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Environmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific

ObjectiveThe rising incidence of inflammatory bowel disease in Asia supports the importance of environmental risk factors in disease aetiology. This prospective population-based case-control study in Asia-Pacific examined risk factors prior to patients developing IBD.Design442 incident cases (186 Cr... Full description

Journal Title: Gut 2015-07, Vol.64 (7), p.1063-1071
Main Author: Ng, Siew C
Other Authors: Tang, Whitney , Leong, Rupert W , Chen, Minhu , Ko, Yanna , Studd, Corrie , Niewiadomski, Ola , Bell, Sally , Kamm, Michael A , de Silva, H J , Kasturiratne, Anuradhani , Senanayake, Yasith Udara , Ooi, Choon Jin , Ling, Khoon-Lin , Ong, David , Goh, Khean Lee , Hilmi, Ida , Ouyang, Qin , Wang, Yu-Fang , Hu, PinJin , Zhu, Zhenhua , Zeng, Zhirong , Wu, Kaichun , Wang, Xin , Xia, Bing , Li, Jin , Pisespongsa, Pises , Manatsathit, Sathaporn , Aniwan, Satimai , Simadibrata, Marcellus , Abdullah, Murdani , Tsang, Steve W C , Wong, Tai Chiu , Hui, Aric J , Chow, Chung Mo , Yu, Hon Ho , Li, Mo Fong , Ng, Ka Kei , Ching, Jessica , Wu, Justin C Y , Chan, Francis K L , Sung, Joseph J Y
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: British Medical Association
ID: ISSN: 0017-5749
Link: https://www.ncbi.nlm.nih.gov/pubmed/25217388
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title: Environmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific
format: Article
creator:
  • Ng, Siew C
  • Tang, Whitney
  • Leong, Rupert W
  • Chen, Minhu
  • Ko, Yanna
  • Studd, Corrie
  • Niewiadomski, Ola
  • Bell, Sally
  • Kamm, Michael A
  • de Silva, H J
  • Kasturiratne, Anuradhani
  • Senanayake, Yasith Udara
  • Ooi, Choon Jin
  • Ling, Khoon-Lin
  • Ong, David
  • Goh, Khean Lee
  • Hilmi, Ida
  • Ouyang, Qin
  • Wang, Yu-Fang
  • Hu, PinJin
  • Zhu, Zhenhua
  • Zeng, Zhirong
  • Wu, Kaichun
  • Wang, Xin
  • Xia, Bing
  • Li, Jin
  • Pisespongsa, Pises
  • Manatsathit, Sathaporn
  • Aniwan, Satimai
  • Simadibrata, Marcellus
  • Abdullah, Murdani
  • Tsang, Steve W C
  • Wong, Tai Chiu
  • Hui, Aric J
  • Chow, Chung Mo
  • Yu, Hon Ho
  • Li, Mo Fong
  • Ng, Ka Kei
  • Ching, Jessica
  • Wu, Justin C Y
  • Chan, Francis K L
  • Sung, Joseph J Y
subjects:
  • Abridged Index Medicus
  • Adult
  • Antibiotics
  • Asia - epidemiology
  • Australia - epidemiology
  • Breast Feeding
  • Breastfeeding & lactation
  • Care and treatment
  • Case-Control Studies
  • Crohns disease
  • Diet
  • Environmental aspects
  • Epidemiology
  • Female
  • Gastroenterology
  • Health risk assessment
  • Humans
  • Immunology
  • Incidence
  • Infections
  • Inflammatory bowel disease
  • Inflammatory bowel diseases
  • Inflammatory Bowel Diseases - epidemiology
  • Intestines - microbiology
  • Male
  • Management
  • Measles
  • Microbiota
  • Middle Aged
  • Multivariate Analysis
  • Pathogenesis
  • Patients
  • Pets
