementia - mortality
  • Disease
  • Educational attainment
  • England - epidemiology
  • Epidemiology
  • Ethnicity
  • Female
  • Forced Expiratory Volume - physiology
  • Health risk assessment
  • Health services
  • Health Surveys
  • Humans
  • Illnesses
  • Lung - physiology
  • Lung - physiopathology
  • Lung diseases
  • Male
  • Medical research
  • Meta-analysis
  • Middle Aged
  • Mortality
  • Peak Expiratory Flow Rate - physiology
  • Population
  • Proportional Hazards Models
  • Public health
  • Research reports
  • Risk Factors
  • Scotland - epidemiology
  • Social classes
  • Social research
  • Spirometry - instrumentation
  • Spirometry - methods
  • Studies
  • Systematic review
  • United Kingdom
  • Usage
  • Vital Capacity - physiology
ispartof: Journal of epidemiology and community health (1979), 2015, Vol.69 (6), p.550-556
description: Background In addition to being associated with all-cause mortality and cardiovascular disease mortality, lung function has been linked with dementia. However, existing studies typically provide imprecise estimates due to small numbers of outcome events and are based on unrepresentative samples of the general population. Methods Individual participant meta-analysis of six cohort studies from the Health Survey for England and the Scottish Health Survey (total N=54 671). Dementia-related mortality was identified by mention of dementia on any part of the death certificate (mean follow-up 11.7 years). Study-specific Cox proportional hazard models of the association between lung function and dementia-related death were pooled using random effect meta-analysis to produce overall results. Results There was a dose–response association between poorer lung function and a higher risk of dementia-related death (age- and sex-adjusted HR compared to highest quartile of forced expiratory volume in 1 s (FEV1), 95% CI: second quartile 1.32, 0.99 to 1.76; third quartile 1.78, 1.30 to 2.43; fourth (lowest) quartile 2.74, 1.73 to 4.32). There was no significant heterogeneity in study-specific estimates (I2=0%). Controlling for height, socioeconomic status, smoking and general health attenuated but did not remove the association (second quartile 1.15, 0.82 to 1.62; third quartile 1.37, 0.96 to 1.94; fourth quartile 2.09, 1.17 to 3.71). Results for forced vital capacity and peak flow were similar. Conclusions In these general population samples, the relation between three measures of lung function and dementia death followed a dose–response gradient. Being in the bottom quartile of lung function was associated with a doubling of the risk.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0143-005X
fulltext: fulltext
issn:
  • 0143-005X
  • 1470-2738
url: Link


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titlePulmonary function as a risk factor for dementia death: an individual participant meta-analysis of six UK general population cohort studies
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creatorRuss, Tom C ; Starr, John M ; Stamatakis, Emmanuel ; Kivimäki, Mika ; Batty, G David
creatorcontribRuss, Tom C ; Starr, John M ; Stamatakis, Emmanuel ; Kivimäki, Mika ; Batty, G David
descriptionBackground In addition to being associated with all-cause mortality and cardiovascular disease mortality, lung function has been linked with dementia. However, existing studies typically provide imprecise estimates due to small numbers of outcome events and are based on unrepresentative samples of the general population. Methods Individual participant meta-analysis of six cohort studies from the Health Survey for England and the Scottish Health Survey (total N=54 671). Dementia-related mortality was identified by mention of dementia on any part of the death certificate (mean follow-up 11.7 years). Study-specific Cox proportional hazard models of the association between lung function and dementia-related death were pooled using random effect meta-analysis to produce overall results. Results There was a dose–response association between poorer lung function and a higher risk of dementia-related death (age- and sex-adjusted HR compared to highest quartile of forced expiratory volume in 1 s (FEV1), 95% CI: second quartile 1.32, 0.99 to 1.76; third quartile 1.78, 1.30 to 2.43; fourth (lowest) quartile 2.74, 1.73 to 4.32). There was no significant heterogeneity in study-specific estimates (I2=0%). Controlling for height, socioeconomic status, smoking and general health attenuated but did not remove the association (second quartile 1.15, 0.82 to 1.62; third quartile 1.37, 0.96 to 1.94; fourth quartile 2.09, 1.17 to 3.71). Results for forced vital capacity and peak flow were similar. Conclusions In these general population samples, the relation between three measures of lung function and dementia death followed a dose–response gradient. Being in the bottom quartile of lung function was associated with a doubling of the risk.
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subjectAdult ; Aged ; Alcohol ; Analysis ; Cohort analysis ; Cohort Studies ; Complications and side effects ; Councils ; Dementia ; Dementia - mortality ; Disease ; Educational attainment ; England - epidemiology ; Epidemiology ; Ethnicity ; Female ; Forced Expiratory Volume - physiology ; Health risk assessment ; Health services ; Health Surveys ; Humans ; Illnesses ; Lung - physiology ; Lung - physiopathology ; Lung diseases ; Male ; Medical research ; Meta-analysis ; Middle Aged ; Mortality ; Peak Expiratory Flow Rate - physiology ; Population ; Proportional Hazards Models ; Public health ; Research reports ; Risk Factors ; Scotland - epidemiology ; Social classes ; Social research ; Spirometry - instrumentation ; Spirometry - methods ; Studies ; Systematic review ; United Kingdom ; Usage ; Vital Capacity - physiology
ispartofJournal of epidemiology and community health (1979), 2015, Vol.69 (6), p.550-556
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descriptionBackground In addition to being associated with all-cause mortality and cardiovascular disease mortality, lung function has been linked with dementia. However, existing studies typically provide imprecise estimates due to small numbers of outcome events and are based on unrepresentative samples of the general population. Methods Individual participant meta-analysis of six cohort studies from the Health Survey for England and the Scottish Health Survey (total N=54 671). Dementia-related mortality was identified by mention of dementia on any part of the death certificate (mean follow-up 11.7 years). Study-specific Cox proportional hazard models of the association between lung function and dementia-related death were pooled using random effect meta-analysis to produce overall results. Results There was a dose–response association between poorer lung function and a higher risk of dementia-related death (age- and sex-adjusted HR compared to highest quartile of forced expiratory volume in 1 s (FEV1), 95% CI: second quartile 1.32, 0.99 to 1.76; third quartile 1.78, 1.30 to 2.43; fourth (lowest) quartile 2.74, 1.73 to 4.32). There was no significant heterogeneity in study-specific estimates (I2=0%). Controlling for height, socioeconomic status, smoking and general health attenuated but did not remove the association (second quartile 1.15, 0.82 to 1.62; third quartile 1.37, 0.96 to 1.94; fourth quartile 2.09, 1.17 to 3.71). Results for forced vital capacity and peak flow were similar. Conclusions In these general population samples, the relation between three measures of lung function and dementia death followed a dose–response gradient. Being in the bottom quartile of lung function was associated with a doubling of the risk.
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abstractBackground In addition to being associated with all-cause mortality and cardiovascular disease mortality, lung function has been linked with dementia. However, existing studies typically provide imprecise estimates due to small numbers of outcome events and are based on unrepresentative samples of the general population. Methods Individual participant meta-analysis of six cohort studies from the Health Survey for England and the Scottish Health Survey (total N=54 671). Dementia-related mortality was identified by mention of dementia on any part of the death certificate (mean follow-up 11.7 years). Study-specific Cox proportional hazard models of the association between lung function and dementia-related death were pooled using random effect meta-analysis to produce overall results. Results There was a dose–response association between poorer lung function and a higher risk of dementia-related death (age- and sex-adjusted HR compared to highest quartile of forced expiratory volume in 1 s (FEV1), 95% CI: second quartile 1.32, 0.99 to 1.76; third quartile 1.78, 1.30 to 2.43; fourth (lowest) quartile 2.74, 1.73 to 4.32). There was no significant heterogeneity in study-specific estimates (I2=0%). Controlling for height, socioeconomic status, smoking and general health attenuated but did not remove the association (second quartile 1.15, 0.82 to 1.62; third quartile 1.37, 0.96 to 1.94; fourth quartile 2.09, 1.17 to 3.71). Results for forced vital capacity and peak flow were similar. Conclusions In these general population samples, the relation between three measures of lung function and dementia death followed a dose–response gradient. Being in the bottom quartile of lung function was associated with a doubling of the risk.
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