  • Population
  • Prospective Studies
  • Questionnaires
  • Recall
  • Risk Factors
  • Smoking - epidemiology
  • Studies
  • Tuberculosis
  • Whooping cough
ispartof: Gut, 2015-07, Vol.64 (7), p.1063-1071
description: ObjectiveThe rising incidence of inflammatory bowel disease in Asia supports the importance of environmental risk factors in disease aetiology. This prospective population-based case-control study in Asia-Pacific examined risk factors prior to patients developing IBD.Design442 incident cases (186 Crohn's disease (CD); 256 UC; 374 Asians) diagnosed between 2011 and 2013 from eight countries in Asia and Australia and 940 controls (frequency-matched by sex, age and geographical location; 789 Asians) completed an environmental factor questionnaire at diagnosis. Unconditional logistic regression models were used to estimate adjusted ORs (aOR) and 95% CIs.ResultsIn multivariate model, being breast fed >12 months (aOR 0.10; 95% CI 0.04 to 0.30), antibiotic use (aOR 0.19; 0.07 to 0.52), having dogs (aOR 0.54; 0.35 to 0.83), daily tea consumption (aOR 0.62; 0.43 to 0.91) and daily physical activity (aOR 0.58; 0.35 to 0.96) decreased the odds for CD in Asians. In UC, being breast fed >12 months (aOR 0.16; 0.08 to 0.31), antibiotic use (aOR 0.48; 0.27 to 0.87), daily tea (aOR 0.63; 0.46 to 0.86) or coffee consumption (aOR 0.51; 0.36 to 0.72), presence of hot water tap (aOR 0.65; 0.46 to 0.91) and flush toilet in childhood (aOR 0.71; 0.51 to 0.98) were protective for UC development whereas ex-smoking (aOR 2.02; 1.22 to 3.35) increased the risk of UC.ConclusionsThis first population-based study of IBD risk factors in Asia-Pacific supports the importance of childhood immunological, hygiene and dietary factors in the development of IBD, suggesting that markers of altered intestinal microbiota may modulate risk of IBD later in life.
language: eng
source:
identifier: ISSN: 0017-5749
fulltext: no_fulltext
issn:
  • 0017-5749
  • 1468-3288
url: Link


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titleEnvironmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific
creatorNg, Siew C ; Tang, Whitney ; Leong, Rupert W ; Chen, Minhu ; Ko, Yanna ; Studd, Corrie ; Niewiadomski, Ola ; Bell, Sally ; Kamm, Michael A ; de Silva, H J ; Kasturiratne, Anuradhani ; Senanayake, Yasith Udara ; Ooi, Choon Jin ; Ling, Khoon-Lin ; Ong, David ; Goh, Khean Lee ; Hilmi, Ida ; Ouyang, Qin ; Wang, Yu-Fang ; Hu, PinJin ; Zhu, Zhenhua ; Zeng, Zhirong ; Wu, Kaichun ; Wang, Xin ; Xia, Bing ; Li, Jin ; Pisespongsa, Pises ; Manatsathit, Sathaporn ; Aniwan, Satimai ; Simadibrata, Marcellus ; Abdullah, Murdani ; Tsang, Steve W C ; Wong, Tai Chiu ; Hui, Aric J ; Chow, Chung Mo ; Yu, Hon Ho ; Li, Mo Fong ; Ng, Ka Kei ; Ching, Jessica ; Wu, Justin C Y ; Chan, Francis K L ; Sung, Joseph J Y
creatorcontribNg, Siew C ; Tang, Whitney ; Leong, Rupert W ; Chen, Minhu ; Ko, Yanna ; Studd, Corrie ; Niewiadomski, Ola ; Bell, Sally ; Kamm, Michael A ; de Silva, H J ; Kasturiratne, Anuradhani ; Senanayake, Yasith Udara ; Ooi, Choon Jin ; Ling, Khoon-Lin ; Ong, David ; Goh, Khean Lee ; Hilmi, Ida ; Ouyang, Qin ; Wang, Yu-Fang ; Hu, PinJin ; Zhu, Zhenhua ; Zeng, Zhirong ; Wu, Kaichun ; Wang, Xin ; Xia, Bing ; Li, Jin ; Pisespongsa, Pises ; Manatsathit, Sathaporn ; Aniwan, Satimai ; Simadibrata, Marcellus ; Abdullah, Murdani ; Tsang, Steve W C ; Wong, Tai Chiu ; Hui, Aric J ; Chow, Chung Mo ; Yu, Hon Ho ; Li, Mo Fong ; Ng, Ka Kei ; Ching, Jessica ; Wu, Justin C Y ; Chan, Francis K L ; Sung, Joseph J Y ; Asia-Pacific Crohn's and Colitis Epidemiology Study ACCESS Group
descriptionObjectiveThe rising incidence of inflammatory bowel disease in Asia supports the importance of environmental risk factors in disease aetiology. This prospective population-based case-control study in Asia-Pacific examined risk factors prior to patients developing IBD.Design442 incident cases (186 Crohn's disease (CD); 256 UC; 374 Asians) diagnosed between 2011 and 2013 from eight countries in Asia and Australia and 940 controls (frequency-matched by sex, age and geographical location; 789 Asians) completed an environmental factor questionnaire at diagnosis. Unconditional logistic regression models were used to estimate adjusted ORs (aOR) and 95% CIs.ResultsIn multivariate model, being breast fed >12 months (aOR 0.10; 95% CI 0.04 to 0.30), antibiotic use (aOR 0.19; 0.07 to 0.52), having dogs (aOR 0.54; 0.35 to 0.83), daily tea consumption (aOR 0.62; 0.43 to 0.91) and daily physical activity (aOR 0.58; 0.35 to 0.96) decreased the odds for CD in Asians. In UC, being breast fed >12 months (aOR 0.16; 0.08 to 0.31), antibiotic use (aOR 0.48; 0.27 to 0.87), daily tea (aOR 0.63; 0.46 to 0.86) or coffee consumption (aOR 0.51; 0.36 to 0.72), presence of hot water tap (aOR 0.65; 0.46 to 0.91) and flush toilet in childhood (aOR 0.71; 0.51 to 0.98) were protective for UC development whereas ex-smoking (aOR 2.02; 1.22 to 3.35) increased the risk of UC.ConclusionsThis first population-based study of IBD risk factors in Asia-Pacific supports the importance of childhood immunological, hygiene and dietary factors in the development of IBD, suggesting that markers of altered intestinal microbiota may modulate risk of IBD later in life.
identifier
0ISSN: 0017-5749
1EISSN: 1468-3288
2DOI: 10.1136/gutjnl-2014-307410
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languageeng
publisherEngland: British Medical Association
subjectAbridged Index Medicus ; Adult ; Antibiotics ; Asia - epidemiology ; Australia - epidemiology ; Breast Feeding ; Breastfeeding & lactation ; Care and treatment ; Case-Control Studies ; Crohns disease ; Diet ; Environmental aspects ; Epidemiology ; Female ; Gastroenterology ; Health risk assessment ; Humans ; Immunology ; Incidence ; Infections ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - epidemiology ; Intestines - microbiology ; Male ; Management ; Measles ; Microbiota ; Middle Aged ; Multivariate Analysis ; Pathogenesis ; Patients ; Pets ; Population ; Prospective Studies ; Questionnaires ; Recall ; Risk Factors ; Smoking - epidemiology ; Studies ; Tuberculosis ; Whooping cough
ispartofGut, 2015-07, Vol.64 (7), p.1063-1071
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0Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
1Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
2Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
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0Ng, Siew C
1Tang, Whitney
2Leong, Rupert W
3Chen, Minhu
4Ko, Yanna
5Studd, Corrie
6Niewiadomski, Ola
7Bell, Sally
8Kamm, Michael A
9de Silva, H J
10Kasturiratne, Anuradhani
11Senanayake, Yasith Udara
12Ooi, Choon Jin
13Ling, Khoon-Lin
14Ong, David
15Goh, Khean Lee
16Hilmi, Ida
17Ouyang, Qin
18Wang, Yu-Fang
19Hu, PinJin
20Zhu, Zhenhua
21Zeng, Zhirong
22Wu, Kaichun
23Wang, Xin
24Xia, Bing
25Li, Jin
26Pisespongsa, Pises
27Manatsathit, Sathaporn
28Aniwan, Satimai
29Simadibrata, Marcellus
30Abdullah, Murdani
31Tsang, Steve W C
32Wong, Tai Chiu
33Hui, Aric J
34Chow, Chung Mo
35Yu, Hon Ho
36Li, Mo Fong
37Ng, Ka Kei
38Ching, Jessica
39Wu, Justin C Y
40Chan, Francis K L
41Sung, Joseph J Y
42Asia-Pacific Crohn's and Colitis Epidemiology Study ACCESS Group
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descriptionObjectiveThe rising incidence of inflammatory bowel disease in Asia supports the importance of environmental risk factors in disease aetiology. This prospective population-based case-control study in Asia-Pacific examined risk factors prior to patients developing IBD.Design442 incident cases (186 Crohn's disease (CD); 256 UC; 374 Asians) diagnosed between 2011 and 2013 from eight countries in Asia and Australia and 940 controls (frequency-matched by sex, age and geographical location; 789 Asians) completed an environmental factor questionnaire at diagnosis. Unconditional logistic regression models were used to estimate adjusted ORs (aOR) and 95% CIs.ResultsIn multivariate model, being breast fed >12 months (aOR 0.10; 95% CI 0.04 to 0.30), antibiotic use (aOR 0.19; 0.07 to 0.52), having dogs (aOR 0.54; 0.35 to 0.83), daily tea consumption (aOR 0.62; 0.43 to 0.91) and daily physical activity (aOR 0.58; 0.35 to 0.96) decreased the odds for CD in Asians. In UC, being breast fed >12 months (aOR 0.16; 0.08 to 0.31), antibiotic use (aOR 0.48; 0.27 to 0.87), daily tea (aOR 0.63; 0.46 to 0.86) or coffee consumption (aOR 0.51; 0.36 to 0.72), presence of hot water tap (aOR 0.65; 0.46 to 0.91) and flush toilet in childhood (aOR 0.71; 0.51 to 0.98) were protective for UC development whereas ex-smoking (aOR 2.02; 1.22 to 3.35) increased the risk of UC.ConclusionsThis first population-based study of IBD risk factors in Asia-Pacific supports the importance of childhood immunological, hygiene and dietary factors in the development of IBD, suggesting that markers of altered intestinal microbiota may modulate risk of IBD later in life.
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3Asia - epidemiology
4Australia - epidemiology
5Breast Feeding
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8Case-Control Studies
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21Inflammatory bowel diseases
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34Prospective Studies
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36Recall
37Risk Factors
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40Tuberculosis
41Whooping cough
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9de Silva, H J
10Kasturiratne, Anuradhani
11Senanayake, Yasith Udara
12Ooi, Choon Jin
13Ling, Khoon-Lin
14Ong, David
15Goh, Khean Lee
16Hilmi, Ida
17Ouyang, Qin
18Wang, Yu-Fang
19Hu, PinJin
20Zhu, Zhenhua
21Zeng, Zhirong
22Wu, Kaichun
23Wang, Xin
24Xia, Bing
25Li, Jin
26Pisespongsa, Pises
27Manatsathit, Sathaporn
28Aniwan, Satimai
29Simadibrata, Marcellus
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32Wong, Tai Chiu
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titleEnvironmental risk factors in inflammatory bowel disease: a population-based case-control study in Asia-Pacific
authorNg, Siew C ; Tang, Whitney ; Leong, Rupert W ; Chen, Minhu ; Ko, Yanna ; Studd, Corrie ; Niewiadomski, Ola ; Bell, Sally ; Kamm, Michael A ; de Silva, H J ; Kasturiratne, Anuradhani ; Senanayake, Yasith Udara ; Ooi, Choon Jin ; Ling, Khoon-Lin ; Ong, David ; Goh, Khean Lee ; Hilmi, Ida ; Ouyang, Qin ; Wang, Yu-Fang ; Hu, PinJin ; Zhu, Zhenhua ; Zeng, Zhirong ; Wu, Kaichun ; Wang, Xin ; Xia, Bing ; Li, Jin ; Pisespongsa, Pises ; Manatsathit, Sathaporn ; Aniwan, Satimai ; Simadibrata, Marcellus ; Abdullah, Murdani ; Tsang, Steve W C ; Wong, Tai Chiu ; Hui, Aric J ; Chow, Chung Mo ; Yu, Hon Ho ; Li, Mo Fong ; Ng, Ka Kei ; Ching, Jessica ; Wu, Justin C Y ; Chan, Francis K L ; Sung, Joseph J Y
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1Adult
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33Population
34Prospective Studies
35Questionnaires
36Recall
37Risk Factors
38Smoking - epidemiology
39Studies
40Tuberculosis
41Whooping cough
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8Kamm, Michael A
9de Silva, H J
10Kasturiratne, Anuradhani
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34Chow, Chung Mo
35Yu, Hon Ho
36Li, Mo Fong
37Ng, Ka Kei
38Ching, Jessica
39Wu, Justin C Y
40Chan, Francis K L
41Sung, Joseph J Y
42Asia-Pacific Crohn's and Colitis Epidemiology Study ACCESS Group
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jtitleGut
addtitleGut
date2015-07
risdate2015
volume64
issue7
spage1063
epage1071
pages1063-1071
issn0017-5749
eissn1468-3288
codenGUTTAK
abstractObjectiveThe rising incidence of inflammatory bowel disease in Asia supports the importance of environmental risk factors in disease aetiology. This prospective population-based case-control study in Asia-Pacific examined risk factors prior to patients developing IBD.Design442 incident cases (186 Crohn's disease (CD); 256 UC; 374 Asians) diagnosed between 2011 and 2013 from eight countries in Asia and Australia and 940 controls (frequency-matched by sex, age and geographical location; 789 Asians) completed an environmental factor questionnaire at diagnosis. Unconditional logistic regression models were used to estimate adjusted ORs (aOR) and 95% CIs.ResultsIn multivariate model, being breast fed >12 months (aOR 0.10; 95% CI 0.04 to 0.30), antibiotic use (aOR 0.19; 0.07 to 0.52), having dogs (aOR 0.54; 0.35 to 0.83), daily tea consumption (aOR 0.62; 0.43 to 0.91) and daily physical activity (aOR 0.58; 0.35 to 0.96) decreased the odds for CD in Asians. In UC, being breast fed >12 months (aOR 0.16; 0.08 to 0.31), antibiotic use (aOR 0.48; 0.27 to 0.87), daily tea (aOR 0.63; 0.46 to 0.86) or coffee consumption (aOR 0.51; 0.36 to 0.72), presence of hot water tap (aOR 0.65; 0.46 to 0.91) and flush toilet in childhood (aOR 0.71; 0.51 to 0.98) were protective for UC development whereas ex-smoking (aOR 2.02; 1.22 to 3.35) increased the risk of UC.ConclusionsThis first population-based study of IBD risk factors in Asia-Pacific supports the importance of childhood immunological, hygiene and dietary factors in the development of IBD, suggesting that markers of altered intestinal microbiota may modulate risk of IBD later in life.
copEngland
pubBritish Medical Association
pmid25217388
doi10.1136/gutjnl-2014-307410
oafree_for_read